HUP0401936A2 - Benzamid- és heteroaril-karbonsavamid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények P2X7 által szabályozott betegség kezelésére - Google Patents

Benzamid- és heteroaril-karbonsavamid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények P2X7 által szabályozott betegség kezelésére

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Publication number
HUP0401936A2
HUP0401936A2 HU0401936A HUP0401936A HUP0401936A2 HU P0401936 A2 HUP0401936 A2 HU P0401936A2 HU 0401936 A HU0401936 A HU 0401936A HU P0401936 A HUP0401936 A HU P0401936A HU P0401936 A2 HUP0401936 A2 HU P0401936A2
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Hungary
Prior art keywords
group
groups
benzamide
treatment
pharmaceutical compositions
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Application number
HU0401936A
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English (en)
Inventor
Allen Jacob Duplantier
Chakrapani Subramanyam
Original Assignee
Pfizer Products Inc.
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Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0401936A2 publication Critical patent/HUP0401936A2/hu
Publication of HUP0401936A3 publication Critical patent/HUP0401936A3/hu

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

A találmány tárgyát képezik az (I) általános képletű vegyületek ahol aképletben A jelentése -C(=O)NH- vagy -NH(C=O)-csoport; X; Y és Zjelentése sorrendben =(CR6)-, =(CR7)- és =(CR8)-csoport; vagy =N- és=(CR7)- és =(CR8)-csoport; vagy =(CR6)-, =N- és =(CR8)-csoport; vagy=(CR6)-, =(CR7)- és =N-csoport; vagy =N-, =(CR7)- és =N-csoport; vagy=(CR6)-, =N- és =N- csoport; R6, R7 és R8 jelentései a leírásbanmegadottak; Rl jelentése egyebek mellett nitrogénhez kapcsolódó 1-10szénatomos heterociklilcsoport, amely 1-6 heteroatomot tartalmaz az -N=, -N<F255>, -NH-, -O- és -S(O)n-csoport köréből egymástólfüggetlenül választva; R2 jelentése klór-, brómatom, 1-4 szénatomosalkil-, CF3- vagy -CN-csoport; R3 jelentése egyebek mellett 4-10szénatomos alkilcsoport, vagy az említett vegyületek gyógyászatilagelfogadható sói, szolvátjai vagy elővegyületei. A találmány tárgyátképezik továbbá a fenti vegyületeket tartalmazó gyógyászatikészítmények. Ó
HU0401936A 2001-11-12 2002-11-04 Benzamide and heteroaryl carboxylic amide derivatives and pharmaceutical compositions containing them for the treatment of a p2x7 mediated disease HUP0401936A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33678101P 2001-11-12 2001-11-12
PCT/IB2002/004613 WO2003042191A1 (en) 2001-11-12 2002-11-04 Benzamide and heteroarylamide as p2x7 receptor antagonists

Publications (2)

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HUP0401936A2 true HUP0401936A2 (hu) 2005-01-28
HUP0401936A3 HUP0401936A3 (en) 2006-04-28

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HU0401936A HUP0401936A3 (en) 2001-11-12 2002-11-04 Benzamide and heteroaryl carboxylic amide derivatives and pharmaceutical compositions containing them for the treatment of a p2x7 mediated disease

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US (2) US7214677B2 (hu)
EP (1) EP1448535B1 (hu)
JP (1) JP4365218B2 (hu)
KR (1) KR20050043785A (hu)
CN (1) CN1585755A (hu)
AP (1) AP2004003028A0 (hu)
AR (1) AR038365A1 (hu)
AT (1) ATE502020T1 (hu)
BR (1) BR0214044A (hu)
CA (1) CA2466724C (hu)
CY (1) CY1111405T1 (hu)
DE (1) DE60239485D1 (hu)
DK (1) DK1448535T3 (hu)
EA (1) EA200400488A1 (hu)
EC (1) ECSP045097A (hu)
ES (1) ES2358988T3 (hu)
GT (1) GT200200224A (hu)
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