BR0014973A - Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 - Google Patents
Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38Info
- Publication number
- BR0014973A BR0014973A BR0014973-0A BR0014973A BR0014973A BR 0014973 A BR0014973 A BR 0014973A BR 0014973 A BR0014973 A BR 0014973A BR 0014973 A BR0014973 A BR 0014973A
- Authority
- BR
- Brazil
- Prior art keywords
- protein kinase
- nitrogen heterocycles
- kinase inhibitors
- heterocycles substituted
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
"HETEROCICLOS DE NITROGêNIO BICìCLICO DE ALQUILAMINO SUBSTITUìDO COMO INIBIDORES DE PROTEìNA QUINASE P38". Derivados de diidropirimido[4,5-d] pirimidinona de alquilamino substituído da fórmula (I) são proporcionados em que R^ 1^-R^ 3^ são como definidos no pedido que são úteis como inibidores de P38, junto com um processo para sua fabricação e preparações farmacêuticas contendo os mesmos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16080499P | 1999-10-21 | 1999-10-21 | |
US21371800P | 2000-06-22 | 2000-06-22 | |
PCT/EP2000/010077 WO2001029041A1 (en) | 1999-10-21 | 2000-10-13 | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0014973A true BR0014973A (pt) | 2002-07-16 |
Family
ID=26857242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0014973-0A BR0014973A (pt) | 1999-10-21 | 2000-10-13 | Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 |
Country Status (25)
Country | Link |
---|---|
US (1) | US6642241B1 (pt) |
EP (1) | EP1226144B1 (pt) |
KR (1) | KR100537241B1 (pt) |
CN (1) | CN1156477C (pt) |
AR (1) | AR026187A1 (pt) |
AT (1) | ATE349447T1 (pt) |
AU (1) | AU776695B2 (pt) |
BR (1) | BR0014973A (pt) |
CA (1) | CA2388140C (pt) |
CO (1) | CO5251408A1 (pt) |
CZ (1) | CZ20021743A3 (pt) |
DE (1) | DE60032623T2 (pt) |
ES (1) | ES2277858T3 (pt) |
HK (1) | HK1051040A1 (pt) |
HR (1) | HRP20020327A2 (pt) |
HU (1) | HUP0203477A3 (pt) |
IL (1) | IL149230A0 (pt) |
MA (1) | MA26836A1 (pt) |
MX (1) | MXPA02003841A (pt) |
NO (1) | NO20021783L (pt) |
PE (1) | PE20010760A1 (pt) |
PL (1) | PL357494A1 (pt) |
TR (1) | TR200201058T2 (pt) |
WO (1) | WO2001029041A1 (pt) |
YU (1) | YU29202A (pt) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999061444A2 (en) | 1998-05-26 | 1999-12-02 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
US20040044012A1 (en) * | 1998-05-26 | 2004-03-04 | Dobrusin Ellen Myra | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
RU2004133811A (ru) * | 2002-04-19 | 2005-04-20 | Смитклайн Бичам Корпорейшн (US) | Новые соединения |
EP1534282B1 (en) | 2002-07-09 | 2006-12-27 | Boehringer Ingelheim Pharma GmbH & Co.KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
DE60316581T2 (de) * | 2002-08-06 | 2008-07-03 | F. Hoffmann-La Roche Ag | 6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase |
KR100793688B1 (ko) * | 2002-08-06 | 2008-01-10 | 에프. 호프만-라 로슈 아게 | P-38 미토겐 활성 단백질 키나제 억제제로서6-알콕시-피리도-피리미딘 |
US7084270B2 (en) * | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
US7112676B2 (en) * | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
MXPA05010765A (es) | 2003-04-10 | 2005-12-12 | Hoffmann La Roche | Compuestos pirimido. |
JP4659736B2 (ja) * | 2004-04-27 | 2011-03-30 | 武田薬品工業株式会社 | スクリーニング方法 |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
DE602005013248D1 (de) | 2004-08-31 | 2009-04-23 | Hoffmann La Roche | Amidderivate von 3-phenyldihydropyrimidoä4,5-düpyrimidinonen, deren herstellung und verwendung als pharmazeutische mittel |
US7494993B2 (en) | 2004-08-31 | 2009-02-24 | Hoffmann-La Roche Inc. | Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
KR20080083046A (ko) | 2006-01-31 | 2008-09-12 | 에프. 호프만-라 로슈 아게 | 7h-피리도[3,4-d]피리미딘-8-온, 이의 제조 및 단백질키나아제 억제제로서의 용도 |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
EP2108641A1 (en) * | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
BR112014030812B1 (pt) | 2012-06-13 | 2022-11-08 | Incyte Holdings Corporation | Compostos tricíclicos substituídos como inibidores de fgfr, seus usos, composição farmacêutica e método para inibir uma enzima fgfr |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
EP2968337B1 (en) | 2013-03-15 | 2021-07-21 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
KR102350704B1 (ko) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
NZ762856A (en) | 2017-10-05 | 2020-07-31 | Fulcrum Therapeutics Inc | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
KR20210018265A (ko) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Fgfr 억제제의 고체 형태 및 이의 제조 방법 |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
JP2022552324A (ja) | 2019-10-14 | 2022-12-15 | インサイト・コーポレイション | Fgfr阻害剤としての二環式複素環 |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
GB201915828D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
EP4069695A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Derivatives of an fgfr inhibitor |
AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8814352D0 (en) | 1988-06-16 | 1988-07-20 | Smith Kline French Lab | Chemical compounds |
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
NZ503685A (en) * | 1997-10-20 | 2002-05-31 | F | Fused pyrrole compounds as kinase inhibitors |
WO1999061444A2 (en) * | 1998-05-26 | 1999-12-02 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
ES2228123T3 (es) * | 1998-10-23 | 2005-04-01 | F. Hoffmann-La Roche Ag | Heterociclos de nitrogeno biciclicos. |
-
2000
- 2000-10-13 BR BR0014973-0A patent/BR0014973A/pt not_active IP Right Cessation
- 2000-10-13 MX MXPA02003841A patent/MXPA02003841A/es active IP Right Grant
- 2000-10-13 CA CA002388140A patent/CA2388140C/en not_active Expired - Fee Related
- 2000-10-13 PL PL00357494A patent/PL357494A1/xx not_active Application Discontinuation
- 2000-10-13 TR TR2002/01058T patent/TR200201058T2/xx unknown
- 2000-10-13 ES ES00972755T patent/ES2277858T3/es not_active Expired - Lifetime
- 2000-10-13 WO PCT/EP2000/010077 patent/WO2001029041A1/en not_active Application Discontinuation
- 2000-10-13 KR KR10-2002-7005056A patent/KR100537241B1/ko not_active IP Right Cessation
- 2000-10-13 CZ CZ20021743A patent/CZ20021743A3/cs unknown
- 2000-10-13 HU HU0203477A patent/HUP0203477A3/hu unknown
- 2000-10-13 AT AT00972755T patent/ATE349447T1/de not_active IP Right Cessation
- 2000-10-13 IL IL14923000A patent/IL149230A0/xx unknown
- 2000-10-13 YU YU29202A patent/YU29202A/sh unknown
- 2000-10-13 DE DE60032623T patent/DE60032623T2/de not_active Expired - Fee Related
- 2000-10-13 AU AU11375/01A patent/AU776695B2/en not_active Ceased
- 2000-10-13 EP EP00972755A patent/EP1226144B1/en not_active Expired - Lifetime
- 2000-10-13 CN CNB00814544XA patent/CN1156477C/zh not_active Expired - Fee Related
- 2000-10-17 PE PE2000001106A patent/PE20010760A1/es not_active Application Discontinuation
- 2000-10-19 CO CO00079670A patent/CO5251408A1/es not_active Application Discontinuation
- 2000-10-20 US US09/693,364 patent/US6642241B1/en not_active Expired - Fee Related
- 2000-10-20 AR ARP000105524A patent/AR026187A1/es not_active Application Discontinuation
-
2002
- 2002-04-12 HR HR20020327A patent/HRP20020327A2/hr not_active Application Discontinuation
- 2002-04-16 NO NO20021783A patent/NO20021783L/no not_active Application Discontinuation
- 2002-04-19 MA MA26611A patent/MA26836A1/fr unknown
-
2003
- 2003-05-06 HK HK03103209A patent/HK1051040A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20020039375A (ko) | 2002-05-25 |
HRP20020327A2 (en) | 2004-02-29 |
KR100537241B1 (ko) | 2005-12-19 |
NO20021783D0 (no) | 2002-04-16 |
EP1226144B1 (en) | 2006-12-27 |
YU29202A (sh) | 2004-12-31 |
WO2001029041A1 (en) | 2001-04-26 |
CA2388140C (en) | 2008-09-02 |
HUP0203477A2 (hu) | 2003-01-28 |
CA2388140A1 (en) | 2001-04-26 |
HUP0203477A3 (en) | 2004-12-28 |
JP2003512377A (ja) | 2003-04-02 |
NO20021783L (no) | 2002-04-16 |
AR026187A1 (es) | 2003-01-29 |
PE20010760A1 (es) | 2001-07-21 |
PL357494A1 (en) | 2004-07-26 |
CN1156477C (zh) | 2004-07-07 |
AU1137501A (en) | 2001-04-30 |
CZ20021743A3 (cs) | 2002-08-14 |
JP4028236B2 (ja) | 2007-12-26 |
CN1382142A (zh) | 2002-11-27 |
TR200201058T2 (tr) | 2002-07-22 |
HK1051040A1 (en) | 2003-07-18 |
EP1226144A1 (en) | 2002-07-31 |
IL149230A0 (en) | 2002-11-10 |
ES2277858T3 (es) | 2007-08-01 |
DE60032623T2 (de) | 2007-10-11 |
MA26836A1 (fr) | 2004-12-20 |
US6642241B1 (en) | 2003-11-04 |
AU776695B2 (en) | 2004-09-16 |
CO5251408A1 (es) | 2003-02-28 |
MXPA02003841A (es) | 2002-09-30 |
ATE349447T1 (de) | 2007-01-15 |
DE60032623D1 (de) | 2007-02-08 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |