DE60217062D1 - Verfahren zur herstellung von clopidogrel - Google Patents
Verfahren zur herstellung von clopidogrelInfo
- Publication number
- DE60217062D1 DE60217062D1 DE60217062T DE60217062T DE60217062D1 DE 60217062 D1 DE60217062 D1 DE 60217062D1 DE 60217062 T DE60217062 T DE 60217062T DE 60217062 T DE60217062 T DE 60217062T DE 60217062 D1 DE60217062 D1 DE 60217062D1
- Authority
- DE
- Germany
- Prior art keywords
- optically active
- compounds
- racemic
- formula
- bromine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN84MU2001 IN191030B (de) | 2001-01-24 | 2001-01-24 | |
INMU008401 | 2001-01-24 | ||
US54101 | 2001-10-22 | ||
US10/054,101 US6635763B2 (en) | 2001-01-24 | 2001-10-22 | Process to prepare clopidogrel |
PCT/IN2002/000012 WO2002059128A2 (en) | 2001-01-24 | 2002-01-21 | Process for preparing clopidogrel |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60217062D1 true DE60217062D1 (de) | 2007-02-08 |
DE60217062T2 DE60217062T2 (de) | 2007-06-21 |
Family
ID=26324902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60217062T Expired - Lifetime DE60217062T2 (de) | 2001-01-24 | 2002-01-21 | Verfahren zur herstellung von clopidogrel |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1353928B1 (de) |
JP (1) | JP5000841B2 (de) |
KR (1) | KR20060040758A (de) |
CN (1) | CN100338068C (de) |
AT (1) | ATE349451T1 (de) |
AU (1) | AU2002228325B2 (de) |
BR (1) | BR0207064A (de) |
CA (1) | CA2436323C (de) |
CY (1) | CY1106346T1 (de) |
DE (1) | DE60217062T2 (de) |
DK (1) | DK1353928T3 (de) |
EA (1) | EA006198B2 (de) |
ES (1) | ES2278010T3 (de) |
MX (1) | MXPA03006133A (de) |
NO (1) | NO327807B1 (de) |
PL (1) | PL365281A1 (de) |
WO (1) | WO2002059128A2 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN191030B (de) * | 2001-01-24 | 2003-09-13 | Cadila Healthcare Ltd | |
GB0125708D0 (en) * | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
US6800759B2 (en) | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
WO2004074215A1 (en) * | 2003-02-03 | 2004-09-02 | Sunil Sadanand Nadkarni | Process for preparation of clopidogrel, its salts and pharmaceutical compositions |
CA2530446A1 (en) | 2003-07-02 | 2005-01-13 | Egis Gyogyszergyar Rt. | Process for the preparation of amorphous form of a platelet aggregation inhibitor drug |
CN1812993B (zh) * | 2003-07-02 | 2011-06-29 | 埃吉斯药物工厂 | 制备抑制血小板聚集药物的结晶性多晶型物的方法 |
US8907090B2 (en) | 2003-11-03 | 2014-12-09 | Cadila Healthcare Limited | Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate |
CA2457459A1 (en) * | 2004-02-11 | 2005-08-11 | Brantford Chemicals Inc. | Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate |
KR100553398B1 (ko) | 2004-03-12 | 2006-02-16 | 한미약품 주식회사 | 티에노[3,2-c]피리딘 유도체의 제조 방법 및 이에사용되는 중간체 |
CN1938319B (zh) | 2004-04-09 | 2010-05-12 | 韩美药品株式会社 | 结晶氯吡格雷萘磺酸盐或其水合物、其制备方法及含其的药物组合物 |
CZ295920B6 (cs) * | 2004-10-18 | 2005-11-16 | Zentiva, A. S | Způsob výroby klopidogrelu |
CN100406568C (zh) * | 2005-02-18 | 2008-07-30 | 淮北市辉克药业有限公司 | 氯吡格雷新生产工艺 |
CZ299213B6 (cs) * | 2005-03-08 | 2008-05-21 | Zentiva, A. S | Zpusob racemizace R(-) izomeru methylesteru kyseliny (2-chlorfenyl)-6,7-dihydro-thieno[3,2-c]pyridin-5(4H)-octové |
KR100678287B1 (ko) | 2005-06-23 | 2007-02-02 | 한미약품 주식회사 | 클로피도그렐의 제조방법 및 이에 사용되는 중간체 |
CN100463909C (zh) * | 2005-09-08 | 2009-02-25 | 浙江华海药业股份有限公司 | 一种噻吩并四氢吡啶乙腈化合物的合成方法 |
WO2007028337A1 (en) * | 2005-09-08 | 2007-03-15 | Zhejiang Huahai Pharmaceutical Co., Ltd. | Preparation of clopidogrel and its analogues methyl tetrahydrothienopyridine acetate compounds |
CN100417653C (zh) * | 2005-09-08 | 2008-09-10 | 浙江华海药业股份有限公司 | 噻吩并四氢吡啶乙酸及其盐的制备方法 |
CN100390180C (zh) * | 2005-12-15 | 2008-05-28 | 上海应用技术学院 | 氯吡格雷及其盐的制备方法 |
KR101235117B1 (ko) | 2005-12-26 | 2013-02-20 | 에스케이케미칼주식회사 | 광학분리에 의한 (s)-(+)-클로피도그렐의 제조방법 |
CN100396687C (zh) * | 2006-05-26 | 2008-06-25 | 浙江海翔药业股份有限公司 | (+)-(s-)-氯吡格雷硫酸氢盐(i型)的制备方法 |
WO2007144895A1 (en) * | 2006-06-12 | 2007-12-21 | Cadila Healthcare Limited | Process for the preparation of (s) - (+)-clopidogrel |
SI22383A (sl) * | 2006-09-22 | 2008-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli |
PL380849A1 (pl) * | 2006-10-17 | 2008-04-28 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Krystaliczna postać racemicznego -(2-chlorofenylo)-6,7-dihydrotieno[3,2-c]pirydylo-5(4H)-octanu metylu, sposób jej wytwarzania i zastosowanie |
WO2008146249A1 (en) * | 2007-05-30 | 2008-12-04 | Wockhardt Research Centre | Processes for the preparation of clopidogrel |
EP2220484A2 (de) * | 2007-12-14 | 2010-08-25 | Generics [UK] Limited | Hplc-verfahren zur analyse von clopidogrel |
EP2107061A1 (de) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Herstellungsverfahren für optisch angereichertes Clopidogrel |
KR100990949B1 (ko) * | 2008-06-09 | 2010-10-29 | 엔자이텍 주식회사 | 클로피도그렐 및 그의 유도체의 제조방법 |
CN101787033B (zh) * | 2010-03-16 | 2011-08-31 | 天津市中央药业有限公司 | 一种硫酸氢氯吡格雷有关物质c的合成方法 |
CN101812071A (zh) * | 2010-05-10 | 2010-08-25 | 杭州和素化学技术有限公司 | 硫酸氢氯吡格雷中间体拆分后的母液处理方法 |
CN102241690B (zh) | 2010-05-13 | 2015-08-12 | 天津药物研究院 | 一类含腈基的噻吩并吡啶酯类衍生物、其制备方法和用途 |
CN101845050A (zh) * | 2010-06-01 | 2010-09-29 | 上虞京新药业有限公司 | 一种氯吡格雷的制备方法 |
CN101974016A (zh) * | 2010-10-14 | 2011-02-16 | 天津药物研究院 | 酰胺类化合物及其制备方法和用途 |
CN101962388B (zh) * | 2010-10-14 | 2012-12-19 | 天津药物研究院 | 乙酰胺衍生物及其制备方法和用途 |
CN104045652A (zh) * | 2014-07-09 | 2014-09-17 | 沈健芬 | 一种氯吡格雷中间体的制备方法 |
CN110627808B (zh) * | 2018-06-21 | 2022-04-01 | 江苏同禾药业有限公司 | 一种硫酸氢氯吡格雷拆分母液的回收处理工艺 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
JPS5980664A (ja) * | 1982-09-30 | 1984-05-10 | Fujisawa Pharmaceut Co Ltd | α−アリ−ル−α−ピリジル脂肪酸誘導体およびその製法 |
JPS60112762A (ja) * | 1983-11-21 | 1985-06-19 | Fujisawa Pharmaceut Co Ltd | α−アリ−ル−α−ピリジル脂肪酸誘導体およびその製法 |
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2652575B1 (fr) * | 1989-09-29 | 1992-01-24 | Sanofi Sa | Procede de preparation d'acides alpha-bromo phenylacetiques. |
FR2664276B1 (fr) * | 1990-07-04 | 1992-10-23 | Sanofi Sa | Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese. |
-
2002
- 2002-01-21 ES ES02710298T patent/ES2278010T3/es not_active Expired - Lifetime
- 2002-01-21 WO PCT/IN2002/000012 patent/WO2002059128A2/en active IP Right Grant
- 2002-01-21 JP JP2002559430A patent/JP5000841B2/ja not_active Expired - Fee Related
- 2002-01-21 DK DK02710298T patent/DK1353928T3/da active
- 2002-01-21 PL PL02365281A patent/PL365281A1/xx not_active Application Discontinuation
- 2002-01-21 CN CNB02803998XA patent/CN100338068C/zh not_active Expired - Fee Related
- 2002-01-21 KR KR1020067008009A patent/KR20060040758A/ko not_active Application Discontinuation
- 2002-01-21 CA CA2436323A patent/CA2436323C/en not_active Expired - Fee Related
- 2002-01-21 BR BR0207064-2A patent/BR0207064A/pt active Search and Examination
- 2002-01-21 MX MXPA03006133A patent/MXPA03006133A/es active IP Right Grant
- 2002-01-21 EP EP02710298A patent/EP1353928B1/de not_active Expired - Lifetime
- 2002-01-21 AU AU2002228325A patent/AU2002228325B2/en not_active Ceased
- 2002-01-21 EA EA200300831A patent/EA006198B2/ru not_active IP Right Cessation
- 2002-01-21 AT AT02710298T patent/ATE349451T1/de active
- 2002-01-21 DE DE60217062T patent/DE60217062T2/de not_active Expired - Lifetime
-
2003
- 2003-06-24 NO NO20032898A patent/NO327807B1/no not_active IP Right Cessation
-
2007
- 2007-02-28 CY CY20071100280T patent/CY1106346T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1106346T1 (el) | 2011-10-12 |
EA006198B1 (ru) | 2005-10-27 |
PL365281A1 (en) | 2004-12-27 |
ATE349451T1 (de) | 2007-01-15 |
NO327807B1 (no) | 2009-09-28 |
JP2004522744A (ja) | 2004-07-29 |
CA2436323C (en) | 2012-02-21 |
WO2002059128A3 (en) | 2002-12-19 |
MXPA03006133A (es) | 2004-05-04 |
NO20032898L (no) | 2003-09-03 |
DE60217062T2 (de) | 2007-06-21 |
BR0207064A (pt) | 2004-03-30 |
ES2278010T3 (es) | 2007-08-01 |
EA200300831A1 (ru) | 2003-12-25 |
EP1353928B1 (de) | 2006-12-27 |
WO2002059128A2 (en) | 2002-08-01 |
KR20060040758A (ko) | 2006-05-10 |
AU2002228325B2 (en) | 2006-05-04 |
CN1487943A (zh) | 2004-04-07 |
CA2436323A1 (en) | 2002-08-01 |
DK1353928T3 (da) | 2007-03-26 |
NO20032898D0 (no) | 2003-06-24 |
JP5000841B2 (ja) | 2012-08-15 |
EA006198B2 (ru) | 2007-10-26 |
CN100338068C (zh) | 2007-09-19 |
EP1353928A2 (de) | 2003-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |