HUP0402378A2 - Gyulladáskeltő citokinokat gátló spirociklikus 6,7-dihidro-5H-pirazolo[1,2-a]pirazol-1-onok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Gyulladáskeltő citokinokat gátló spirociklikus 6,7-dihidro-5H-pirazolo[1,2-a]pirazol-1-onok és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0402378A2
HUP0402378A2 HU0402378A HUP0402378A HUP0402378A2 HU P0402378 A2 HUP0402378 A2 HU P0402378A2 HU 0402378 A HU0402378 A HU 0402378A HU P0402378 A HUP0402378 A HU P0402378A HU P0402378 A2 HUP0402378 A2 HU P0402378A2
Authority
HU
Hungary
Prior art keywords
together form
groups
inflammatory cytokines
spirocyclic
atoms
Prior art date
Application number
HU0402378A
Other languages
English (en)
Inventor
Matthew J. Laufersweiler
Michael Phillip Clark
Jane Far-Jine Djung
Adam Golebiowski
Biswanath De
Todd Andrew Brugel
Original Assignee
The Procter & Gamble Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Co. filed Critical The Procter & Gamble Co.
Publication of HUP0402378A2 publication Critical patent/HUP0402378A2/hu
Publication of HUP0402378A3 publication Critical patent/HUP0402378A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

Abstract

A találmány tárgyát gyulladáskeltő citokinokat gátló (I) általánosképletű vegyületek - ahol R éter- vagy amino kötésű csoport; R1: a)szubsztituált vagy szubsztituálatlan aril; vagy b) szubsztituált vagyszubsztituálatian heteroaril-csoport; két azonos szénatomon levő R2csoport együtt 4-7 atomos spirociklikus gyűrűt képez, a maradék R2csoportok jelentése: a) hidrogénatom; b) -O (CH2)jR8; c) -(CH2)jNR9aR9b; d) - (CH2)jCO2R10; e) - (CH2)jOCO2R10; f) -(CH2)jCON(R10)2 általános képletű csoport; vagy g) két R2 csoportegyütt karbonilcsoportot képez; R8, R9a, R9b és R10 jelentésehidrogénatom, 1-4 szénatomos alkilcsoport és ezek keverékei; R9a ésR9b együtt 3-7 atomos karbociklikus vagy heterociklikus gyűrűt képez;két R10 csoport együtt 3-7 atomos karbociklikus vagy heterociklikusgyűrűt képez; j értéke 0-5 közötti; n értéke 3-5 közötti-, enantiomerés diasztereomer formák, gyógyászatilag elfogadható sóik és ezekettartalmazó gyógyszerkészítmények képezik. Ó
HU0402378A 2001-09-20 2002-09-20 Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones controlling inflammatory cytokines and pharmaceutical compositions containing them HUP0402378A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20
PCT/US2002/030133 WO2003024973A1 (en) 2001-09-20 2002-09-20 Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Publications (2)

Publication Number Publication Date
HUP0402378A2 true HUP0402378A2 (hu) 2005-02-28
HUP0402378A3 HUP0402378A3 (en) 2008-10-28

Family

ID=23259997

Family Applications (3)

Application Number Title Priority Date Filing Date
HU0402500A HUP0402500A3 (en) 2001-09-20 2002-09-20 Heterocondenzated pyrazol-3-one compounds which inhibit the release of inflammatory cytokines and pharmaceutical compositions containing them
HU0500752A HUP0500752A2 (en) 2001-09-20 2002-09-20 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
HU0402378A HUP0402378A3 (en) 2001-09-20 2002-09-20 Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones controlling inflammatory cytokines and pharmaceutical compositions containing them

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HU0402500A HUP0402500A3 (en) 2001-09-20 2002-09-20 Heterocondenzated pyrazol-3-one compounds which inhibit the release of inflammatory cytokines and pharmaceutical compositions containing them
HU0500752A HUP0500752A2 (en) 2001-09-20 2002-09-20 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Country Status (33)

Country Link
US (2) US6821971B2 (hu)
EP (3) EP1427728B1 (hu)
JP (3) JP2005504081A (hu)
KR (4) KR20040035837A (hu)
CN (3) CN1257905C (hu)
AR (3) AR037145A1 (hu)
AT (3) ATE356126T1 (hu)
AU (2) AU2002334641B2 (hu)
BR (3) BR0212905A (hu)
CA (3) CA2461071A1 (hu)
CO (3) CO5560590A2 (hu)
CY (1) CY1106398T1 (hu)
CZ (3) CZ2004361A3 (hu)
DE (3) DE60202782T2 (hu)
DK (2) DK1427732T3 (hu)
EG (2) EG24363A (hu)
ES (3) ES2282459T3 (hu)
HK (2) HK1071366A1 (hu)
HU (3) HUP0402500A3 (hu)
IL (3) IL160682A0 (hu)
MA (3) MA27064A1 (hu)
MX (3) MXPA04002574A (hu)
MY (2) MY129329A (hu)
NO (2) NO20041594L (hu)
NZ (3) NZ531063A (hu)
PE (3) PE20030474A1 (hu)
PL (3) PL370362A1 (hu)
PT (3) PT1427727E (hu)
RU (3) RU2299885C2 (hu)
SA (1) SA03230529B1 (hu)
SK (3) SK1482004A3 (hu)
WO (3) WO2003024971A1 (hu)
ZA (3) ZA200401260B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7473695B2 (en) 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
ATE355839T1 (de) * 2002-09-09 2007-03-15 Amgen Inc 1,4,5-substituierte 1,2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivate als tnf-alpha und interleukin senkende wirkstoffe zur behandlung von entzündungen
ES2285444T3 (es) * 2003-04-03 2007-11-16 Merck Patent Gmbh Derivados de la 1-(fenil)-amida)-2-(fenil)-amida) del acido pirazolidin-1,2-dicarboxilico como inhibidores del factor de coagulacion xa para el tratamiento de la trombosis.
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7482356B2 (en) * 2003-11-10 2009-01-27 The Procter & Gamble Company Bicyclic pyrazolone cytokine inhibitors
RU2450006C2 (ru) * 2006-04-18 2012-05-10 Эбботт Лэборетриз Антагонисты ванилоидного рецептора подтипа 1(vr1) и их применение
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
RU2011151603A (ru) * 2009-05-19 2013-06-27 ДАУ АГРОСАЙЕНСИЗ ЭлЭсСи Соединения и способы борьбы с грибами
EP3308059B1 (en) 2015-06-15 2021-05-26 Cummins, Inc. Combustion chamber elasticity device
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CN107033090B (zh) * 2017-05-16 2019-05-07 无锡捷化医药科技有限公司 一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) * 2019-09-06 2020-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
WO2023076133A1 (en) * 2021-10-27 2023-05-04 Merck Sharp & Dohme Llc Spirotricycle ripk1 inhibitors and methods of uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054291A (hu) 1963-02-26
GB1124982A (en) * 1965-02-09 1968-08-21 Lepetit Spa Diazabicyclo octanes and derivatives thereof
CH529154A (fr) 1969-10-27 1972-10-15 Lepetit Spa Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) * 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
RU2269537C2 (ru) * 1999-09-07 2006-02-10 Зингента Партисипейшнс Аг Фенилзамещенные гетероциклические 1,3-кетоенолы, способ их получения, гербицидное средство на их основе и способ борьбы с ростом нежелательной растительности
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Also Published As

Publication number Publication date
ES2282459T3 (es) 2007-10-16
IL160741A0 (en) 2004-08-31
PE20030430A1 (es) 2003-06-24
BR0212716A (pt) 2004-08-03
KR20040035836A (ko) 2004-04-29
EP1427728A1 (en) 2004-06-16
CN1250551C (zh) 2006-04-12
MXPA04002570A (es) 2004-05-31
JP2005504081A (ja) 2005-02-10
CA2461072A1 (en) 2003-03-27
EP1427727A1 (en) 2004-06-16
CO5560579A2 (es) 2005-09-30
US6821971B2 (en) 2004-11-23
DE60213108D1 (de) 2006-08-24
RU2272040C2 (ru) 2006-03-20
SA03230529B1 (ar) 2008-06-21
AU2002334641B2 (en) 2007-03-29
DE60202782T2 (de) 2006-01-19
WO2003024971A1 (en) 2003-03-27
WO2003024973A1 (en) 2003-03-27
ES2268154T3 (es) 2007-03-16
RU2004111805A (ru) 2005-04-10
EP1427728B1 (en) 2007-03-07
CN1249066C (zh) 2006-04-05
AR037237A1 (es) 2004-11-03
PT1427728E (pt) 2007-05-31
HUP0402500A2 (hu) 2005-03-29
CY1106398T1 (el) 2011-10-12
HUP0402500A3 (en) 2008-10-28
US20030105084A1 (en) 2003-06-05
HUP0500752A2 (en) 2006-01-30
KR100623879B1 (ko) 2006-09-19
US6566357B1 (en) 2003-05-20
PL370362A1 (en) 2005-05-16
AR037502A1 (es) 2004-11-17
DE60202782D1 (de) 2005-03-03
PE20030474A1 (es) 2003-07-22
KR20040035835A (ko) 2004-04-29
IL160742A0 (en) 2004-08-31
SK1502004A3 (en) 2004-09-08
BR0212673A (pt) 2004-08-24
JP2005504082A (ja) 2005-02-10
DK1427728T3 (da) 2007-07-09
ZA200401402B (en) 2004-08-27
ATE356126T1 (de) 2007-03-15
NO20041594L (no) 2004-06-21
PE20030446A1 (es) 2003-07-21
PL370415A1 (en) 2005-05-30
EP1427732B1 (en) 2006-07-12
CA2461071A1 (en) 2003-03-27
NZ531063A (en) 2007-08-31
CN1257905C (zh) 2006-05-31
PT1427732E (pt) 2006-12-29
DE60218704D1 (de) 2007-04-19
MXPA04002574A (es) 2004-06-18
MA27064A1 (fr) 2004-12-20
MXPA04002569A (es) 2004-05-31
JP2005504083A (ja) 2005-02-10
WO2003024970A1 (en) 2003-03-27
AR037145A1 (es) 2004-10-27
IL160682A0 (en) 2004-08-31
ES2237691T3 (es) 2005-08-01
EG24363A (en) 2009-03-04
MA27066A1 (fr) 2004-12-20
RU2004111806A (ru) 2005-03-27
CZ2004345A3 (cs) 2004-06-16
ZA200401403B (en) 2004-08-30
CO5560590A2 (es) 2005-09-30
HK1071565A1 (en) 2005-07-22
RU2278864C2 (ru) 2006-06-27
ATE332901T1 (de) 2006-08-15
NZ531122A (en) 2005-09-30
EP1427727B1 (en) 2005-01-26
PL370351A1 (en) 2005-05-16
RU2299885C2 (ru) 2007-05-27
ATE287887T1 (de) 2005-02-15
HUP0402378A3 (en) 2008-10-28
DE60218704T2 (de) 2007-11-08
CN1555375A (zh) 2004-12-15
NO20041605L (no) 2004-06-21
CZ2004361A3 (cs) 2004-07-14
HK1071366A1 (en) 2005-07-15
NZ531123A (en) 2006-08-31
EG24413A (en) 2009-05-25
CO5560589A2 (es) 2005-09-30
KR20060036125A (ko) 2006-04-27
EP1427732A1 (en) 2004-06-16
DE60213108T2 (de) 2007-02-08
ZA200401260B (en) 2004-08-30
CZ2004358A3 (cs) 2004-07-14
SK1482004A3 (en) 2004-08-03
BR0212905A (pt) 2004-10-13
MY129069A (en) 2007-03-30
MA27065A1 (fr) 2004-12-20
RU2004111803A (ru) 2005-10-10
AU2002327690B2 (en) 2006-07-20
SK1492004A3 (en) 2004-11-03
CN1556811A (zh) 2004-12-22
KR100656126B1 (ko) 2006-12-12
PT1427727E (pt) 2005-06-30
CN1555379A (zh) 2004-12-15
MY129329A (en) 2007-03-30
KR20040035837A (ko) 2004-04-29
DK1427732T3 (da) 2006-10-30
CA2461073A1 (en) 2003-03-27

Similar Documents

Publication Publication Date Title
HUP0402378A2 (hu) Gyulladáskeltő citokinokat gátló spirociklikus 6,7-dihidro-5H-pirazolo[1,2-a]pirazol-1-onok és az ezeket tartalmazó gyógyszerkészítmények
HUP0203575A2 (hu) Th2 differenciálódás inhibitorokat tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0300138A2 (en) Cyclic amine derivatives as ccr5 antagonists, their production and use and pharmaceutical compositions containing them
HUP0002208A2 (en) Use of sulphonamide derivatives for the preparation of pharmaceutical compositions potentiating glutamate receptor function
HUP0204474A2 (hu) 1H-imidazopiridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0401898A2 (hu) 3-Szubsztituált-4-pirimidon-származékok, ezeket tartalmazó gyógyászati készítmények és intermedierjeik
CA2475432A1 (en) 2,4,6-triamino-1,3,5-triazine derivative
WO2003055441A3 (en) Medicaments
HUP0204496A2 (en) Novel piperidine compounds and pharmaceutical compositions containing the same and process for preparation the same
HUP0300974A2 (hu) Ciklin-dependens kinázok N-{5-[(5--alkil-2-oxazolil)-metil-tio]-2-tiazolil}-karboxamid inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0003921A2 (hu) VLA-4 által közvetített leukocitaadhéziót gátló szulfonilezett dipeptidszármazékok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
HUP0401982A2 (hu) Indolizinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
HUP0301607A2 (hu) Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0004595A2 (hu) Aciklikus metalloproteáz inhibitorok
HUP0300832A2 (hu) Új, lassú hatású bétamimetikumok, eljárás előállításukra és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
DK0657458T3 (da) Inhibitorer af proteinkinase-C
HUP0202799A2 (hu) Herbicid hatású izoxazolinszármazékok és azt tartalmazó készítmény
MY130830A (en) Inhibitors
IL113778A (en) Condensed-indan derivatives pharmaceutical compositions containing the same and methods for the preparation thereof
NO20015446L (no) Kinolin-derivater som inhibitorer for MEK-enzymer
HUP0302968A2 (hu) (Aminoalkilbenzoil)benzofuránok vagy -benzotiofének, eljárás a vegyületek előállítására és a vegyületeket tartalmazó készítmények
MY140749A (en) Novel piperidine compound
HUP0004142A2 (hu) 5-HT1F agonista hatású karboxamidszármazékok és a vegyületeket tartalmazó gyógyászati készítmények
AU2001269540A1 (en) Serotonin reuptake inhibitors
HUP0102931A2 (hu) Új N-(triazolil-metil)-piperazin-származékok mint neurokininreceptor-antagonisták

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees