HRP20210255T1 - Postupak priprave derivata karbamoilpiridona i međuprodukata - Google Patents
Postupak priprave derivata karbamoilpiridona i međuprodukata Download PDFInfo
- Publication number
- HRP20210255T1 HRP20210255T1 HRP20210255TT HRP20210255T HRP20210255T1 HR P20210255 T1 HRP20210255 T1 HR P20210255T1 HR P20210255T T HRP20210255T T HR P20210255TT HR P20210255 T HRP20210255 T HR P20210255T HR P20210255 T1 HRP20210255 T1 HR P20210255T1
- Authority
- HR
- Croatia
- Prior art keywords
- intermediates
- preparing
- carbamoylpyridone derivatives
- carbamoylpyridone
- derivatives
- Prior art date
Links
- OHEKQGOBJIKKIF-AWEZNQCLSA-N (12as)-n-[(4-fluorophenyl)methyl]-7-hydroxy-6,8-dioxo-3,4,12,12a-tetrahydro-2h-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide Chemical class C([C@@H]1OCCCN1C(=O)C1=C(C2=O)O)N1C=C2C(=O)NCC1=CC=C(F)C=C1 OHEKQGOBJIKKIF-AWEZNQCLSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- XAXGEECGULRZGN-UHFFFAOYSA-N 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid Chemical compound COC(OC)CN1C=C(C(O)=O)C(=O)C(OC)=C1C(=O)OC XAXGEECGULRZGN-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Claims (2)
1. Spoj formule (IV)
[image]
,
naznačen time što je R alkil, aril ili benzil.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je 1-[2,2-bis(metiloksi)etil]-5-(metiloksi)-6-[(metiloksi)karbonil]-4-okso-1,4-dihidro-3-piridinkarboksilna kiselina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31642110P | 2010-03-23 | 2010-03-23 | |
EP17165935.2A EP3260457B1 (en) | 2010-03-23 | 2011-03-22 | Process for preparing carbamoylpyridone derivatives and intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210255T1 true HRP20210255T1 (hr) | 2021-04-02 |
Family
ID=44673569
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170961TT HRP20170961T1 (hr) | 2010-03-23 | 2017-06-26 | Postupak dobivanja karbamoilpiridonskih derivata i međuprodukata |
HRP20210255TT HRP20210255T1 (hr) | 2010-03-23 | 2021-02-15 | Postupak priprave derivata karbamoilpiridona i međuprodukata |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170961TT HRP20170961T1 (hr) | 2010-03-23 | 2017-06-26 | Postupak dobivanja karbamoilpiridonskih derivata i međuprodukata |
Country Status (19)
Country | Link |
---|---|
US (9) | US8889877B2 (hr) |
EP (2) | EP3260457B1 (hr) |
JP (1) | JP5490305B2 (hr) |
KR (1) | KR101440278B1 (hr) |
CN (1) | CN102933080B (hr) |
CY (2) | CY1119143T1 (hr) |
DK (2) | DK2549870T3 (hr) |
ES (2) | ES2632346T3 (hr) |
HR (2) | HRP20170961T1 (hr) |
HU (2) | HUE033863T2 (hr) |
LT (2) | LT2549870T (hr) |
ME (1) | ME02703B (hr) |
PL (2) | PL2549870T3 (hr) |
PT (2) | PT3260457T (hr) |
RS (2) | RS61436B1 (hr) |
SG (1) | SG184186A1 (hr) |
SI (2) | SI3260457T1 (hr) |
TW (1) | TWI582097B (hr) |
WO (1) | WO2011119566A1 (hr) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5586602B2 (ja) | 2008-07-25 | 2014-09-10 | ビーブ・ヘルスケア・カンパニー | 化合物 |
KR101682058B1 (ko) | 2008-12-11 | 2016-12-02 | 비이브 헬쓰케어 컴퍼니 | 카르바모일피리돈 hiv 인테그라제 억제제를 위한 제조방법 및 중간체 |
AU2009325128B2 (en) | 2008-12-11 | 2015-01-29 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
ES2608377T3 (es) * | 2010-08-05 | 2017-04-10 | Shionogi & Co., Ltd. | Procedimiento de preparación de un compuesto que tiene actividad inhibidora de la integrasa del HIV |
CA3012242C (en) | 2012-12-21 | 2021-11-02 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
US9573965B2 (en) | 2013-02-19 | 2017-02-21 | Aurobindo Pharma Ltd | Process for the preparation of Dolutegravir |
NO2865735T3 (hr) | 2013-07-12 | 2018-07-21 | ||
JP6411491B2 (ja) | 2013-07-12 | 2018-10-24 | ギリアード サイエンシス インコーポレーテッド | 多環式カルバモイルピリドン化合物およびhiv感染症を処置するためのその使用 |
WO2015019310A1 (en) * | 2013-08-07 | 2015-02-12 | Mylan Laboratories Ltd | Process for the preparation of dolute-gravir and intermediates thereof |
US9808428B2 (en) | 2014-01-14 | 2017-11-07 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
US9856271B2 (en) | 2014-01-21 | 2018-01-02 | Laurus Labs Limited | Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
WO2015177537A1 (en) * | 2014-05-20 | 2015-11-26 | Cipla Limited | Process for preparing polycyclic carbamoyl pyridone derivatives and intermediates thereof |
TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
NO2717902T3 (hr) | 2014-06-20 | 2018-06-23 | ||
WO2016057866A1 (en) | 2014-10-09 | 2016-04-14 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
CN104557686A (zh) * | 2014-12-29 | 2015-04-29 | 徐俊烨 | 一种吡啶酮类化合物的合成方法 |
EP3045461A1 (en) | 2015-01-16 | 2016-07-20 | LEK Pharmaceuticals d.d. | Processes for preparing dolutegravir and analogues thereof |
EP3253767A2 (en) * | 2015-02-06 | 2017-12-13 | Mylan Laboratories Ltd. | Processes for the preparation of dolute-gravir |
AU2016244035B2 (en) | 2015-04-02 | 2018-11-01 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
WO2017109649A1 (en) | 2015-12-21 | 2017-06-29 | Lupin Limited | Process for the preparation of hiv integrase inhibitors |
WO2017205585A1 (en) * | 2016-05-27 | 2017-11-30 | Viiv Healthcare Company | Combinations and uses treatments thereof |
CN106565747A (zh) * | 2016-11-10 | 2017-04-19 | 顾世海 | 一种制备度鲁特韦的新方法 |
JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
WO2018149608A1 (en) | 2017-02-16 | 2018-08-23 | Sandoz Ag | Crystalline forms of cabotegravir sodium |
EP3363802B1 (en) | 2017-02-16 | 2019-11-20 | Sandoz AG | Crystalline form of cabotegravir sodium |
US11839623B2 (en) | 2018-01-12 | 2023-12-12 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
WO2019159199A1 (en) * | 2018-02-16 | 2019-08-22 | Cipla Limited | Continues flow process for the preparation of active pharmaceutical ingredients - polycyclic carbamoyl pyridone derivatives and intermediates thereof |
WO2019199756A1 (en) | 2018-04-09 | 2019-10-17 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
WO2020012408A2 (en) | 2018-07-12 | 2020-01-16 | Laurus Labs Limited | A process for purification of protected polycyclic carbamoylpyridone derivatives |
CN109438334A (zh) * | 2018-10-29 | 2019-03-08 | 南京杰运医药科技有限公司 | 一种度鲁特韦中间体的合成方法 |
CN109293675A (zh) * | 2018-11-19 | 2019-02-01 | 遵义医学院 | 一种改进的度鲁特韦制备工艺 |
CN110128448A (zh) * | 2019-05-22 | 2019-08-16 | 博诺康源(北京)药业科技有限公司 | 一种度鲁特韦原料及中间体中非对映异构体杂质的合成方法 |
RU2717101C1 (ru) | 2019-06-03 | 2020-03-18 | Андрей Александрович Иващенко | Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения |
US20200398978A1 (en) | 2019-06-20 | 2020-12-24 | Bell Helicopter Textron Inc. | Low-drag rotor blade extension |
US11248005B2 (en) | 2019-07-08 | 2022-02-15 | Lupin Limited | Process for preparation of intermediates used for the synthesis of HIV integrase inhibitor |
CN111620891B (zh) * | 2020-05-27 | 2023-07-14 | 上海启讯医药科技有限公司 | 一种多替拉韦关键中间体溶剂化物多晶型物及其制备方法和用途 |
CN112500336A (zh) * | 2020-12-15 | 2021-03-16 | 内蒙古永太化学有限公司 | 一种度鲁特韦母核中间体的制备方法 |
CN115572257A (zh) * | 2021-06-21 | 2023-01-06 | 江西帝劢药业有限公司 | 一种吡啶酮类化合物的合成方法 |
CN113816972B (zh) * | 2021-11-17 | 2022-03-18 | 奥锐特药业(天津)有限公司 | 一种hiv抑制剂的制备方法及其中间体晶型 |
CN114605437A (zh) * | 2022-04-01 | 2022-06-10 | 遵义医科大学 | 连续一锅法制备三个替拉韦药物的合成工艺 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4524149A (en) | 1982-03-15 | 1985-06-18 | Sterling Drug Inc. | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use |
US4769380A (en) | 1983-04-29 | 1988-09-06 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates |
US4603144A (en) | 1984-08-16 | 1986-07-29 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
US4735964A (en) | 1984-08-16 | 1988-04-05 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
US4812474A (en) | 1984-08-16 | 1989-03-14 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
DE59611243D1 (de) | 1995-09-29 | 2005-08-11 | Novartis Ag | Hydroxypyridinone |
GB9711093D0 (en) | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
US7256286B2 (en) | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
WO2003013528A1 (en) * | 2001-08-02 | 2003-02-20 | Neurocrine Biosciences, Inc. | Substituted pyridin-4-ones and their use as gonadotropin-releasing hormone receptor antagonists. |
US6426418B1 (en) | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
CA2379370A1 (en) | 2002-03-28 | 2003-09-28 | Apotex Inc. | Carboxylic acid derivatives of 3-hydroxy-4-oxo-1,4-dihydropyridine as iron chelators |
CA2498111A1 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
AU2003301439A1 (en) | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
DE10349500A1 (de) | 2003-10-23 | 2005-06-02 | Bayer Cropscience Ag | Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern |
US7645292B2 (en) | 2003-10-27 | 2010-01-12 | Boston Scientific Scimed, Inc. | Vaso-occlusive devices with in-situ stiffening elements |
AU2005227258A1 (en) | 2004-03-09 | 2005-10-06 | Merck & Co., Inc. | HIV integrase inhibitors |
WO2005087766A1 (en) | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv integrase inhibitors |
CA2562713A1 (en) | 2004-04-14 | 2005-12-15 | Gilead Sciences, Inc. | Phosphonate analogs of hiv integrase inhibitor compounds |
WO2006030807A1 (ja) | 2004-09-15 | 2006-03-23 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
CA2488034C (en) | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
JP5068663B2 (ja) | 2004-12-16 | 2012-11-07 | ジェネラル・ケーブル・テクノロジーズ・コーポレーション | フィラーエレメントを有する異質のクロストークが軽減された電気ケーブル |
CA2634499A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
WO2006088173A1 (ja) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体 |
UA96568C2 (en) * | 2005-04-28 | 2011-11-25 | Глаксосмиткляйн Ллк | Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor |
NZ562339A (en) * | 2005-04-28 | 2011-01-28 | Smithkline Beecham Corp | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
TW200716632A (en) | 2005-05-16 | 2007-05-01 | Gilead Sciences Inc | Integrase inhibitor compounds |
JP2006342115A (ja) | 2005-06-10 | 2006-12-21 | Shionogi & Co Ltd | Hivインテグラーゼ阻害活性を有する多環性化合物 |
KR101170120B1 (ko) * | 2005-07-27 | 2012-07-31 | 삼성전자주식회사 | 비안경식 3차원 디스플레이 장치 |
EP1762250A1 (en) | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
WO2007049676A1 (ja) | 2005-10-27 | 2007-05-03 | Kao Corporation | 脱酸素剤、脱酸素剤中間体、脱酸素剤複合体及びその製造方法 |
TW200800988A (en) | 2005-10-27 | 2008-01-01 | Shionogi & Amp Co Ltd | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
EP2114898A2 (en) | 2007-02-16 | 2009-11-11 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors |
JP5586602B2 (ja) * | 2008-07-25 | 2014-09-10 | ビーブ・ヘルスケア・カンパニー | 化合物 |
WO2010011819A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
SI2320908T1 (sl) | 2008-07-25 | 2014-05-30 | Viiv Healthcare Company | Predzdravila dolutegravirja |
AU2009325128B2 (en) | 2008-12-11 | 2015-01-29 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
KR101682058B1 (ko) | 2008-12-11 | 2016-12-02 | 비이브 헬쓰케어 컴퍼니 | 카르바모일피리돈 hiv 인테그라제 억제제를 위한 제조방법 및 중간체 |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
ES2608377T3 (es) | 2010-08-05 | 2017-04-10 | Shionogi & Co., Ltd. | Procedimiento de preparación de un compuesto que tiene actividad inhibidora de la integrasa del HIV |
-
2011
- 2011-03-21 TW TW100109585A patent/TWI582097B/zh active
- 2011-03-22 WO PCT/US2011/029369 patent/WO2011119566A1/en active Application Filing
- 2011-03-22 DK DK11760040.3T patent/DK2549870T3/en active
- 2011-03-22 HU HUE11760040A patent/HUE033863T2/en unknown
- 2011-03-22 PL PL11760040T patent/PL2549870T3/pl unknown
- 2011-03-22 LT LTEP11760040.3T patent/LT2549870T/lt unknown
- 2011-03-22 JP JP2013501383A patent/JP5490305B2/ja active Active
- 2011-03-22 DK DK17165935.2T patent/DK3260457T3/da active
- 2011-03-22 SG SG2012070124A patent/SG184186A1/en unknown
- 2011-03-22 US US13/636,237 patent/US8889877B2/en active Active
- 2011-03-22 EP EP17165935.2A patent/EP3260457B1/en active Active
- 2011-03-22 PT PT171659352T patent/PT3260457T/pt unknown
- 2011-03-22 HU HUE17165935A patent/HUE052848T2/hu unknown
- 2011-03-22 RS RS20210153A patent/RS61436B1/sr unknown
- 2011-03-22 CN CN201180015527.6A patent/CN102933080B/zh active Active
- 2011-03-22 ES ES11760040.3T patent/ES2632346T3/es active Active
- 2011-03-22 EP EP11760040.3A patent/EP2549870B1/en active Active
- 2011-03-22 ME MEP-2017-132A patent/ME02703B/me unknown
- 2011-03-22 LT LTEP17165935.2T patent/LT3260457T/lt unknown
- 2011-03-22 PL PL17165935T patent/PL3260457T3/pl unknown
- 2011-03-22 SI SI201131955T patent/SI3260457T1/sl unknown
- 2011-03-22 ES ES17165935T patent/ES2856020T3/es active Active
- 2011-03-22 KR KR1020127027667A patent/KR101440278B1/ko active IP Right Grant
- 2011-03-22 PT PT117600403T patent/PT2549870T/pt unknown
- 2011-03-22 SI SI201131218A patent/SI2549870T1/sl unknown
- 2011-03-22 RS RS20170586A patent/RS56072B1/sr unknown
-
2014
- 2014-10-14 US US14/513,265 patent/US9120817B2/en active Active
-
2015
- 2015-07-28 US US14/810,518 patent/US9643981B2/en active Active
-
2017
- 2017-03-31 US US15/475,377 patent/US9938296B2/en active Active
- 2017-06-21 CY CY20171100654T patent/CY1119143T1/el unknown
- 2017-06-26 HR HRP20170961TT patent/HRP20170961T1/hr unknown
-
2018
- 2018-02-28 US US15/907,626 patent/US10174051B2/en active Active
- 2018-02-28 US US15/907,683 patent/US10233196B2/en active Active
- 2018-12-03 US US16/207,243 patent/US10654870B2/en active Active
- 2018-12-03 US US16/207,273 patent/US10647728B2/en active Active
- 2018-12-03 US US16/207,288 patent/US10654871B2/en active Active
-
2021
- 2021-02-10 CY CY20211100112T patent/CY1123958T1/el unknown
- 2021-02-15 HR HRP20210255TT patent/HRP20210255T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20210255T1 (hr) | Postupak priprave derivata karbamoilpiridona i međuprodukata | |
HRP20171028T1 (hr) | Indolski i indazolski spojevi koji aktiviraju ampk | |
HRP20200538T1 (hr) | Derivati pirimidina za liječenje virusnih infekcija | |
WO2014028589A3 (en) | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | |
CA2826751C (en) | Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds | |
MD20140072A2 (ro) | Noi compuşi ai pirolului, procedeu de obţinere a lor şi compoziţii farmaceutice care îi conţin | |
PH12014502524B1 (en) | Carboxylic acid compounds | |
WO2011156610A3 (en) | Quinoline and isoquinoline derivatives as inhibitors of hepatitis c virus | |
HRP20221304T1 (hr) | Kombinacija koja sadrži inhibitor mek i inhibitor b-raf | |
PH12015501452A1 (en) | Novel quinolone derivatives | |
MD4490C1 (ro) | Noi compuşi de indolizină, procedeu de obţinere a lor şi compoziţii farmaceutice care îi conţin | |
EA201591390A1 (ru) | Пиразол[1,5-a]пиримидины для противовирусного лечения | |
MX2016006336A (es) | Compuestos pirazolopirimidina. | |
BR112014010765A2 (pt) | Cristal de sal de ácido carboxílico - 7 {(3s, 4s) -3- [ciclopropilamino] -4- fluoropirolidina-1- ila-}6 fluor-1-(2-fluor-etila)-8-metoxi-4- oxo-1,4-dihidroquinole-3 | |
GEP201706774B (en) | Heterocyclyl compounds | |
FR2957914B1 (fr) | Nouveau procede de preparation de silices precipitees contenant de l'aluminium | |
AU2018236805B2 (en) | Glutarimide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing glutarimide derivatives | |
PH12015500457A1 (en) | Alkoxy pyrazoles as soluble guanylate cyclase activators | |
WO2009115562A3 (en) | Crystalline forms and two solvated forms of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one lactic acid salts | |
CA2920410C (en) | Thienopiperidine derivative and use thereof | |
WO2013109388A3 (en) | 1,5-naphthyridine derivatives and melk inhibitors containing the same | |
MX2014005075A (es) | Formulaciones de sal de meglumina del acido 1-(5,6-dicloro-1h-benz o[d]imidazol-2-il)-1h-pirazol-4-carboxilico. | |
WO2014036502A8 (en) | Tetracycline compounds | |
ZA201500362B (en) | Novel compound having ability to inhibit 11b-hsd1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient | |
CA2922375C (en) | Alpha-tea salt forms: compositions and uses for treating disease |