HUP0204246A2 - Új tiazolo[4,5-d]pirimidin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Új tiazolo[4,5-d]pirimidin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0204246A2 HUP0204246A2 HU0204246A HUP0204246A HUP0204246A2 HU P0204246 A2 HUP0204246 A2 HU P0204246A2 HU 0204246 A HU0204246 A HU 0204246A HU P0204246 A HUP0204246 A HU P0204246A HU P0204246 A2 HUP0204246 A2 HU P0204246A2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- pyrimidine compounds
- thiazolo
- Prior art date
Links
- YWBULOYFCXZCGF-UHFFFAOYSA-N [1,3]thiazolo[4,5-d]pyrimidine Chemical class C1=NC=C2SC=NC2=N1 YWBULOYFCXZCGF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 150000008634 thiazolopyrimidines Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
A találmány tárgyát bizonyos általános képletű tiazolo-pirimidin-származékok - ahol R1 adott esetben szubsztituált cikloalkil-, alkil-,alkenil- vagy alkinil-csoport; R2 és R3 egymástól függetlenülhidrogénatom vagy adott esetben egy vagy több szubsztituenst hordozócikloalkil-, alkil-, alkinil- vagy alkinilcsoport - vagygyógyszerészetileg elfogadható sóik vagy szolvátjaik, előállításuk ésintermediereik, valamint ezeket a vegyületeket tartalmazógyógyszerkészítmények és terápiás alkalmazásuk képezik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9903544A SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Novel compounds |
PCT/GB2000/003692 WO2001025242A1 (en) | 1999-10-01 | 2000-09-26 | Novel thiazolo(4,5-d)pyrimidine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0204246A2 true HUP0204246A2 (hu) | 2003-04-28 |
HUP0204246A3 HUP0204246A3 (en) | 2006-01-30 |
Family
ID=20417218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204246A HUP0204246A3 (en) | 1999-10-01 | 2000-09-26 | Novel thiazolo[4,5-d]pyrimidine compounds, process for their preparation, pharmaceutical compositions containing them and their use |
Country Status (27)
Country | Link |
---|---|
US (3) | US6790850B1 (hu) |
EP (2) | EP1348709B1 (hu) |
JP (1) | JP4824889B2 (hu) |
KR (1) | KR100765051B1 (hu) |
CN (1) | CN1210279C (hu) |
AT (2) | ATE257838T1 (hu) |
AU (1) | AU777872B2 (hu) |
BR (1) | BR0014334A (hu) |
CA (1) | CA2385269C (hu) |
CZ (1) | CZ20021113A3 (hu) |
DE (2) | DE60037836T2 (hu) |
DK (1) | DK1222195T3 (hu) |
EE (1) | EE05037B1 (hu) |
ES (2) | ES2298451T3 (hu) |
HK (1) | HK1052009A1 (hu) |
HU (1) | HUP0204246A3 (hu) |
IL (2) | IL148910A0 (hu) |
IS (1) | IS2229B (hu) |
MX (1) | MXPA02003263A (hu) |
NO (1) | NO327706B1 (hu) |
NZ (1) | NZ517880A (hu) |
PT (1) | PT1222195E (hu) |
SE (1) | SE9903544D0 (hu) |
TW (1) | TWI260324B (hu) |
UA (1) | UA73521C2 (hu) |
WO (1) | WO2001025242A1 (hu) |
ZA (1) | ZA200202380B (hu) |
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SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
GB2359081A (en) * | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
AU2001232556A1 (en) * | 2000-02-11 | 2001-08-20 | Astrazeneca Ab | Pyrimidine compounds and their use as modulators of chemokine receptor activity |
GB2359078A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
GB2359551A (en) * | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
SE0003828D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
SE0101322D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Novel compounds |
SE0102716D0 (sv) * | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
AU2002351183B2 (en) | 2001-12-06 | 2008-05-08 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
DE60232994D1 (de) | 2001-12-06 | 2009-08-27 | Merck & Co Inc | Inhibitoren von mitotischem kinesin |
GB0217431D0 (en) * | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
AU2003246972A1 (en) | 2002-08-06 | 2004-02-23 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
AU2003255819A1 (en) | 2002-08-24 | 2004-03-11 | Astrazeneca Ab | Pyrimidine derivatives as modulators of chemokine receptor activity |
GB0221828D0 (en) | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
GB0221829D0 (en) * | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
EP1675862A1 (en) * | 2003-10-07 | 2006-07-05 | AstraZeneca AB | New 2-substituted, 4-amino-thiazolo 4,5-d pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1 |
GB0328243D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
BRPI0514735B8 (pt) | 2004-08-28 | 2021-05-25 | Astrazeneca Ab | derivados de pirimidino sulfonamida como moduladores do receptor de quimiocina. |
WO2006064228A2 (en) * | 2004-12-17 | 2006-06-22 | Astrazeneca Ab | Thiazolopyramidine compounds for the modulation of chemokine receptor activity |
TW200700727A (en) * | 2005-03-23 | 2007-01-01 | Astrazeneca Ab | Screen |
UA90707C2 (en) * | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
AR053347A1 (es) * | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
TW200820973A (en) | 2006-09-29 | 2008-05-16 | Astrazeneca Ab | Novel compounds 480 |
AR071036A1 (es) * | 2008-03-26 | 2010-05-19 | Astrazeneca Ab | Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1. |
CN101671336B (zh) | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
CN101899058B (zh) * | 2010-05-24 | 2012-05-23 | 中国人民解放军第四军医大学 | 一种噻唑并嘧啶化合物及其制备方法和应用 |
US10301378B2 (en) | 2013-06-18 | 2019-05-28 | New York University | Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets |
CA2920172C (en) * | 2013-08-02 | 2020-03-10 | Syntrix Biosystems, Inc. | 2- [5- [n- (4-fluorophenyl) carbamoyl] pyrimidin-2-ylsulfanylmethyl] -4- (trifluoromethoxy) phenyl] boronic acid |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
WO2018073248A1 (en) | 2016-10-17 | 2018-04-26 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Prognosis of demyelinating diseases patients and treatment thereof |
CN110172067B (zh) * | 2019-04-11 | 2021-06-15 | 河南科技大学第一附属医院 | 一种具有杀菌活性的噻唑类药物分子及其制备方法 |
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GB0328243D0 (en) | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
WO2005082865A1 (ja) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
WO2006064228A2 (en) | 2004-12-17 | 2006-06-22 | Astrazeneca Ab | Thiazolopyramidine compounds for the modulation of chemokine receptor activity |
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