HRP20180196T1 - Diketoni i hidroksiketoni kao aktivatori puta signalizacije katenina - Google Patents

Diketoni i hidroksiketoni kao aktivatori puta signalizacije katenina Download PDF

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HRP20180196T1
HRP20180196T1 HRP20180196TT HRP20180196T HRP20180196T1 HR P20180196 T1 HRP20180196 T1 HR P20180196T1 HR P20180196T T HRP20180196T T HR P20180196TT HR P20180196 T HRP20180196 T HR P20180196T HR P20180196 T1 HRP20180196 T1 HR P20180196T1
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compound
substituted
formula
pharmaceutical preparation
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Sunil Kumar Kc
David Mark Wallace
John Hood
Charlene F. Barroga
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Samumed, Llc
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    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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Claims (16)

1. Spoj ili njegova farmaceutski prihvatljiva sol koji ima strukturu s Formulom I: [image] naznačen time da R1 je supstituiran ili nesupstituiran heteroaril, pri čemu heteroaril je odabran iz skupine koju čine: [image] uz uvjet da ugljikov atom iz R1 heteroarila je vezan na karbonil; R2 je supstituiran ili nesupstituiran aril, pri čemu je aril odabran od fenila ili naftila; i R3, R4, R5 i R6 su H.
2. Spoj prema zahtjevu 1, naznačen time da R1 je [image]
3. Spoj prema zahtjevu 1, naznačen time da R2 je supstituiran ili nesupstituiran fenil.
4. Spoj prema zahtjevu 1, naznačen time da R1 je [image] i R2 je supstituiran ili nesupstituiran fenil.
5. Spoj prema zahtjevu 4, naznačen time da spoj s Formulom I je: [image]
6. Spoj prema zahtjevu 4, naznačen time da spoj s Formulom I je: [image]
7. Spoj prema zahtjevu 4, naznačen time da spoj s Formulom I je: [image]
8. Spoj prema zahtjevu 1 naznačen time da ima strukturu odabranu iz skupine koju čine: [image] [image] [image] [image] i [image]
9. Farmaceutski pripravak naznačen time da sadrži terapeutski učinkovitu količinu spoja prema zahtjevu 1 ili njegovu farmaceutski prihvatljivu sol koji ima strukturu s Formulom I: [image] pri čemu R1 je supstituiran ili nesupstituiran heteroaril, pri čemu je heteroaril odabran iz skupine koju čine [image] i [image] uz uvjet da ugljikov atom iz R1 heteroarila je vezan na karbonil; R2 je supstituiran ili nesupstituiran aril, pri čemu je aril odabran od fenila ili naftila; i R3, R4, R5 i R6 su H; i farmaceutski prihvatljivo pomoćno sredstvo.
10. Farmaceutski pripravak prema zahtjevu 9, naznačen time da R1 je [image]
11. Farmaceutski pripravak prema zahtjevu 9, naznačen time da R2 je supstituiran ili nesupstituiran fenil.
12. Farmaceutski pripravak prema zahtjevu 9, naznačen time da R1 je [image] i R2 je supstituiran ili nesupstituiran fenil.
13. Farmaceutski pripravak prema zahtjevu 9 naznačen time da ima strukturu odabranu iz skupine koju čine: [image] [image] [image] [image] i [image] ili njegova farmaceutski prihvatljiva sol.
14. Farmaceutski pripravak prema zahtjevu 9, naznačen time da spoj s Formulom I je: [image] ili njegova farmaceutski prihvatljiva sol.
15. Farmaceutski pripravak prema zahtjevu 9, naznačen time da spoj s Formulom I je: [image] ili njegova farmaceutski prihvatljiva sol.
16. Farmaceutski pripravak prema zahtjevu 9, naznačen time da spoj s Formulom I je: [image] ili njegova farmaceutski prihvatljiva sol.
HRP20180196TT 2010-08-18 2018-02-01 Diketoni i hidroksiketoni kao aktivatori puta signalizacije katenina HRP20180196T1 (hr)

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US37468710P 2010-08-18 2010-08-18
US201061427974P 2010-12-29 2010-12-29
PCT/US2011/048086 WO2012024404A1 (en) 2010-08-18 2011-08-17 Diketones and hydroxyketones as catenin signaling pathway activators
EP11818727.7A EP2605652B1 (en) 2010-08-18 2011-08-17 Diketones and hydroxyketones as catenin signaling pathway activators

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