HUP9701652A2 - Eljárás L-aminosav előállítására fermentáció útján - Google Patents

Eljárás L-aminosav előállítására fermentáció útján

Info

Publication number
HUP9701652A2
HUP9701652A2 HU9701652A HUP9701652A HUP9701652A2 HU P9701652 A2 HUP9701652 A2 HU P9701652A2 HU 9701652 A HU9701652 A HU 9701652A HU P9701652 A HUP9701652 A HU P9701652A HU P9701652 A2 HUP9701652 A2 HU P9701652A2
Authority
HU
Hungary
Prior art keywords
fermentation
amino acid
producing
mutation
enzyme
Prior art date
Application number
HU9701652A
Other languages
English (en)
Inventor
Yoshimi Kikuchi
Hiroyuki Kojima
Kauzo Nakanishi
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17509288&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9701652(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of HU9701652D0 publication Critical patent/HU9701652D0/hu
Publication of HUP9701652A2 publication Critical patent/HUP9701652A2/hu
Publication of HUP9701652A3 publication Critical patent/HUP9701652A3/hu
Publication of HU225538B1 publication Critical patent/HU225538B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány tárgyát őlyan műtációs hőrdőzó E. cőli aszpartőkináz-IIIenzimet kódőló DNS képezi, mely műtáció által az enzim fel vanszabadítva a lizin által kiváltőtt visszacsatőlásős gátlás alól. Atalálmány tárgyát képezik tővábbá a találmány szerinti DNS-t hőrdőzóvektőrők, a vektőrőkkal transzfőrmált mikrőőrganizműsők és eljárásőkL-aminősav előállítására fermentáció útján, a találmány szerintimikrőőrganizműsők alkalmazásával. A találmány szerinti megőldásalkalmas L-aminősavak ipari termelésére. ŕ
HU9701652A 1996-10-15 1997-10-15 Process for producing l-amino acid through fermentation HU225538B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27211496A JP4088982B2 (ja) 1996-10-15 1996-10-15 発酵法によるｌ−アミノ酸の製造法

Publications (4)

Publication Number Publication Date
HU9701652D0 HU9701652D0 (en) 1997-12-29
HUP9701652A2 true HUP9701652A2 (hu) 1999-06-28
HUP9701652A3 HUP9701652A3 (en) 2000-12-28
HU225538B1 HU225538B1 (en) 2007-02-28

Family

ID=17509288

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701652A HU225538B1 (en) 1996-10-15 1997-10-15 Process for producing l-amino acid through fermentation

Country Status (17)

Country Link
US (1) US5932453A (hu)
EP (1) EP0837134A3 (hu)
JP (1) JP4088982B2 (hu)
KR (1) KR100430168B1 (hu)
CN (1) CN1110560C (hu)
AU (1) AU725935B2 (hu)
BR (1) BR9705038B1 (hu)
CA (1) CA2214498C (hu)
CZ (1) CZ295853B6 (hu)
HU (1) HU225538B1 (hu)
ID (1) ID18631A (hu)
MY (1) MY138770A (hu)
PE (1) PE44399A1 (hu)
PL (1) PL192391B1 (hu)
RU (1) RU2204604C2 (hu)
SK (1) SK139297A3 (hu)
ZA (1) ZA979229B (hu)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2175351C2 (ru) * 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
MXPA02007154A (es) 2000-01-21 2004-09-06 Ajinomoto Kk Procedimiento para producir l-lisina.
DE10046934A1 (de) * 2000-09-21 2002-04-18 Consortium Elektrochem Ind Verfahren zur fermentativen Herstellung von nicht-proteinogenen L-Aminosäuren
US20030017554A1 (en) * 2000-11-15 2003-01-23 Mechthild Rieping Process for the fermentative preparation of L-amino acids using strains of the enterobacteriaceae family
JP2002209596A (ja) * 2001-01-19 2002-07-30 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
US20030054503A1 (en) * 2001-04-03 2003-03-20 Degussa Ag Process for the production of L-amino acids using strains of the family enterobacteriaceae that contain an attenuated dgsA gene
CA2453008C (en) * 2001-07-06 2011-03-22 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
JP2007185184A (ja) * 2005-12-16 2007-07-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2007086546A1 (en) * 2006-01-26 2007-08-02 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of enterobacteriaceae family with attenuated expression of the aldh gene
WO2007086618A1 (en) 2006-01-30 2007-08-02 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009095237A (ja) 2006-02-02 2009-05-07 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2009118740A (ja) * 2006-03-03 2009-06-04 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2007119574A2 (en) * 2006-03-23 2007-10-25 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna
JP2009060791A (ja) 2006-03-30 2009-03-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2007119890A1 (en) * 2006-04-18 2007-10-25 Ajinomoto Co., Inc. A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE sfmACDFH-fimZ CLUSTER OR THE fimZ GENE
JP2009165355A (ja) * 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
EP2035569A1 (en) * 2006-06-01 2009-03-18 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the rcsa gene
RU2337961C2 (ru) * 2006-07-04 2008-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-ТРЕОНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН rspAB
EP2046949B1 (en) * 2006-07-19 2014-01-15 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family
CN1928104B (zh) * 2006-09-07 2010-09-22 山东西王糖业有限公司 一种赖氨酸发酵液的二次发酵方法
JP2010017082A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010017081A (ja) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2008072761A2 (en) * 2006-12-11 2008-06-19 Ajinomoto Co., Inc. Method for producing an l-amino acid
RU2006143864A (ru) * 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2006145712A (ru) * 2006-12-22 2008-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной способностью к утилизации глицерина
JP2010088301A (ja) * 2007-02-01 2010-04-22 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010110216A (ja) 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
JP2010110217A (ja) 2007-02-22 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
RU2395579C2 (ru) * 2007-12-21 2010-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
JP2010263790A (ja) * 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
JP5217780B2 (ja) * 2008-02-08 2013-06-19 味の素株式会社 Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
ES2510865T3 (es) 2008-03-03 2014-10-21 Global Bio-Chem Technology Group Company Limited Microorganismo recombinante y procedimiento para producir L-lisina
GB0809169D0 (en) 2008-05-20 2008-06-25 Sinvent As Method of L-lysine production
JP5504608B2 (ja) * 2008-10-23 2014-05-28 東レ株式会社 １，５−ペンタンジアミンの製造方法
JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2382320B1 (en) 2009-01-23 2018-04-18 Ajinomoto Co., Inc. Process for producing l-amino acids employing bacteria of the enterobacteriacea family in a culture medium with controlled glycerol concentration
JP5521347B2 (ja) 2009-02-16 2014-06-11 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JPWO2011013707A1 (ja) 2009-07-29 2013-01-10 味の素株式会社 Ｌ−アミノ酸の製造法
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2363489A1 (en) * 2010-03-03 2011-09-07 Technische Universität Hamburg-Harburg Enzyme Aspartokinase III having a reduced L-lysine feedback inhibition
JP6071887B2 (ja) * 2010-10-28 2017-02-01 アディッソ・フランス・エス．エー．エス．Ａｄｉｓｓｅｏ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． ２，４−ジヒドロキシ酪酸の生成の方法
JP2015013812A (ja) 2011-11-01 2015-01-22 味の素株式会社 植物ウイルスの感染抑制剤およびそれを用いた植物ウイルス感染抑制方法
CN103773745B (zh) * 2012-10-18 2018-03-23 中粮生物化学（安徽）股份有限公司 天冬氨酸激酶iii突变体及其宿主细胞和应用
CN103215286B (zh) * 2012-11-12 2015-11-25 江南大学 用于发酵生产l-赖氨酸的重组dna、菌株及其应用
CN104099308B (zh) * 2013-04-03 2019-05-31 上海凯赛生物技术研发中心有限公司 一种具有天冬氨酸激酶活性的多肽及其应用
WO2014185430A1 (ja) 2013-05-13 2014-11-20 味の素株式会社 Ｌ－アミノ酸の製造法
CN103361289B (zh) * 2013-07-08 2014-12-31 南京工业大学 一株产l-赖氨酸的菌株及其生产l-赖氨酸的方法
RU2628696C1 (ru) 2013-10-02 2017-08-21 Адзиномото Ко., Инк. Способ получения основной аминокислоты (варианты)
RU2013144250A (ru) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА, КОДИРУЮЩЕГО ФОСФАТНЫЙ ТРАНСПОРТЕР
JP6459962B2 (ja) 2013-10-21 2019-01-30 味の素株式会社 Ｌ−アミノ酸の製造法
EP3061828A4 (en) 2013-10-23 2017-03-15 Ajinomoto Co., Inc. Method for producing target substance
US10889842B2 (en) 2014-01-16 2021-01-12 Calysta, Inc. Microorganisms for the enhanced production of amino acids and related methods
CN105505969A (zh) * 2014-09-26 2016-04-20 中国科学院天津工业生物技术研究所 一种提高l-苏氨酸转化率的方法及其应用
RU2015120052A (ru) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. Способ получения L-аминокислоты с использованием бактерии семейства Enterobacteriaceae, в которой ослаблена экспрессия гена gshA
CN106978405B (zh) * 2016-01-18 2021-03-12 中国科学院天津工业生物技术研究所 天冬氨酸激酶/高丝氨酸脱氢酶突变体及其应用
CN109121422B (zh) 2016-02-25 2021-12-21 味之素株式会社 使用过表达编码铁输出蛋白基因的肠杆菌科的细菌生产l-氨基酸的方法
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
BR112021011882A2 (pt) 2018-12-27 2021-09-08 Ajinomoto Co., Inc. Método para produzir um l-aminoácido básico
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
BR112021017870A2 (pt) 2019-04-05 2021-12-07 Ajinomoto Kk Método para produzir um l-aminoácido
JP2022550084A (ja) 2019-09-25 2022-11-30 味の素株式会社 細菌の発酵によるｌ－アミノ酸の製造方法

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Also Published As

Publication number Publication date
EP0837134A3 (en) 1999-09-22
HUP9701652A3 (en) 2000-12-28
PE44399A1 (es) 1999-05-05
SK139297A3 (en) 1998-06-03
AU725935B2 (en) 2000-10-26
HU225538B1 (en) 2007-02-28
HU9701652D0 (en) 1997-12-29
BR9705038B1 (pt) 2014-11-04
RU2204604C2 (ru) 2003-05-20
ZA979229B (en) 1998-05-11
CN1110560C (zh) 2003-06-04
JPH10113183A (ja) 1998-05-06
AU4096597A (en) 1998-04-23
KR19980032831A (ko) 1998-07-25
PL322611A1 (en) 1998-04-27
KR100430168B1 (ko) 2004-07-19
EP0837134A2 (en) 1998-04-22
MX9707921A (es) 1998-10-31
US5932453A (en) 1999-08-03
PL192391B1 (pl) 2006-10-31
ID18631A (id) 1998-04-30
CZ327297A3 (cs) 1998-06-17
CZ295853B6 (cs) 2005-11-16
CN1182133A (zh) 1998-05-20
JP4088982B2 (ja) 2008-05-21
BR9705038A (pt) 1999-04-06
CA2214498C (en) 2011-09-13
CA2214498A1 (en) 1998-04-15
MY138770A (en) 2009-07-31

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