HUE059580T2 - Kináz inhibitor oxi-fluorpiperidin származékok - Google Patents

Kináz inhibitor oxi-fluorpiperidin származékok

Info

Publication number
HUE059580T2
HUE059580T2 HUE18896304A HUE18896304A HUE059580T2 HU E059580 T2 HUE059580 T2 HU E059580T2 HU E18896304 A HUE18896304 A HU E18896304A HU E18896304 A HUE18896304 A HU E18896304A HU E059580 T2 HUE059580 T2 HU E059580T2
Authority
HU
Hungary
Prior art keywords
oxy
kinase inhibitor
fluoropiperidine
derivative
fluoropiperidine derivative
Prior art date
Application number
HUE18896304A
Other languages
English (en)
Inventor
In Woo Kim
Sun Ah Jun
Nam Youn Kim
Jun Hee Lee
Original Assignee
Daewoong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewoong Pharmaceutical Co Ltd filed Critical Daewoong Pharmaceutical Co Ltd
Publication of HUE059580T2 publication Critical patent/HUE059580T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
HUE18896304A 2017-12-28 2018-12-28 Kináz inhibitor oxi-fluorpiperidin származékok HUE059580T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20170183061 2017-12-28

Publications (1)

Publication Number Publication Date
HUE059580T2 true HUE059580T2 (hu) 2022-11-28

Family

ID=67067864

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18896304A HUE059580T2 (hu) 2017-12-28 2018-12-28 Kináz inhibitor oxi-fluorpiperidin származékok

Country Status (32)

Country Link
US (1) US11339167B2 (hu)
EP (1) EP3733673B1 (hu)
JP (1) JP6995428B2 (hu)
KR (2) KR102318929B1 (hu)
CN (1) CN111527091B (hu)
AU (1) AU2018394997B2 (hu)
BR (1) BR112020013141B1 (hu)
CA (1) CA3084962C (hu)
CL (1) CL2020001752A1 (hu)
CO (1) CO2020007162A2 (hu)
DO (1) DOP2020000112A (hu)
EC (1) ECSP20035590A (hu)
ES (1) ES2922633T3 (hu)
HR (1) HRP20221043T1 (hu)
HU (1) HUE059580T2 (hu)
IL (1) IL275207B (hu)
LT (1) LT3733673T (hu)
MA (1) MA51431B1 (hu)
MX (1) MX2020006799A (hu)
MY (1) MY194468A (hu)
NZ (1) NZ764644A (hu)
PE (1) PE20201146A1 (hu)
PH (1) PH12020551013A1 (hu)
PL (1) PL3733673T3 (hu)
PT (1) PT3733673T (hu)
RS (1) RS63515B1 (hu)
RU (1) RU2758370C1 (hu)
SA (1) SA520412335B1 (hu)
SG (1) SG11202004917UA (hu)
SI (1) SI3733673T1 (hu)
TN (1) TN2020000082A1 (hu)
WO (1) WO2019132562A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA49570A (fr) 2017-08-01 2020-05-20 Theravance Biopharma R&D Ip Llc Composés bicycliques pyrazolo et triazolo utilisés en tant qu'inhibiteurs de kinase jak
KR102577242B1 (ko) 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체
SI3733673T1 (sl) * 2017-12-28 2022-09-30 Daewoong Pharmaceutical Co., Ltd. Oksi-fluoropiperidinski derivat kot kinazni inhibitor
CA3125039A1 (en) 2019-01-23 2020-07-30 Theravance Biopharma R&D Ip, Llc Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors
WO2021108803A1 (en) 2019-11-26 2021-06-03 Theravance Biopharma R&D Ip, Llc Fused pyrimidine pyridinone compounds as jak inhibitors
WO2021147952A1 (zh) * 2020-01-21 2021-07-29 江苏先声药业有限公司 嘧啶并吡咯类化合物
CN115244055A (zh) * 2020-01-21 2022-10-25 江苏先声药业有限公司 嘧啶并五元环类衍生物及其应用
TW202214643A (zh) * 2020-09-22 2022-04-16 大陸商江蘇先聲藥業有限公司 嘧啶并吡咯類化合物
CN114315838A (zh) * 2020-09-30 2022-04-12 江苏先声药业有限公司 嘧啶并吡咯类化合物
WO2023165562A1 (zh) * 2022-03-02 2023-09-07 南京明德新药研发有限公司 含氮杂环类化合物及其应用

Family Cites Families (20)

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Publication number Priority date Publication date Assignee Title
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
WO2009026107A1 (en) * 2007-08-17 2009-02-26 Portola Pharmaceuticals, Inc. Protein kinase inhibitors
EP2271631B1 (en) 2008-04-22 2018-07-04 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
CN102159214A (zh) 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
ES2659725T3 (es) * 2009-05-05 2018-03-19 Dana-Farber Cancer Institute, Inc. Inhibidores de EGFR y procedimiento de tratamiento de trastornos
AU2011269989B2 (en) 2010-06-23 2014-12-11 Hanmi Science Co., Ltd. Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity
MD20140023A2 (ro) * 2011-09-22 2014-06-30 Pfizer Inc. Derivaţi de pirolpirimidină şi purină
CA2881275C (en) 2012-08-06 2020-10-20 Acea Biosciences Inc. Pyrrolopyrimidine compounds as inhibitors of protein kinases
NZ630467A (en) 2013-01-16 2017-02-24 Signal Pharm Llc Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
JP2016513621A (ja) 2013-03-05 2016-05-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトンチロシンキナーゼの阻害剤
JP6458039B2 (ja) 2013-09-18 2019-01-23 北京韓美薬品有限公司 Ｂｔｋ及び／又はｊａｋ３キナーゼの活性を抑制する化合物
MA39092B1 (fr) 2013-12-05 2018-09-28 Pfizer Pyrrolo[2,3-d]pyrimidinyle, pyrrolo[2,3-b]pyrazinyle et pyrollo[2,3-d]pyridinyle acrylamides
CN105777756B (zh) 2014-07-02 2019-03-01 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
CN105732637B (zh) 2014-12-30 2020-04-21 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
JP2018537502A (ja) * 2015-12-16 2018-12-20 サウザーン リサーチ インスチチュート ピロロピリミジン化合物、キナーゼｌｒｒｋ２阻害剤としての使用、及びその調製方法
CN113135920A (zh) * 2016-06-30 2021-07-20 株式会社大熊制药 吡唑并嘧啶衍生物作为激酶抑制剂
KR102032418B1 (ko) 2017-06-15 2019-10-16 한국화학연구원 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물
KR102577241B1 (ko) 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체
SI3733673T1 (sl) * 2017-12-28 2022-09-30 Daewoong Pharmaceutical Co., Ltd. Oksi-fluoropiperidinski derivat kot kinazni inhibitor
KR102577242B1 (ko) 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체

Also Published As

Publication number Publication date
JP6995428B2 (ja) 2022-01-14
IL275207B (en) 2022-09-01
MA51431A (fr) 2021-04-07
EP3733673B1 (en) 2022-06-29
EP3733673A1 (en) 2020-11-04
PL3733673T3 (pl) 2022-09-26
MA51431B1 (fr) 2022-08-31
WO2019132562A1 (ko) 2019-07-04
CN111527091B (zh) 2023-03-28
IL275207A (en) 2020-07-30
SI3733673T1 (sl) 2022-09-30
TN2020000082A1 (en) 2022-01-06
DOP2020000112A (es) 2020-08-31
KR102592083B1 (ko) 2023-10-20
MY194468A (en) 2022-11-30
RS63515B1 (sr) 2022-09-30
JP2021506818A (ja) 2021-02-22
PE20201146A1 (es) 2020-10-26
PT3733673T (pt) 2022-07-18
LT3733673T (lt) 2022-08-10
CA3084962C (en) 2022-08-09
HRP20221043T1 (hr) 2022-11-11
CL2020001752A1 (es) 2020-11-27
KR102318929B1 (ko) 2021-10-28
MX2020006799A (es) 2020-09-03
PH12020551013A1 (en) 2021-08-16
NZ764644A (en) 2023-06-30
ES2922633T3 (es) 2022-09-19
SG11202004917UA (en) 2020-06-29
CN111527091A (zh) 2020-08-11
CO2020007162A2 (es) 2020-06-19
BR112020013141B1 (pt) 2022-03-15
US11339167B2 (en) 2022-05-24
CA3084962A1 (en) 2019-07-04
ECSP20035590A (es) 2020-07-31
SA520412335B1 (ar) 2022-09-19
EP3733673A4 (en) 2021-06-09
AU2018394997B2 (en) 2021-02-04
US20200308177A1 (en) 2020-10-01
BR112020013141A2 (pt) 2021-02-23
RU2758370C1 (ru) 2021-10-28
KR20210062618A (ko) 2021-05-31
KR20190080803A (ko) 2019-07-08
AU2018394997A1 (en) 2020-06-11

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