HRP20080608T3 - Triazolopiridinilsulfanilni derivati kao inhibitori p38 map kinaze - Google Patents

Triazolopiridinilsulfanilni derivati kao inhibitori p38 map kinaze

Info

Publication number
HRP20080608T3
HRP20080608T3 HR20080608T HRP20080608T HRP20080608T3 HR P20080608 T3 HRP20080608 T3 HR P20080608T3 HR 20080608 T HR20080608 T HR 20080608T HR P20080608 T HRP20080608 T HR P20080608T HR P20080608 T3 HRP20080608 T3 HR P20080608T3
Authority
HR
Croatia
Prior art keywords
independently selected
optionally substituted
halogen
alkyl
co2h
Prior art date
Application number
HR20080608T
Other languages
English (en)
Inventor
Paul Mathias John
Simon Millan David
Andrew Lewthwaite Russell
Phillips Christopher
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0418015A external-priority patent/GB0418015D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HRP20080608T3 publication Critical patent/HRP20080608T3/hr

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

Spoj formule (I), ili njegova farmaceutski prihvatljiva sol i/ili solvat (uključujući hidrat); ,gdjeR1 je CH3, SCH3, SCH2CH3, CH2CH3, H ili CH2SCH3; R1a je CH3 ili CH2CH3;R2 je heteroaril, heterociklil, aril ili karbociklil; R3 je heteroaril, heterociklil, aril, karbociklil ili R7;R7 je (C1-C6)alkil izborno supstituirani s jednim ili više supstituenata, koje se neovisno bira između OH, halogena, NR5R6, (C1-C8)alkoksi, -S(O)p(C1-C8)alkila, CO2H, CONR5R6, heteroarila, heterociklila, arila, karbociklila, ariloksi, karbocikliloksi, heteroariloksi,te heterocikliloksi; p je 0, 1 ili 2; svakog od R5 i R6 se neovisno bira između H i (C1-C4)alkila, gdje je navedeni (C1-C4)alkil izborno supstitiran s jednim ili više supstituenata, koje se neovisno bira između OH i halogena, ili R5 i R6, zajedno s dušikom, na kojeg su vezani, tvore piperazinilnu, piperidinilnu, morfolinilnu ili pirolidinilna skupinu, gdje je svaki od navedenih piperazinila, piperidinila, morfolinila i pirolidinila izborno supstituiran s jednim ili više OH; "aril" znači fenil ili naftil, gdje su navedeni fenil ili naftil izborno supstituirani s jednim ili više supstituenata, koje se neovisno bira između halogena, -CN, -CO2H,ON, CONR5R6, R7, te R8;R8 se bira između (C1-C6)alkila, (C1-C6)alkoksi, -CO2(C1-C6)alkila, -S(O)p(C1-C6)alkila, -CO(C1-C6) alkila, te (C3-C7)cikloalkila; svaki R5 je izborno supstituiran s jednim iliviše supstituenata, koje se neovisno bira između:(C1-C6)alkoksi, izborno supstituiranog s jednim ili više supstituenata, koje se neovisno bira između OH, halogena, CO2H, CONR5R6, te NR5R6,-S(O)p(C1-C6)alkila, izborno supstituiranog s jednim ili više supstituenata, koje se neovisno bira između OH, halogena, CO2H, CONR5R6, te NR5R6,OH, halogena, NR5R6,CO2H, CONR5R6, teR9;R9 je heteroaril2, heterociklil2, aril2, karbociklil2, aril2oksi, karbociklil2oksi, heteroaril2oksi ili heterociklil2oksi; "aril2" znači fenil ili naftil, gdje su navedeni fenil ili naftil izborno supstituirani s jednim ili više supstituenata, koje se neovisno bira između halogena, -CN, CO2H, OH, te CONR5R6;"karbociklil" znači mono- ili biciklički, zasićeni ili djelomično nezasićeni prstenasti sustav, koji sadrži 3 do 10 atoma ugljika u prstenu, izborno supstituiran s jednim ili više supstituenata, koje se neovisno bira između halogena, -CN, -CO2H, OH, CONR5R6, R8, te R9;"karbociklil2" znači mono- ili biciklički, zasićeni ili djelomično nezasićeni prstenasti sustav, koji sadrži 3 do 10 atoma ugljika u prstenu, izborno supstituiran s jednim ili više supstituenata, koje se neovisno bira između halogena, -CN, -CO2H, OH, te CONR5R6;svaki "heterociklil", i "heterociklil2" neovisno znači 3- do 10- člana, zasićena ili djelomično nezasićena, mono- ili biciklička skupina, koja sadrži 1 do 4 heteroatoma u prstenu, koje se neovisno bira između N, O, te S; svaki "heteroaril", te svaki "heteroaril2", neovisno znači 5- do 10- člana, mono- ili biciklička, aromatska skupina, koja sadrži 1 do 4 heteroatoma u prstenu, koje se neo
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