HUP0202202A2 - Kemokin receptor antagonista hatású benzoxepino [2,3-b]-piridin-származékok és analógjaik, azok alkalmazása - Google Patents
Kemokin receptor antagonista hatású benzoxepino [2,3-b]-piridin-származékok és analógjaik, azok alkalmazásaInfo
- Publication number
- HUP0202202A2 HUP0202202A2 HU0202202A HUP0202202A HUP0202202A2 HU P0202202 A2 HUP0202202 A2 HU P0202202A2 HU 0202202 A HU0202202 A HU 0202202A HU P0202202 A HUP0202202 A HU P0202202A HU P0202202 A2 HUP0202202 A2 HU P0202202A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- group
- aliphatic group
- nrc
- substituted aliphatic
- Prior art date
Links
- 229940122444 Chemokine receptor antagonist Drugs 0.000 title 1
- PBEGUZILPWUYGX-UHFFFAOYSA-N [1]benzoxepino[2,3-b]pyridine Chemical class C1=CC2=CC=CN=C2OC2=CC=CC=C21 PBEGUZILPWUYGX-UHFFFAOYSA-N 0.000 title 1
- 239000002559 chemokine receptor antagonist Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
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- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Immunology (AREA)
- Diabetes (AREA)
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- Neurology (AREA)
- Hematology (AREA)
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- Pain & Pain Management (AREA)
- Cardiology (AREA)
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Abstract
A találmány tárgyát az (I) általános képletű vegyületek ésalkalmazásuk képezi. Az (I) általános képletben Z jelentése melyképletben: X1 jelentése -S-, -CH2-, -CH2-CH2-, -CH2-S-, -S-CH2-, -O-CH2-, -CH2-O-, -NRc-CH2-, -CH2-NRc-, -SO-CH2-, -CH2-SO-, -S (O)2-CH2-,-CH2-S(O)2-, -CH=CH-, -NRc-CO-, kötés, -O-, vagy -CO-NRc-; n értéke 1és kb. 4 közötti egész szám; M jelentése NR2, CR1R2, -O-CR1R2-O- vagy-CH2-CR1R2-O Az M-t tartalmazó gyűrű adott esetben szubsztituált; R1jelentése -H, -OH, -N3, halogén, adott esetben szubsztituált alifáscsoport, amino-alkilcsoport, -O- adott esetben szubsztuált alifáscsoport, -SH, -S- adott esetben szubsztituált alifás csoport -O-C (O)-adott esetben szubsztituált alifás csoport, -C(O)O- adott esetbenszubsztituált alifás csoport), -COOH, -CN, -CO-NR3R4, -NR3R4 vagy R1kovalens kötés M és az M-t tartalmazó gyűrű szomszédos szénatomjaközött; R2 jelentése -OH, adott esetben szubsztituált acilcsoport, -NR5R6 adott esetben szubsztituált alifás csoport, adott esetbenszubsztituált aromás csoport, adott esetben szubsztituáltbenzilcsoport, szubsztituált nemaromás heterociklusos csoport, vagy-O-(adott esetben szubsztituált aromás csoport) q1 és q2 értéke 0-2. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/362,837 US6509346B2 (en) | 1998-01-21 | 1999-07-28 | Chemokine receptor antagonists and methods of use therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0202202A2 true HUP0202202A2 (hu) | 2002-11-28 |
HUP0202202A3 HUP0202202A3 (en) | 2003-05-28 |
Family
ID=23427735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0202202A HUP0202202A3 (en) | 1999-07-28 | 2000-07-28 | Benzoxepino [2,3-b]pyridine derivatives and analogues as chemokine receptor antagonists and the use thereof |
Country Status (17)
Country | Link |
---|---|
US (2) | US6509346B2 (hu) |
EP (1) | EP1204665B1 (hu) |
JP (1) | JP4903333B2 (hu) |
KR (1) | KR20020016926A (hu) |
CN (1) | CN1471536A (hu) |
AT (1) | ATE420090T1 (hu) |
AU (1) | AU6391400A (hu) |
BR (1) | BR0013065A (hu) |
CA (1) | CA2391267A1 (hu) |
DE (1) | DE60041336D1 (hu) |
EA (1) | EA200200194A1 (hu) |
ES (1) | ES2321798T3 (hu) |
HK (1) | HK1044333A1 (hu) |
HU (1) | HUP0202202A3 (hu) |
IL (1) | IL147852A0 (hu) |
MX (1) | MXPA02000978A (hu) |
WO (1) | WO2001009138A2 (hu) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003045942A2 (en) * | 1998-09-04 | 2003-06-05 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
US6919313B2 (en) * | 2001-03-30 | 2005-07-19 | President & Fellows Of Harvard College | Protein waving a PDZ and a RGS domain |
US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
JP4889920B2 (ja) * | 2001-11-21 | 2012-03-07 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | ケモカイン受容体アンタゴニストおよびその使用方法 |
EP1553098A1 (en) * | 2002-10-18 | 2005-07-13 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
IE20040202A1 (en) * | 2003-03-28 | 2004-10-06 | Sigmoid Biotechnologies Ltd | Solid oral dosage form containing seamless microcapsules |
MY140489A (en) * | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
US20060276465A1 (en) * | 2003-12-26 | 2006-12-07 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic) substituted benzene compounds |
DE102004004719A1 (de) * | 2004-01-29 | 2005-08-18 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen |
US20080020018A1 (en) * | 2004-09-27 | 2008-01-24 | Joey Moodley | Combination Products |
US7960549B2 (en) | 2004-12-17 | 2011-06-14 | Carole Neves | Solid forms of a chemokine receptor antagonist and methods of use thereof |
CA2591757C (en) | 2004-12-20 | 2014-03-25 | Makoto Kotake | Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexyl)phenyl]piperazine |
US7410971B2 (en) * | 2004-12-24 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
MY144974A (en) * | 2005-06-14 | 2011-11-30 | Eisai R&D Man Co Ltd | 1,2-di(cyclic) substituted benzene derivatives |
CA2683415C (en) | 2007-04-04 | 2020-12-08 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
ES2963291T3 (es) | 2007-04-26 | 2024-03-26 | Sublimity Therapeutics Ltd | Fabricación de múltiples minicápsulas |
EP2073798A2 (en) * | 2007-05-01 | 2009-07-01 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
US20090286823A1 (en) * | 2007-12-17 | 2009-11-19 | Millennium Pharmaceuticals Inc. | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders |
EP2432455B1 (en) | 2009-05-18 | 2014-11-12 | Sigmoid Pharma Limited | Composition comprising oil drops |
BR112012002963A2 (pt) | 2009-08-12 | 2017-10-24 | Sigmoid Pharma Ltd | composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa |
WO2011137331A2 (en) * | 2010-04-30 | 2011-11-03 | Kinentia Biosciences Llc | 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
KR101102335B1 (ko) * | 2011-09-06 | 2012-01-03 | (주)칠칠공사 | 수영 연습용 가변형 풀 |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
ES2858517T3 (es) | 2014-11-07 | 2021-09-30 | Sublimity Therapeutics Ltd | Composiciones que comprenden ciclosporina |
CN115389659A (zh) * | 2022-08-23 | 2022-11-25 | 浙江中医药大学 | 一种细胞膜键合磁性碳球复合材料及其制备方法和应用 |
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-
1999
- 1999-07-28 US US09/362,837 patent/US6509346B2/en not_active Expired - Lifetime
-
2000
- 2000-07-28 CN CNA008131481A patent/CN1471536A/zh active Pending
- 2000-07-28 EP EP00950880A patent/EP1204665B1/en not_active Expired - Lifetime
- 2000-07-28 IL IL14785200A patent/IL147852A0/xx unknown
- 2000-07-28 AT AT00950880T patent/ATE420090T1/de not_active IP Right Cessation
- 2000-07-28 EA EA200200194A patent/EA200200194A1/ru unknown
- 2000-07-28 WO PCT/US2000/020732 patent/WO2001009138A2/en active Application Filing
- 2000-07-28 MX MXPA02000978A patent/MXPA02000978A/es unknown
- 2000-07-28 AU AU63914/00A patent/AU6391400A/en not_active Abandoned
- 2000-07-28 JP JP2001514341A patent/JP4903333B2/ja not_active Expired - Fee Related
- 2000-07-28 DE DE60041336T patent/DE60041336D1/de not_active Expired - Lifetime
- 2000-07-28 HU HU0202202A patent/HUP0202202A3/hu unknown
- 2000-07-28 CA CA002391267A patent/CA2391267A1/en not_active Abandoned
- 2000-07-28 BR BR0013065-6A patent/BR0013065A/pt not_active Application Discontinuation
- 2000-07-28 ES ES00950880T patent/ES2321798T3/es not_active Expired - Lifetime
- 2000-07-28 KR KR1020027001177A patent/KR20020016926A/ko not_active Application Discontinuation
-
2002
- 2002-06-06 HK HK02104294.3A patent/HK1044333A1/zh unknown
- 2002-08-13 US US10/217,865 patent/US20030045516A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA200200194A1 (ru) | 2002-08-29 |
MXPA02000978A (es) | 2002-08-12 |
ATE420090T1 (de) | 2009-01-15 |
JP2003506377A (ja) | 2003-02-18 |
US6509346B2 (en) | 2003-01-21 |
BR0013065A (pt) | 2002-07-30 |
CN1471536A (zh) | 2004-01-28 |
US20030045516A1 (en) | 2003-03-06 |
US20020119973A1 (en) | 2002-08-29 |
AU6391400A (en) | 2001-02-19 |
WO2001009138A2 (en) | 2001-02-08 |
IL147852A0 (en) | 2002-08-14 |
HUP0202202A3 (en) | 2003-05-28 |
JP4903333B2 (ja) | 2012-03-28 |
DE60041336D1 (de) | 2009-02-26 |
HK1044333A1 (zh) | 2002-10-18 |
ES2321798T3 (es) | 2009-06-12 |
WO2001009138A3 (en) | 2001-09-13 |
EP1204665A2 (en) | 2002-05-15 |
KR20020016926A (ko) | 2002-03-06 |
CA2391267A1 (en) | 2001-02-08 |
EP1204665B1 (en) | 2009-01-07 |
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