HRP20030277B1 - Method for producing powdery formulations - Google Patents

Method for producing powdery formulations

Info

Publication number: HRP20030277B1
Authority: HR; Croatia
Prior art keywords: substance; representing; layers; size distribution; particle size
Prior art date: 2000-10-12

Application number

HR20030277A

Other languages

English (en)

Croatian (hr)

Inventor

B�ck Georg

Walz Michael

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co. Kg.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2003-04-10

Publication date

2011-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26007343&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20030277(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-08-10 Priority claimed from DE2001138022 external-priority patent/DE10138022A1/de

2003-04-10 Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg.

2005-02-28 Publication of HRP20030277A2 publication Critical patent/HRP20030277A2/hr

2011-09-30 Publication of HRP20030277B1 publication Critical patent/HRP20030277B1/xx

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000002245 particle Substances 0.000 abstract 4
239000000126 substance Substances 0.000 abstract 2
239000013543 active substance Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)
Cosmetics (AREA)

HR20030277A 2000-10-12 2003-04-10 Method for producing powdery formulations HRP20030277B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10050635		2000-10-12
DE2001138022 DE10138022A1 (de)	2001-08-10	2001-08-10	Verfahren zur Herstellung von Pulverformulierungen
PCT/EP2001/011636 WO2002030390A2 (de)	2000-10-12	2001-10-09	Verfahren zur herstellung von pulverformulierungen

Publications (2)

Publication Number	Publication Date
HRP20030277A2 HRP20030277A2 (en)	2005-02-28
HRP20030277B1 true HRP20030277B1 (en)	2011-09-30

Family

ID=26007343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20030277A HRP20030277B1 (en)	2000-10-12	2003-04-10	Method for producing powdery formulations

Country Status (40)

Country	Link
US (2)	US6585959B2 (da)
EP (1)	EP1326585B2 (da)
JP (2)	JP4986369B2 (da)
KR (1)	KR100849837B1 (da)
CN (1)	CN1269470C (da)
AR (1)	AR034166A1 (da)
AT (1)	ATE319422T1 (da)
AU (2)	AU1822002A (da)
BG (1)	BG66194B1 (da)
BR (1)	BR0114316A (da)
CA (1)	CA2425005C (da)
CY (1)	CY1105037T1 (da)
CZ (1)	CZ300022B6 (da)
DE (1)	DE50109178D1 (da)
DK (1)	DK1326585T4 (da)
EA (1)	EA004689B1 (da)
EE (1)	EE05146B1 (da)
EG (1)	EG24478A (da)
ES (1)	ES2259046T5 (da)
HK (1)	HK1060522A1 (da)
HR (1)	HRP20030277B1 (da)
HU (1)	HU229512B1 (da)
IL (2)	IL154919A0 (da)
ME (1)	ME02762B (da)
MX (1)	MXPA03003219A (da)
MY (1)	MY155912A (da)
NO (1)	NO333719B1 (da)
NZ (1)	NZ525781A (da)
PE (1)	PE20020424A1 (da)
PL (1)	PL204733B1 (da)
PT (1)	PT1326585E (da)
RS (1)	RS50495B (da)
SA (1)	SA01220518B1 (da)
SI (1)	SI1326585T2 (da)
SK (1)	SK285841B6 (da)
TW (1)	TWI283180B (da)
UA (1)	UA75375C2 (da)
UY (1)	UY26960A1 (da)
WO (1)	WO2002030390A2 (da)
ZA (1)	ZA200301349B (da)

Families Citing this family (55)

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EP1430887A1 (de) *	2000-10-12	2004-06-23	Boehringer Ingelheim Pharma GmbH & Co.KG	Tiotropium-haltige Inhalationspulver
US6443152B1 (en) *	2001-01-12	2002-09-03	Becton Dickinson And Company	Medicament respiratory delivery device
WO2002096422A2 (en) *	2001-05-25	2002-12-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Combination of a dopamine d2-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways
US20030070679A1 (en) *	2001-06-01	2003-04-17	Boehringer Ingelheim Pharma Kg	Capsules containing inhalable tiotropium
US20030008001A1 (en) *	2001-06-13	2003-01-09	Boehringer Ingelheim Pharma Kg	Process for cleaning hard gelatine capsules
US20030018019A1 (en) *	2001-06-23	2003-01-23	Boehringer Ingelheim Pharma Kg	Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) *	2001-08-23	2003-03-13	Boehringer Ingelheim Pharma	Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10141376A1 (de) *	2001-08-23	2003-03-13	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Inhalationspulvern
US7309707B2 (en) *	2002-03-20	2007-12-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) *	2002-03-28	2007-07-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations of an anhydrate
ES2272968T3 (es) *	2002-04-04	2007-05-01	BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG	Formulaciones en polvo, adecuadas para inhalacion.
JP4744876B2 (ja) *	2002-08-21	2011-08-10	ノートン・ヘルスケアーリミテッド	乾燥粉末吸入組成物の製造方法
GB0219513D0 (en)	2002-08-21	2002-10-02	Norton Healthcare Ltd	Inhalation compositions including coarse carrier
US20050158248A1 (en) *	2002-08-21	2005-07-21	Xian-Ming Zeng	Method of preparing dry powder inhalation compositions
NZ538965A (en) *	2002-08-21	2006-11-30	Norton Healthcare Ltd	Dry powder inhalation compositions
GB0219511D0 (en) *	2002-08-21	2002-10-02	Norton Healthcare Ltd	Method of preparing dry powder inhalation compositions
DE10255387A1 (de) *	2002-11-28	2004-06-09	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Tiotropium-haltige Pulverformulierung für die Inhalation
US7763280B2 (en)	2002-11-28	2010-07-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Tiotropium containing powder formulation for inhalation
DE10351663A1 (de) *	2002-12-20	2004-07-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pulverförmige Arzneimittel enthaltend ein Tiotropiumsalz und Salmeterolxinafoat
DE10317461A1 (de)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
US20040226556A1 (en)	2003-05-13	2004-11-18	Deem Mark E.	Apparatus for treating asthma using neurotoxin
US7462367B2 (en)	2003-07-11	2008-12-09	Boehringer Ingelheim International Gmbh	Anticholinergic powder formulations for inhalation
DE10331350A1 (de) *	2003-07-11	2005-01-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pulverformulierungen für die Inhalation enthaltend ein neues Anticholinergikum
PL1699434T3 (pl)	2003-09-02	2011-09-30	Norton Healthcare Ltd	Sposób wytwarzania leku
GB0327723D0 (en) *	2003-09-15	2003-12-31	Vectura Ltd	Pharmaceutical compositions
SG149876A1 (en)	2003-11-03	2009-02-27	Boehringer Ingelheim Int	Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
SG137859A1 (en)	2003-11-03	2007-12-28	Boehringer Ingelheim Int	Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
EP1691783B1 (en) *	2003-12-03	2009-11-25	Boehringer Ingelheim International GmbH	Pre-metered dry powder inhaler for moisture-sensitive medicaments
DE102004048389A1 (de)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
MX2007009656A (es)	2005-02-10	2007-11-07	Glaxo Group Ltd	Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma.
GB0507835D0 (en) *	2005-04-18	2005-05-25	Solexa Ltd	Method and device for nucleic acid sequencing using a planar wave guide
CN101166738B (zh)	2005-05-02	2011-06-01	贝林格尔·英格海姆国际有限公司	噻托溴铵的新晶型
DE102005059602A1 (de)	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
EP2011538B1 (en)	2007-07-06	2016-02-17	Vectura Delivery Devices Limited	Inhaler
EP2264042B1 (en) *	2007-07-27	2012-07-18	Cargill, Incorporated	Micronization of polyols
EP2082767A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
EP2082772A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
EP2082771A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
EP2082766A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Blister Strip Coil Forming
EP2082768A1 (en)	2008-01-24	2009-07-29	Vectura Delivery Devices Limited	Inhaler
US8483831B1 (en)	2008-02-15	2013-07-09	Holaira, Inc.	System and method for bronchial dilation
EP2662027B1 (en)	2008-05-09	2017-09-27	Holaira, Inc.	Systems, assemblies, and methods for treating a bronchial tree
KR101657029B1 (ko) *	2008-07-24	2016-09-12	레르 리키드 쏘시에떼 아노님 뿌르 레드 에렉스뿔라따시옹 데 프로세데 조르즈 클로드	전이 금속 함유 필름의 침착을 위한 헤테로렙틱 시클로펜타디에닐 전이 금속 전구체
TWI491416B (zh)	2008-12-24	2015-07-11	Daiichi Sankyo Co Ltd	吸入用乾燥粉末醫藥組成物
GB0918450D0 (en)	2009-10-21	2009-12-09	Innovata Ltd	Composition
CN104042322B (zh)	2009-10-27	2017-06-06	赫莱拉公司	具有可冷却的能量发射组件的递送装置
US8911439B2 (en)	2009-11-11	2014-12-16	Holaira, Inc.	Non-invasive and minimally invasive denervation methods and systems for performing the same
EP4111995A1 (en)	2009-11-11	2023-01-04	Nuvaira, Inc.	Device for treating tissue and controlling stenosis
US9259376B2 (en)	2010-06-03	2016-02-16	Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti.	Process for dry powder formulations
TR201007251A2 (tr) *	2010-09-01	2012-03-21	Bi̇lgi̇ç Mahmut	Kalsiyum kanal blokörü formülasyonu.
US9398933B2 (en)	2012-12-27	2016-07-26	Holaira, Inc.	Methods for improving drug efficacy including a combination of drug administration and nerve modulation
ES2701525T3 (es)	2014-07-09	2019-02-22	Arven Ilac Sanayi Ve Ticaret As	Un procedimiento para la preparación de formulaciones para inhalación
PT3175842T (pt) *	2015-12-03	2020-03-04	Tiefenbacher Alfred E Gmbh & Co Kg	Processo de mistura de pó seco
WO2020013793A2 (en) *	2018-07-12	2020-01-16	Arven Ilac Sanayi Ve Ticaret Anonim Sirketi	Inhalation compositions comprising dopamine agonists
WO2022146255A1 (en) *	2020-12-31	2022-07-07	Arven Ilac Sanayi Ve Ticaret Anonim Sirketi	A process for the preparation of dry powder compositions for inhalation

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WO1993011746A1 (de) *	1991-12-10	1993-06-24	Boehringer Ingelheim Kg	Inhalationspulver und verfahren zu ihrer herstellung
DE4425255A1 (de) *	1994-07-16	1996-01-18	Asta Medica Ag	Formulierung zur inhalativen Applikation

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2001
- 2001-09-10 UA UA2003054184A patent/UA75375C2/uk unknown
- 2001-10-09 ME MEP-2008-427A patent/ME02762B/me unknown
- 2001-10-09 JP JP2002533833A patent/JP4986369B2/ja not_active Expired - Lifetime
- 2001-10-09 CN CNB01817146XA patent/CN1269470C/zh not_active Expired - Lifetime
- 2001-10-09 WO PCT/EP2001/011636 patent/WO2002030390A2/de active IP Right Grant
- 2001-10-09 EP EP01986599A patent/EP1326585B2/de not_active Expired - Lifetime
- 2001-10-09 TW TW090124981A patent/TWI283180B/zh not_active IP Right Cessation
- 2001-10-09 BR BR0114316-6A patent/BR0114316A/pt active Pending
- 2001-10-09 ES ES01986599T patent/ES2259046T5/es not_active Expired - Lifetime
- 2001-10-09 AT AT01986599T patent/ATE319422T1/de active
- 2001-10-09 KR KR1020037005039A patent/KR100849837B1/ko active IP Right Grant
- 2001-10-09 IL IL15491901A patent/IL154919A0/xx active IP Right Grant
- 2001-10-09 EE EEP200300170A patent/EE05146B1/xx unknown
- 2001-10-09 SK SK437-2003A patent/SK285841B6/sk not_active IP Right Cessation
- 2001-10-09 HU HU0301268A patent/HU229512B1/hu unknown
- 2001-10-09 DK DK01986599.7T patent/DK1326585T4/da active
- 2001-10-09 AU AU1822002A patent/AU1822002A/xx active Pending
- 2001-10-09 CZ CZ20031024A patent/CZ300022B6/cs not_active IP Right Cessation
- 2001-10-09 NZ NZ525781A patent/NZ525781A/en not_active IP Right Cessation
- 2001-10-09 EA EA200300429A patent/EA004689B1/ru not_active IP Right Cessation
- 2001-10-09 SI SI200130509T patent/SI1326585T2/sl unknown
- 2001-10-09 CA CA 2425005 patent/CA2425005C/en not_active Expired - Lifetime
- 2001-10-09 DE DE50109178T patent/DE50109178D1/de not_active Expired - Lifetime
- 2001-10-09 AU AU2002218220A patent/AU2002218220B2/en not_active Expired
- 2001-10-09 PL PL362511A patent/PL204733B1/pl unknown
- 2001-10-09 PT PT01986599T patent/PT1326585E/pt unknown
- 2001-10-09 MX MXPA03003219A patent/MXPA03003219A/es active IP Right Grant
- 2001-10-09 RS YUP-274/03A patent/RS50495B/sr unknown
- 2001-10-10 MY MYPI20014704A patent/MY155912A/en unknown
- 2001-10-10 PE PE2001001002A patent/PE20020424A1/es active IP Right Grant
- 2001-10-10 EG EG2001101063A patent/EG24478A/xx active
- 2001-10-10 UY UY26960A patent/UY26960A1/es not_active IP Right Cessation
- 2001-10-11 US US09/977,911 patent/US6585959B2/en not_active Ceased
- 2001-10-12 AR ARP010104784A patent/AR034166A1/es active Pending
- 2001-11-11 SA SA01220518A patent/SA01220518B1/ar unknown
2003
- 2003-02-19 ZA ZA2003/01349A patent/ZA200301349B/en unknown
- 2003-03-13 IL IL154919A patent/IL154919A/en unknown
- 2003-03-26 BG BG107673A patent/BG66194B1/bg active Active
- 2003-04-10 HR HR20030277A patent/HRP20030277B1/xx not_active IP Right Cessation
- 2003-04-11 NO NO20031692A patent/NO333719B1/no not_active IP Right Cessation
2004
- 2004-01-28 US US10/766,748 patent/USRE38912E1/en not_active Expired - Lifetime
- 2004-05-20 HK HK04103581A patent/HK1060522A1/xx not_active IP Right Cessation
2006
- 2006-05-19 CY CY20061100654T patent/CY1105037T1/el unknown
2009
- 2009-06-08 JP JP2009136927A patent/JP2009197025A/ja active Pending

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993011746A1 (de) *	1991-12-10	1993-06-24	Boehringer Ingelheim Kg	Inhalationspulver und verfahren zu ihrer herstellung
DE4425255A1 (de) *	1994-07-16	1996-01-18	Asta Medica Ag	Formulierung zur inhalativen Applikation

Also Published As

Publication number	Publication date
NO333719B1 (no)	2013-09-02
EP1326585B1 (de)	2006-03-08
PL362511A1 (en)	2004-11-02
PE20020424A1 (es)	2002-07-02
UA75375C2 (en)	2006-04-17
CN1469733A (zh)	2004-01-21
MY155912A (en)	2015-12-15
BG66194B1 (bg)	2012-01-31
EP1326585A2 (de)	2003-07-16
EE05146B1 (et)	2009-04-15
ES2259046T3 (es)	2006-09-16
RS50495B (sr)	2010-03-02
SI1326585T1 (sl)	2006-06-30
DE50109178D1 (de)	2006-05-04
CA2425005C (en)	2008-08-05
CY1105037T1 (el)	2010-03-03
NO20031692D0 (no)	2003-04-11
AR034166A1 (es)	2004-02-04
HUP0301268A2 (hu)	2003-10-28
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