HUP0301514A2 - Benzimidazol származékok, elżállításuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Benzimidazol származékok, elżállításuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0301514A2 HUP0301514A2 HU0301514A HUP0301514A HUP0301514A2 HU P0301514 A2 HUP0301514 A2 HU P0301514A2 HU 0301514 A HU0301514 A HU 0301514A HU P0301514 A HUP0301514 A HU P0301514A HU P0301514 A2 HUP0301514 A2 HU P0301514A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen atom
- atom
- alkyl
- preparation
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052799 carbon Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000005156 substituted alkylene group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
Abstract
A találmány (I) általános képletű benzimidazolszármazékokra, aképletben R1 jelentése hidrogénatom, alkilcsoport, halogénatom,nitrocsoport vagy alkoxicsoport, R2 és R2' jelentése egymástólfüggetlenül hidrogénatom vagy alkilcsoport, X jelentése nitrogénatomvagy szénatom, n értéke 1 vagy 2, m értéke 1 vagy 2, és, amikor Xjelentése nitrogénatom: R3 jelentése hidrogénatom vagy 1-4 szénatomosalkilcsoport, így az (I) általános képletű vegyület egy kvaternerammónium-vegyület, vagy az R3 nincs jelen, ekkor az (I) általánosképletű vegyület egy szekunder vagy tercier amin, R4 jelentésehidrogénatom, alkilcsoport, cikloalkilcsoport,heterocikloalkilcsoport, amely adott esetben helyettesített;helyettesített alkiléncsoport, heteroaril-, fenil- vagyalkilkarbonilcsoport, adott esetben helyettesítettfenilszulfonilcsoport, és, amikor X jelentése szénatom: R3 jelentésehidrogénatom, helyettesített amino- vagy karbamoilcsoport, alkil-,alkoxi- vagy heterociklilkarbonilcsoport, -NHCONH2, -OH vagy -CH2OHcsoport, R4 jelentése hidrogénatom vagy helyettesített alkiléncsoport,és a vegyületek előállítására és terápiás alkalmazására szolgálógyógyszerkészítmény előállítására vonatkozik Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0010419A FR2812878B1 (fr) | 2000-08-08 | 2000-08-08 | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| FR0014696A FR2816619B1 (fr) | 2000-11-15 | 2000-11-15 | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| PCT/FR2001/002556 WO2002012239A1 (fr) | 2000-08-08 | 2001-08-06 | Derives de benzimidazole, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0301514A2 true HUP0301514A2 (hu) | 2003-09-29 |
Family
ID=26212570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301514A HUP0301514A2 (hu) | 2000-08-08 | 2001-08-06 | Benzimidazol származékok, elżállításuk és ezeket tartalmazó gyógyszerkészítmények |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6794382B2 (hu) |
| EP (1) | EP1309594B1 (hu) |
| JP (1) | JP2004505975A (hu) |
| KR (1) | KR20030020450A (hu) |
| CN (1) | CN1446218A (hu) |
| AR (1) | AR030121A1 (hu) |
| AT (1) | ATE284886T1 (hu) |
| AU (1) | AU2001282267A1 (hu) |
| BG (1) | BG107460A (hu) |
| BR (1) | BR0113046A (hu) |
| CA (1) | CA2412368A1 (hu) |
| CZ (1) | CZ294493B6 (hu) |
| DE (1) | DE60107859T2 (hu) |
| EA (1) | EA005950B1 (hu) |
| EE (1) | EE200300048A (hu) |
| ES (1) | ES2233671T3 (hu) |
| HK (1) | HK1053118A1 (hu) |
| HR (1) | HRP20030081A2 (hu) |
| HU (1) | HUP0301514A2 (hu) |
| IL (1) | IL153708A0 (hu) |
| IS (1) | IS6661A (hu) |
| MX (1) | MXPA03000753A (hu) |
| NO (1) | NO20030596L (hu) |
| PL (1) | PL365080A1 (hu) |
| PT (1) | PT1309594E (hu) |
| SK (1) | SK1582003A3 (hu) |
| WO (1) | WO2002012239A1 (hu) |
| YU (1) | YU7203A (hu) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| US20040014744A1 (en) * | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
| AU2003240742A1 (en) * | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo (4,5,1-ij) quinolin-6-ones derivatives and their use as poly (adp-ribosyl) transferase (parp) inhibitors |
| AU2003236686A1 (en) * | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo(4,5,1-j) quinolin-6-ones as parp inhibitors |
| WO2004108723A1 (en) * | 2003-06-04 | 2004-12-16 | Altana Pharma Ag | 4,5-dihydro-imidazo[4,5,1-ii]quinolin-6-ones as parp inhibitors |
| GB0317466D0 (en) * | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
| DK2305221T3 (en) | 2003-12-01 | 2015-08-24 | Kudos Pharm Ltd | DNA damage repair inhibitors for the treatment of cancer |
| CA2580844A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
| BRPI0515488A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
| AU2005286731A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| WO2006034312A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd) |
| BRPI0515505A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase |
| BRPI0515483A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase |
| TW200626139A (en) * | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| BRPI0515489A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase |
| CN101090724A (zh) * | 2004-09-20 | 2007-12-19 | 泽农医药公司 | 用于抑制人硬脂酰CoA去饱和酶的吡啶衍生物 |
| JP2008526815A (ja) * | 2005-01-11 | 2008-07-24 | ノイロサーチ アクティーゼルスカブ | 低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用 |
| WO2007130075A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| JP2009503069A (ja) * | 2005-08-05 | 2009-01-29 | アストラゼネカ アクチボラグ | 三環式ベンゾイミダゾール類、および代謝性グルタミン酸塩受容体のモジュレータとしてのそれらの使用 |
| US20090239880A1 (en) * | 2006-07-03 | 2009-09-24 | Ulrik Svane Sorensen | Combinations of monoamine reuptake inhibitors and potassium channel activators |
| GB0716532D0 (en) | 2007-08-24 | 2007-10-03 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| GB201220157D0 (en) | 2012-11-08 | 2012-12-26 | Selvita Sa | Substitute tricyclic benzimidazoles as kinase inhibitors |
| CN103923088B (zh) * | 2013-01-11 | 2016-09-07 | 上海汇伦生命科技有限公司 | 2,5-二氮杂双环[2.2.1]庚烷类化合物和制备方法、其药用组合物及其在医药上的应用 |
| EA038494B1 (ru) * | 2013-03-15 | 2021-09-07 | Инсайт Холдингс Корпорейшн | Трициклические гетероциклы как ингибиторы белков бэт |
| CN104230896A (zh) * | 2013-06-17 | 2014-12-24 | 上海汇伦生命科技有限公司 | 苯并咪唑-2-哌嗪杂环类化合物、其药物组合物及其制备方法和用途 |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| SI3674302T1 (sl) | 2014-04-23 | 2023-07-31 | Incyte Holdings Corporation | 1h-pirolo(2,3-c)piridin-7(6h)-oni in pirazolo(3,4-c)piridin-7(6h)-oni kot zaviralci proteinov bet |
| JP6614585B2 (ja) * | 2015-05-29 | 2019-12-04 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害作用を有する含窒素３環性誘導体 |
| UA125476C2 (uk) | 2016-06-20 | 2022-03-23 | Інсайт Корпорейшн | Спосіб отримання 2,2,4-триметил-8-(6-метил-7-оксо-6,7-дигідро-1н-піроло[2,3-c]піридин-4-іл)-6-(метилсульфоніл)-2н-бензо[b][1,4]оксазин-3(4н)-ону і проміжних сполук |
| CN110661676B (zh) * | 2018-06-29 | 2022-06-28 | 大唐移动通信设备有限公司 | 一种带宽部分的测量方法、配置方法、终端及网络设备 |
| CN111349094B (zh) * | 2020-04-23 | 2021-02-02 | 杭州师范大学 | 一种6H-咪唑[4,5,1-ij]并喹诺酮及其合成方法和应用 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2710915B1 (fr) * | 1993-10-04 | 1995-11-24 | Synthelabo | Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique. |
| FR2731708B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de piperidine, leur procede de preparation et leur application en therapeutique |
| SK285529B6 (sk) * | 1998-11-27 | 2007-03-01 | Basf Aktiengesellschaft | Substituované benzimidazoly, farmaceutická kompozícia s ich obsahom a ich použitie ako inhibítorov PARP |
-
2001
- 2001-08-06 ES ES01960871T patent/ES2233671T3/es not_active Expired - Lifetime
- 2001-08-06 WO PCT/FR2001/002556 patent/WO2002012239A1/fr active IP Right Grant
- 2001-08-06 AU AU2001282267A patent/AU2001282267A1/en not_active Abandoned
- 2001-08-06 AT AT01960871T patent/ATE284886T1/de not_active IP Right Cessation
- 2001-08-06 CZ CZ2003354A patent/CZ294493B6/cs not_active IP Right Cessation
- 2001-08-06 PT PT01960871T patent/PT1309594E/pt unknown
- 2001-08-06 CA CA002412368A patent/CA2412368A1/fr not_active Abandoned
- 2001-08-06 KR KR10-2003-7001760A patent/KR20030020450A/ko not_active Application Discontinuation
- 2001-08-06 IL IL15370801A patent/IL153708A0/xx unknown
- 2001-08-06 EA EA200201259A patent/EA005950B1/ru not_active IP Right Cessation
- 2001-08-06 JP JP2002518214A patent/JP2004505975A/ja active Pending
- 2001-08-06 MX MXPA03000753A patent/MXPA03000753A/es unknown
- 2001-08-06 EP EP01960871A patent/EP1309594B1/fr not_active Expired - Lifetime
- 2001-08-06 US US10/343,467 patent/US6794382B2/en not_active Expired - Fee Related
- 2001-08-06 CN CN01813895A patent/CN1446218A/zh active Pending
- 2001-08-06 YU YU7203A patent/YU7203A/sh unknown
- 2001-08-06 BR BR0113046-3A patent/BR0113046A/pt not_active IP Right Cessation
- 2001-08-06 DE DE60107859T patent/DE60107859T2/de not_active Expired - Lifetime
- 2001-08-06 SK SK158-2003A patent/SK1582003A3/sk unknown
- 2001-08-06 HU HU0301514A patent/HUP0301514A2/hu unknown
- 2001-08-06 PL PL01365080A patent/PL365080A1/xx not_active Application Discontinuation
- 2001-08-06 AR ARP010103751A patent/AR030121A1/es not_active Application Discontinuation
- 2001-08-06 EE EEP200300048A patent/EE200300048A/xx unknown
-
2002
- 2002-12-19 IS IS6661A patent/IS6661A/is unknown
-
2003
- 2003-01-14 BG BG107460A patent/BG107460A/bg unknown
- 2003-02-06 HR HR20030081A patent/HRP20030081A2/hr not_active Application Discontinuation
- 2003-02-06 NO NO20030596A patent/NO20030596L/no not_active Application Discontinuation
- 2003-07-28 HK HK03105435A patent/HK1053118A1/xx not_active IP Right Cessation
-
2004
- 2004-09-13 US US10/939,910 patent/US20050032779A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6794382B2 (en) | 2004-09-21 |
| ATE284886T1 (de) | 2005-01-15 |
| PL365080A1 (en) | 2004-12-27 |
| EE200300048A (et) | 2004-12-15 |
| HRP20030081A2 (en) | 2005-02-28 |
| EP1309594A1 (fr) | 2003-05-14 |
| BR0113046A (pt) | 2003-07-01 |
| BG107460A (bg) | 2003-09-30 |
| DE60107859D1 (de) | 2005-01-20 |
| KR20030020450A (ko) | 2003-03-08 |
| CA2412368A1 (fr) | 2002-02-14 |
| EA200201259A1 (ru) | 2003-06-26 |
| YU7203A (sh) | 2006-01-16 |
| EA005950B1 (ru) | 2005-08-25 |
| CZ2003354A3 (cs) | 2003-05-14 |
| IL153708A0 (en) | 2003-07-06 |
| AU2001282267A1 (en) | 2002-02-18 |
| AR030121A1 (es) | 2003-08-13 |
| IS6661A (is) | 2002-12-19 |
| CN1446218A (zh) | 2003-10-01 |
| DE60107859T2 (de) | 2005-12-22 |
| JP2004505975A (ja) | 2004-02-26 |
| CZ294493B6 (cs) | 2005-01-12 |
| US20030203893A1 (en) | 2003-10-30 |
| NO20030596D0 (no) | 2003-02-06 |
| MXPA03000753A (es) | 2003-10-15 |
| US20050032779A1 (en) | 2005-02-10 |
| NO20030596L (no) | 2003-04-01 |
| PT1309594E (pt) | 2005-04-29 |
| SK1582003A3 (en) | 2003-08-05 |
| EP1309594B1 (fr) | 2004-12-15 |
| ES2233671T3 (es) | 2005-06-16 |
| HK1053118A1 (en) | 2003-10-10 |
| WO2002012239A1 (fr) | 2002-02-14 |
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