MX9710529A - Compuestos terapeuticos. - Google Patents
Compuestos terapeuticos.Info
- Publication number
- MX9710529A MX9710529A MX9710529A MX9710529A MX9710529A MX 9710529 A MX9710529 A MX 9710529A MX 9710529 A MX9710529 A MX 9710529A MX 9710529 A MX9710529 A MX 9710529A MX 9710529 A MX9710529 A MX 9710529A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- compounds
- oac
- therapeutic compounds
- nhac
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Percussion Or Vibration Massage (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
Se describen compuestos de la formula (I), en donde R es halogeno, Y es hidrogeno; NH2, SH u OH; X es (11) en donde cualquiera de R1 o R2 es un enlace, con el otro siendo hidrogeno; cualquiera de R3 o R4 es hidrogeno, con el otro siendo hidrogeno; OH, OAc o NHAc; R5 es OH u OAc; cualquiera de R7 o R8 es hidrogeno, con el otro siendo OH u OAc; Rg es hidrogeno, CH2OH o CH2OAc; con la condicion de que cuando R4 es OH, OAc o NHAc entonces R8 es hidrogeno, y anantiomeros de dichos compuestos. También se proveen formulaciones farmacéuticas que comprenden dichos compuestos, su uso en el tratamiento de varios estados de enfermedad y métodos de tratamiento que emplean los compuestos.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9512868.2A GB9512868D0 (en) | 1995-06-23 | 1995-06-23 | Therapeutic compounds |
GB9512868.2 | 1995-06-23 | ||
GBGB9608372.0A GB9608372D0 (en) | 1996-04-23 | 1996-04-23 | Therapeutic compounds |
GB9608372.0 | 1996-04-23 | ||
GB9608547.7 | 1996-04-25 | ||
GBGB9608547.7A GB9608547D0 (en) | 1996-04-25 | 1996-04-25 | Therapeutic compounds |
US1676296P | 1996-05-03 | 1996-05-03 | |
US016762 | 1996-05-03 | ||
US1697396P | 1996-05-07 | 1996-05-07 | |
US016973 | 1996-05-07 | ||
PCT/GB1996/001519 WO1997000882A1 (en) | 1995-06-23 | 1996-06-24 | Therapeutic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9710529A true MX9710529A (es) | 1998-08-30 |
MXPA97010529A MXPA97010529A (es) | 1998-11-12 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
ATE204878T1 (de) | 2001-09-15 |
EP0851866B1 (en) | 2001-08-29 |
NO976043L (no) | 1998-02-20 |
JPH11507942A (ja) | 1999-07-13 |
HUP9901438A3 (en) | 2000-07-28 |
HUP9901438A2 (hu) | 1999-08-30 |
EP0851866A1 (en) | 1998-07-08 |
ID16479A (id) | 1997-10-02 |
DE69614867D1 (de) | 2001-10-04 |
WO1997000882A1 (en) | 1997-01-09 |
IL122700A0 (en) | 1998-12-06 |
ES2162078T3 (es) | 2001-12-16 |
NO976043D0 (no) | 1997-12-22 |
US5945406A (en) | 1999-08-31 |
AU6234296A (en) | 1997-01-22 |
KR19990028344A (ko) | 1999-04-15 |
CA2225247A1 (en) | 1997-01-09 |
DE69614867T2 (de) | 2002-04-11 |
CN1196059A (zh) | 1998-10-14 |
PL328266A1 (en) | 1999-01-18 |
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