HUP0004142A2 - 5-HT1F agonista hatású karboxamidszármazékok és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

5-HT1F agonista hatású karboxamidszármazékok és a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0004142A2
HUP0004142A2 HU0004142A HUP0004142A HUP0004142A2 HU P0004142 A2 HUP0004142 A2 HU P0004142A2 HU 0004142 A HU0004142 A HU 0004142A HU P0004142 A HUP0004142 A HU P0004142A HU P0004142 A2 HUP0004142 A2 HU P0004142A2
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
compositions containing
carboxamide derivatives
compounds
ht1f agonists
Prior art date
Application number
HU0004142A
Other languages
English (en)
Inventor
Michael Edward Flaugh
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP0004142A2 publication Critical patent/HUP0004142A2/hu
Publication of HUP0004142A3 publication Critical patent/HUP0004142A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A találmány tárgyát az (I) általános képletűvegyületek, amelyekben R1 és R2 jelentése egymástól függetlenülhidrogénatom, 1-4 szénatomos alkilcsoport vagy -CH2-CH2-aril- csoport,ahol az arilcsoport jelentése fenilcsoport, halogénatommal.helyettesített fenilcsoport vagy 1-(1-6 szénatomos alkil)-pirazol-4-il-csoport, R3 jelentése 3-6 szénatomos cikloalkil-csoport vagyheterociklusos csoport, és n értéke 1 vagy 2, és ezen vegyületekgyógyászatilag elfogadható sói vagy szolvátjai képezik. A fentivegyületeket neuronális fehérjekiszivárgás gátlására, és migrénkezelésére alkalmazhatóak. Ó
HU0004142A 1997-06-04 1998-06-01 Carboxamide derivatives as 5-ht1f agonists and pharmaceutical compositions containing them HUP0004142A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4858497P 1997-06-04 1997-06-04
PCT/US1998/003340 WO1998055115A1 (en) 1997-06-04 1998-06-01 Carboxamides useful as 5-ht1f agonists

Publications (2)

Publication Number Publication Date
HUP0004142A2 true HUP0004142A2 (hu) 2001-05-28
HUP0004142A3 HUP0004142A3 (en) 2002-10-28

Family

ID=21955349

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004142A HUP0004142A3 (en) 1997-06-04 1998-06-01 Carboxamide derivatives as 5-ht1f agonists and pharmaceutical compositions containing them

Country Status (21)

Country Link
EP (1) EP0882726B1 (hu)
JP (1) JP2002502419A (hu)
KR (1) KR20010013409A (hu)
CN (1) CN1259049A (hu)
AT (1) ATE240953T1 (hu)
AU (1) AU729786B2 (hu)
BR (1) BR9810610A (hu)
CA (1) CA2291624A1 (hu)
DE (1) DE69814735T2 (hu)
DK (1) DK0882726T3 (hu)
EA (1) EA001718B1 (hu)
ES (1) ES2199410T3 (hu)
HU (1) HUP0004142A3 (hu)
ID (1) ID23053A (hu)
IL (1) IL133279A0 (hu)
NO (1) NO995963D0 (hu)
NZ (1) NZ501569A (hu)
PL (1) PL337221A1 (hu)
PT (1) PT882726E (hu)
TR (1) TR199903014T2 (hu)
WO (1) WO1998055115A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034266A1 (en) * 1998-12-11 2000-06-15 Eli Lilly And Company Indole derivatives and their use as 5-ht1f agonists
US6713473B1 (en) 1999-04-20 2004-03-30 Meiji Seika Kaisha, Ltd. Tricyclic compounds
AU772075B2 (en) * 1999-08-04 2004-04-08 Icagen, Inc. Methods for treating or preventing pain and anxiety
US6495550B2 (en) 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
NZ516610A (en) 1999-08-04 2004-05-28 Icagen Inc Benzanilides as potassium channel openers
TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
EP1626958B1 (en) 2003-04-18 2012-06-27 Eli Lilly And Company (piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht 1f agonists
UA82711C2 (en) 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
EP1697305B1 (en) 2003-12-17 2007-08-15 Eli Lilly And Company Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists
CN101243046A (zh) 2005-08-08 2008-08-13 安斯泰来制药有限公司 酰基胍衍生物或其盐
US20100324017A1 (en) * 2007-02-07 2010-12-23 Isao Kinoyama Acylguanidine derivative
PT2558447E (pt) * 2010-03-22 2014-11-25 Actelion Pharmaceuticals Ltd Derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9hcarbazol e o seu uso como moduladores do receptor de prostaglandina d2
WO2011123654A1 (en) 2010-04-02 2011-10-06 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists
WO2014167326A1 (en) * 2013-04-09 2014-10-16 Cresset Biomolecular Discovery Ltd The local treatment of inflammatory ophthalmic diseases
TWI829107B (zh) 2019-07-09 2024-01-11 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN112125836A (zh) * 2020-10-15 2020-12-25 濮阳惠成电子材料股份有限公司 有机电致光电材料中间体n-苯基咔唑-3-羧酸乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
CA2179678A1 (en) * 1995-06-23 1996-12-24 Michael Edward Flaugh 6-substituted-1,2,3,4-tetrahydro-9h-carbazoles and 7-substituted-10h-cyclohepta¬7,6-b| indoles

Also Published As

Publication number Publication date
ATE240953T1 (de) 2003-06-15
TR199903014T2 (xx) 2000-05-22
IL133279A0 (en) 2001-04-30
EA199901113A1 (ru) 2000-08-28
DE69814735T2 (de) 2004-03-25
JP2002502419A (ja) 2002-01-22
CN1259049A (zh) 2000-07-05
PT882726E (pt) 2003-09-30
ID23053A (id) 2000-01-20
HUP0004142A3 (en) 2002-10-28
PL337221A1 (en) 2000-08-14
DK0882726T3 (da) 2003-09-22
AU729786B2 (en) 2001-02-08
ES2199410T3 (es) 2004-02-16
EA001718B1 (ru) 2001-08-27
EP0882726B1 (en) 2003-05-21
NO995963L (no) 1999-12-03
NZ501569A (en) 2001-11-30
WO1998055115A1 (en) 1998-12-10
KR20010013409A (ko) 2001-02-26
DE69814735D1 (de) 2003-06-26
EP0882726A1 (en) 1998-12-09
NO995963D0 (no) 1999-12-03
CA2291624A1 (en) 1998-12-10
AU7795598A (en) 1998-12-21
BR9810610A (pt) 2000-09-12

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