HRP20181033T1 - Postupak za odabir sredstava koja djeluju na poremećaj pokretljivosti crijeva i bol - Google Patents
Postupak za odabir sredstava koja djeluju na poremećaj pokretljivosti crijeva i bol Download PDFInfo
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- HRP20181033T1 HRP20181033T1 HRP20181033TT HRP20181033T HRP20181033T1 HR P20181033 T1 HRP20181033 T1 HR P20181033T1 HR P20181033T T HRP20181033T T HR P20181033TT HR P20181033 T HRP20181033 T HR P20181033T HR P20181033 T1 HRP20181033 T1 HR P20181033T1
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- agent
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- mmc
- gastrointestinal
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- 238000000034 method Methods 0.000 title claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 4
- 208000035475 disorder Diseases 0.000 title claims 4
- 230000008991 intestinal motility Effects 0.000 title claims 3
- 230000002496 gastric effect Effects 0.000 claims 5
- 210000005036 nerve Anatomy 0.000 claims 5
- 238000010304 firing Methods 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 3
- 230000005176 gastrointestinal motility Effects 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 238000009530 blood pressure measurement Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000013507 mapping Methods 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 230000008050 pain signaling Effects 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 210000001630 jejunum Anatomy 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- G—PHYSICS
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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- G06T7/0002—Inspection of images, e.g. flaw detection
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- G06—COMPUTING; CALCULATING OR COUNTING
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- G06T7/10—Segmentation; Edge detection
- G06T7/13—Edge detection
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30092—Stomach; Gastric
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Toxicology (AREA)
- Quality & Reliability (AREA)
- Radiology & Medical Imaging (AREA)
Claims (11)
1. Postupak za odabir sredstva djelotvornog za liječenje poremećaja pokretljivosti intestinalnog trakta, naznačen time da navedeni postupak obuhvaća:
a) korak spaciotemporalnog (ST) mapiranja proveden na gastrointestinalnom segmentu radi analize učinka navedenog sredstva na gastrointestinalnu pokretljivost; i
b) korak ex vivo snimanja živčanih snopova koji se provodi na gastrointestinalnom segmentu, kako bi se analizirao učinak navedenog sredstva na mezenterijalno aferentno okidanje živaca.
2. Postupak prema zahtjevu 1, naznačen time da se ST mapiranje u koraku a) provodi pomoću video snimanja; i/ili
pri čemu korak a) sadrži korištenje ST mape za mjerenje frekvencije migrirajućeg motornog kompleksa (MMC) i/ili brzine migrirajućeg motornog kompleksa (MMC) u navedenom gastrointestinalnom segmentu.
3. Postupak prema zahtjevu 1 ili zahtjevu 2, naznačen time da korak a) nadalje obuhvaća mjerenje intraluminalnog tlaka, poželjno pri čemu navedeno mjerenje intraluminalnog tlaka je intraluminalni vršni tlak (PPr).
4. Postupak prema bilo kojem od zahtjeva 1 do 3, naznačen time da korak b) obuhvaća mjerenje spontanih frekvencija okidanja mezenterijalnih aferentnih snopova živaca.
5. Postupak prema bilo kojem od zahtjeva 1 do 4, naznačen time da navedeni gastrointestinalni segment je ex vivo segment jejunuma ili debelog crijeva; i/ili
pri čemu navedeni gastrointestinalni segment je iz miša.
6. Postupak prema bilo kojem od zahtjeva 1 do 5, naznačen time da su koraci a) i b) provode prije i poslije intraluminalne primjene sredstva.
7. Postupak prema bilo kojem od zahtjeva 1 do 6, naznačen time da je navedeno sredstvo cijela stanica, mikroorganizam, protein, peptid, enzim ili drugi biološki ili kemijski materijal, poželjno pri čemu navedeno sredstvo je mikroorganizam, poželjnije bakterijski soj.
8. Postupak prema bilo kojem od zahtjeva 1 do 7, naznačen time da je poremećaj pokretljivosti crijeva onaj u kojem se želi smanjiti vrijeme transporta materijala kroz probavni trakt i pri čemu u koraku a) navedeno sredstvo pokazuje sposobnost povećanja gastrointestinalne pokretljivosti i u koraku b) navedeno sredstvo pokazuje sposobnost smanjenja mezenterijalnog aferentnog okidanja živaca, poželjno
pri čemu u koraku a) navedeno sredstvo pokazuje sposobnost povećanja frekvencije MMC ili povećanja brzine MMC ili povećanja intraluminalnog tlaka i u koraku b) navedeno sredstvo pokazuje sposobnost smanjenja signalizacije boli.
9. Postupak prema zahtjevu 8, naznačen time da je navedeno sredstvo bakterijski soj i navedeni soj je LG345 A, koji ima pristupni broj DSM 27123.
10. Postupak prema bilo kojem od zahtjeva 1 do 7, naznačen time da je poremećaj pokretljivosti crijeva onaj u kojem se želi povećati vrijeme transporta materijala kroz probavni trakt i pri čemu u koraku a) navedeno sredstvo pokazuje sposobnost smanjenja gastrointestinalne pokretljivosti i u koraku b) navedeno sredstvo pokazuje sposobnost smanjenja mezenterijalnog aferentnog okidanja živaca, poželjno
pri čemu u koraku a) navedeno sredstvo pokazuje sposobnost smanjenja frekvencije MMC ili smanjenja brzine MMC ili smanjenja intraluminalnog tlaka i u koraku b) navedeno sredstvo pokazuje sposobnost smanjenja signalizacije boli.
11. Postupak prema zahtjevu 10, naznačen time da je navedeno sredstvo bakterijski soj i navedeni soj je LG62 1A, koji ima pristupni broj DSM 27126.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696277P | 2012-09-03 | 2012-09-03 | |
| EP13756897.8A EP2893045B1 (en) | 2012-09-03 | 2013-09-03 | A method for selection of agents influencing intestinal motility disorders and pain |
| PCT/EP2013/068202 WO2014033330A1 (en) | 2012-09-03 | 2013-09-03 | A method for selection of agents influencing intestinal motility disorders and pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20181033T1 true HRP20181033T1 (hr) | 2018-08-24 |
Family
ID=49115523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181033TT HRP20181033T1 (hr) | 2012-09-03 | 2018-07-04 | Postupak za odabir sredstava koja djeluju na poremećaj pokretljivosti crijeva i bol |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9555065B2 (hr) |
| EP (2) | EP2893045B1 (hr) |
| JP (3) | JP6259458B2 (hr) |
| KR (1) | KR102293438B1 (hr) |
| CN (4) | CN108904545A (hr) |
| AU (1) | AU2013308299B2 (hr) |
| CA (1) | CA2883440A1 (hr) |
| CL (2) | CL2015000490A1 (hr) |
| CO (1) | CO7350654A2 (hr) |
| DK (1) | DK2893045T3 (hr) |
| ES (1) | ES2681974T3 (hr) |
| GE (1) | GEP201706775B (hr) |
| HK (3) | HK1211848A1 (hr) |
| HR (1) | HRP20181033T1 (hr) |
| IL (2) | IL237397B (hr) |
| IN (1) | IN2015DN01572A (hr) |
| LT (1) | LT2893045T (hr) |
| MX (2) | MX362495B (hr) |
| MY (2) | MY182358A (hr) |
| NZ (1) | NZ705358A (hr) |
| PH (1) | PH12015500452A1 (hr) |
| RU (1) | RU2701348C2 (hr) |
| SG (3) | SG10202101556WA (hr) |
| SI (1) | SI2893045T1 (hr) |
| UA (2) | UA118339C2 (hr) |
| WO (1) | WO2014033330A1 (hr) |
| ZA (1) | ZA201501472B (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2013109251A (ru) | 2010-08-04 | 2014-09-10 | Томас Джулиус БОРОДИ | Композиции для трансплантации фекальной флоры и способы их получения и применения и устройства для их доставки |
| CN108094541A (zh) * | 2018-01-11 | 2018-06-01 | 黑龙江完达山林海液奶有限公司 | 一种具有保健益生功能的风味发酵乳及其制备方法 |
| HUE059963T2 (hu) | 2018-07-24 | 2023-01-28 | Biogaia Ab | Melatonintámogató baktériumok szelektálása és felhasználása az infantilis kólika csökkentésére |
| CN113966284A (zh) * | 2019-06-05 | 2022-01-21 | Avl动力工程公司 | 车辆轴组件 |
| CN110186922B (zh) * | 2019-06-25 | 2021-07-23 | 西安交通大学医学院第一附属医院 | 一种监测结肠移行性复合运动的实验装置及方法 |
| US11843097B2 (en) | 2019-09-10 | 2023-12-12 | Avl Powertrain Engineering, Inc. | Power supply control systems and methods |
| CN112710823B (zh) * | 2020-12-17 | 2024-03-29 | 中国科学院深圳先进技术研究院 | 一种肠移行性复合运动的离体检测***及其应用 |
| CN114342878B (zh) * | 2022-01-10 | 2022-09-30 | 南京鼓楼医院 | 一种慢传输型便秘动物模型的建立方法 |
| CN117384804A (zh) * | 2023-12-12 | 2024-01-12 | 北京三元食品股份有限公司 | 格氏乳杆菌b1-26及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5438989A (en) * | 1990-08-10 | 1995-08-08 | Hochman; Darryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
| PL200132B1 (pl) * | 1998-08-21 | 2008-12-31 | Novartis Ag | Zastosowanie 3-(5-metoksy-1H-indol-3-ilometyleno)-N-pentylokarbazyimidoamidu |
| EP1196164A2 (en) * | 1999-07-06 | 2002-04-17 | Enpharma L.P. | Methods and compositions for regulating gut motility and food intake |
| EP1384483A1 (en) * | 2002-07-23 | 2004-01-28 | Nestec S.A. | Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function |
| TWI241912B (en) * | 2002-10-30 | 2005-10-21 | Food Industry Res & Dev Inst | Novel Acid-and bile salt-resistant Lactobacillus isolates having the ability to lower and assimilate cholesterol |
| CN1663573B (zh) * | 2004-03-04 | 2010-04-28 | 青岛东海药业有限公司 | 一种稳定安全的微生态制剂及其制备方法和用途 |
| US20090233888A1 (en) * | 2005-03-23 | 2009-09-17 | Usc Stevens, University Of Southern California | Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth |
| JP5036020B2 (ja) * | 2005-11-30 | 2012-09-26 | 雪印メグミルク株式会社 | 腎周囲脂肪蓄積抑制剤 |
| US7374924B2 (en) * | 2006-06-05 | 2008-05-20 | Biogaia Ab | Use of selected lactic acid bacteria for reducing infantile colic |
| JP5019563B2 (ja) * | 2006-06-16 | 2012-09-05 | 旭化成ケミカルズ株式会社 | 腸内細菌賦活剤 |
| EP2200443B2 (en) * | 2007-09-17 | 2021-06-30 | Cornell University | Branched chain fatty acids for prevention or treatment of gastrointestinal disorders |
| MX2012001362A (es) * | 2009-07-31 | 2012-02-22 | Nestec Sa | Composicion nutricional para lactantes o mascotas alimentados con leche maternal con probioticos y nutrientes seleccionados. |
| US20110110905A1 (en) * | 2009-11-06 | 2011-05-12 | Ritchie Jennifer A | Infant Colic Supplement |
| WO2011148219A1 (en) * | 2010-05-28 | 2011-12-01 | Compagnie Gervais Danone | Probiotic strains for use in improving the enteric nervous system |
| US20120034198A1 (en) * | 2010-08-04 | 2012-02-09 | Microbios, Inc. | Carriers for storage and delivery of biologics |
| CN102304489B (zh) * | 2011-09-23 | 2013-06-12 | 北京龙科方舟生物工程技术有限公司 | 一株罗伊氏乳杆菌及其应用 |
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- 2013-03-09 UA UAA201503061A patent/UA118339C2/uk unknown
- 2013-09-03 KR KR1020157007682A patent/KR102293438B1/ko active IP Right Grant
- 2013-09-03 SG SG10202101556WA patent/SG10202101556WA/en unknown
- 2013-09-03 LT LTEP13756897.8T patent/LT2893045T/lt unknown
- 2013-09-03 IN IN1572DEN2015 patent/IN2015DN01572A/en unknown
- 2013-09-03 CN CN201810593302.2A patent/CN108904545A/zh active Pending
- 2013-09-03 UA UAA201808043A patent/UA126374C2/uk unknown
- 2013-09-03 GE GEAP201313744A patent/GEP201706775B/en unknown
- 2013-09-03 JP JP2015529067A patent/JP6259458B2/ja active Active
- 2013-09-03 MX MX2015002792A patent/MX362495B/es active IP Right Grant
- 2013-09-03 AU AU2013308299A patent/AU2013308299B2/en active Active
- 2013-09-03 SG SG10201608055XA patent/SG10201608055XA/en unknown
- 2013-09-03 MY MYPI2015700601A patent/MY182358A/en unknown
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