HUP0203477A3 - Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase, pharmaceutical compositions containing them and their preparations - Google Patents
Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase, pharmaceutical compositions containing them and their preparationsInfo
- Publication number
- HUP0203477A3 HUP0203477A3 HU0203477A HUP0203477A HUP0203477A3 HU P0203477 A3 HUP0203477 A3 HU P0203477A3 HU 0203477 A HU0203477 A HU 0203477A HU P0203477 A HUP0203477 A HU P0203477A HU P0203477 A3 HUP0203477 A3 HU P0203477A3
- Authority
- HU
- Hungary
- Prior art keywords
- preparations
- inhibitors
- pharmaceutical compositions
- compositions containing
- protein kinase
- Prior art date
Links
- 125000003282 alkyl amino group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16080499P | 1999-10-21 | 1999-10-21 | |
US21371800P | 2000-06-22 | 2000-06-22 | |
PCT/EP2000/010077 WO2001029041A1 (en) | 1999-10-21 | 2000-10-13 | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203477A2 HUP0203477A2 (hu) | 2003-01-28 |
HUP0203477A3 true HUP0203477A3 (en) | 2004-12-28 |
Family
ID=26857242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203477A HUP0203477A3 (en) | 1999-10-21 | 2000-10-13 | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase, pharmaceutical compositions containing them and their preparations |
Country Status (25)
Country | Link |
---|---|
US (1) | US6642241B1 (hu) |
EP (1) | EP1226144B1 (hu) |
KR (1) | KR100537241B1 (hu) |
CN (1) | CN1156477C (hu) |
AR (1) | AR026187A1 (hu) |
AT (1) | ATE349447T1 (hu) |
AU (1) | AU776695B2 (hu) |
BR (1) | BR0014973A (hu) |
CA (1) | CA2388140C (hu) |
CO (1) | CO5251408A1 (hu) |
CZ (1) | CZ20021743A3 (hu) |
DE (1) | DE60032623T2 (hu) |
ES (1) | ES2277858T3 (hu) |
HK (1) | HK1051040A1 (hu) |
HR (1) | HRP20020327A2 (hu) |
HU (1) | HUP0203477A3 (hu) |
IL (1) | IL149230A0 (hu) |
MA (1) | MA26836A1 (hu) |
MX (1) | MXPA02003841A (hu) |
NO (1) | NO20021783D0 (hu) |
PE (1) | PE20010760A1 (hu) |
PL (1) | PL357494A1 (hu) |
TR (1) | TR200201058T2 (hu) |
WO (1) | WO2001029041A1 (hu) |
YU (1) | YU29202A (hu) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1138778C (zh) | 1998-05-26 | 2004-02-18 | 沃尼尔·朗伯公司 | 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途 |
US20040044012A1 (en) * | 1998-05-26 | 2004-03-04 | Dobrusin Ellen Myra | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
CA2482022A1 (en) * | 2002-04-19 | 2003-10-30 | Smithkline Beecham Corporation | Novel compounds |
AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
PA8577501A1 (es) | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
KR100793688B1 (ko) * | 2002-08-06 | 2008-01-10 | 에프. 호프만-라 로슈 아게 | P-38 미토겐 활성 단백질 키나제 억제제로서6-알콕시-피리도-피리미딘 |
CA2492112A1 (en) | 2002-08-06 | 2004-02-19 | F. Hoffmann-La Roche Ag | 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors |
US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
US7129351B2 (en) * | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
CN100497339C (zh) * | 2003-04-10 | 2009-06-10 | 霍夫曼-拉罗奇有限公司 | 嘧啶并化合物 |
EP1743945A4 (en) * | 2004-04-27 | 2009-06-10 | Takeda Pharmaceutical | SCREENING METHOD |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
WO2006024486A2 (en) | 2004-08-31 | 2006-03-09 | F. Hoffmann-La Roche Ag | Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents |
RU2007111758A (ru) | 2004-08-31 | 2008-10-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Аминопроизводные 7- амино-3-фенилдигидропиримидо [4,5-d] пиримидинонов, их получение и применение в качестве ингибиторов протеинкиназ |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
AU2007211684A1 (en) | 2006-01-31 | 2007-08-09 | F. Hoffmann-La Roche Ag | 7H-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
EP2108641A1 (en) * | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
EP3822273B1 (en) | 2012-06-13 | 2024-04-10 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
CN105307657B (zh) | 2013-03-15 | 2020-07-10 | 西建卡尔有限责任公司 | 杂芳基化合物和其用途 |
TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
UA120248C2 (uk) | 2013-03-15 | 2019-11-11 | Селджен Кар Ллс | Гетероарильні сполуки та їх застосування |
SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
MX2017010673A (es) | 2015-02-20 | 2018-03-21 | Incyte Corp | Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr). |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
CN112566912A (zh) | 2018-05-04 | 2021-03-26 | 因赛特公司 | Fgfr抑制剂的盐 |
CN112867716A (zh) | 2018-05-04 | 2021-05-28 | 因赛特公司 | Fgfr抑制剂的固体形式和其制备方法 |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
AU2020366006A1 (en) | 2019-10-14 | 2022-04-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
GB201915828D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8814352D0 (en) | 1988-06-16 | 1988-07-20 | Smith Kline French Lab | Chemical compounds |
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
EP1025102B1 (en) * | 1997-10-20 | 2004-05-19 | F. Hoffmann-La Roche Ag | Bicyclic kinase inhibitors |
CN1138778C (zh) * | 1998-05-26 | 2004-02-18 | 沃尼尔·朗伯公司 | 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途 |
CA2347474C (en) | 1998-10-23 | 2008-08-26 | F. Hoffmann-La Roche Ag | Bicyclic nitrogen heterocycles |
-
2000
- 2000-10-13 CN CNB00814544XA patent/CN1156477C/zh not_active Expired - Fee Related
- 2000-10-13 KR KR10-2002-7005056A patent/KR100537241B1/ko not_active IP Right Cessation
- 2000-10-13 ES ES00972755T patent/ES2277858T3/es not_active Expired - Lifetime
- 2000-10-13 MX MXPA02003841A patent/MXPA02003841A/es active IP Right Grant
- 2000-10-13 HU HU0203477A patent/HUP0203477A3/hu unknown
- 2000-10-13 BR BR0014973-0A patent/BR0014973A/pt not_active IP Right Cessation
- 2000-10-13 TR TR2002/01058T patent/TR200201058T2/xx unknown
- 2000-10-13 WO PCT/EP2000/010077 patent/WO2001029041A1/en not_active Application Discontinuation
- 2000-10-13 CZ CZ20021743A patent/CZ20021743A3/cs unknown
- 2000-10-13 AU AU11375/01A patent/AU776695B2/en not_active Ceased
- 2000-10-13 YU YU29202A patent/YU29202A/sh unknown
- 2000-10-13 IL IL14923000A patent/IL149230A0/xx unknown
- 2000-10-13 DE DE60032623T patent/DE60032623T2/de not_active Expired - Fee Related
- 2000-10-13 EP EP00972755A patent/EP1226144B1/en not_active Expired - Lifetime
- 2000-10-13 AT AT00972755T patent/ATE349447T1/de not_active IP Right Cessation
- 2000-10-13 CA CA002388140A patent/CA2388140C/en not_active Expired - Fee Related
- 2000-10-13 PL PL00357494A patent/PL357494A1/xx not_active Application Discontinuation
- 2000-10-17 PE PE2000001106A patent/PE20010760A1/es not_active Application Discontinuation
- 2000-10-19 CO CO00079670A patent/CO5251408A1/es not_active Application Discontinuation
- 2000-10-20 AR ARP000105524A patent/AR026187A1/es not_active Application Discontinuation
- 2000-10-20 US US09/693,364 patent/US6642241B1/en not_active Expired - Fee Related
-
2002
- 2002-04-12 HR HR20020327A patent/HRP20020327A2/hr not_active Application Discontinuation
- 2002-04-16 NO NO20021783A patent/NO20021783D0/no not_active Application Discontinuation
- 2002-04-19 MA MA26611A patent/MA26836A1/fr unknown
-
2003
- 2003-05-06 HK HK03103209A patent/HK1051040A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6642241B1 (en) | 2003-11-04 |
YU29202A (sh) | 2004-12-31 |
WO2001029041A1 (en) | 2001-04-26 |
AU1137501A (en) | 2001-04-30 |
ATE349447T1 (de) | 2007-01-15 |
CZ20021743A3 (cs) | 2002-08-14 |
DE60032623T2 (de) | 2007-10-11 |
KR20020039375A (ko) | 2002-05-25 |
CN1382142A (zh) | 2002-11-27 |
HK1051040A1 (en) | 2003-07-18 |
MXPA02003841A (es) | 2002-09-30 |
EP1226144A1 (en) | 2002-07-31 |
BR0014973A (pt) | 2002-07-16 |
ES2277858T3 (es) | 2007-08-01 |
EP1226144B1 (en) | 2006-12-27 |
JP4028236B2 (ja) | 2007-12-26 |
NO20021783L (no) | 2002-04-16 |
HUP0203477A2 (hu) | 2003-01-28 |
PE20010760A1 (es) | 2001-07-21 |
KR100537241B1 (ko) | 2005-12-19 |
TR200201058T2 (tr) | 2002-07-22 |
AR026187A1 (es) | 2003-01-29 |
CN1156477C (zh) | 2004-07-07 |
NO20021783D0 (no) | 2002-04-16 |
AU776695B2 (en) | 2004-09-16 |
MA26836A1 (fr) | 2004-12-20 |
CO5251408A1 (es) | 2003-02-28 |
HRP20020327A2 (en) | 2004-02-29 |
JP2003512377A (ja) | 2003-04-02 |
DE60032623D1 (de) | 2007-02-08 |
PL357494A1 (en) | 2004-07-26 |
CA2388140C (en) | 2008-09-02 |
IL149230A0 (en) | 2002-11-10 |
CA2388140A1 (en) | 2001-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |