HK1205141A1 - Anti-pcsk9 antibodies, formulations, dosing, and methods of use -pcsk9 - Google Patents

Anti-pcsk9 antibodies, formulations, dosing, and methods of use -pcsk9

Info

Publication number
HK1205141A1
HK1205141A1 HK15105650.3A HK15105650A HK1205141A1 HK 1205141 A1 HK1205141 A1 HK 1205141A1 HK 15105650 A HK15105650 A HK 15105650A HK 1205141 A1 HK1205141 A1 HK 1205141A1
Authority
HK
Hong Kong
Prior art keywords
pcsk9
dosing
formulations
methods
antibodies
Prior art date
Application number
HK15105650.3A
Other languages
English (en)
Chinese (zh)
Inventor
吳岩
塞西莉亞‧培‧芝‧秋
丹尼爾‧
‧柯克霍弗
安德魯‧彼得森
加內什‧
‧科盧曼姆
莫妮卡‧孔‧貝爾特侖
保羅‧莫蘭
李蔚
克森‧拉姆
林‧路易斯
許令攸
惠特莫爾‧廷利
約翰‧道格拉斯‧大衛
納格什沃‧
‧布達
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1205141A1 publication Critical patent/HK1205141A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
HK15105650.3A 2012-06-15 2015-06-15 Anti-pcsk9 antibodies, formulations, dosing, and methods of use -pcsk9 HK1205141A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261660605P 2012-06-15 2012-06-15
US201361786280P 2013-03-14 2013-03-14
PCT/US2013/046032 WO2013188855A1 (en) 2012-06-15 2013-06-14 Anti-pcsk9 antibodies, formulations, dosing, and methods of use

Publications (1)

Publication Number Publication Date
HK1205141A1 true HK1205141A1 (en) 2015-12-11

Family

ID=48746111

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105650.3A HK1205141A1 (en) 2012-06-15 2015-06-15 Anti-pcsk9 antibodies, formulations, dosing, and methods of use -pcsk9

Country Status (13)

Country Link
US (2) US9266961B2 (de)
EP (1) EP2861624A1 (de)
JP (1) JP2015530867A (de)
KR (1) KR20150023711A (de)
CN (1) CN104364266A (de)
AR (1) AR091462A1 (de)
BR (1) BR112014031310A2 (de)
CA (1) CA2875096A1 (de)
HK (1) HK1205141A1 (de)
MX (1) MX2014014830A (de)
RU (1) RU2015101113A (de)
TW (1) TW201410706A (de)
WO (1) WO2013188855A1 (de)

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JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
AU2015289874A1 (en) * 2014-07-14 2017-02-02 Amgen Inc. Crystalline antibody formulations
CN105461809B (zh) * 2015-02-11 2018-10-12 康融东方（广东）医药有限公司 Pcsk9抗体、其药物组合物及其用途
CN106810609A (zh) * 2015-11-27 2017-06-09 苏州君盟生物医药科技有限公司 抗pcsk9抗体及其应用
CA3009904A1 (en) 2015-12-31 2017-07-06 Jiangsu Hengrui Medicine Co., Ltd. Pcsk9 antibody, antigen-binding fragment thereof, and medicinal application thereof
JP2019509714A (ja) * 2016-01-05 2019-04-11 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途
CN107266575B (zh) * 2016-04-07 2021-12-24 天士力生物医药股份有限公司 前蛋白转化酶枯草溶菌素kexin 9型的结合蛋白及其应用
CN107474140B (zh) * 2016-06-08 2022-06-03 常州博嘉生物医药科技有限公司 Pcsk9特异性的结合蛋白mv072及其应用
BR112018076242A2 (pt) * 2016-06-24 2019-03-26 Hoffmann La Roche inibidores de pcsk9, pcsk9 inibido, composição farmacêutica, métodos para modular a atividade de pcsk9, para inibir a ligação de pcsk9 a ldlr, para aumentar a disponibilidade de ldlr, para reduzir um nível de ldl-c, para reduzir o nível sérico de ldl-c, para o tratamento de um distúrbio relacionado com colesterol, métodos para o tratamento de um distúrbio associado a um nível anormal de ldl-c, de uma condição associada a um nível elevado de ldl-c, de dislipidemia, de hipercolesterolemia, usos de um inibidor de pcsk9 e método para identificar um composto candidato como um inibidor de pcsk9 que liga um epítopo da seq id nº 1
WO2018054240A1 (en) * 2016-09-20 2018-03-29 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pcsk9 antibodies
CN107698680B (zh) * 2017-01-22 2019-03-01 北京东方百泰生物科技有限公司 抗pcsk9单克隆抗体
US11325945B2 (en) 2017-04-12 2022-05-10 Cadila Healthcare Limited Peptide based PCSK9 vaccine
CN107177003A (zh) * 2017-06-27 2017-09-19 上海海玫生物科技有限公司 一种特异性抗人pcsk9的抗体及其应用
WO2019001560A1 (zh) 2017-06-30 2019-01-03 江苏恒瑞医药股份有限公司 一种pcsk-9抗体药物组合物及其用途
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.
CN109776680B (zh) * 2019-01-25 2020-05-12 浙江蓝盾药业有限公司 抗人pcsk9单克隆抗体及其用途
EP3969620A1 (de) 2019-05-17 2022-03-23 Regeneron Pharmaceuticals, Inc. Genombasierte verfahren zur verminderung des kardiovaskulären risikos
US20230167188A1 (en) * 2020-07-02 2023-06-01 Biolojic Design Ltd. Anti-tumor necrosis factor receptor (tnfr2) antibodies and uses thereof

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CA2875096A1 (en) 2013-12-19
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BR112014031310A2 (pt) 2017-07-25
MX2014014830A (es) 2015-05-11
EP2861624A1 (de) 2015-04-22
KR20150023711A (ko) 2015-03-05
RU2015101113A (ru) 2016-08-10
WO2013188855A1 (en) 2013-12-19
JP2015530867A (ja) 2015-10-29
US20160355606A1 (en) 2016-12-08
US9266961B2 (en) 2016-02-23
TW201410706A (zh) 2014-03-16

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