FR2880889B1 - Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique - Google Patents

Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique

Info

Publication number
FR2880889B1
FR2880889B1 FR0500422A FR0500422A FR2880889B1 FR 2880889 B1 FR2880889 B1 FR 2880889B1 FR 0500422 A FR0500422 A FR 0500422A FR 0500422 A FR0500422 A FR 0500422A FR 2880889 B1 FR2880889 B1 FR 2880889B1
Authority
FR
France
Prior art keywords
processes
preparation
pharmaceutical compositions
indole
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0500422A
Other languages
English (en)
Other versions
FR2880889A1 (fr
Inventor
Nathalie Adje
Didier Roche
Stephane Yvon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0500422A priority Critical patent/FR2880889B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to PCT/EP2005/013634 priority patent/WO2006074789A1/fr
Priority to MX2007008350A priority patent/MX2007008350A/es
Priority to KR1020077016037A priority patent/KR20070104353A/ko
Priority to JP2007550701A priority patent/JP5042855B2/ja
Priority to DE602005013118T priority patent/DE602005013118D1/de
Priority to CNA2005800465385A priority patent/CN101098865A/zh
Priority to ES05817577T priority patent/ES2321745T3/es
Priority to BRPI0519839-9A priority patent/BRPI0519839A2/pt
Priority to CA2594377A priority patent/CA2594377C/fr
Priority to US11/813,922 priority patent/US7754740B2/en
Priority to AU2005324895A priority patent/AU2005324895B2/en
Priority to AT05817577T priority patent/ATE424394T1/de
Priority to EP05817577A priority patent/EP1836187B1/fr
Publication of FR2880889A1 publication Critical patent/FR2880889A1/fr
Application granted granted Critical
Publication of FR2880889B1 publication Critical patent/FR2880889B1/fr
Priority to ZA200706707A priority patent/ZA200706707B/xx
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR0500422A 2005-01-14 2005-01-14 Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique Expired - Fee Related FR2880889B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR0500422A FR2880889B1 (fr) 2005-01-14 2005-01-14 Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
US11/813,922 US7754740B2 (en) 2005-01-14 2005-12-17 1H-indole-3-carboxylic acid derivatives and their use as PPAR agonists
KR1020077016037A KR20070104353A (ko) 2005-01-14 2005-12-17 1ｈ-인돌-３-카르복실산 유도체 및 ｐｐａｒ 작용제로서의이의 용도
JP2007550701A JP5042855B2 (ja) 2005-01-14 2005-12-17 １ｈ−インドール−３−カルボン酸誘導体およびｐｐａｒアゴニストとしてのその使用
DE602005013118T DE602005013118D1 (de) 2005-01-14 2005-12-17 1h-indol-3-carbonsäurederivate und deren verwendung als ppar-agonisten
CNA2005800465385A CN101098865A (zh) 2005-01-14 2005-12-17 1h-吲哚-3-羧酸衍生物及其作为ppar激动剂的用途
ES05817577T ES2321745T3 (es) 2005-01-14 2005-12-17 Derivados del acido 1h-indol-3-carboxilico y su empleo como agonistas de ppar.
BRPI0519839-9A BRPI0519839A2 (pt) 2005-01-14 2005-12-17 derivados do ácido 1h-indol-3-carboxìlico e seu uso como agonistas de ppar
PCT/EP2005/013634 WO2006074789A1 (fr) 2005-01-14 2005-12-17 Derives d'acide 1h-indole-3-carboxylique et utilisation en tant qu'agonistes de ppar
MX2007008350A MX2007008350A (es) 2005-01-14 2005-12-17 Derivados de acido 1h-indol-3-carboxilico y su uso como agonistas de ppar.
AU2005324895A AU2005324895B2 (en) 2005-01-14 2005-12-17 1H-indole-3-carboxylic acid derivatives and their use as PPAR agonists
AT05817577T ATE424394T1 (de) 2005-01-14 2005-12-17 1h-indol-3-carbonsäurederivate und deren verwendung als ppar-agonisten
EP05817577A EP1836187B1 (fr) 2005-01-14 2005-12-17 Derives d'acide 1h-indole-3-carboxylique et utilisation en tant qu'agonistes de ppar
CA2594377A CA2594377C (fr) 2005-01-14 2005-12-17 Derives d'acide 1h-indole-3-carboxylique et utilisation en tant qu'agonistes de ppar
ZA200706707A ZA200706707B (en) 2005-01-14 2007-08-13 1H-indole-3-carboxylic acid derivatives and their use as PPAR agonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0500422A FR2880889B1 (fr) 2005-01-14 2005-01-14 Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique

Publications (2)

Publication Number Publication Date
FR2880889A1 FR2880889A1 (fr) 2006-07-21
FR2880889B1 true FR2880889B1 (fr) 2007-04-06

Family

ID=34953245

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0500422A Expired - Fee Related FR2880889B1 (fr) 2005-01-14 2005-01-14 Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique

Country Status (15)

Country Link
US (1) US7754740B2 (fr)
EP (1) EP1836187B1 (fr)
JP (1) JP5042855B2 (fr)
KR (1) KR20070104353A (fr)
CN (1) CN101098865A (fr)
AT (1) ATE424394T1 (fr)
AU (1) AU2005324895B2 (fr)
BR (1) BRPI0519839A2 (fr)
CA (1) CA2594377C (fr)
DE (1) DE602005013118D1 (fr)
ES (1) ES2321745T3 (fr)
FR (1) FR2880889B1 (fr)
MX (1) MX2007008350A (fr)
WO (1) WO2006074789A1 (fr)
ZA (1) ZA200706707B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1905769B1 (fr) 2005-07-13 2017-03-29 Msd K.K. Dérivé du benzimidazole à substitution par un hétérocycle
CN103880730A (zh) * 2014-02-26 2014-06-25 南通大学 一种7-硝基吲哚-3-甲酸叔丁酯的化学合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2427499A1 (fr) * 2000-10-10 2002-04-18 Smithkline Beecham Corporation Indoles substituees, compositions pharmaceutiques contenant ces indoles et leur utilisation comme agent de fixation de ppar-.gamma.
JPWO2002046154A1 (ja) * 2000-12-05 2004-04-08 日本ケミファ株式会社 ペルオキシソーム増殖剤応答性受容体δの活性化剤
JP2007521325A (ja) * 2003-10-28 2007-08-02 バーテックス　ファーマシューティカルズ　インコーポレイテッド イオンチャネルのモジュレーターとして有用なベンズイミダゾール

Also Published As

Publication number Publication date
KR20070104353A (ko) 2007-10-25
CN101098865A (zh) 2008-01-02
JP2008526902A (ja) 2008-07-24
ZA200706707B (en) 2008-09-25
EP1836187A1 (fr) 2007-09-26
WO2006074789A1 (fr) 2006-07-20
FR2880889A1 (fr) 2006-07-21
AU2005324895B2 (en) 2011-08-04
MX2007008350A (es) 2007-07-25
ATE424394T1 (de) 2009-03-15
CA2594377C (fr) 2014-02-18
AU2005324895A1 (en) 2006-07-20
BRPI0519839A2 (pt) 2009-03-17
US7754740B2 (en) 2010-07-13
US20080114034A1 (en) 2008-05-15
DE602005013118D1 (de) 2009-04-16
EP1836187B1 (fr) 2009-03-04
CA2594377A1 (fr) 2006-07-20
ES2321745T3 (es) 2009-06-10
JP5042855B2 (ja) 2012-10-03

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Effective date: 20140930