HUP0302477A2 - Szubsztituált indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és ezek alkalmazása PPAR-gamma kötő szerként - Google Patents
Szubsztituált indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és ezek alkalmazása PPAR-gamma kötő szerkéntInfo
- Publication number
- HUP0302477A2 HUP0302477A2 HU0302477A HUP0302477A HUP0302477A2 HU P0302477 A2 HUP0302477 A2 HU P0302477A2 HU 0302477 A HU0302477 A HU 0302477A HU P0302477 A HUP0302477 A HU P0302477A HU P0302477 A2 HUP0302477 A2 HU P0302477A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally substituted
- heterocycloalkyl
- cycloalkenyl
- cycloalkyl
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 2
- 239000011230 binding agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 4
- 125000004434 sulfur atom Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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Abstract
A találmány szerinti vegyületek (I) általános képletében R1 jelentéseegyenként alkilcsoporton, alkenilcsoporton, alkinilcsoporton,alkilszulfonilcsoport vagy alkilkarbonilcsoporton keresztül kapcsolódóés egyenként adott esetben szubsztituált fenilcsoport,cikloalkilcsoport, heterocikloalkilcsoport, cikloalkenilcsoport vagyheterocikloalkenilcsoport, X jelentése adott esetben szubsztituáltiminocsoport, oxigénatom vagy kénatom, R2 jelentése hidrogénatom,alkilcsoport, halogénalkilcsoport vagy egyenkéntalkilszulfonilcsoporton keresztül kapcsolódó és egyenként adottesetben szubsztituált arilcsoport vagy heteroarilcsoport, R3 jelentéseegyenként adott esetben alkilcsoporton, alkenilcsoporton,alkinilcsoporton vagy karbonilcsoporton keresztül kapcsolódó ésegyenként adott esetben szubsztituált cikloalkilcsoport,cikloalkenilcsoport, heterocikloalkilcsoport vagyheterocikloalkenilcsoport vagy adott esetben szubsztituált arilcsoportvagy heteroarilcsoport, R4 jelentése egyenként adott esetbenszubsztituált iminocsoporton, kénatomon vagy oxigénatomon keresztülkapcsolódó és egyenként adott esetben szubsztituált alkilcsoport,cikloalkilcsoport, heterocikloalkilcsoport, cikloalkenilcsoport vagyheterocikloalkenilcsoport, R5 jelentése hidrogénatom, karboxilcsoport,alkilkarboxicsoport, egyenként karbonilcsoporton keresztül kapcsolódóalkilcsoport, cikloalkilcsoport, heterocikloalkilcsoport,cikloalkenilcsoport, heterocikloalkenilcsoport, arilcsoport vagyheteroarilcsoport, cikloalkilcsoport, heterocikloalkilcsoport,cikloalkenilcsoport vagy heterocikloalkenilcsoport, egyenként adottesetben szubsztituált iminocsoporton, kénatomon vagy oxigénatomonkeresztül kapcsolódó és egyenként adott esetben szubsztituáltalkilcsoport, alkenilcsoport, alkinilcsoport,cikloalkilkarbonilcsoport, heterocikloalkilkarbonilcsoport,cikloalkenilkarbonilcsoport, heterocikloalkenilkarbonilcsoport vagyaminokarbonilcsoport, vagy R5 és R6 jelentése együtt két végénegymástól függetlenül adott esetben szubsztituált iminocsoporton,kénatomon vagy oxigénatomon keresztül kapcsolódó alkilénlánc, R6jelentése hidrogénatom, hidroxilcsoport, egyenként adott esetbenszubsztituált iminocsoporton kénatomon vagy oxigénatomon keresztülkapcsolódó és egyenként adott esetben szubsztituált alkilcsoport,cikloalkilcsoport, heterocikloalkilcsoport, cikloalkenilcsoport,heterocikloalkenilcsoport, arilcsoport vagy heteroarilcsoport, R7jelentése hidrogénatom, egyenként karbonilcsoporton keresztülkapcsolódó alkilcsoport, cikloalkilcsoport, heterocikloalkilcsoport,cikloalkenilcsoport, heterocikloalkenilcsoport, arilcsoport vagyheteroarilcsoport, egyenként adott esetben szubsztituáltiminocsoporton, kénatomon vagy oxigénatomon keresztül ka
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US23919500P | 2000-10-10 | 2000-10-10 | |
US24366500P | 2000-10-27 | 2000-10-27 | |
PCT/US2001/042644 WO2002030895A1 (en) | 2000-10-10 | 2001-10-09 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS |
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HUP0302477A2 true HUP0302477A2 (hu) | 2003-12-29 |
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HU0302477A HUP0302477A2 (hu) | 2000-10-10 | 2001-10-09 | Szubsztituált indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és ezek alkalmazása PPAR-gamma kötő szerként |
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US (1) | US6787651B2 (hu) |
EP (1) | EP1341761A1 (hu) |
JP (1) | JP2004529855A (hu) |
KR (1) | KR20030036917A (hu) |
CN (1) | CN1505613A (hu) |
AR (1) | AR035348A1 (hu) |
AU (1) | AU2002211901A1 (hu) |
CA (1) | CA2427499A1 (hu) |
HU (1) | HUP0302477A2 (hu) |
IL (1) | IL154981A0 (hu) |
MX (1) | MXPA03003174A (hu) |
NO (1) | NO20031619L (hu) |
PL (1) | PL366068A1 (hu) |
WO (1) | WO2002030895A1 (hu) |
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US5686481A (en) | 1993-12-21 | 1997-11-11 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
US5891902A (en) | 1994-01-18 | 1999-04-06 | Kyowa Hakko Kogyo Co., Ltd. | Indole derivatives |
US5563157B1 (en) | 1994-10-31 | 1999-02-02 | Hoecst Marion Roussel Inc | Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof |
US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
AU4514496A (en) | 1994-12-13 | 1996-07-03 | Smithkline Beecham Corporation | Novel compounds |
US5902726A (en) | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
EP0782989A4 (en) * | 1995-07-18 | 1999-04-21 | Kyowa Hakko Kogyo Kk | INDOL DERIVATIVES |
JPH09100278A (ja) | 1995-10-03 | 1997-04-15 | Kyowa Hakko Kogyo Co Ltd | インドール誘導体の製造法 |
DE19543639A1 (de) * | 1995-11-23 | 1997-05-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
US5869519A (en) | 1996-12-16 | 1999-02-09 | Idun Pharmaceuticals, Inc. | C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US5877197A (en) | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6090839A (en) | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
JPH10195048A (ja) | 1997-01-17 | 1998-07-28 | Sumitomo Chem Co Ltd | 3−(ニトロベンゾイル)インドール誘導体の製造法 |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB9805716D0 (en) | 1998-03-17 | 1998-05-13 | Merck Sharp & Dohme | Therapeutic agents |
US6121271A (en) | 1998-05-12 | 2000-09-19 | American Home Products Corporation | Naphtho[2,3-B]heteroar-4-yl derivatives |
WO2000023425A1 (en) * | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
GB9824614D0 (en) | 1998-11-11 | 1999-01-06 | Glaxo Group Ltd | Chemical compounds |
WO2000044743A1 (fr) | 1999-01-28 | 2000-08-03 | Nippon Shinyaku Co., Ltd. | Derives d'amides et compositions de medicaments |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
-
2001
- 2001-10-09 JP JP2002534281A patent/JP2004529855A/ja not_active Ceased
- 2001-10-09 IL IL15498101A patent/IL154981A0/xx unknown
- 2001-10-09 CN CNA018203140A patent/CN1505613A/zh active Pending
- 2001-10-09 AU AU2002211901A patent/AU2002211901A1/en not_active Abandoned
- 2001-10-09 KR KR10-2003-7005093A patent/KR20030036917A/ko not_active Application Discontinuation
- 2001-10-09 CA CA002427499A patent/CA2427499A1/en not_active Abandoned
- 2001-10-09 EP EP01979996A patent/EP1341761A1/en not_active Withdrawn
- 2001-10-09 US US09/974,319 patent/US6787651B2/en not_active Expired - Fee Related
- 2001-10-09 MX MXPA03003174A patent/MXPA03003174A/es unknown
- 2001-10-09 WO PCT/US2001/042644 patent/WO2002030895A1/en not_active Application Discontinuation
- 2001-10-09 HU HU0302477A patent/HUP0302477A2/hu unknown
- 2001-10-09 PL PL01366068A patent/PL366068A1/xx not_active Application Discontinuation
- 2001-10-10 AR ARP010104758A patent/AR035348A1/es not_active Application Discontinuation
-
2003
- 2003-04-09 NO NO20031619A patent/NO20031619L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20031619D0 (no) | 2003-04-09 |
IL154981A0 (en) | 2003-10-31 |
PL366068A1 (en) | 2005-01-24 |
WO2002030895A1 (en) | 2002-04-18 |
KR20030036917A (ko) | 2003-05-09 |
JP2004529855A (ja) | 2004-09-30 |
US6787651B2 (en) | 2004-09-07 |
CA2427499A1 (en) | 2002-04-18 |
US20030087902A1 (en) | 2003-05-08 |
AR035348A1 (es) | 2004-05-12 |
EP1341761A1 (en) | 2003-09-10 |
CN1505613A (zh) | 2004-06-16 |
NO20031619L (no) | 2003-06-02 |
AU2002211901A1 (en) | 2002-04-22 |
MXPA03003174A (es) | 2003-07-14 |
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