HRP20000367A2 - Conjugates useful in the treatment of prostate cancer - Google Patents

Conjugates useful in the treatment of prostate cancer Download PDF

Info

Publication number: HRP20000367A2
Authority: HR; Croatia
Prior art keywords: seq; ser; trans; hyp; chg
Prior art date: 1997-12-02

Application number

HR20000367A

Other languages

English (en)

Croatian (hr)

Inventor

F Stephen Brady

Dong-Mei Feng

Victor M Garsky

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-02

Filing date

2000-06-02

Publication date

2000-12-31

1998-03-02 Priority claimed from GBGB9804399.5A external-priority patent/GB9804399D0/en

2000-06-02 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2000-12-31 Publication of HRP20000367A2 publication Critical patent/HRP20000367A2/hr

Links

206010060862 Prostate cancer Diseases 0.000 title claims description 13
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239000011734 sodium Substances 0.000 description 1
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GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
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KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
229960004982 vinblastine sulfate Drugs 0.000 description 1
GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
229960002066 vinorelbine Drugs 0.000 description 1
CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HR20000367A 1997-12-02 2000-06-02 Conjugates useful in the treatment of prostate cancer HRP20000367A2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6711097P	1997-12-02	1997-12-02
GBGB9804399.5A GB9804399D0 (en)	1998-03-02	1998-03-02	Conjugates useful in the treatment of prostate cancer
PCT/US1998/025358 WO1999028345A1 (fr)	1997-12-02	1998-11-25	Conjugues utiles dans le traitement du cancer de la prostate

Publications (1)

Publication Number	Publication Date
HRP20000367A2 true HRP20000367A2 (en)	2000-12-31

Family

ID=26313204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20000367A HRP20000367A2 (en)	1997-12-02	2000-06-02	Conjugates useful in the treatment of prostate cancer

Country Status (26)

Country	Link
US (2)	US20060148718A1 (fr)
EP (1)	EP1036093A1 (fr)
JP (1)	JP2001525337A (fr)
KR (1)	KR100580137B1 (fr)
CN (1)	CN1181092C (fr)
AR (1)	AR016427A1 (fr)
AU (1)	AU744652B2 (fr)
BG (1)	BG65486B1 (fr)
BR (1)	BR9815116A (fr)
CA (1)	CA2311615A1 (fr)
DZ (1)	DZ2665A1 (fr)
EA (1)	EA002745B1 (fr)
EE (1)	EE200000333A (fr)
HR (1)	HRP20000367A2 (fr)
HU (1)	HUP0100350A3 (fr)
ID (1)	ID24735A (fr)
IL (1)	IL136167A0 (fr)
IS (1)	IS5502A (fr)
NO (1)	NO20002804L (fr)
NZ (1)	NZ504615A (fr)
PE (1)	PE20000009A1 (fr)
PL (1)	PL197006B1 (fr)
SK (1)	SK8282000A3 (fr)
TR (1)	TR200002260T2 (fr)
TW (1)	TW577897B (fr)
WO (1)	WO1999028345A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003518000A (ja) *	1998-12-11	2003-06-03	コールターファーマシューティカル，インコーポレイティド	プロドラッグ化合物およびその調製方法
GB9924759D0 (en) *	1999-10-19	1999-12-22	Merck Sharp & Dohme	Process for preparing peptide intermediates
US7842581B2 (en)	2003-03-27	2010-11-30	Samsung Electronics Co., Ltd.	Methods of forming metal layers using oxygen gas as a reaction source and methods of fabricating capacitors using such metal layers
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1998
- 1998-11-25 EE EEP200000333A patent/EE200000333A/xx unknown
- 1998-11-25 WO PCT/US1998/025358 patent/WO1999028345A1/fr active IP Right Grant
- 1998-11-25 NZ NZ504615A patent/NZ504615A/en unknown
- 1998-11-25 ID IDW20001039A patent/ID24735A/id unknown
- 1998-11-25 JP JP2000523236A patent/JP2001525337A/ja active Pending
- 1998-11-25 EP EP98960550A patent/EP1036093A1/fr not_active Withdrawn
- 1998-11-25 AU AU16123/99A patent/AU744652B2/en not_active Ceased
- 1998-11-25 BR BR9815116-9A patent/BR9815116A/pt not_active Application Discontinuation
- 1998-11-25 IL IL13616798A patent/IL136167A0/xx not_active IP Right Cessation
- 1998-11-25 KR KR1020007005969A patent/KR100580137B1/ko not_active IP Right Cessation
- 1998-11-25 HU HU0100350A patent/HUP0100350A3/hu unknown
- 1998-11-25 CN CNB988132826A patent/CN1181092C/zh not_active Expired - Fee Related
- 1998-11-25 TR TR2000/02260T patent/TR200002260T2/xx unknown
- 1998-11-25 PL PL340768A patent/PL197006B1/pl not_active IP Right Cessation
- 1998-11-25 CA CA002311615A patent/CA2311615A1/fr not_active Abandoned
- 1998-11-25 SK SK828-2000A patent/SK8282000A3/sk unknown
- 1998-11-25 EA EA200000603A patent/EA002745B1/ru not_active IP Right Cessation
- 1998-11-30 DZ DZ980275A patent/DZ2665A1/fr active
- 1998-12-01 PE PE1998001170A patent/PE20000009A1/es not_active Application Discontinuation
- 1998-12-01 AR ARP980106090A patent/AR016427A1/es active IP Right Grant
- 1998-12-02 TW TW087119985A patent/TW577897B/zh not_active IP Right Cessation
2000
- 2000-05-19 IS IS5502A patent/IS5502A/is unknown
- 2000-05-31 NO NO20002804A patent/NO20002804L/no not_active Application Discontinuation
- 2000-06-02 HR HR20000367A patent/HRP20000367A2/hr not_active Application Discontinuation
- 2000-06-27 BG BG104563A patent/BG65486B1/bg unknown
2006
- 2006-02-24 US US11/362,251 patent/US20060148718A1/en not_active Abandoned
- 2006-09-26 US US11/481,999 patent/US20070021350A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL136167A0 (en)	2001-05-20
EA200000603A1 (ru)	2000-12-25
CA2311615A1 (fr)	1999-06-10
EA002745B1 (ru)	2002-08-29
US20060148718A1 (en)	2006-07-06
CN1284086A (zh)	2001-02-14
WO1999028345A1 (fr)	1999-06-10
NO20002804D0 (no)	2000-05-31
AU744652B2 (en)	2002-02-28
DZ2665A1 (fr)	2003-03-22
CN1181092C (zh)	2004-12-22
AR016427A1 (es)	2001-07-04
PL197006B1 (pl)	2008-02-29
TW577897B (en)	2004-03-01
TR200002260T2 (tr)	2000-12-21
NZ504615A (en)	2003-05-30
BG104563A (en)	2001-04-30
EP1036093A1 (fr)	2000-09-20
IS5502A (is)	2000-05-19
NO20002804L (no)	2000-07-21
BG65486B1 (bg)	2008-09-30
HUP0100350A2 (hu)	2001-08-28
US20070021350A1 (en)	2007-01-25
JP2001525337A (ja)	2001-12-11
HUP0100350A3 (en)	2001-09-28
EE200000333A (et)	2001-08-15
PL340768A1 (en)	2001-02-26
KR100580137B1 (ko)	2006-05-16
PE20000009A1 (es)	2000-01-27
KR20010032687A (ko)	2001-04-25
AU1612399A (en)	1999-06-16
BR9815116A (pt)	2000-10-10
SK8282000A3 (en)	2000-11-07
ID24735A (id)	2000-08-03

Legal Events

Date	Code	Title
2000-12-31	A1OB	Publication of a patent application
2001-06-28	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2004-03-29	OBST	Application withdrawn

Publication	Publication Date	Title
US20060148718A1 (en)	2006-07-06	Conjugates useful in the treatment of prostate cancer
US20020103136A1 (en)	2002-08-01	Conjugates useful in the treatment of prostate cancer
AU715632B2 (en)	2000-02-03	Conjugates useful in the treatment of prostate cancer
AU726434B2 (en)	2000-11-09	Conjugates useful in the treatment of prostate cancer
EP1009420B1 (fr)	2003-12-17	Conjugues utiles dans le traitement du cancer de la prostate
US5998362A (en)	1999-12-07	Conjugates useful in the treatment of prostate cancer
US6174858B1 (en)	2001-01-16	Conjugates useful in the treatment of prostate cancer
US20070244055A1 (en)	2007-10-18	Conjugates useful in the treatment of prostate cancer
JP2000506494A (ja)	2000-05-30	良性前立腺過形成の治療に有用な複合体
US6127333A (en)	2000-10-03	Conjugates useful in the treatment of prostate cancer
US20020115596A1 (en)	2002-08-22	Conjugates useful in the treatment of prostate cancer
US20040081659A1 (en)	2004-04-29	Conjugates useful in the treatment of prostate cancer
AU749063B2 (en)	2002-06-20	Conjugates useful in the treatment of prostrate cancer
MXPA00005434A (en)	2002-02-26	Conjugates useful in the treatment of prostate cancer
CZ20002056A3 (cs)	2000-11-15	Konjugáty použitelné v léčbě karcinomu prostaty