HUP0100142A2 - Szubsztituált ciklopentán- és ciklopenténszármazékok és alkalmazásuk neuraminidáz-inhibitorokként - Google Patents
Szubsztituált ciklopentán- és ciklopenténszármazékok és alkalmazásuk neuraminidáz-inhibitorokkéntInfo
- Publication number
- HUP0100142A2 HUP0100142A2 HU0100142A HUP0100142A HUP0100142A2 HU P0100142 A2 HUP0100142 A2 HU P0100142A2 HU 0100142 A HU0100142 A HU 0100142A HU P0100142 A HUP0100142 A HU P0100142A HU P0100142 A2 HUP0100142 A2 HU P0100142A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- substituted
- hydrogen atom
- formula
- substituted alkyl
- Prior art date
Links
- 125000002433 cyclopentenyl group Chemical class C1(=CCCC1)* 0.000 title 1
- 125000001511 cyclopentyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 title 1
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 title 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 title 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 title 1
- 239000002911 sialidase inhibitor Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 102000005348 Neuraminidase Human genes 0.000 abstract 1
- 108010006232 Neuraminidase Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány (I), (II) és (III) általános képletű vegyületekre, illetveezek előállításához alkalmazható (IV) és (V) általános képletűintermedierekre vonatkozik. A találmány szerinti vegyületek influenzavírus neuraminidáz gátló hatással rendelkeznek, ígygyógyszerkészítmények hatóanyagaként influenza fertőzés kezelésérealkalmazhatók. A képletekben U jelentése CH, O vagy S, Z jelentésehelyettesített metiléncsoport, R1 és R9 jelentése hidrogénatom vagyhelyettesített alkilcsoport, vagy együttesen =O vagy (c) képletűcsoportot alkotnak, R3 jelentése hidrogénatom, helyettesítettalkilcsoport, helyettesített aminokarbonilcsoport, helyettesítettaminocsoport, R4 jelentése hidrogénatom vagy helyettesítettalkilcsoport, R12 és R13 jelentése hidrogénatom vagy helyettesítettalkilcsoport vagy X-W-Y általános képletű csoport, ahol X jelentése O,S, CH2 vagy NH képletű csoport, W jelentése 1-100 atomot tartalmazótérköztartó csoport, Y jelentése H, OH, SH, NH2, CH=O, CH=CH2, CO2H,CONHNH2 képletű csoport vagy ezek védett formája. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6995697P | 1997-12-17 | 1997-12-17 | |
US8525298P | 1998-05-13 | 1998-05-13 | |
PCT/US1998/026871 WO1999033781A1 (en) | 1997-12-17 | 1998-12-17 | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0100142A2 true HUP0100142A2 (hu) | 2001-05-28 |
HUP0100142A3 HUP0100142A3 (en) | 2002-01-28 |
Family
ID=26750600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0100142A HUP0100142A3 (en) | 1997-12-17 | 1998-12-17 | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
Country Status (28)
Country | Link |
---|---|
US (1) | US6562861B1 (hu) |
EP (1) | EP1040094B9 (hu) |
JP (3) | JP4102022B2 (hu) |
KR (1) | KR20010024743A (hu) |
CN (1) | CN1282316A (hu) |
AR (1) | AR016162A1 (hu) |
AT (1) | ATE425955T1 (hu) |
AU (1) | AU2200199A (hu) |
BE (1) | BE2018C032I2 (hu) |
BR (1) | BR9813480A (hu) |
CA (1) | CA2315262C (hu) |
CY (2) | CY1109153T1 (hu) |
DE (1) | DE69840674D1 (hu) |
DK (1) | DK1040094T3 (hu) |
ES (1) | ES2324746T3 (hu) |
FR (1) | FR18C1037I2 (hu) |
HU (1) | HUP0100142A3 (hu) |
IL (1) | IL136812A0 (hu) |
LT (1) | LTC1040094I2 (hu) |
NL (1) | NL300952I2 (hu) |
NO (1) | NO20003084L (hu) |
PL (1) | PL196674B1 (hu) |
PT (1) | PT1040094E (hu) |
RO (1) | RO121815B1 (hu) |
SI (1) | SI1040094T1 (hu) |
SK (1) | SK8712000A3 (hu) |
WO (1) | WO1999033781A1 (hu) |
ZA (1) | ZA9811595B (hu) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000016669A (ko) | 1996-06-14 | 2000-03-25 | 몽고메리 죤 에이 | 뉴라미니다제 저해제로 유용한 치환된 시클로펜탄 화합물 |
EP1040094B9 (en) * | 1997-12-17 | 2015-09-09 | Biocryst Pharmaceuticals Inc. | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
US6455571B1 (en) * | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
JP2002521312A (ja) * | 1998-04-23 | 2002-07-16 | アボット・ラボラトリーズ | ノイラミニダーゼの阻害剤 |
AU1520300A (en) | 1998-11-05 | 2000-05-29 | Biocryst Pharmaceuticals, Inc. | New cyclopentane and cyclopentene compounds and use for detecting influenza virus |
JP4262920B2 (ja) * | 1999-06-28 | 2009-05-13 | バイオクリスト・ファマシューティカルズ インク. | 置換シクロペンタン誘導体の調製方法及びその新規結晶構造 |
CZ20014656A3 (cs) * | 1999-06-28 | 2002-11-13 | Biocryst Pharmaceuticals, Inc. | Způsob přípravy (-)-(1S,4R) N-chráněných 4-amino-2-cyklopenten-1-karboxylát esterů |
US6762316B1 (en) * | 1999-06-28 | 2004-07-13 | Biocryst Pharmaceuticals, Inc. | Preparation of substituted cyclopentane and cyclopentene compounds and certain intermediates |
JP2003530306A (ja) * | 1999-06-28 | 2003-10-14 | バイオクリスト・ファマシューティカルズ インク. | 置換シクロペンタン及びシクロペンテン化合物及びその中間体の調製 |
US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
US6627396B1 (en) | 1999-10-28 | 2003-09-30 | The Regents Of The University Of California | Influenza sensor |
WO2001062242A1 (en) * | 2000-02-24 | 2001-08-30 | Biocryst Pharmaceuticals, Inc. | Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
WO2001064674A1 (en) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
AU2001252578A1 (en) * | 2000-04-25 | 2001-11-07 | Sankyo Company Limited | Preventives for influenza |
GB0015324D0 (en) * | 2000-06-22 | 2000-08-16 | Biota Scient Management | Medicaments |
AUPR001000A0 (en) | 2000-09-08 | 2000-10-05 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
WO2002032885A1 (fr) * | 2000-10-18 | 2002-04-25 | Kuraray Co., Ltd. | Preparation d'esters d'acide amino-2-aza-1-oxybicyclo[3.3.0]oct-2-ene-6-carboxylique 4-n substitues et preparation de leurs produits intermediaires |
WO2002092555A1 (fr) * | 2001-05-11 | 2002-11-21 | Sankyo Company, Limited | Derives d'acides sialiques |
ES2401285T3 (es) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
WO2007087056A2 (en) * | 2006-01-13 | 2007-08-02 | Scolr Pharma, Inc. | Peramivir derivative for oral administration |
KR20140132778A (ko) * | 2006-02-13 | 2014-11-18 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | 정맥내 항바이러스 치료 |
CN101420948A (zh) | 2006-02-13 | 2009-04-29 | 拜奥克里斯特制药公司 | 静脉内抗病毒治疗 |
CA2649090A1 (en) * | 2006-04-12 | 2007-10-18 | Biocryst Pharmaceuticals, Inc. | Intramuscular antiviral treatments |
US20070244193A1 (en) * | 2006-04-12 | 2007-10-18 | Babu Yarlagadda S | Intramuscular antiviral treatments |
CN100432047C (zh) * | 2006-07-03 | 2008-11-12 | 华南农业大学 | 一种抗流感及禽流感病毒药物帕拉米韦的合成方法 |
EP2125848B1 (en) | 2007-01-23 | 2014-09-10 | Therapicon Srl | Antiviral compounds |
US20080194801A1 (en) * | 2007-02-14 | 2008-08-14 | Swanson Basil I | Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses |
CN101868461B (zh) | 2007-08-02 | 2013-09-25 | 米伦纽姆医药公司 | 合成e1活化酶抑制剂的方法 |
CN101367750B (zh) | 2007-08-14 | 2012-05-23 | 中国人民解放军军事医学科学院毒物药物研究所 | (1s,2s,3s,4r)-3-[(1s)-1-乙酰氨-2-乙基-丁基]-4-胍基-2-羟基-环戊基-1-羧酸水合物及其医药用途 |
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- 1998-12-17 WO PCT/US1998/026871 patent/WO1999033781A1/en not_active Application Discontinuation
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- 1998-12-17 BR BR9813480-9A patent/BR9813480A/pt not_active IP Right Cessation
- 1998-12-17 AT AT98966003T patent/ATE425955T1/de active
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- 1998-12-17 KR KR1020007006646A patent/KR20010024743A/ko not_active Application Discontinuation
- 1998-12-17 PT PT98966003T patent/PT1040094E/pt unknown
- 1998-12-17 CN CN98812351A patent/CN1282316A/zh active Pending
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