HUE060275T2 - Hatóanyaggal való visszaélés és addikció kezelésére alkalmas oxadiazaspiro-vegyületek - Google Patents

Hatóanyaggal való visszaélés és addikció kezelésére alkalmas oxadiazaspiro-vegyületek

Info

Publication number
HUE060275T2
HUE060275T2 HUE16797458A HUE16797458A HUE060275T2 HU E060275 T2 HUE060275 T2 HU E060275T2 HU E16797458 A HUE16797458 A HU E16797458A HU E16797458 A HUE16797458 A HU E16797458A HU E060275 T2 HUE060275 T2 HU E060275T2
Authority
HU
Hungary
Prior art keywords
addiction
treatment
drug abuse
oxadiazaspiro
compounds
Prior art date
Application number
HUE16797458A
Other languages
English (en)
Inventor
Marina Virgili-Bernado
Carmen Almansa-Rosales
Carlos Alegret-Molina
Original Assignee
Esteve Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals Sa filed Critical Esteve Pharmaceuticals Sa
Publication of HUE060275T2 publication Critical patent/HUE060275T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Addiction (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
HUE16797458A 2015-11-16 2016-11-15 Hatóanyaggal való visszaélés és addikció kezelésére alkalmas oxadiazaspiro-vegyületek HUE060275T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15382566 2015-11-16

Publications (1)

Publication Number Publication Date
HUE060275T2 true HUE060275T2 (hu) 2023-02-28

Family

ID=54707728

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16797458A HUE060275T2 (hu) 2015-11-16 2016-11-15 Hatóanyaggal való visszaélés és addikció kezelésére alkalmas oxadiazaspiro-vegyületek

Country Status (30)

Country Link
US (2) US10927128B2 (hu)
EP (1) EP3377500B1 (hu)
JP (1) JP6884974B2 (hu)
KR (1) KR20180080327A (hu)
CN (1) CN108349999A (hu)
AR (1) AR106697A1 (hu)
AU (1) AU2016356488B2 (hu)
BR (1) BR112018009279A8 (hu)
CA (1) CA3002286A1 (hu)
CO (1) CO2018004665A2 (hu)
DK (1) DK3377500T3 (hu)
ES (1) ES2932000T3 (hu)
HR (1) HRP20221343T1 (hu)
HU (1) HUE060275T2 (hu)
IL (1) IL259035B (hu)
LT (1) LT3377500T (hu)
MA (1) MA43250B1 (hu)
MX (1) MX2018005439A (hu)
MY (1) MY193423A (hu)
PH (1) PH12018500814A1 (hu)
PL (1) PL3377500T3 (hu)
PT (1) PT3377500T (hu)
RS (1) RS63734B1 (hu)
SG (1) SG11201803153RA (hu)
SI (1) SI3377500T1 (hu)
TN (1) TN2018000122A1 (hu)
TW (1) TWI756196B (hu)
UA (1) UA123775C2 (hu)
WO (1) WO2017084752A1 (hu)
ZA (1) ZA201802845B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI756196B (zh) 2015-11-16 2022-03-01 西班牙商艾斯提夫製藥股份有限公司 用於治療藥物濫用和成癮之氧雜二氮雜螺環化合物
WO2020157026A1 (en) * 2019-01-28 2020-08-06 Esteve Pharmaceuticals, S.A. Hydroxylated derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
AU2022346825A1 (en) 2021-09-20 2024-03-07 Esteve Pharmaceuticals, S.A. Oxadiazaspiro compounds for use in the treatment of motoneuron degeneration or in neuroprotection

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US4244961A (en) * 1978-10-26 1981-01-13 Syntex (U.S.A.) Inc. 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
US4332804A (en) 1981-03-23 1982-06-01 Syntex (U.S.A.) Inc. 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
US4353901A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones
US4353900A (en) 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
CA2554671A1 (en) * 2004-02-10 2005-08-18 F.Hoffmann-La Roche Ag Chemokine ccr5 receptor modulators
DE602005025979D1 (de) 2004-03-03 2011-03-03 Vital Health Sciences Pty Ltd Alkaloid-formulierungen
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
JP5135795B2 (ja) * 2004-08-27 2013-02-06 小野薬品工業株式会社 塩基性基を含有する化合物およびその用途
CN101228127B (zh) 2005-05-30 2012-05-16 Msdk.K.公司 哌啶衍生物
CN101203567A (zh) * 2005-06-07 2008-06-18 西巴特殊化学品控股有限公司 抗刮擦聚烯烃
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
JP5323485B2 (ja) 2005-10-19 2013-10-23 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 新規バニロイド受容体リガンド及医薬の製造へのその使用
PT1961744E (pt) 2005-11-18 2013-05-15 Ono Pharmaceutical Co Composto que contém um grupo básico e sua utilização
EP1829869A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
AU2008219980B2 (en) 2007-03-01 2012-01-12 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
EP1982714A1 (en) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
JP2010538003A (ja) 2007-08-29 2010-12-09 グラクソスミスクライン エルエルシー チアゾールおよびオキサゾールキナーゼ阻害薬
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
ES2394547T3 (es) 2008-02-06 2013-02-01 Astrazeneca Ab Compuestos
EP2108643A1 (en) * 2008-04-10 2009-10-14 Laboratorios Del. Dr. Esteve, S.A. 4-methyl-4, 5-dihydro-1H-pyrazole-3-carboxamide useful as a cannabinoid CB1 neutral antagonist
GB201016912D0 (en) * 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
CN103517910B (zh) 2011-03-14 2016-12-14 沃泰克斯药物股份有限公司 作为离子通道调节剂的吗啉-螺环哌啶酰胺
GB201107985D0 (en) 2011-05-13 2011-06-29 Astrazeneca Ab Process
WO2013052716A1 (en) * 2011-10-07 2013-04-11 Glaxosmithkline Llc Fatty acid synthase inhibitors
JPWO2013115294A1 (ja) 2012-01-31 2015-05-11 東レ株式会社 ジアザスピロウレア誘導体及びその医薬用途
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TWI685497B (zh) * 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615643A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
US10513518B2 (en) * 2015-01-29 2019-12-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TWI756196B (zh) 2015-11-16 2022-03-01 西班牙商艾斯提夫製藥股份有限公司 用於治療藥物濫用和成癮之氧雜二氮雜螺環化合物

Also Published As

Publication number Publication date
US10927128B2 (en) 2021-02-23
DK3377500T3 (da) 2022-11-21
SI3377500T1 (sl) 2023-02-28
EP3377500A1 (en) 2018-09-26
TW201731854A (zh) 2017-09-16
IL259035B (en) 2021-06-30
KR20180080327A (ko) 2018-07-11
BR112018009279A2 (pt) 2018-11-06
CA3002286A1 (en) 2017-05-26
BR112018009279A8 (pt) 2019-02-26
WO2017084752A1 (en) 2017-05-26
PH12018500814A1 (en) 2018-10-29
TN2018000122A1 (en) 2019-10-04
LT3377500T (lt) 2022-12-12
AR106697A1 (es) 2018-02-07
UA123775C2 (uk) 2021-06-02
CN108349999A (zh) 2018-07-31
AU2016356488A1 (en) 2018-05-10
PL3377500T3 (pl) 2023-01-23
EP3377500B1 (en) 2022-10-19
SG11201803153RA (en) 2018-06-28
MA43250B1 (fr) 2022-12-30
US20210115062A1 (en) 2021-04-22
JP2018533598A (ja) 2018-11-15
JP6884974B2 (ja) 2021-06-09
RU2018120748A (ru) 2019-12-05
MY193423A (en) 2022-10-12
US11649248B2 (en) 2023-05-16
CO2018004665A2 (es) 2018-07-19
MX2018005439A (es) 2018-11-09
IL259035A (en) 2018-06-28
PT3377500T (pt) 2022-11-25
ES2932000T3 (es) 2023-01-09
RU2018120748A3 (hu) 2020-02-07
RS63734B1 (sr) 2022-12-30
US20180327422A1 (en) 2018-11-15
TWI756196B (zh) 2022-03-01
HRP20221343T1 (hr) 2022-12-23
AU2016356488B2 (en) 2020-10-22
MA43250A (fr) 2021-04-14
ZA201802845B (en) 2021-10-27

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