MX2022009302A - Compuestos de unión a il-7r¿. - Google Patents

Compuestos de unión a il-7r¿.

Info

Publication number
MX2022009302A
MX2022009302A MX2022009302A MX2022009302A MX2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A
Authority
MX
Mexico
Prior art keywords
binding compounds
ligands
compounds
binding
agonists
Prior art date
Application number
MX2022009302A
Other languages
English (en)
Inventor
William J Dower
Michael C Needels
Ronald W Barrett
Alice V Bakker
Steven E Cwirla
Original Assignee
Medikine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medikine Inc filed Critical Medikine Inc
Publication of MX2022009302A publication Critical patent/MX2022009302A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Se describen ligandos de IL-7Ra y compuestos que comprenden ligandos de IL-7Ra. Los compuestos de unión a IL-7Ra incluyen proteínas de fusión que comprenden los ligandos de IL-7Ra y pueden actuar como agonistas de IL-7R.
MX2022009302A 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿. MX2022009302A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062969432P 2020-02-03 2020-02-03
PCT/US2021/016356 WO2021158619A1 (en) 2020-02-03 2021-02-03 IL-7Rα BINDING COMPOUNDS

Publications (1)

Publication Number Publication Date
MX2022009302A true MX2022009302A (es) 2022-11-16

Family

ID=77200522

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009302A MX2022009302A (es) 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿.

Country Status (12)

Country Link
US (2) US11254729B2 (es)
EP (1) EP4100046A4 (es)
JP (1) JP2023512687A (es)
KR (1) KR20220156533A (es)
CN (1) CN115297886A (es)
AU (1) AU2021217959A1 (es)
BR (1) BR112022014401A2 (es)
CA (1) CA3169452A1 (es)
IL (1) IL295303A (es)
MX (1) MX2022009302A (es)
TW (1) TWI823054B (es)
WO (1) WO2021158619A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020033312A1 (en) 2018-08-06 2020-02-13 Medikine, Inc. Il-2 receptor binding compounds
WO2021092081A1 (en) 2019-11-05 2021-05-14 Medikine, Inc. Dual il-2r and il-7r binding compounds
BR112022008744A2 (pt) 2019-11-05 2022-07-19 Medikine Inc Ligante de il-2rss, ligante de il-2r¿c, composto de ligação a il-2r¿¿c, composição farmacêutica, método para tratar uma doença em um paciente, método para expandir células imunes, método de uma terapia celular, método para reforçar uma vacina, método para modificar a resposta imune e ácido nucleico
TW202342505A (zh) 2020-02-03 2023-11-01 美商麥地金公司 IL-7Rαγc結合化合物
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
US20230322880A1 (en) * 2022-04-07 2023-10-12 Medikine, Inc. Il-7ralpha-gamma ligand immunoglobulin fusion proteins
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
US20240100159A1 (en) 2022-09-06 2024-03-28 Medikine, Inc. Use of il-7r-alpha-gamma agonist peptides in cell manufacturing
US20240101959A1 (en) 2022-09-06 2024-03-28 Medikine, Inc. Use of il-2r-beta-gamma agonist peptides in cell manufacturing

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
US6890734B2 (en) * 2000-11-10 2005-05-10 Schering Corporation Nucleic acids encoding a cytokine receptor complex
RU2312677C9 (ru) 2001-12-04 2008-03-27 Мерк Патент Гмбх Иммуноцитокины с модулированной селективностью
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
AU2004309050B2 (en) 2003-12-30 2010-10-14 Merck Patent Gmbh IL-7 fusion proteins
ES2342964T3 (es) * 2004-12-09 2010-07-20 Merck Patent Gmbh Variantes de la interleucina-7 con inmunogenicidad reducida.
US20120210458A9 (en) 2009-02-27 2012-08-16 Yongwei Cao Isolated Novel Nucleic Acid and Protein Molecules from Corn and Methods of Using Thereof
RS61854B1 (sr) 2010-11-12 2021-06-30 Nektar Therapeutics Konjugati il-2 dela i polimera
WO2012128806A1 (en) * 2010-12-10 2012-09-27 University Of Central Florida Research Foundation, Inc. Methods and compositions comprising il-7 receptor ligands
RS60050B1 (sr) 2011-01-18 2020-04-30 Bioniz Llc Kompozicije za modulaciju aktivnosti gama-c-citokina
WO2015164815A1 (en) 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
DK3172227T3 (da) 2014-07-21 2019-12-02 Delinia Inc Molekyler der selektivt aktiverer regulatoriske t-celler til behandlingen af autoimmune sygdomme
US10472421B2 (en) 2015-08-06 2019-11-12 Agency For Science, Technology And Research Method for expansion of a population of cells with IL2R beta/common gamma chain antibodies
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
EP3411414A4 (en) 2016-02-05 2019-10-23 Washington University COMPOSITIONS AND METHOD FOR TARGETED CYTOKINE RELIEF
JP2019532996A (ja) 2016-11-08 2019-11-14 デリニア，インコーポレーテッド 自己免疫疾患を処置するためのｉｌ−２変異体
KR20190094222A (ko) 2016-12-13 2019-08-12 데리니아, 인크. 다가 조절성 t 세포 조절제
WO2020033312A1 (en) 2018-08-06 2020-02-13 Medikine, Inc. Il-2 receptor binding compounds

Also Published As

Publication number Publication date
BR112022014401A2 (pt) 2022-11-16
TW202142559A (zh) 2021-11-16
IL295303A (en) 2022-10-01
WO2021158619A8 (en) 2022-04-28
US20220119493A1 (en) 2022-04-21
CN115297886A (zh) 2022-11-04
KR20220156533A (ko) 2022-11-25
AU2021217959A1 (en) 2022-08-18
EP4100046A1 (en) 2022-12-14
TWI823054B (zh) 2023-11-21
JP2023512687A (ja) 2023-03-28
WO2021158619A1 (en) 2021-08-12
US20210253669A1 (en) 2021-08-19
CA3169452A1 (en) 2021-08-12
EP4100046A4 (en) 2024-03-06
US11254729B2 (en) 2022-02-22

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