HK1219477A1 - 合成含有乙內酰脲的肽產物 - Google Patents

合成含有乙內酰脲的肽產物

Info

Publication number
HK1219477A1
HK1219477A1 HK16107440.3A HK16107440A HK1219477A1 HK 1219477 A1 HK1219477 A1 HK 1219477A1 HK 16107440 A HK16107440 A HK 16107440A HK 1219477 A1 HK1219477 A1 HK 1219477A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
containing peptide
peptide products
hydantoin containing
hydantoin
Prior art date
Application number
HK16107440.3A
Other languages
English (en)
Inventor
Bernd Henkel
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HK1219477A1 publication Critical patent/HK1219477A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK16107440.3A 2013-03-21 2016-06-27 合成含有乙內酰脲的肽產物 HK1219477A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13160384 2013-03-21
PCT/EP2014/055506 WO2014147124A1 (en) 2013-03-21 2014-03-19 Synthesis of hydantoin containing peptide products

Publications (1)

Publication Number Publication Date
HK1219477A1 true HK1219477A1 (zh) 2017-04-07

Family

ID=47900954

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16107440.3A HK1219477A1 (zh) 2013-03-21 2016-06-27 合成含有乙內酰脲的肽產物

Country Status (11)

Country Link
US (1) US10087221B2 (zh)
EP (1) EP2976331B1 (zh)
CN (1) CN105189465B (zh)
AU (1) AU2014234400B2 (zh)
CA (1) CA2907454C (zh)
ES (1) ES2623979T3 (zh)
HK (1) HK1219477A1 (zh)
HU (1) HUE034308T2 (zh)
MX (1) MX363522B (zh)
SG (1) SG11201506804VA (zh)
WO (1) WO2014147124A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170123607A (ko) 2014-12-11 2017-11-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포 괴사 억제제 및 관련 방법
CN106928340A (zh) * 2015-12-31 2017-07-07 深圳翰宇药业股份有限公司 一种利西拉来的制备方法

Family Cites Families (223)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835175A (en) 1971-03-15 1974-09-10 Research Corp 9-fluorenylmethanol haloformates, carbonates and thiocarbonates
US3906031A (en) 1971-03-15 1975-09-16 Research Corp Novel 9-fluorenylmethoxycarbonyl compounds
US4108846A (en) 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
DE3542442A1 (de) 1985-11-30 1987-06-04 Hoechst Ag Verfahren zur herstellung von peptiden unter der verwendung von perchloraten
US5175254A (en) 1988-09-24 1992-12-29 Societe D'expansion Scientifque Expansia Solid phase peptide synthesis using a polyacrylic support in aqueous solution
GB8913089D0 (en) 1989-06-07 1989-07-26 Ciba Geigy Japan Ltd Novel endothelin derivative
US5169932A (en) 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5296468A (en) 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
US5580957A (en) 1989-10-30 1996-12-03 The Salk Institute For Biological Studies GnRH analogs
US5352796A (en) 1989-10-30 1994-10-04 The Salk Institute For Biological Studies Amino acids useful in making GnRH analogs
EP0445801A3 (en) 1990-03-08 1992-07-01 Kuraray Co., Ltd. Peptide and its use
IT1241395B (it) 1990-04-02 1994-01-10 Eniricerche Spa Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria
DE4014655A1 (de) 1990-05-08 1991-11-14 Behringwerke Ag Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren
TW295589B (zh) 1990-08-30 1997-01-11 Hoechst Ag
US6040423A (en) 1990-08-31 2000-03-21 Gsellschaft Fur Biotechnologische Forschung Mbh (Gbf) Process for synthesis of peptides
IL101074A (en) 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
US5744450A (en) 1991-03-14 1998-04-28 The Salk Institute For Biological Studies GnRH analogs
US5576296A (en) 1991-05-15 1996-11-19 Aktiebolaget Astra Galanin antagonist
SE9101472D0 (sv) 1991-05-15 1991-05-15 Trion Forskning & Utveckling Galanin antagonist
GB9112825D0 (en) 1991-06-14 1991-07-31 Ici Plc Process for making peptides
US6028168A (en) 1991-08-09 2000-02-22 Winfried Kolbeck Lanthionine bridged peptides
AU664855B2 (en) 1991-08-09 1995-12-07 Winfried Kolbeck Lanthionine bridged peptides
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
EP0602194A1 (en) 1991-12-18 1994-06-22 Centocor, Inc. Peptide inhibitors of inflammation mediated by selectins
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
US6165730A (en) 1992-03-06 2000-12-26 N.V. Innogenetics S.A. Hepatitis C virus peptides obtained from the NS4 coding region and their use in diagnostic assays
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
EP0656904A1 (en) 1992-05-28 1995-06-14 Centocor Inc. Peptide inhibitors of selectin binding
IE921942A1 (en) 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives
US5516891A (en) 1992-06-16 1996-05-14 Kinerton, Ltd. Liquid phase synthesis of peptides and peptide derivatives
WO1994005314A1 (en) 1992-09-08 1994-03-17 Centocor, Inc. Peptide inhibitors of leukocyte adhesion
US5563032A (en) 1992-10-21 1996-10-08 The United States Of America As Represented By The Department Of Health And Human Services Mosaic polypeptide and methods for detecting the hepatitis E virus
US5736315A (en) 1992-10-21 1998-04-07 National Institute Of Health Methods and compositions for detecting anti-hepatitis E virus activity
WO1994014836A1 (en) 1992-12-18 1994-07-07 Centocor, Inc. Peptide inhibitors of selectin binding
DE4244565A1 (de) 1992-12-30 1994-07-07 Forssmann Wolf Georg Verfahren und Anwendung des LPAP (Lymphocytoma Proliferation Activating Peptide
ES2133428T3 (es) 1993-02-19 1999-09-16 Hoffmann La Roche Fabricacion de amidas y peptidos, exenta de racemizacion, en presencia de cantidades cataliticas de un compuesto n-hidroxi.
JPH06256384A (ja) 1993-02-26 1994-09-13 Shimadzu Corp クリーベイジ装置
GB9319776D0 (en) 1993-09-24 1993-11-10 Medical Res Council Azapeptide synthesis
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
GB2298863B (en) 1993-11-02 1998-03-11 Affymax Tech Nv Apparatus and process for the synthesis of diverse compounds especially for generating and screening compound libraries
WO1995014787A1 (en) 1993-11-22 1995-06-01 Centocor, Inc. Peptide inhibitors of selecting binding
DE4341471A1 (de) 1993-12-02 1995-06-08 Schering Ag Tumor-Nekrose-Faktor-alpha-inaktivierende CDR-Peptide
US5502165A (en) 1994-04-04 1996-03-26 Merck & Co., Inc. Process for peptide segment condensation
US5614608A (en) 1995-01-20 1997-03-25 Selectide Corporation Apparatus and method for multiple synthesis of organic compounds on polymer support
EP0822939A1 (en) 1995-04-28 1998-02-11 Takeda Chemical Industries, Ltd. Cyclic pentapeptide lh-rh receptor antagonists
GB9511474D0 (en) 1995-06-07 1995-08-02 Ciba Geigy Ag Antiviral peptoid compounds
DE19534988A1 (de) 1995-09-21 1997-03-27 Forssmann Wolf Georg Verfahren zur Herstellung und Anwendung synthetischer, biotinylierter Peptide
DE19543628A1 (de) 1995-11-24 1997-05-28 Forssmann Wolf Georg Humanes, im Blut zirkulierendes Peptid mit insulinotroper Wirkung (GCAP-II-(89-112), (Guanylyl Cyclase C Aktivierendes Peptid II) und seine GCAP-Analoga, insbesondere das GCAP-I-(99-115), seine Anwendung als pharmakologischer Wirkstoff und Benutzung seines Wirkungsprinzipes zur Bereitstellung neuer GC-C-abhängiger insulinotroper Wirkstoffe
TW505654B (en) 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
CA2265454A1 (en) 1996-09-09 1998-03-19 Zealand Pharmaceuticals A/S Peptide prodrugs containing an alpha-hydroxyacid linker
AU723268B2 (en) 1996-09-09 2000-08-24 Zealand Pharma A/S Improved solid-phase peptide synthesis and agent for use in such synthesis
US7176282B1 (en) 1996-09-09 2007-02-13 Zealand Pharma A/S Solid-phase peptide synthesis and agent for use in such synthesis
PT895537E (pt) 1997-01-21 2005-04-29 Aventis Pasteur Fragmento de iga1-protease como peptido veiculo
JP4394279B2 (ja) 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体
JP3786533B2 (ja) 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
AU773420B2 (en) 1998-12-11 2004-05-27 Medarex, Inc. Prodrug compounds and process for preparation thereof
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
FR2792631B1 (fr) 1999-04-21 2004-03-19 Pasteur Institut Support solide fonctionnalise pour la synthese de composes comportant au moins une fonction alpha oxoaldehyde et ses applications.
US6469136B1 (en) 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
US6703480B1 (en) 1999-11-24 2004-03-09 Palani Balu Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
FR2803594B1 (fr) 2000-01-11 2002-07-19 Centre Nat Rech Scient Oligomeres de mimes contraints non peptidiques de dipeptides ou de tripeptides, et leurs utilisations
MXPA02007231A (es) 2000-01-27 2002-12-09 Lilly Co Eli Proceso para solubilizar los compuestos de peptido 1 similares a glucagon.
US6476186B1 (en) 2000-05-23 2002-11-05 Institute Of Nuclear Energy Research Process for preparing octreotide and derivatives thereof
CA2411660C (en) 2000-06-14 2011-03-01 Medarex, Inc. Enzyme-cleavable prodrug compounds
US20020058788A1 (en) 2000-08-25 2002-05-16 Sheppeck James E. Facile deprotection of Fmoc protected amino groups
NO314588B1 (no) 2000-09-04 2003-04-14 Bionor Immuno As HIV-peptider, antigener, vaksinesammensetning, immunoassay- testsett og en fremgangsmåte for å påvise antistoffer indusert av HIV
AU2002227925A1 (en) 2000-11-14 2002-05-27 Ipf Pharmaceuticals Gmbh Human beta-defensin-3
DK1263800T3 (da) 2001-01-04 2007-03-19 Council Scient Ind Res Linker-baseret fast understötning tl peptidsyntese og lille-molekyle organisk syntese
US20090281032A1 (en) 2001-03-01 2009-11-12 Peter Raymond Flatt Modified CCK peptides
GB0105069D0 (en) 2001-03-01 2001-04-18 Univ Ulster The Modified peptide
BR0101088A (pt) 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.
WO2002083606A1 (en) 2001-04-17 2002-10-24 University Of Alberta A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
CN1162446C (zh) 2001-05-10 2004-08-18 上海华谊生物技术有限公司 促胰岛素分泌肽衍生物
FR2825095B1 (fr) 2001-05-28 2003-09-26 Dev Des Antigenes Combinatoire Dispositif de presentation de polypeptides, utilisable comme "puce" pour la detection miniaturisee de molecules
AU2002326103A1 (en) 2001-08-24 2003-03-10 University Of British Columbia Solid-phase synthesis of oligosaccharides and glycopeptides using glycosynthases
WO2003084983A1 (fr) 2002-04-11 2003-10-16 Daiichi Suntory Pharma Co., Ltd. Procede de production d'un peptide modifie
US6809190B2 (en) 2002-04-24 2004-10-26 Credia Japan Co., Ltd. Functional peptide nucleic acid and its production method
GB0210183D0 (en) 2002-05-03 2002-06-12 Avecia Ltd Process
DE60309019T2 (de) 2002-05-03 2007-05-16 Avecia Ltd., Blackley Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase
GB0210185D0 (en) 2002-05-03 2002-06-12 Avecia Ltd Process
EP1504094A2 (en) 2002-05-10 2005-02-09 Pharmacia Corporation Peptide compounds and their use as protease substrates
ES2195787B1 (es) 2002-05-20 2005-06-01 Diverdrugs, S.L. Compuestos capaces de bloquear la respuesta a sustancias quimicas o estimulos termicos o mediadores de la inflamacion de los nociceptores, un metodo para su obtencion y composiciones que los continen.
ES2299749T3 (es) 2002-08-09 2008-06-01 Astellas Pharma Europe B.V. Compuestos que se unen a p-selectina.
US20040137469A1 (en) 2002-09-08 2004-07-15 Casale Ralph A Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis
US7544657B2 (en) 2002-10-02 2009-06-09 Zealand Pharma A/S Stabilized Exendin-4 compounds
EP1445260A1 (de) 2003-02-04 2004-08-11 Jerini AG Verfahren zur Immobilisierung von chemischen Verbindungen an Festphasen
EP1613409B1 (en) 2003-04-08 2019-08-07 Novo Nordisk A/S Regeneration of chromatographic stationary phases
BRPI0408978B8 (pt) 2003-04-08 2021-07-27 Novo Nordisk As processos para regenerar uma fase estacionária cromatográfica
EP1614750A4 (en) 2003-04-15 2006-09-20 Credia Japan Co Ltd NOVEL FUNCTIONAL PEPTIDE NUCLEIC ACID AND PROCESS FOR PRODUCING THE SAME
WO2004105685A2 (en) 2003-05-22 2004-12-09 Gryphon Therapeutics, Inc. Displaceable linker solid phase chemical ligation
JP2007524592A (ja) 2003-06-03 2007-08-30 ノボ・ノルデイスク・エー／エス 安定化された薬学的ペプチド組成物
US7414106B2 (en) 2003-06-19 2008-08-19 Lawrence Livermore National Security, Llc Synthesis of peptide α-thioesters
US7902488B2 (en) 2003-06-23 2011-03-08 Cem Corporation Microwave-assisted peptide synthesis
US7393920B2 (en) 2003-06-23 2008-07-01 Cem Corporation Microwave-assisted peptide synthesis
EP1664109B1 (en) 2003-08-21 2009-07-22 Novo Nordisk A/S Purification of glucagon-like peptides
ATE376556T1 (de) 2003-12-31 2007-11-15 Hoffmann La Roche Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel
FR2864830B1 (fr) 2004-01-06 2006-03-10 Centre Nat Rech Scient Procede de synthese sur support solide de composes peptidiques, notamment de composes peptidiques comportant un residu arginine
WO2005080424A2 (en) 2004-02-23 2005-09-01 Rheoscience A/S Peptide yy analogues
CA2458084A1 (en) 2004-03-12 2005-09-12 Dalton Chemical Laboratories Inc. Novel process for octreotide synthesis
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
US20070021346A1 (en) 2005-05-26 2007-01-25 Ewing William R N-terminally modified GLP-1 receptor modulators
US20080200648A1 (en) 2004-07-16 2008-08-21 Lonza Ag Method of Peptide Synthesis
DE602005026035D1 (en) 2004-10-12 2011-03-03 Hoffmann La Roche Festphasenpeptidsynthese
WO2006054310A1 (en) 2004-11-22 2006-05-26 Biosight Ltd. Activated labeling reagents and methods for preparing and using the same
US7745570B2 (en) 2004-12-17 2010-06-29 Kansas State University Research Foundation PH dependent adhesive peptides
EP1845105A4 (en) 2005-01-14 2009-02-18 Wuxi Grandchamp Pharmaceutical MODIFIED EXENDINES AND CORRESPONDING USES
US8716221B2 (en) 2005-01-14 2014-05-06 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Modified exendins and uses thereof
ES2336245T3 (es) 2005-04-08 2010-04-09 Lonza Ag Sintesis peptidica de helices alfa sobre resina de peg.
ES2332666T3 (es) 2005-05-04 2010-02-10 Lonza Ag Timosina alfa1 unida a fase solida y metodo de sintesis.
CN1298732C (zh) 2005-05-17 2007-02-07 南京工业大学 多肽微波固相合成法
EP1805204A2 (en) 2005-09-14 2007-07-11 Novetide Ltd. Process for production of bivalirudin
PL1965823T3 (pl) 2005-11-04 2017-08-31 Glaxosmithkline Llc Sposoby podawania środków hipoglikemicznych
CN100374462C (zh) 2005-11-21 2008-03-12 大连帝恩生物工程有限公司 截短胰高血糖素样肽1(sGLP-1)、制法及其应用
JP2009518345A (ja) 2005-12-07 2009-05-07 テフニーシェ ウニヴェルジテート ミュンヘン 因子ｖｉｉｉおよび因子ｖｉｉｉ様タンパク質に対する小型ペプチドおよびペプチド模倣物の親和性リガンド
WO2007068474A1 (en) 2005-12-14 2007-06-21 Medivir Ab (2,5-dioxoimidazolidin-i-yl)-n-hydroxy-acetamides as metalloproteinase inhibitors
JP5328345B2 (ja) 2006-03-29 2013-10-30 株式会社糖鎖工学研究所 ペプチドのチオエステル化合物の製造方法
ES2283212B1 (es) 2006-03-31 2008-08-16 Lipotec S.A. Peptidos sinteticos utiles en el tratamiento de la piel y su uso en composiciones cosmeticas o dermofarmaceuticas.
US20070231258A1 (en) 2006-03-31 2007-10-04 Karyon Ctt Ltd. Peptide conjugates
US20100022457A1 (en) 2006-05-26 2010-01-28 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
GB2440388A (en) 2006-06-30 2008-01-30 Ucl Biomedica Plc Methods of linking a carbohydrate or polyalkylene oxide to a protein, precursors and the resultant products
WO2008028974A1 (en) 2006-09-08 2008-03-13 Novo Nordisk A/S Methods of optimizing chromatographic separation of polypeptides
WO2008044890A1 (en) 2006-10-12 2008-04-17 Dong Kook Pharm. Co., Ltd A method for preparing peptides using by solid phase synthesis
ES2322882B1 (es) 2006-10-25 2010-04-22 Lipotec Sa Peptidos inhibidores de la exocitosis neuronal.
EP1923397B1 (en) 2006-11-14 2009-10-28 NERVIANO MEDICAL SCIENCES S.r.l. Fluorinated amino acids and peptides
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
WO2008076904A1 (en) 2006-12-14 2008-06-26 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US7981998B2 (en) 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
MX2009008241A (es) 2007-02-15 2009-10-08 Univ Indiana Res & Tech Corp Co-agonistas de receptor de glucagon/glp-1.
EP2057183A2 (en) 2007-03-01 2009-05-13 Novetide Ltd. High purity peptides
WO2008137165A1 (en) 2007-05-07 2008-11-13 President And Fellows Of Harvard College Anti-glycated cd59 antibodies and uses thereof
US7994122B2 (en) 2007-06-15 2011-08-09 Zealand Pharma A/S Glucagon analogues
KR20100036326A (ko) 2007-06-29 2010-04-07 론자 아게 프람린타이드의 생산 방법
CN101357937B (zh) 2007-07-31 2012-11-07 上海苏豪逸明制药有限公司 固相多肽合成阿托西般的制备方法
CN101357938B (zh) 2007-07-31 2013-07-03 周逸明 固相多肽合成Exenatide的制备方法
JP2011506376A (ja) 2007-12-11 2011-03-03 エフ．ホフマン−ラ ロシュ アーゲー 固相及び溶液相の組み合わせ技術を使用したインシュリン分泌性ペプチド合成
KR101257330B1 (ko) 2008-02-06 2013-04-23 바이오콘 리미티드 펩타이드 정제 방법
ES2330291B1 (es) 2008-02-29 2010-10-18 Lipotec Sa Peptidos utiles en el tratamiento de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosmeticas o farmaceuticas.
CN101525370A (zh) 2008-03-06 2009-09-09 海南建邦制药科技有限公司 一种新型高效多肽合成缩合剂
CN101525368B (zh) 2008-03-06 2012-05-30 海南建邦制药科技有限公司 一种多肽合成脱保护剂
CN101255191A (zh) 2008-03-12 2008-09-03 中国药科大学 微波促进固相合成胰高血糖素样肽-1(glp-1)类似物及其应用
RU2545347C2 (ru) 2008-04-24 2015-03-27 Теримьюнекс Фармасьютикалз, Инк. Пептидил-диацилглицериды
CN102027005A (zh) 2008-05-15 2011-04-20 诺沃-诺迪斯克有限公司 通过固相合成制备的肽的纯化
MX2010013454A (es) 2008-06-17 2011-01-21 Tion Indiana University Res And Technology Corpora Co-agonistas de receptor de glucagon/glp-1.
SG192405A1 (en) 2008-06-17 2013-08-30 Univ Indiana Res & Tech Corp Gip-based mixed agonists for treatment of metabolic disorders and obesity
KR20110056536A (ko) 2008-09-03 2011-05-30 시노팜 타이완 리미티드 프람린티드의 제조 방법
CA2737921C (en) 2008-09-22 2019-01-15 Aileron Therapeutics, Inc. Methods for preparing purified alpha-helical peptidomimetic macrocycle compositions with low metal ppm levels
TW201012829A (en) 2008-09-22 2010-04-01 Ipsen Mfg Ireland Ltd Process for the synthesis of (Aib8,35)hGLP-1(7-36)-NH2
CN102307904A (zh) 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
RU2011125366A (ru) 2008-12-05 2013-01-10 Ангиочем Инк. Конъюгаты терапевтических пептидов и их применение
CN102272163A (zh) 2008-12-05 2011-12-07 安吉奥开米公司 瘦素和瘦素类似物结合物及其用途
PL2370462T3 (pl) 2008-12-15 2015-01-30 Zealand Pharma As Analogi glukagonu
CA2747155A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
US8685919B2 (en) 2008-12-15 2014-04-01 Zealand Pharma A/S Glucagon analogues
CN102292347A (zh) 2008-12-15 2011-12-21 西兰制药公司 胰高血糖素类似物
CN101463081B (zh) 2009-01-12 2012-07-04 华东师范大学 一种glp-1衍生物
CN101463078B (zh) 2009-01-12 2011-07-27 华东师范大学 一种Exendin-4衍生物及其固相化学合成
CN101538324B (zh) 2009-01-13 2013-01-16 深圳翰宇药业股份有限公司 一种制备艾塞那肽的方法
ES2349972B1 (es) 2009-02-16 2011-11-24 Lipotec, S.A. Péptidos útiles en el tratamiento y/o cuidado de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosméticas o farmacéuticas.
WO2010096052A1 (en) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Oxyntomodulin analogs
WO2010118880A1 (en) 2009-04-17 2010-10-21 Lipotec S.A. Peptides used in the treatment and/or care of the skin and/or hair and their use in cosmetic or pharmaceutical compositions
CN101555274B (zh) 2009-05-15 2013-08-21 海南双成药业股份有限公司 一种多肽固相合成比法卢定粗品的制备方法
AU2010260058B2 (en) 2009-06-16 2015-09-24 Indiana University Research And Technology Corporation GIP receptor-active glucagon compounds
SI2454282T1 (sl) 2009-07-13 2015-06-30 Zealand Pharma A/S Acilirani glukagonski analogi
BR112012001322B1 (pt) 2009-07-24 2022-05-03 Lipotec S.A. Peptideo e composição cosmetica ou farmaceutica
CN101987865B (zh) * 2009-07-29 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 含有乙内酰脲结构的促***释放激素拮抗剂
ES2358829B1 (es) 2009-10-23 2012-06-25 Lipotec, S.A. Péptidos útiles en el tratamiento y/o cuidado de la piel, mucosas y/o cabello y su uso en composiciones cosméticas o farmacéuticas.
EP2512503A4 (en) 2009-12-18 2013-08-21 Univ Indiana Res & Tech Corp COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR
JP2013518115A (ja) 2010-01-27 2013-05-20 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション 代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐ｇｉｐアゴニスト複合体及び組成物
CN102770440A (zh) 2010-03-01 2012-11-07 诺沃—诺迪斯克有限公司 纯化肽的制备性rp-hplc方法
AR080592A1 (es) 2010-03-26 2012-04-18 Lilly Co Eli Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
US8620595B2 (en) 2010-03-26 2013-12-31 University Of Manitoba Methods for determining the retention of peptides in reverse phase chromatography using linear solvent strength theory
EP2552951A1 (en) 2010-03-26 2013-02-06 Novo Nordisk A/S Novel glucagon analogues
US20130059093A1 (en) 2010-05-31 2013-03-07 Jtekt Corporation Method of producing coated member
JP5702376B2 (ja) 2010-06-01 2015-04-15 本田技研工業株式会社 Ｄｃ／ｄｃコンバータの制御装置
US20110313131A1 (en) 2010-06-21 2011-12-22 Christelle Carl Reversed phase hplc purification of a glp-1 analogue
UY33462A (es) 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon
CN101906150B (zh) 2010-06-28 2013-01-09 上海昂博生物技术有限公司 一种比法卢定的制备方法
WO2012057624A1 (en) 2010-10-25 2012-05-03 Pepscan Systems B.V. Novel bicyclic peptide mimetics
WO2012055509A1 (en) 2010-10-29 2012-05-03 Lonza Ltd Diketopiperazine forming dipeptidyl linker
NZ612297A (en) 2010-12-22 2015-10-30 Univ Indiana Res & Tech Corp Glucagon analogs exhibiting gip receptor activity
US9290537B2 (en) 2010-12-23 2016-03-22 Universiteit Gent Method for cross-linking peptides
CN102643339B (zh) 2011-02-21 2014-04-09 天津药物研究院 一种glp-1类似物、制备方法及其应用
CN102174082B (zh) 2011-02-23 2014-08-27 上海昂博生物技术有限公司 一种艾塞那肽的制备方法
ES2397889B1 (es) 2011-03-25 2014-02-07 Lipotec, S.A. PÉPTIDOS MODULADORES DE PGC-1Alfa.
CN102718858B (zh) 2011-03-29 2014-07-02 天津药物研究院 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
DK2694095T3 (en) 2011-04-05 2018-05-28 Longevity Biotech Inc COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME
CN102786590A (zh) 2011-05-19 2012-11-21 江苏豪森药业股份有限公司 分枝型peg修饰的glp-1类似物及其可药用盐
US8933196B2 (en) 2011-05-20 2015-01-13 National Central University Peptide chromatographic purification assisted by combining of solubility parameter and solution conformation energy calculations
CN102286076B (zh) 2011-06-23 2014-03-12 成都圣诺科技发展有限公司 比伐卢定的制备方法
CN102286092B (zh) 2011-09-14 2014-01-01 深圳翰宇药业股份有限公司 利拉鲁肽的固相合成方法
NL2007536C2 (en) 2011-10-05 2013-04-08 Academisch Ziekenhuis Leiden Lumc Adjuvant compound.
KR101996700B1 (ko) 2011-12-23 2019-07-04 입센 메뉴팩츄링 아일랜드 리미티드 치료 펩티드의 합성 방법
CN103242443A (zh) 2012-02-06 2013-08-14 长春百克生物科技股份公司 一种胸腺素α1及其类似物的制备方法
CN102584944B (zh) 2012-02-06 2014-12-17 成都圣诺生物科技股份有限公司 一种依非巴特的制备方法
CN102558338B (zh) 2012-02-10 2014-09-17 深圳翰宇药业股份有限公司 一种合成利西拉来的方法
CN102584982B (zh) 2012-02-10 2014-02-05 深圳翰宇药业股份有限公司 一种纯化固相合成利拉鲁肽粗肽的方法
KR102113998B1 (ko) 2012-04-16 2020-05-25 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 피부 및／또는 점막의 치료 및／또는 관리용 화합물 및 미용적 또는 약학적 조성물에서의 이의 용도
US20130289241A1 (en) 2012-04-26 2013-10-31 Shanghai Ambiopharm, Inc. Method for preparing exenatide
US9850471B2 (en) 2012-05-16 2017-12-26 Noxxon Pharma Ag Enzymatic synthesis of L-nucleic acids
CN102875663B (zh) 2012-09-26 2014-06-11 深圳翰宇药业股份有限公司 利西拉来的纯化方法
WO2014118797A1 (en) 2013-01-29 2014-08-07 Neuland Health Sciences Private Limited Purification of organic compounds using surrogate stationary phases on reversed phase columns
CN103965285B (zh) 2013-02-06 2016-12-28 北京大学 一种以超顺磁纳米颗粒为固相进行多肽合成及同步构建多肽磁纳米探针的方法
CN103333237B (zh) 2013-05-07 2015-03-11 海南双成药业股份有限公司 一种固相片段法合成艾塞那肽
WO2015009701A1 (en) 2013-07-15 2015-01-22 North Carolina State University Protease-resistant peptide ligands
US9263194B2 (en) 2013-09-06 2016-02-16 Gwangju Institute Of Science And Technology Porphyrin-peptoid conjugate and the preparation process thereof
US9605344B2 (en) 2013-09-15 2017-03-28 Stc.Unm Method for atomic layer deposition
CN103536912B (zh) 2013-09-30 2015-05-13 重庆理工大学 一种猪圆环病毒2型表位肽疫苗及其制备方法
CN103613655B (zh) 2013-11-20 2015-05-13 陕西东大生化科技有限责任公司 一种低成本纯化艾塞那肽的方法
KR20160091980A (ko) 2013-12-01 2016-08-03 유니버시티 오브 코펜하겐 Psd-95의 이량체 억제제의 지방산 유도체
HU230584B1 (hu) 2014-02-28 2017-01-30 Szegedi Tudományegyetem Eljárás peptidek előállítására
CN104086631A (zh) 2014-07-10 2014-10-08 成都天台山制药有限公司 卡贝缩宫素和制法
CN104211801A (zh) 2014-07-25 2014-12-17 杭州诺泰制药技术有限公司 一种制备利西拉来的方法
WO2016020349A1 (en) 2014-08-07 2016-02-11 F. Hoffmann-La Roche Ag Processes for the preparation of oxytocin analogues
WO2016057683A2 (en) 2014-10-07 2016-04-14 Ann And Robert H. Lurie Children's Hospital Of Chicago Novel anti-nodal antibodies and methods of using same
CN105585612B (zh) 2014-10-20 2020-05-05 北京益生康华医药技术有限公司 八肽修饰的***、制备、纳米结构和应用
US10344069B2 (en) 2014-10-31 2019-07-09 Auro Peptides Ltd. Process for the preparation of liraglutide
WO2016084100A2 (en) 2014-11-26 2016-06-02 Alaparthi Lakshmi Prasad Novel and efficient method for large scale synthesis of romidepsin
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
CN105111303B (zh) 2015-06-23 2019-07-26 济南康和医药科技有限公司 一种固液结合制备利拉鲁肽的方法
CA3018627A1 (en) 2016-03-23 2017-09-28 Bachem Holding Ag Purification of glucagon-like peptide 1 analogs

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