HRP20210642T1 - Konjugati il-2 ostatka i polimera - Google Patents
Konjugati il-2 ostatka i polimera Download PDFInfo
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- HRP20210642T1 HRP20210642T1 HRP20210642TT HRP20210642T HRP20210642T1 HR P20210642 T1 HRP20210642 T1 HR P20210642T1 HR P20210642T T HRP20210642T T HR P20210642TT HR P20210642 T HRP20210642 T HR P20210642T HR P20210642 T1 HRP20210642 T1 HR P20210642T1
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- Prior art keywords
- ethylene glycol
- interleukin
- residue
- branched
- water
- Prior art date
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- 229920000642 polymer Polymers 0.000 title claims 11
- -1 poly(ethylene glycol) Polymers 0.000 claims 20
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 102000000588 Interleukin-2 Human genes 0.000 claims 12
- 108010002350 Interleukin-2 Proteins 0.000 claims 12
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 125000006850 spacer group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000021615 conjugation Effects 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (15)
1. Konjugat koji sadrži jedan, dva, tri, četiri, pet, šest, sedam ili osam razgranatih, u vodi topivih poli (etilen glikol) polimera, kovalentno vezanih preko oslobodive karbamatske veze na amino skupinu interleukin-2 ostatka, svaki razgranati u vodi topivi poli(etilen glikol) polimer ima ukupnu prosječnu molekulsku masu u rasponu od 500 Daltona do 100,000 Daltona,
naznačen time što, se po oslobađanju, razgranati, u vodi topivi poli (etilen glikol) polimer odvaja od interleukin-2 ostatka in vivo ne ostavljajući fragment vezan za interleukin-2 ostatak, te konjugat ima formulu
[image]
pri čemu POLY1 je prvi poli (etilen glikol); POLY2 je drugi poli (etilen glikol); X1 je prvi razmakni dio; X2 je drugi razmakni dio; Hα je ionizirajući atom vodika; R1 je H ili organski radikal; R2 je H ili organski radikal; (a) je ili nula ili jedan; (b) je ili nula ili jedan; Re1, kada je prisutan, je prva skupina koja mijenja elektrone; Re2, kada je prisutan, je druga skupina koja mijenja elektrone; Y1 je O; Y2 je O; n je cijeli broj od 1-8; i (IL-2) je interleukin-2 ostatak koji ima aminokiselinsku sekvencu SEQ ID NO:3 ili ima 95% ili veću istovjetnost sekvence sa SEQ ID NO:3.
2. Konjugat prema patentnom zahtjevu 1, naznačen time što su POLY1 i POLY2 su oba terminalno zatvoreni s alkoksi zaklopnim dijelom.
3. Konjugat prema patentnom zahtjevu 2, naznačen time što je alkoksi zaklopni dio C1-6 alkoksi skupina.
4. Konjugat prema patentnom zahtjevu 1, naznačen time što svaki razgranati, u vodi topivi poli (etilen glikol) polimer ima ponderiranu prosječnu molekulsku masu u rasponu od 20,000 Daltona do 85,000 Daltona.
5. Konjugat prema patentnom zahtjevu 1 ili zahtjevu 2, naznačen time što su jedan, dva, tri ili četiri razgranata, u vodi topiva poli (etilen glikol) polimera kovalentno vezani za interleukin-2 ostatak.
6. Farmaceutski pripravak naznačen time što sadrži konjugat prema bilo kojem od zahtjeva 1-5 i farmaceutski prihvatljivu pomoćnu tvar.
7. Farmaceutski pripravak prema patentnom zahtjevu 6, naznačen time što se koristi u terapiji.
8. Postupak za dobivanje konjugata interleukina-2, te postupak uključuje dovođenje u kontakt, u uvjetima konjugacije, interleukin-2 ostatka koji ima aminokiselinsku sekvencu SEQ ID NO:3 ili koji ima 95% istovjetnosti sekvence sa SEQ ID NO:3 i sadrži amino skupine dostupne za kovalentno vezanje na polimer, sa sukcinimidil esterom aktiviranim razgranatim, u vodi topivim poli (etilen glikol) polimerom koji ima formulu,
[image]
pri čemu POLY1 je prvi poli (etilen glikol); POLY2 je drugi poli (etilen glikol); X1 je prvi razmakni dio; X2 je drugi razmakni dio; Hα je ionizirajući atom vodika; R1 je H ili organski radikal; R2 je H ili organski radikal; (a) je ili nula ili jedan; (b) je ili nula ili jedan; Re1, kada je prisutan, je prva skupina koja mijenja elektrone; Re2, kada je prisutan, je druga skupina koja mijenja elektrone, i (FG) je sukcinimidil ester, koji djeluje tako da tvori karbamatnu vezu koja se može osloboditi kada je kovalentno vezan za amino skupinu interleukin-2 ostatka, pri čemu navedeni uvjeti konjugacije sadrže vodeni medij koji ima pH od 7 do 9.0.
9. Konjugat prema patentnom zahtjevu 1, naznačen time što svaki razgranati, u vodi topivi poli (etilen glikol) polimer ima ponderiranu prosječnu molekulsku masu od oko 20,000 Daltona.
10. Pripravak naznačen time što sadrži smjesu konjugata prema patentnom zahtjevu 1.
11. Farmaceutski pripravak za uporabu prema zahtjevu 7, naznačen time što pripravak ima malu ili nikakvu aktivnost interleukina-2.
12. Farmaceutski pripravak za uporabu prema zahtjevu 7, naznačen time što je pripravak za uporabu u liječenju stanja odabranog iz skupine koja se sastoji od karcinoma bubrežnih stanica, metastatskog melanoma, virusa hepatitisa C (HCV), virusa humane imunodeficijencije (HIV), akutne mijeloične leukemije, ne-Hodgkinovog limfoma, kožnog limfoma T-stanica, juvenilnog reumatoidnog artritisa, atopijskog dermatitisa, raka dojke i raka mokraćnog mjehura.
13. Farmaceutski pripravak za uporabu prema zahtjevu 7 naznačen time što je u obliku pogodnom za parenteralnu primjenu.
14. Pripravak prema patentnom zahtjevu 10, naznačen time što konjugati sadržani u pripravku imaju četiri, pet, šest, sedam ili osam razgranatih, u vodi topljivih poli (etilen glikol) polimera kovalentno vezanih za interleukin-2 ostatak.
15. Pripravak prema patentnom zahtjevu 10, naznačen time što konjugati sadržani u pripravku imaju u prosjeku od jednog, dva, tri, četiri, pet, šest, sedam ili osam razgranatih, u vodi topljivih poli (etilen glikol) polimera po interleukin-2 ostatku.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41323610P | 2010-11-12 | 2010-11-12 | |
EP11840401.1A EP2637694B1 (en) | 2010-11-12 | 2011-11-11 | Conjugates of an il-2 moiety and a polymer |
PCT/US2011/060408 WO2012065086A1 (en) | 2010-11-12 | 2011-11-11 | Conjugates of an il-2 moiety and a polymer |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210642T1 true HRP20210642T1 (hr) | 2021-05-28 |
Family
ID=46051324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20210642TT HRP20210642T1 (hr) | 2010-11-12 | 2021-04-23 | Konjugati il-2 ostatka i polimera |
Country Status (21)
Country | Link |
---|---|
US (5) | US9861705B2 (hr) |
EP (2) | EP2637694B1 (hr) |
JP (6) | JP2014506116A (hr) |
KR (5) | KR102591732B1 (hr) |
CN (2) | CN110812488A (hr) |
AU (6) | AU2011325990C1 (hr) |
CA (2) | CA3144697A1 (hr) |
CY (1) | CY1124659T1 (hr) |
DK (1) | DK2637694T3 (hr) |
EA (2) | EA202092025A1 (hr) |
ES (1) | ES2866674T3 (hr) |
HR (1) | HRP20210642T1 (hr) |
HU (1) | HUE054318T2 (hr) |
IL (2) | IL295201A (hr) |
LT (1) | LT2637694T (hr) |
MX (1) | MX358399B (hr) |
PL (1) | PL2637694T3 (hr) |
PT (1) | PT2637694T (hr) |
RS (1) | RS61854B1 (hr) |
SI (1) | SI2637694T1 (hr) |
WO (1) | WO2012065086A1 (hr) |
Families Citing this family (156)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2637694T (pt) | 2010-11-12 | 2021-05-05 | Nektar Therapeutics | Conjugados de uma fração de il-2 e um polímero |
BR102013017626A2 (pt) * | 2013-06-14 | 2015-02-10 | Univ Rio De Janeiro | Bioconjugados não aglomerantes de amilinomiméticos com polietilenoglicol, uso de bioconjugados não aglomerantes de amilinomiméticos com polietilenoglicol, composições farmacêuticas de baixa toxicidade, adjuvante para a prevenção ou tratamento das doenças, medicamento, método de tratamento ou prevenção de doenças. |
EA202191796A2 (ru) | 2013-08-08 | 2022-03-31 | Дзе Скриппс Рисёч Инститьют | Способ сайт-специфического ферментативного мечения нуклеиновых кислот in vitro введением не встречающихся в природе нуклеотидов |
WO2015125159A1 (en) * | 2014-02-21 | 2015-08-27 | Nektar Therapeutics (India) Pvt. Ltd. | Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody |
MA39711A (fr) * | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
US10513706B2 (en) | 2014-04-09 | 2019-12-24 | The Scripps Research Institute | Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters |
WO2015157636A1 (en) | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
SG11201700629TA (en) | 2014-08-11 | 2017-02-27 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
KR20170125839A (ko) * | 2015-03-11 | 2017-11-15 | 넥타르 테라퓨틱스 | Il-7 부분 및 중합체의 접합체 |
JP7407511B2 (ja) * | 2015-10-08 | 2024-01-04 | ネクター セラピューティクス | IL-2Rβ選択的作動薬と長時間作用型IL-15作動薬との併用 |
WO2017106767A1 (en) | 2015-12-18 | 2017-06-22 | The Scripps Research Institute | Production of unnatural nucleotides using a crispr/cas9 system |
US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
HUE060123T2 (hu) | 2016-06-24 | 2023-01-28 | Scripps Research Inst | Új nukleozid-trifoszfát-transzporter és alkalmazásai |
CA3030156A1 (en) | 2016-07-07 | 2018-01-11 | Iovance Biotherapeutics, Inc. | Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof |
US10858428B2 (en) | 2016-09-28 | 2020-12-08 | Xoma (Us) Llc | Antibodies that bind interleukin-2 and uses thereof |
BR112019008305A2 (pt) | 2016-10-26 | 2019-08-06 | Iovance Biotherapeutics Inc | métodos para expansão de linfócitos infiltrantes de tumor, para avaliação da atividade metabólica de uma população de células til, para tratamento de um sujeito com câncer e para ensaiar tils, e, população de tils expandidos |
TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
JP2019534308A (ja) * | 2016-11-10 | 2019-11-28 | ネクター セラピューティクス | 免疫療法的腫瘍治療方法 |
CA3044250A1 (en) | 2016-11-17 | 2018-05-24 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
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