HK1205758A1 - 治療β-聯蛋白相關疾病的有機組合物 - Google Patents

治療β-聯蛋白相關疾病的有機組合物

Info

Publication number
HK1205758A1
HK1205758A1 HK15106407.7A HK15106407A HK1205758A1 HK 1205758 A1 HK1205758 A1 HK 1205758A1 HK 15106407 A HK15106407 A HK 15106407A HK 1205758 A1 HK1205758 A1 HK 1205758A1
Authority
HK
Hong Kong
Prior art keywords
related diseases
rnai agents
beta catenin
treat beta
catenin related
Prior art date
Application number
HK15106407.7A
Other languages
English (en)
Inventor
Dieter Huesken
Brian Bettencourt
David Bumcrot
Satyanarayana Kuchimanchi
Stuart Milstein
Jr Michael Schlabach
Frank P Stegmeier
Markus Warmuth
Jan Weiler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1205758A1 publication Critical patent/HK1205758A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
HK15106407.7A 2012-01-09 2015-07-06 治療β-聯蛋白相關疾病的有機組合物 HK1205758A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261584530P 2012-01-09 2012-01-09
US201261598530P 2012-02-14 2012-02-14
PCT/IB2013/050159 WO2013105022A2 (en) 2012-01-09 2013-01-08 Organic compositions to treat beta-catenin-related diseases

Publications (1)

Publication Number Publication Date
HK1205758A1 true HK1205758A1 (zh) 2015-12-24

Family

ID=47720548

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15106407.7A HK1205758A1 (zh) 2012-01-09 2015-07-06 治療β-聯蛋白相關疾病的有機組合物

Country Status (9)

Country Link
US (2) US10023862B2 (zh)
EP (1) EP2802658A2 (zh)
JP (1) JP6158833B2 (zh)
CN (1) CN104302768A (zh)
AU (1) AU2013208720A1 (zh)
BR (1) BR112014016870A2 (zh)
CA (1) CA2860676A1 (zh)
HK (1) HK1205758A1 (zh)
WO (1) WO2013105022A2 (zh)

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CN110022880B (zh) * 2016-10-31 2022-04-01 社会福祉法人三星生命公益财团 包含胆汁酸的用于预防或治疗缺血性再灌注损伤的药学组合物
WO2019136157A2 (en) 2018-01-05 2019-07-11 Dicerna Pharmaceuticals, Inc. Reducing beta-catenin and ido expression to potentiate immunotherapy
MX2020008533A (es) * 2018-02-14 2020-11-06 Deep Genomics Incorporated Terapia con oligonucleotidos para la enfermedad de wilson.
CN111500694B (zh) * 2019-01-31 2023-02-24 中国科学院脑科学与智能技术卓越创新中心 Baz2b基因作为靶点在缓解衰老中的应用
WO2022125725A1 (en) * 2020-12-09 2022-06-16 The Regents Of The University Of Michigan Compositions and methods for treating wnt-driven cancer
EP4301339A2 (en) * 2021-03-01 2024-01-10 Steadman Philippon Research Institute Compositions comprising catenin mrna and their use for healing bone fractures
KR20240037293A (ko) * 2021-07-23 2024-03-21 알닐람 파마슈티칼스 인코포레이티드 베타-카테닌(CTNNB1) iRNA 조성물 및 이의 사용 방법

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Also Published As

Publication number Publication date
CA2860676A1 (en) 2013-07-18
US10023862B2 (en) 2018-07-17
EP2802658A2 (en) 2014-11-19
BR112014016870A2 (pt) 2017-06-27
WO2013105022A3 (en) 2013-10-31
JP6158833B2 (ja) 2017-07-05
CN104302768A (zh) 2015-01-21
US20180282728A1 (en) 2018-10-04
JP2015503608A (ja) 2015-02-02
AU2013208720A1 (en) 2014-07-24
WO2013105022A2 (en) 2013-07-18
US20150291954A1 (en) 2015-10-15

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