HRP20020539B1 - New modulators of dopamine neurotransmission - Google Patents

New modulators of dopamine neurotransmission

Info

Publication number: HRP20020539B1
Authority: HR; Croatia
Prior art keywords: group; alkyl; dopamine neurotransmission; new modulators; oso
Prior art date: 1999-12-22

Application number

HR20020539A

Other languages

English (en)

Croatian (hr)

Inventor

Sonesson Clas

Waters Susanna

Waters Nicholas

Tedroff Joakim

pok. Andersson Bengt

Original Assignee

Neurosearch Sweden Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-22

Filing date

2002-06-20

Publication date

2009-06-30

2002-06-20 Application filed by Neurosearch Sweden Ab filed Critical Neurosearch Sweden Ab

2004-08-31 Publication of HRP20020539A2 publication Critical patent/HRP20020539A2/hr

2009-06-30 Publication of HRP20020539B1 publication Critical patent/HRP20020539B1/xx

Links

VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
229960003638 dopamine Drugs 0.000 title 1
230000005062 synaptic transmission Effects 0.000 title 1
-1 CONHR 3 Inorganic materials 0.000 abstract 4
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Liquid Crystal Substances (AREA)
Control Of El Displays (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Error Detection And Correction (AREA)

HR20020539A 1999-12-22 2002-06-20 New modulators of dopamine neurotransmission HRP20020539B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9904723A SE9904723D0 (sv)	1999-12-22	1999-12-22	New modulators of dopamine neurotransmission II
PCT/SE2000/002675 WO2001046146A1 (en)	1999-12-22	2000-12-22	New modulators of dopamine neurotransmission

Publications (2)

Publication Number	Publication Date
HRP20020539A2 HRP20020539A2 (en)	2004-08-31
HRP20020539B1 true HRP20020539B1 (en)	2009-06-30

Family

ID=20418252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020539A HRP20020539B1 (en)	1999-12-22	2002-06-20	New modulators of dopamine neurotransmission

Country Status (30)

Country	Link
US (2)	USRE41315E1 (zh)
EP (2)	EP1240143A1 (zh)
JP (1)	JP5096654B2 (zh)
KR (1)	KR100771287B1 (zh)
CN (1)	CN1196680C (zh)
AT (1)	ATE397446T1 (zh)
AU (1)	AU778183B2 (zh)
BG (1)	BG65698B1 (zh)
BR (1)	BR0016635A (zh)
CA (1)	CA2394606C (zh)
CZ (1)	CZ302907B6 (zh)
DE (1)	DE60039131D1 (zh)
DK (1)	DK1419773T3 (zh)
EE (1)	EE05083B1 (zh)
ES (1)	ES2307861T3 (zh)
HK (1)	HK1054228B (zh)
HR (1)	HRP20020539B1 (zh)
HU (1)	HUP0203874A3 (zh)
IL (2)	IL150350A0 (zh)
MX (1)	MXPA02006317A (zh)
NO (1)	NO323329B1 (zh)
NZ (2)	NZ519566A (zh)
PL (1)	PL205092B1 (zh)
PT (1)	PT1419773E (zh)
RU (1)	RU2262504C2 (zh)
SE (1)	SE9904723D0 (zh)
SK (1)	SK287366B6 (zh)
UA (1)	UA73337C2 (zh)
WO (1)	WO2001046146A1 (zh)
ZA (1)	ZA200204813B (zh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9904724D0 (sv) *	1999-12-22	1999-12-22	Carlsson A Research Ab	New modulators of dopamine neurotransmission I
USRE46117E1 (en)	1999-12-22	2016-08-23	Teva Pharmaceuticals International Gmbh	Modulators of dopamine neurotransmission
SE9904723D0 (sv)	1999-12-22	1999-12-22	Carlsson A Research Ab	New modulators of dopamine neurotransmission II
WO2004113297A2 (en) *	2003-06-24	2004-12-29	Neurosearch A/S	Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
DE10361259A1 (de) *	2003-12-24	2005-07-28	Schwarz Pharma Ag	Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes
MXPA06013941A (es)	2004-06-08	2007-12-10	Neurosearch Sweden Ab	Fenilpiperidinas disustituidas, novedosas, como moduladores de la neurotransmision de dopamina y serotonina.
DK1765779T3 (da) *	2004-06-08	2010-04-06	Nsab Af Neurosearch Sweden Ab	Nye substituerede piperidiner som modulatorer for dopamin-neurotransmission
US7851629B2 (en)	2004-06-08	2010-12-14	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
SE0401464D0 (sv) *	2004-06-08	2004-06-08	Carlsson A Research Ab	New disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission
CA2569843A1 (en)	2004-06-08	2005-12-22	A. Carlsson Research Ab	New disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
SE0401465D0 (sv) *	2004-06-08	2004-06-08	Carlsson A Research Ab	New substituted piperdines as modulators of dopamine neurotransmission
AU2005254726A1 (en) *	2004-06-18	2005-12-29	Neurosearch A/S	Novel alkyl substituted piperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CN101068782A (zh) *	2004-10-13	2007-11-07	神经研究瑞典公司	合成4－(3－磺酰基苯基)－哌啶类的方法
WO2006040155A1 (en)	2004-10-13	2006-04-20	Neurosearch Sweden Ab	Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
ITMI20051193A1 (it) *	2005-06-24	2006-12-25	Acraf	Uso farmaceutico di una 1-3-clorofenil-3-alchilpiperazina
SE529246C2 (sv) *	2005-10-13	2007-06-12	Neurosearch Sweden Ab	Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
WO2007065655A1 (en)	2005-12-07	2007-06-14	Neurosearch Sweden Ab	Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission
ES2458592T3 (es) *	2007-04-12	2014-05-06	IVAX International GmbH	Derivados de N-óxido y/o di-N-óxido de estabilizadores/moduladores de receptores de dopamina que muestran perfiles de efectos secundarios cardiovasculares mejorados
KR20100038295A (ko)	2007-06-05	2010-04-14	엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게	피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘
CA2689692A1 (en)	2007-06-05	2008-12-11	Clas Sonesson	New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
MX2010011724A (es) *	2008-04-29	2010-11-30	Nsab Af Neurosearch Sweden Ab	Moduladores de neurotransmision de dopamina.
DK2271638T3 (da) *	2008-04-29	2011-11-28	Nsab Af Neurosearch Sweden Ab	Modulatorer af dopaminneurotransmission
JP2011519839A (ja) *	2008-04-29	2011-07-14	エヌエスエイビー、フィリアルアヴノイロサーチスウェーデンエービー、スヴェーリエ	ドーパミン神経伝達のモジュレーター
WO2011107583A1 (en)	2010-03-04	2011-09-09	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
JP2013536825A (ja)	2010-09-03	2013-09-26	イバックス・インターナショナル・ゲーエムベーハー	ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体
WO2013034622A1 (en)	2011-09-07	2013-03-14	Neurosearch A/S	Polymorphic form of pridopidine hydrochloride
MX347209B (es)	2011-12-08	2017-04-19	Teva Pharmaceuticals Int Gmbh	La sal de bromhidrato de pridopidina.
KR20150013476A (ko)	2012-04-04	2015-02-05	아이백스 인터내셔널 게엠베하	조합요법용 약학적 조성물
AR105434A1 (es)	2015-07-22	2017-10-04	Teva Pharmaceuticals Int Gmbh	Proceso para preparar pridopidina

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2083476A (en) *	1980-09-12	1982-03-24	Wyeth John & Brother Ltd	Heterocyclic compounds
WO1991009594A1 (en) *	1989-12-28	1991-07-11	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
WO1993000313A2 (en) *	1991-06-27	1993-01-07	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
US5502050A (en) *	1993-11-29	1996-03-26	Cornell Research Foundation, Inc.	Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
WO2002005819A1 (en) *	2000-07-15	2002-01-24	Smithkline Beecham Corporation	Compounds and methods

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2027703A (en) *	1934-06-21	1936-01-14	Ribar Peter	Shoe jack
DE1019308B (de) *	1954-07-19	1957-11-14	Hoechst Ag	Verfahren zur Herstellung gegen Bilharzia-Infektionen wirksamer 4-Phenyl-piperazine
GB850662A (en)	1956-10-22	1960-10-05	Parke Davis & Co	Substituted piperazines and processes for their production
BE662455A (zh)	1964-04-14
GB1060160A (en)	1964-08-05	1967-03-01	Allen & Hanburys Ltd	4-phenylpiperidine derivatives
NL6607959A (zh) *	1965-06-10	1966-12-12
US3539573A (en)	1967-03-22	1970-11-10	Jean Schmutz	11-basic substituted dibenzodiazepines and dibenzothiazepines
CA1061356A (en) *	1975-10-03	1979-08-28	Dieter H. Klaubert	2-cyano-3- or 4-(substituted amino) oxanilic acid derivatives
GB1560271A (en) *	1977-01-14	1980-02-06	Joullie International Sa	Therapeutically useful m-trifluoromethylphenylpiperazine derivatives
US4202898A (en)	1978-06-05	1980-05-13	Synthelabo	Method of treating anxiety and depression
FR2459797A2 (fr) *	1978-08-01	1981-01-16	Synthelabo	Derives de phenyl-1 piperazine et leur application en therapeutique
US4267328A (en)	1978-08-01	1981-05-12	Synthelabo	1-Phenylpiperazines
US4333942A (en)	1979-08-03	1982-06-08	Byk Gulden Lomberg Chemische Fabrik Gmbh	Anti-depressant and analgesic 4-phenoxypiperidines
US4518712A (en) *	1980-06-30	1985-05-21	Taiho Pharmaceutical Company Limited	Piperazine derivative and analgesic composition containing the same
JPS5714585A (en) *	1980-06-30	1982-01-25	Taiho Yakuhin Kogyo Kk	1-cycloalkylmethylpiperazine derivative
FR2501506A1 (fr)	1981-03-11	1982-09-17	Sanofi Sa	Compositions pharmaceutiques a action anorexigene contenant des derives de la tetrahydropyridine
JPS5815979A (ja) *	1981-07-11	1983-01-29	Kyowa Hakko Kogyo Co Ltd	新規なピペリジン誘導体およびその製造法
US4415736A (en)	1981-12-28	1983-11-15	E. I. Du Pont De Nemours & Co.	Certain tetrahydropyridine intermediates
ATE50987T1 (de)	1982-05-10	1990-03-15	Takeda Chemical Industries Ltd	Dihydropyridinderivate, deren herstellung und verwendung.
US4504660A (en) *	1982-07-06	1985-03-12	American Home Products Corporation	Process for the production of 2,6-diaminobenzonitrile derivatives
ES540226A0 (es) *	1985-02-07	1985-12-01	Inst Investigacion Desarrollo	Un nuevo procedimiento de obtencion de derivados del acido quinolincarboxilico
US4892975A (en)	1987-09-28	1990-01-09	President And Fellows Of Harvard College	Diethynyl monomers and polymers thereof
HU198454B (en)	1987-12-14	1989-10-30	Richter Gedeon Vegyeszet	Process for production of new derivatives of tetrahydrospiridin and medical compositions containing these compounds
FR2639226B1 (fr)	1988-11-18	1993-11-05	Sanofi	Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
CA2105666C (en)	1991-04-17	2006-02-14	Kjell Anders Ivan Svensson	New centrally acting substituted phenylazacycloalkanes
NZ240863A (en)	1991-09-11	1995-04-27	Mcneilab Inc	Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
GB9119932D0 (en)	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds
GB9119920D0 (en)	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds
DE69232003T2 (de)	1991-09-18	2002-04-25	Glaxo Group Ltd	Benzanilidderivate als 5-HT1D-Antagonisten
TW240217B (zh) *	1992-12-30	1995-02-11	Glaxo Group Ltd
GB2276160A (en) *	1993-03-17	1994-09-21	Glaxo Group Ltd	Ethanone compounds.
EP0659743A1 (en)	1993-12-27	1995-06-28	Hoechst Aktiengesellschaft	Piperidine derivatives as inhibitors of platelet aggregation and their preparation
CA2144669A1 (en)	1994-03-29	1995-09-30	Kozo Akasaka	Biphenyl derivatives
US5571822A (en) *	1994-09-30	1996-11-05	The University Of North Carolina At Chapel Hill	Antitumor compounds
WO1997003986A1 (fr)	1995-07-19	1997-02-06	Yoshitomi Pharmaceutical Industries, Ltd.	Composes fusionnes de triazole
FR2740134B1 (fr) *	1995-10-18	1998-01-09	Pf Medicament	Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant
US5892041A (en)	1996-08-12	1999-04-06	Neurogen Corporation	Fused indolecarboxamides: dopamine receptor subtype specific ligands
DE19637237A1 (de)	1996-09-13	1998-03-19	Merck Patent Gmbh	Piperazin-Derivate
DZ2376A1 (fr) *	1996-12-19	2002-12-28	Smithkline Beecham Plc	Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
US6232326B1 (en)	1998-07-14	2001-05-15	Jodi A. Nelson	Treatment for schizophrenia and other dopamine system dysfunctions
JP2000086603A (ja)	1998-07-15	2000-03-28	Yoshitomi Pharmaceut Ind Ltd	桂皮酸アミド誘導体および３―フェニルプロピオン酸アミド誘導体
EP1194410B1 (en)	1999-06-22	2006-01-18	Neurosearch A/S	Benzimidazole derivatives and pharmaceutical compositions comprising these compounds
SE9904723D0 (sv)	1999-12-22	1999-12-22	Carlsson A Research Ab	New modulators of dopamine neurotransmission II
SE9904724D0 (sv)	1999-12-22	1999-12-22	Carlsson A Research Ab	New modulators of dopamine neurotransmission I
US6906120B1 (en)	2000-06-20	2005-06-14	General Electric	Poly(arylene ether) adhesive compositions
ATE301652T1 (de)	2001-01-23	2005-08-15	Lilly Co Eli	Piperazinderivate als agonisten des melanocortin- rezeptors
US6663587B2 (en) *	2001-06-22	2003-12-16	Medela Holding Ag	Breastshield with multi-pressure and expansible chamber construction, related breastpump and method
US20050004164A1 (en)	2003-04-30	2005-01-06	Caggiano Thomas J.	2-Cyanopropanoic acid amide and ester derivatives and methods of their use
US7160888B2 (en)	2003-08-22	2007-01-09	Warner Lambert Company Llc	[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
MXPA06013941A (es)	2004-06-08	2007-12-10	Neurosearch Sweden Ab	Fenilpiperidinas disustituidas, novedosas, como moduladores de la neurotransmision de dopamina y serotonina.
US7851629B2 (en)	2004-06-08	2010-12-14	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
CA2569843A1 (en)	2004-06-08	2005-12-22	A. Carlsson Research Ab	New disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
SE0401465D0 (sv)	2004-06-08	2004-06-08	Carlsson A Research Ab	New substituted piperdines as modulators of dopamine neurotransmission
SE529246C2 (sv)	2005-10-13	2007-06-12	Neurosearch Sweden Ab	Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
WO2007065655A1 (en)	2005-12-07	2007-06-14	Neurosearch Sweden Ab	Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission

1999
- 1999-12-22 SE SE9904723A patent/SE9904723D0/xx unknown
2000
- 2000-12-22 CZ CZ20022074A patent/CZ302907B6/cs not_active IP Right Cessation
- 2000-12-22 CA CA002394606A patent/CA2394606C/en not_active Expired - Fee Related
- 2000-12-22 NZ NZ519566A patent/NZ519566A/en unknown
- 2000-12-22 EE EEP200200345A patent/EE05083B1/xx not_active IP Right Cessation
- 2000-12-22 WO PCT/SE2000/002675 patent/WO2001046146A1/en not_active Application Discontinuation
- 2000-12-22 PL PL362251A patent/PL205092B1/pl not_active IP Right Cessation
- 2000-12-22 DK DK03027034T patent/DK1419773T3/da active
- 2000-12-22 PT PT03027034T patent/PT1419773E/pt unknown
- 2000-12-22 DE DE60039131T patent/DE60039131D1/de not_active Expired - Lifetime
- 2000-12-22 HU HU0203874A patent/HUP0203874A3/hu unknown
- 2000-12-22 RU RU2002119417/04A patent/RU2262504C2/ru not_active IP Right Cessation
- 2000-12-22 BR BR0016635-9A patent/BR0016635A/pt not_active IP Right Cessation
- 2000-12-22 US US11/904,013 patent/USRE41315E1/en not_active Expired - Lifetime
- 2000-12-22 EP EP00989163A patent/EP1240143A1/en not_active Withdrawn
- 2000-12-22 ES ES03027034T patent/ES2307861T3/es not_active Expired - Lifetime
- 2000-12-22 CN CNB008182582A patent/CN1196680C/zh not_active Expired - Fee Related
- 2000-12-22 JP JP2001547057A patent/JP5096654B2/ja not_active Expired - Fee Related
- 2000-12-22 US US10/168,019 patent/US6924374B2/en not_active Ceased
- 2000-12-22 NZ NZ531643A patent/NZ531643A/en not_active IP Right Cessation
- 2000-12-22 SK SK866-2002A patent/SK287366B6/sk not_active IP Right Cessation
- 2000-12-22 KR KR1020027008066A patent/KR100771287B1/ko not_active IP Right Cessation
- 2000-12-22 AT AT03027034T patent/ATE397446T1/de active
- 2000-12-22 IL IL15035000A patent/IL150350A0/xx unknown
- 2000-12-22 UA UA2002076054A patent/UA73337C2/uk unknown
- 2000-12-22 AU AU25706/01A patent/AU778183B2/en not_active Ceased
- 2000-12-22 EP EP03027034A patent/EP1419773B1/en not_active Expired - Lifetime
- 2000-12-22 MX MXPA02006317A patent/MXPA02006317A/es active IP Right Grant
2002
- 2002-06-14 ZA ZA200204813A patent/ZA200204813B/xx unknown
- 2002-06-17 NO NO20022879A patent/NO323329B1/no not_active IP Right Cessation
- 2002-06-19 BG BG106845A patent/BG65698B1/bg unknown
- 2002-06-20 IL IL150350A patent/IL150350A/en not_active IP Right Cessation
- 2002-06-20 HR HR20020539A patent/HRP20020539B1/xx not_active IP Right Cessation
2003
- 2003-09-09 HK HK03106410.6A patent/HK1054228B/zh not_active IP Right Cessation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2083476A (en) *	1980-09-12	1982-03-24	Wyeth John & Brother Ltd	Heterocyclic compounds
WO1991009594A1 (en) *	1989-12-28	1991-07-11	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
WO1993000313A2 (en) *	1991-06-27	1993-01-07	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
US5502050A (en) *	1993-11-29	1996-03-26	Cornell Research Foundation, Inc.	Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
WO2002005819A1 (en) *	2000-07-15	2002-01-24	Smithkline Beecham Corporation	Compounds and methods

Also Published As

Publication number	Publication date
JP2003518096A (ja)	2003-06-03
PT1419773E (pt)	2008-07-01
CZ302907B6 (cs)	2012-01-18
HK1054228B (zh)	2005-09-16
PL205092B1 (pl)	2010-03-31
USRE41315E1 (en)	2010-05-04
US6924374B2 (en)	2005-08-02
DK1419773T3 (da)	2008-09-22
ZA200204813B (en)	2003-08-27
WO2001046146A1 (en)	2001-06-28
NO323329B1 (no)	2007-03-26
HUP0203874A3 (en)	2005-03-29
DE60039131D1 (de)	2008-07-17
IL150350A0 (en)	2002-12-01
CZ20022074A3 (cs)	2002-10-16
SE9904723D0 (sv)	1999-12-22
BG106845A (en)	2003-04-30
CA2394606C (en)	2009-06-02
EP1240143A1 (en)	2002-09-18
HRP20020539A2 (en)	2004-08-31
AU778183B2 (en)	2004-11-18
SK287366B6 (sk)	2010-08-09
EE05083B1 (et)	2008-10-15
CA2394606A1 (en)	2001-06-28
NZ531643A (en)	2005-03-24
CN1420870A (zh)	2003-05-28
EP1419773A2 (en)	2004-05-19
EP1419773B1 (en)	2008-06-04
KR100771287B1 (ko)	2007-10-29
BG65698B1 (bg)	2009-07-31
CN1196680C (zh)	2005-04-13
NO20022879L (no)	2002-08-21
US20030004169A1 (en)	2003-01-02
BR0016635A (pt)	2002-10-15
ES2307861T3 (es)	2008-12-01
EP1419773A3 (en)	2004-05-26
RU2262504C2 (ru)	2005-10-20
AU2570601A (en)	2001-07-03
RU2002119417A (ru)	2004-01-10
KR20020067565A (ko)	2002-08-22
MXPA02006317A (es)	2004-05-14
JP5096654B2 (ja)	2012-12-12
NZ519566A (en)	2004-05-28
SK8662002A3 (en)	2003-02-04
NO20022879D0 (no)	2002-06-17
PL362251A1 (en)	2004-10-18
HK1054228A1 (en)	2003-11-21
ATE397446T1 (de)	2008-06-15
UA73337C2 (en)	2005-07-15
IL150350A (en)	2010-05-31
EE200200345A (et)	2003-06-16
HUP0203874A2 (hu)	2003-03-28

Legal Events

Date	Code	Title	Description
2004-08-31	A1OB	Publication of a patent application
2005-02-24	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2007-12-07	PNAN	Change of the applicant name, address/residence	Owner name: A. CARLSSON RESEARCH AB, SE Owner name: NEUROSEARCH SWEDEN AB, SE
2009-06-30	B1PR	Patent granted
2010-06-30	PPPP	Transfer of rights	Owner name: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE C/O
2012-11-08	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20121108 Year of fee payment: 13
2014-07-01	PBON	Lapse due to non-payment of renewal fee	Effective date: 20131222

Publication	Publication Date	Title
HRP20020539B1 (en)	2009-06-30	New modulators of dopamine neurotransmission
HRP20020540B1 (en)	2007-12-31	New modulators of dopamine neurotransmission
PE20030890A1 (es)	2003-12-05	Cumarinas utiles como biomarcadores
HRP20030771B1 (en)	2008-10-31	N-(2-arylethyl)benzylamines as antagonists of the 5-ht<sub>6</sub> receptor
HRP20020175B1 (en)	2008-07-31	N-heterocyclikc derivatives as nos inhibitors
HRP20070529T3 (en)	2008-05-31	Imidazole derivatives as glutmate receptor antagonists
RS51186B (sr)	2010-10-31	Derivati oksadiazolona kao ppar delta agonisti
HRP20070194T3 (en)	2007-06-30	N-thiazol-2-yl-benzamide derivatives
HRP20070510T3 (en)	2007-12-31	Benzimidazole derivative and its use as a ii receptor antagonist
PE20021091A1 (es)	2003-02-04	Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
RS53029B (en)	2014-04-30	CARBONYLAMINE PIROLOPYRAZOLES, POWERFUL KINASE INHIBITORS
CA2054339A1 (en)	1992-05-03	3-amidoindolyl derivatives
ATE282614T1 (de)	2004-12-15	Phenylharnstoff und phenylthioharnstoffderivate
HUP0301607A2 (hu)	2003-12-29	Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
CO4970840A1 (es)	2000-11-07	Ciertas 1-(2-naftil) y 1-(azanaftil)-4-(1-fenilmetil) pipe- razinas; ligandos especificos del subtipo receptor de la dopamina
PE20020253A1 (es)	2002-04-08	Derivados de 3-azabiciclo[3.1.0]hexano como ligandos de receptores opiaceos
FR2770842B1 (fr)	1999-12-17	Nouveaux composes derives de n-aryl 2-hydroxy alkylamides
DE60130766D1 (de)	2007-11-15	Serotoninwiederaufnahme-inhibitoren
TW200505446A (en)	2005-02-16	Inhibitor of cox
HRP20030381B1 (en)	2007-05-31	3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
DE69906481D1 (de)	2003-05-08	Cellulosische partikel und verfahren zur herstellung derselben
HRP20030713B1 (en)	2006-02-28	Imidazolidine derivatives their preparation, and their use as antiflamatory agent
RS51933B (en)	2012-02-29	NEW UNITS AND THEIR USE
ATE449071T1 (de)	2009-12-15	Neue substituierte piperidine als modulatoren der dopamin neurotransmission
YU196491A (sh)	1994-05-10	Artropodicioni karboksianilidi