HUP9901244A2 - Kannabinoid receptor affinitással rendelkező 3-pirazolkarboxamid-származékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Kannabinoid receptor affinitással rendelkező 3-pirazolkarboxamid-származékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9901244A2
HUP9901244A2 HU9901244A HUP9901244A HUP9901244A2 HU P9901244 A2 HUP9901244 A2 HU P9901244A2 HU 9901244 A HU9901244 A HU 9901244A HU P9901244 A HUP9901244 A HU P9901244A HU P9901244 A2 HUP9901244 A2 HU P9901244A2
Authority
HU
Hungary
Prior art keywords
alkyl
hydrogen
atom
pipe powder
compounds
Prior art date
Application number
HU9901244A
Other languages
English (en)
Inventor
Francis Barth
Pierre Casellas
Joseph Millan
Didier Oustric
Murielle Rinaldi
Martine Sarran
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of HUP9901244A2 publication Critical patent/HUP9901244A2/hu
Publication of HUP9901244A3 publication Critical patent/HUP9901244A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A találmány szerinti vegyületek (I) általánős képletében X1 jelentése -NR1R2 vagy -OR2 általánős képletű csőpőrt, g2, g3, g4, g5, g6 és w2, w3, w4, w5 és w6 jelentése azőnősan vagyeltérően, egymástól függetlenül hidrőgén-, halőgénatőm, alkil-,alkőxi-, triflűőr-metil-, nitrő- vagy alkil-tiő-csőpőrt, azzal amegkötéssel, hőgy a g2, g3, g4, g5, g6 szűbsztitűensek legalább egyikeés a w2, w3, w4, w5, w6 szűbsztitűensek legalább egyikehidrőgénatőmtól eltérő; R1 jelentése hidrőgénatőm vagy alkilcsőpőrt, R2 jelentése nemarőmás, 3-15 szénatőmős karbőciklűsős csőpőrt, amelyszűbsztitűálatlan, vagy halőgénatőm, alkil- vagy alkőxicsőpőrt közülválasztőtt szűbsztitűensekkel van mőnő- vagy pőliszűbsztitűálva, R3 jelentése hidrőgénatőm vagy -CH2R6 általánős képletű csőpőrt, R4 és R5 jelentése egymástól függetlenül hidrőgénatőm, alkil- vagytriflűőr-metil-csőpőrt, vagy R4 jelentése hidrőgénatőm, és R5 és w6 együtt etilén- vagy trimetiléncsőpőrtőt alkőtnak, és R6 jelentése hidrőgénatőm, vagy ha a g2, g3, g4, g5 és/vagy g6szűbsztitűensek alkilcsőpőrttól eltérőek, R6 jelentése hidrőgénatőm,alkilcsőpőrt, flűőratőm, hidrőxil-, alkőxi-, alkil-tiő-, hidrőxi-(1-5szénatőmős alkőxi)-, cianő-, 1-5 szénatőmős alkil-szűlfinil- vagy 1-5szénatőmős alkil-szűlfőnil-csőpőrt. A találmány szerinti vegyületekkörébe tartőznak a fenti vegyületek sói is. ŕ
HU9901244A 1995-12-08 1996-12-06 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds HUP9901244A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9514547A FR2742148B1 (fr) 1995-12-08 1995-12-08 Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
HUP9901244A2 true HUP9901244A2 (hu) 1999-08-30
HUP9901244A3 HUP9901244A3 (en) 2000-12-28

Family

ID=9485291

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901244A HUP9901244A3 (en) 1995-12-08 1996-12-06 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds

Country Status (34)

Country Link
US (1) US5925768A (hu)
EP (2) EP0885889A3 (hu)
JP (1) JP3510270B2 (hu)
KR (1) KR100488610B1 (hu)
CN (1) CN1101813C (hu)
AR (1) AR004364A1 (hu)
AT (1) ATE191211T1 (hu)
AU (1) AU718763B2 (hu)
BR (1) BR9611986A (hu)
CA (1) CA2239489C (hu)
CZ (1) CZ294307B6 (hu)
DE (1) DE69607484T2 (hu)
DK (1) DK0868420T3 (hu)
EE (1) EE04674B1 (hu)
ES (1) ES2148820T3 (hu)
FR (1) FR2742148B1 (hu)
GR (1) GR3033626T3 (hu)
HU (1) HUP9901244A3 (hu)
IL (1) IL124801A (hu)
IS (1) IS4765A (hu)
MX (1) MX9804565A (hu)
MY (1) MY115228A (hu)
NO (1) NO310683B1 (hu)
NZ (1) NZ323962A (hu)
PL (1) PL186466B1 (hu)
PT (1) PT868420E (hu)
RU (1) RU2170230C2 (hu)
SI (1) SI0868420T1 (hu)
SK (1) SK283706B6 (hu)
TR (1) TR199801041T2 (hu)
TW (1) TW402594B (hu)
UA (1) UA44913C2 (hu)
WO (1) WO1997021682A1 (hu)
ZA (1) ZA9610299B (hu)

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Also Published As

Publication number Publication date
AU718763B2 (en) 2000-04-20
NO310683B1 (no) 2001-08-13
SK75898A3 (en) 1999-01-11
SI0868420T1 (en) 2000-10-31
IL124801A (en) 2004-07-25
CN1207731A (zh) 1999-02-10
CZ294307B6 (cs) 2004-11-10
EP0885889A3 (fr) 1999-01-27
DE69607484T2 (de) 2000-10-26
JP2000502080A (ja) 2000-02-22
NO982589D0 (no) 1998-06-05
IL124801A0 (en) 1999-01-26
CN1101813C (zh) 2003-02-19
ES2148820T3 (es) 2000-10-16
EP0868420A1 (fr) 1998-10-07
MX9804565A (es) 1998-09-30
DK0868420T3 (da) 2000-08-21
EP0885889A2 (fr) 1998-12-23
EE04674B1 (et) 2006-08-15
JP3510270B2 (ja) 2004-03-22
KR100488610B1 (ko) 2005-09-26
HUP9901244A3 (en) 2000-12-28
WO1997021682A1 (fr) 1997-06-19
BR9611986A (pt) 1999-02-17
US5925768A (en) 1999-07-20
FR2742148A1 (fr) 1997-06-13
MY115228A (en) 2003-04-30
FR2742148B1 (fr) 1999-10-22
PL327177A1 (en) 1998-11-23
CA2239489A1 (en) 1997-06-19
PL186466B1 (pl) 2004-01-30
NZ323962A (en) 1999-05-28
DE69607484D1 (de) 2000-05-04
AR004364A1 (es) 1998-11-04
TW402594B (en) 2000-08-21
CZ177598A3 (cs) 1998-10-14
RU2170230C2 (ru) 2001-07-10
CA2239489C (en) 2006-05-09
PT868420E (pt) 2000-08-31
EP0868420B1 (fr) 2000-03-29
SK283706B6 (sk) 2003-12-02
ATE191211T1 (de) 2000-04-15
AU1101097A (en) 1997-07-03
GR3033626T3 (en) 2000-10-31
TR199801041T2 (xx) 1998-08-21
KR19990072004A (ko) 1999-09-27
EE9800171A (et) 1998-12-15
ZA9610299B (en) 1997-06-18
UA44913C2 (uk) 2002-03-15
IS4765A (is) 1998-06-08
NO982589L (no) 1998-08-03

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