HUP0302157A2 - 4-(2-Fenil-tiazol-5-il)-1,4-diazabiciklo[3.2.2]nonán-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
4-(2-Fenil-tiazol-5-il)-1,4-diazabiciklo[3.2.2]nonán-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0302157A2 HUP0302157A2 HU0302157A HUP0302157A HUP0302157A2 HU P0302157 A2 HUP0302157 A2 HU P0302157A2 HU 0302157 A HU0302157 A HU 0302157A HU P0302157 A HUP0302157 A HU P0302157A HU P0302157 A2 HUP0302157 A2 HU P0302157A2
- Authority
- HU
- Hungary
- Prior art keywords
- phenylthiazol
- diazabicyclo
- preparation
- pharmaceutical compositions
- nonane derivatives
- Prior art date
Links
- KTZBXHQABAEHNW-UHFFFAOYSA-N 5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-phenyl-1,3-thiazole Chemical class C1CN(CC2)CCC1N2C(S1)=CN=C1C1=CC=CC=C1 KTZBXHQABAEHNW-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 nitro, amino Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgya (I) általános képletű vegyület, ahol R1, R2, R3, R4és R5 egymástól függetlenül jelenthet hidrogénatomot vagyhalogénatomot, nitro, amino, trifluor-metil, trifluor-alkoxi, ciano,hidroxil, (C1-C6)alkil, vagy (C1-C6)alkoxi csoportot bázis formában,vagy valamely savval adott addíciós sója formájában, eljáráselőállítására, és az azt tartalmazó, neurológiai betegségekgyógyításában alkalmazható gyógyszerkészítmények. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0006978A FR2809732B1 (fr) | 2000-05-31 | 2000-05-31 | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
PCT/FR2001/001650 WO2001092260A1 (fr) | 2000-05-31 | 2001-05-29 | Derives de 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-[3.2.2]nonane, leur preparation et leur application en therapeutique |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0302157A2 true HUP0302157A2 (hu) | 2003-10-28 |
HUP0302157A3 HUP0302157A3 (en) | 2011-03-28 |
HU229600B1 HU229600B1 (en) | 2014-02-28 |
Family
ID=8850829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302157A HU229600B1 (en) | 2000-05-31 | 2001-05-29 | 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and pharmaceutical compositions thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US7001902B2 (hu) |
EP (1) | EP1289987B1 (hu) |
JP (1) | JP4939720B2 (hu) |
AR (1) | AR028649A1 (hu) |
AT (1) | ATE267201T1 (hu) |
AU (1) | AU2001264043A1 (hu) |
DE (1) | DE60103394T2 (hu) |
FR (1) | FR2809732B1 (hu) |
HU (1) | HU229600B1 (hu) |
TW (1) | TW591028B (hu) |
WO (1) | WO2001092260A1 (hu) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
FR2832713B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
JP4890762B2 (ja) | 2002-09-25 | 2012-03-07 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール、ベンゾチアゾール、及びベンゾイソチアゾール、並びにそれらの調製及び使用 |
CN1326857C (zh) * | 2002-09-30 | 2007-07-18 | 神经研究公司 | 新的1,4-二氮杂双环烷烃衍生物、其制备和应用 |
DE60311853T2 (de) * | 2002-09-30 | 2007-06-21 | Neurosearch A/S | Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung |
JP2006508109A (ja) * | 2002-11-11 | 2006-03-09 | ニューロサーチ、アクティーゼルスカブ | 1,4−ジアザビシクロ(3,2,2)ノナン誘導体、その製造方法及びその使用 |
US7223753B2 (en) | 2002-11-11 | 2007-05-29 | Neurosearch A/S | Diazabicyclic biaryl derivatives |
DE602004010299T2 (de) | 2003-12-22 | 2008-09-18 | Memory Pharmaceuticals Corp. | Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen |
CN100432075C (zh) * | 2004-02-04 | 2008-11-12 | 神经研究公司 | 作为烟碱样乙酰胆碱受体配体的二氮杂双环芳基衍生物 |
BRPI0506890A (pt) * | 2004-02-04 | 2007-07-17 | Neurosearch As | derivado de arila diazabicìclica, composição farmacêutica, uso de um derivado de arila diazabicìclica, e, método de tratamento, prevenção ou alìvio de uma doença, distúrbio ou condição de um corpo de animal vivo |
CN103724343A (zh) | 2004-03-25 | 2014-04-16 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
WO2006001894A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
BRPI0510212A (pt) * | 2004-05-07 | 2007-10-16 | Memory Pharm Corp | 1h-indazóis, benzotiazóis, 1,2 - benzoisoxazóis, 1,2-benzoisotiazóis, e cromonas e a preparação e usos dos mesmos |
KR20070090922A (ko) * | 2004-12-15 | 2007-09-06 | 아스트라제네카 아베 | 니코틴성 아세틸콜린 수용체 리간드 |
MX2007007328A (es) | 2004-12-22 | 2007-07-25 | Memory Pharm Corp | Ligandos del receptor alfa-7 nicotinico y preparacion y sus usos. |
DE602006019561D1 (de) | 2005-02-16 | 2011-02-24 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin-acetylcholin-rezeptoren |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
US8173658B2 (en) | 2005-12-06 | 2012-05-08 | Neurosearch A/S | Diazabicycylic aryl derivatives and their medical use |
US7910578B2 (en) | 2006-05-23 | 2011-03-22 | Neurosearch A/S | 8,10-diaza-bicyclo[4.3.1]decane derivatives and their medical use |
CA2653769A1 (en) | 2006-05-30 | 2007-12-06 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN166416B (hu) * | 1985-09-18 | 1990-05-05 | Pfizer | |
NZ226000A (en) * | 1987-09-10 | 1991-06-25 | Merck Sharp & Dohme | Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions |
US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
-
2000
- 2000-05-31 FR FR0006978A patent/FR2809732B1/fr not_active Expired - Fee Related
-
2001
- 2001-05-29 WO PCT/FR2001/001650 patent/WO2001092260A1/fr active IP Right Grant
- 2001-05-29 HU HU0302157A patent/HU229600B1/hu not_active IP Right Cessation
- 2001-05-29 EP EP01938362A patent/EP1289987B1/fr not_active Expired - Lifetime
- 2001-05-29 JP JP2002500873A patent/JP4939720B2/ja not_active Expired - Fee Related
- 2001-05-29 US US10/276,822 patent/US7001902B2/en not_active Expired - Lifetime
- 2001-05-29 DE DE60103394T patent/DE60103394T2/de not_active Expired - Lifetime
- 2001-05-29 AU AU2001264043A patent/AU2001264043A1/en not_active Abandoned
- 2001-05-29 AT AT01938362T patent/ATE267201T1/de not_active IP Right Cessation
- 2001-05-30 TW TW090113055A patent/TW591028B/zh not_active IP Right Cessation
- 2001-05-30 AR ARP010102576A patent/AR028649A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW591028B (en) | 2004-06-11 |
AU2001264043A1 (en) | 2001-12-11 |
US7001902B2 (en) | 2006-02-21 |
US20040029884A1 (en) | 2004-02-12 |
HUP0302157A3 (en) | 2011-03-28 |
EP1289987A1 (fr) | 2003-03-12 |
JP4939720B2 (ja) | 2012-05-30 |
DE60103394D1 (de) | 2004-06-24 |
JP2003535090A (ja) | 2003-11-25 |
ATE267201T1 (de) | 2004-06-15 |
FR2809732A1 (fr) | 2001-12-07 |
AR028649A1 (es) | 2003-05-21 |
HU229600B1 (en) | 2014-02-28 |
FR2809732B1 (fr) | 2002-07-19 |
DE60103394T2 (de) | 2005-06-02 |
WO2001092260A1 (fr) | 2001-12-06 |
EP1289987B1 (fr) | 2004-05-19 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of definitive patent protection due to non-payment of fees |