HK1204656A1 - Methods and compositions involving mirna and mirna inhibitor molecules mirna mirna - Google Patents

Methods and compositions involving mirna and mirna inhibitor molecules mirna mirna

Info

Publication number
HK1204656A1
HK1204656A1 HK15105287.4A HK15105287A HK1204656A1 HK 1204656 A1 HK1204656 A1 HK 1204656A1 HK 15105287 A HK15105287 A HK 15105287A HK 1204656 A1 HK1204656 A1 HK 1204656A1
Authority
HK
Hong Kong
Prior art keywords
mirna
methods
inhibitor molecules
compositions involving
compositions
Prior art date
Application number
HK15105287.4A
Other languages
English (en)
Chinese (zh)
Inventor
David Brown
Lance Ford
Angie Cheng
Rich Jarvis
Mike Byrom
Dmitriy Ovcharenko
Eric Devroe
Kevin Kelnar
Original Assignee
Asuragen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37570916&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1204656(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asuragen Inc filed Critical Asuragen Inc
Publication of HK1204656A1 publication Critical patent/HK1204656A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3535—Nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
HK15105287.4A 2004-11-12 2015-06-03 Methods and compositions involving mirna and mirna inhibitor molecules mirna mirna HK1204656A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62717104P 2004-11-12 2004-11-12
US64963405P 2005-02-03 2005-02-03
US68373605P 2005-05-23 2005-05-23

Publications (1)

Publication Number Publication Date
HK1204656A1 true HK1204656A1 (en) 2015-11-27

Family

ID=37570916

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105287.4A HK1204656A1 (en) 2004-11-12 2015-06-03 Methods and compositions involving mirna and mirna inhibitor molecules mirna mirna

Country Status (11)

Country Link
US (25) US8173611B2 (fr)
EP (21) EP2302056B1 (fr)
JP (11) JP2008519606A (fr)
AU (1) AU2005333165B2 (fr)
CA (7) CA2850323A1 (fr)
DK (1) DK2302055T3 (fr)
ES (13) ES2503740T3 (fr)
HK (1) HK1204656A1 (fr)
PL (1) PL2302055T3 (fr)
SI (1) SI2302055T1 (fr)
WO (1) WO2006137941A2 (fr)

Families Citing this family (376)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2428568B1 (fr) 2001-09-28 2018-04-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Molécules de micro arn
EP2471924A1 (fr) * 2004-05-28 2012-07-04 Asuragen, INC. Procédés et compositions impliquant du microARN
EP1791954A1 (fr) * 2004-09-07 2007-06-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Agents, compositions et methodes de traitement de pathologies dans lesquelles la regulation d'une voie biologique associee a l'acetylcholinesterase (ache) est benefique
US7825229B2 (en) * 2005-03-25 2010-11-02 Rosetta Genomics Ltd. Lung cancer-related nucleic acids
US7642348B2 (en) * 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
US20090186353A1 (en) * 2004-10-04 2009-07-23 Rosetta Genomics Ltd. Cancer-related nucleic acids
CA2850323A1 (fr) 2004-11-12 2006-12-28 Asuragen, Inc. Procedes et compositions comprenant des molecules de micro-arn et des molecules d'inhibiteur de micro-arn
US8592384B2 (en) 2005-04-04 2013-11-26 The Board Of Regents Of The University Of Texas System Micro-RNA's that regulate muscle cells
CA2605701C (fr) 2005-04-29 2015-12-08 Rockefeller University Micro-arn humains et procedes d'inhibition de ceux-ci
US20090209621A1 (en) * 2005-06-03 2009-08-20 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
CN105902559A (zh) * 2005-08-01 2016-08-31 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
CN101296702B (zh) * 2005-09-12 2012-11-28 俄亥俄州立大学研究基金会 用于诊断或治疗bcl2相关癌症的组合物和方法
WO2007044413A2 (fr) * 2005-10-05 2007-04-19 The Ohio State University Research Foundation Gene wwox, vecteurs renfermant celui-ci et utilisations de ceux-ci dans le traitement de cancer
NZ593688A (en) * 2005-12-12 2013-01-25 Univ North Carolina Micrornas that regulate muscle cell proliferation and differentiation
CN103993082B (zh) * 2006-01-05 2017-01-11 俄亥俄州立大学研究基金会 用于肺癌的诊断、预后和治疗的基于微小rna 的方法和组合物
EP2586455B1 (fr) 2006-01-05 2014-06-25 The Ohio State University Research Foundation Anomalies d'expressions de MicroARN dans des tumeurs endocrines pancréatiques acinaires
AU2016203848B2 (en) * 2006-01-05 2017-12-14 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
EP2468890B1 (fr) * 2006-01-05 2014-03-19 The Ohio State University Research Foundation Procédés à base de micro ARN et compositions pour le diagnostic et le traitement des cancers solides du poumons ou de seins
EP2369013A1 (fr) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Empreintes digitales micro-ARN pendant une mégacaryocytopoïese
EA201100811A1 (ru) 2006-04-03 2012-06-29 Сантарис Фарма А/С Фармацевтическая композиция
US20100004320A1 (en) 2006-04-03 2010-01-07 Santaris Pharma A/S Pharmaceutical Composition
EP2455492B1 (fr) 2006-07-13 2013-11-20 The Ohio State University Research Foundation Procédés basés sur le micro-ARN et compositions pour le diagnostic et le traitement de maladies liées au côlon
EP2434017A3 (fr) 2006-08-01 2012-09-05 Board of Regents of the University of Texas System Identification d'un micro-ARN qui active l'expression d'une chaîne lourde de bêta-myosine
CA2658301A1 (fr) † 2006-08-04 2008-02-07 Dublin City University Procede d'obtention de produits biologiques recombinants
ES2534430T3 (es) * 2006-08-28 2015-04-22 The University Of Western Australia Método de modulación de la expresión del receptor del factor de crecimiento epidérmico (EGFR) que implica miARN
US20110021600A1 (en) * 2006-09-04 2011-01-27 Kyowa Hakko Kirin Co., Ltd. Novel nucleic acid
EP2145001A2 (fr) * 2006-09-19 2010-01-20 Asuragen, Inc. Gènes régulés mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p et voies de signalisation utiles comme cibles dans une intervention thérapeutique
ES2374446T3 (es) 2006-09-19 2012-02-16 The Ohio State University Research Foundation Expresión de tcl1 en la leucemia linfocítica crónica (llc) regulada por mir-29 y mir-181.
WO2008057234A2 (fr) 2006-10-24 2008-05-15 The Board Of Trustees Of The Leland Stanford Junior University Modulation du seuil de signalisation des lymphocytes t et de la sensibilité des lymphocytes t aux antigènes
WO2008054828A2 (fr) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Signature de l'expression de microarn pour la prédiction de la survie et des métastases dans le carcinome hépato-cellulaire
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
CN101622348A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
AU2007333109A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro RNAs
EP2104736B1 (fr) * 2006-12-08 2011-11-23 Asuragen, INC. Gènes et voies régulés par mir-126 comme cibles d'intervention thérapeutique
AU2007333107A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. miR-21 regulated genes and pathways as targets for therapeutic intervention
EP2104734A2 (fr) * 2006-12-08 2009-09-30 Asuragen, INC. Gènes et voies génétiques régulés par le mir-20 en tant que cibles en vue d'une intervention thérapeutique
CA2671270A1 (fr) * 2006-12-29 2008-07-17 Asuragen, Inc. Genes et voies regules par mir-16 utiles comme cibles pour intervention therapeutique
WO2008088858A2 (fr) * 2007-01-17 2008-07-24 The Johns Hopkins University Compositions et procédés comprenant des microarn pour traiter une néoplasie
EP2109687B1 (fr) 2007-01-31 2014-06-04 The Ohio State University Research Foundation Méthodes utilisant des micro-arn pour le traitement de la leucémie aigüe myéloïde (lam)
WO2008104974A2 (fr) * 2007-02-27 2008-09-04 Rosetta Genomics Ltd. Composition et méthodes de modulation de la prolifération et de la mort cellulaire
US9006206B2 (en) 2007-02-27 2015-04-14 Rosetta Genomics Ltd. Composition and methods for modulating cell proliferation and cell death
US20100216868A1 (en) * 2007-03-07 2010-08-26 Yissum Research Development Company Of The Hebrew Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial
US8841436B2 (en) * 2007-03-15 2014-09-23 University Hospitals Cleveland Medical Center Screening, diagnosing, treating and prognosis of pathophysiologic status by RNA regulation
AU2008232316A1 (en) 2007-03-26 2008-10-02 Newcastle Innovation Limited Therapeutic targets and molecules
US20100273172A1 (en) * 2007-03-27 2010-10-28 Rosetta Genomics Ltd. Micrornas expression signature for determination of tumors origin
US20090117562A1 (en) 2007-04-09 2009-05-07 Valerie Wailin Hu Method and kit for diagnosing Autism using gene expression profiling
EP2610347B1 (fr) * 2007-04-30 2015-04-15 The Ohio State University Research Foundation Procédés de détermination du pronostic d'un sujet avec un cancer du pancréas
EP1990414A1 (fr) * 2007-05-10 2008-11-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Moyen de traitement pour maladies inflammatoires, maladies auto-immunes et le cancer
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US8415096B2 (en) * 2007-05-23 2013-04-09 University Of South Florida Micro-RNAs modulating immunity and inflammation
CN101801419A (zh) * 2007-06-08 2010-08-11 米尔纳疗法公司 作为治疗干预的靶标的miR-34调控的基因和路径
AU2008262252B2 (en) 2007-06-08 2013-09-12 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells
US8053186B2 (en) 2007-06-15 2011-11-08 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing
WO2009006577A2 (fr) * 2007-07-03 2009-01-08 The Regents Of The University Of Michigan Compositions et méthodes pour inhiber la protéine ezh2
KR101554996B1 (ko) 2007-07-31 2015-09-23 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 섬유증을 조절하는 마이크로-ｒｎａ 집단 및 이의 용도
KR20100057022A (ko) 2007-07-31 2010-05-28 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 마이오신 발현 및 근섬유 동일성을 제어하는 마이크로-ｒｎａｓ
JP2010535782A (ja) 2007-07-31 2010-11-25 ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン Ｄｎｍｔ３ａ及びｄｎｍｔ３ｂを標的にすることによるメチル化を元に戻す方法
US7812003B2 (en) * 2007-08-02 2010-10-12 Safe Stephen H Antisense microRNA and uses therefor
EP2173908B1 (fr) 2007-08-03 2016-01-06 The Ohio State University Research Foundation Régions ultra-conservées codant pour des arnnc
US20120070442A1 (en) * 2007-08-09 2012-03-22 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for treating cancer
US8716255B2 (en) 2007-08-10 2014-05-06 British Columbia Cancer Agency Branch Microrna compositions and methods for the treatment of myelogenous leukemia
CA2696887C (fr) 2007-08-22 2016-06-28 The Ohio State University Research Foundation Procedes et compositions pour induire une deregulation de la phosphorylation de epha7 et de erk dans des cas de leucemies humaines aigues
CN101376910B (zh) * 2007-08-27 2012-01-11 中国科学院上海生命科学研究院 微小rna基因在***性红斑狼疮疾病诊断和治疗中的作用
JP5401460B2 (ja) * 2007-09-06 2014-01-29 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション ヒト卵巣癌中のマイクロｒｎａシグネチャー
WO2009036332A1 (fr) 2007-09-14 2009-03-19 Asuragen, Inc. Microarn exprimés de manière différentielle dans le cancer du col de l'utérus et leurs utilisations
WO2009044895A1 (fr) * 2007-10-03 2009-04-09 Kyowa Hakko Kirin Co., Ltd. Composition inhibant l'expression d'un gène cible
WO2009044899A1 (fr) * 2007-10-03 2009-04-09 Kyowa Hakko Kirin Co., Ltd. Acide nucléique capable de réguler la prolifération d'une cellule
US8440637B2 (en) 2007-10-04 2013-05-14 Santaris Pharma A/S Combination treatment for the treatment of hepatitis C virus infection
US20100285471A1 (en) * 2007-10-11 2010-11-11 The Ohio State University Research Foundation Methods and Compositions for the Diagnosis and Treatment of Esphageal Adenocarcinomas
WO2009052386A1 (fr) * 2007-10-18 2009-04-23 Asuragen, Inc. Micro arn exprimés différentiellement dans des maladies pulmonaires et leurs utilisations
AU2008316577B2 (en) 2007-10-26 2014-04-10 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
CN101980712B (zh) 2007-10-29 2015-02-18 雷古拉斯治疗公司 用于肝癌治疗的靶向微小rna
WO2009061832A1 (fr) * 2007-11-05 2009-05-14 Kci Licensing Inc. Identification de tissu pour un débridement
CN101951924B (zh) * 2007-11-09 2015-06-24 得克萨斯***大学董事会 Mir-15家族的微小rna调控心肌细胞存活和心脏修复
ITRM20070595A1 (it) * 2007-11-15 2009-05-16 Univ Roma Mirna e sirna e loro uso in terapia
EP2520649A3 (fr) * 2007-11-23 2013-02-20 Panagene, Inc. Acides nucléiques peptidiques (ANP) antisens à microARN, compositions les comprenant, et procédés pour les utiliser et les évaluer
JP2011505143A (ja) * 2007-11-30 2011-02-24 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション マイクロｒｎａ発現プロファイリング及び肺癌における末梢血ターゲティング
US8071562B2 (en) * 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
WO2009086156A2 (fr) * 2007-12-21 2009-07-09 Asuragen, Inc. Gènes et voies régulés par mir-10 servant de cibles dans le cadre d'une intervention thérapeutique
JP5116026B2 (ja) 2008-01-23 2013-01-09 富士フイルム株式会社 癌の検出方法および癌抑制剤
KR101325186B1 (ko) 2008-01-23 2013-11-07 (주)바이오니아 이중가닥 ｍｉＲＮＡ를 유효성분으로 포함하는 항암제
EP2234483A4 (fr) 2008-01-27 2011-04-27 Rosetta Genomics Ltd Procédés et compositions pour diagnostiquer des complications de grossesse
WO2009100430A2 (fr) * 2008-02-08 2009-08-13 Asuragen, Inc Micro arn (mirna) exprimés différentiellement dans des nœuds lymphoïdes prélevés chez des patients atteints d’un cancer
US20110052502A1 (en) * 2008-02-28 2011-03-03 The Ohio State University Research Foundation MicroRNA Signatures Associated with Human Chronic Lymphocytic Leukemia (CCL) and Uses Thereof
US20110054009A1 (en) * 2008-02-28 2011-03-03 The Ohio State University Research Foundation MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders
CA2716906A1 (fr) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation Procedes et compositions fondes sur microarn pour le diagnostic, le pronostic et le traitement du cancer de l'estomac
WO2009109665A1 (fr) 2008-03-07 2009-09-11 Santaris Pharma A/S Compositions pharmaceutiques pour le traitement de maladies associées aux microarn
CA2718520C (fr) 2008-03-17 2020-01-07 The Board Of Regents Of The University Of Texas System Identification des micro-arn dans l'entretien et la regeneration de synapses neuromusculaires
US8252760B2 (en) 2008-03-24 2012-08-28 New York University Compositions and methods for diagnosing and treating melanoma
US20090253780A1 (en) * 2008-03-26 2009-10-08 Fumitaka Takeshita COMPOSITIONS AND METHODS RELATED TO miR-16 AND THERAPY OF PROSTATE CANCER
EP2977468B1 (fr) * 2008-03-27 2019-06-19 Vascular Biosciences, Inc. Procédés d'identification de nouveaux candidats thérapeutiques par analyse de l'expression génétique dans l'hypertension artérielle pulmonaire
US9179654B2 (en) * 2008-04-07 2015-11-10 Cornell Research Foundation, Inc. Inhibition of angiogenesis
US20090258928A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc. Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
CA2723716A1 (fr) * 2008-05-07 2009-11-12 Abraxis Bioscience, Llc Amelioration de pharmacotherapie par precurseurs arn
US8258111B2 (en) * 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
WO2009137801A2 (fr) * 2008-05-08 2009-11-12 The Trustees Of Columbia University In The City Of New York Arn inhibiteurs régulant les cellules hématopoïétiques
US20110071215A1 (en) * 2008-06-02 2011-03-24 Harvey Pass Compositions and methods for diagnosis, prognosis and treatment of mesothelioma
EP2300017A4 (fr) * 2008-06-05 2012-12-12 Univ New York State Res Found Arnmi en tant que cibles thérapeutiques dans le cancer
WO2009148631A1 (fr) * 2008-06-06 2009-12-10 The Board Of Trustees Of The Leland Stanford Junior University Rôle d'un arnmi dans une leucémie à lymphocytes t
EP2306978A2 (fr) * 2008-06-06 2011-04-13 Mirna Therapeutics, Inc. Nouvelles compositions pour l'administration in vivo d'agents arni
JP5745401B2 (ja) 2008-06-11 2015-07-08 アメリカ合衆国 肝細胞癌についての予測マーカーとしてのＭｉＲ−２６ファミリーの使用および療法に対する反応性
US8252534B2 (en) * 2008-06-12 2012-08-28 City Of Hope Micro RNAs and their methods of use for the treatment and diagnosis of schizophrenia and schizophrenia spectrum disorders
WO2009153775A2 (fr) * 2008-06-17 2009-12-23 Rosetta Genomics Ltd. Procédés permettant de différencier différents types de cancers du poumon
US9540695B2 (en) 2008-06-17 2017-01-10 Rosetta Genomics Ltd. Compositions and methods for prognosis of ovarian cancer
US20110256534A1 (en) 2008-06-27 2011-10-20 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Mischer Institute for Biomedical Researc Prediction of antiviral therapy response
CN106995819B (zh) * 2008-07-01 2020-10-20 孟山都技术公司 用于调控靶基因表达的重组dna构建体和方法
US20110117567A1 (en) * 2008-07-03 2011-05-19 National University Corporation Kobe University Micro-RNA Associated With Rheumatoid Arthritis
ES2541442T3 (es) 2008-08-01 2015-07-20 Roche Innovation Center Copenhagen A/S Modulación mediada por microARN de factores estimulantes de colonias
KR101042052B1 (ko) * 2008-08-05 2011-06-16 사회복지법인 삼성생명공익재단 항-ｍｉｃｒｏＲＮＡ를 포함하는 고형암 예방 또는 치료용조성물
US20110280861A1 (en) * 2008-08-08 2011-11-17 Massachusetts Institute Of Technology Method for mir-125a in promoting hematopoietic stem cell self renewal and expansion
US8685937B2 (en) 2008-08-09 2014-04-01 University Of Iowa Research Foundation Nucleic acid aptamers
US20110196017A1 (en) * 2008-08-11 2011-08-11 Olson Eric N Micro-rna that promotes vascular integrity and uses thereof
JP2012500389A (ja) * 2008-08-12 2012-01-05 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法
US20120149586A1 (en) * 2008-08-15 2012-06-14 Scottsdale Healthcare Methods of predicting the risk of recurrence of cancer
AU2009283906A1 (en) * 2008-08-19 2010-02-25 Maine Institute For Human Genetics And Health Micro RNA and Neurofibromatosis Type 1 in diagnosis and therapy
US20120040851A1 (en) * 2008-09-19 2012-02-16 Immune Disease Institute, Inc. miRNA TARGETS
WO2010054386A2 (fr) * 2008-11-10 2010-05-14 Battelle Memorial Institute Procédés, compositions et dispositifs utilisant du microarn pour déterminer des conditions physiologiques
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
ES2554765T3 (es) 2008-12-05 2015-12-23 Yeda Research And Development Co. Ltd. miRNA-9 o miRNA-9* para uso en el tratamiento de ELA
US20120041048A1 (en) * 2008-12-05 2012-02-16 Whitehead Institute For Biomedical Research COMPOSITIONS AND METHODS RELATING TO miR-31
EP2208785A1 (fr) 2009-01-15 2010-07-21 Newbiotechnic, S.A. Procédés et kits pour générer des vecteurs d'expression d'ARNm et petit ARN et leurs applications pour le développement de bibliothèques d'expression de lentivirus
JP2012515532A (ja) 2009-01-20 2012-07-12 ラモット アット テル アビブ ユニバーシティ， リミテッド Ｍｉｒ−２１プロモーター駆動性標的がん治療
CA2751213A1 (fr) * 2009-02-02 2010-08-05 Cepheid Methodes de detection d'une sepsie
KR20110128838A (ko) * 2009-02-04 2011-11-30 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 심장 질환 치료에서 ｍｉｒ－208 및 ｍｉｒ－499의 이중 표적화
EP2218458A1 (fr) * 2009-02-13 2010-08-18 Fondazione Telethon Molécules capables de moduler l'expression d'au moins un gène impliqué dans les voies de dégradation et leurs utilisations
US20100311815A1 (en) * 2009-02-23 2010-12-09 The Regents Of The University Of Michigan Mir-101 cancer markers
AU2010218147A1 (en) * 2009-02-26 2011-10-20 The Government Of The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services MicroRNAs in never-smokers and related materials and methods
US20120029055A1 (en) * 2009-03-19 2012-02-02 Agecy for Science, Technology and Research Modulators of apoptosis and the uses thereof
WO2010108192A1 (fr) * 2009-03-20 2010-09-23 The Research Foundation Of State University Of New York Miarn comme cibles thérapeutiques en cas de cancer
AU2010234806B2 (en) 2009-03-31 2014-05-22 The United States Of America As Represented By The Secretary Department Of Health And Human Services Differentially expressed microRNAs as biomarkers for the diagnosis and treatment of Sjogren's syndrome
WO2010120969A1 (fr) * 2009-04-15 2010-10-21 Board Of Regents, The University Of Texas System Ciblage de la famille mir-30 et de la famille let-7 pour le traitement de la maladie cardiaque
EP2421970B1 (fr) 2009-04-24 2016-09-07 Roche Innovation Center Copenhagen A/S Compositions pharmaceutiques pour le traitement de patients souffrant du vhc ne réagissant pas aux interférons
CN104087662A (zh) 2009-04-29 2014-10-08 阿姆斯特丹大学学术医学中心 对抗、预防和/或测定心力衰竭或心力衰竭的风险的工具和方法
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20120264626A1 (en) * 2009-05-08 2012-10-18 The Ohio State University Research Foundation MicroRNA Expression Profiling and Targeting in Chronic Obstructive Pulmonary Disease (COPD) Lung Tissue and Methods of Use Thereof
US20130177624A1 (en) * 2009-05-08 2013-07-11 David Brian Corry Mirna expression in allergic disease
WO2010131162A2 (fr) * 2009-05-11 2010-11-18 Koninklijke Philips Electronics N.V. Dispositif et procédé de comparaison de signatures moléculaires
CN105935365B (zh) 2009-05-20 2018-12-21 Eth苏黎世公司 用于代谢紊乱的靶向微小rna
CA2763156A1 (fr) * 2009-05-20 2010-11-25 Board Of Regents, The University Of Texas System Identification de micro-arn impliques dans un remodelage post-infarctus du myocarde et une insuffisance cardiaque
US20120059159A1 (en) * 2009-05-25 2012-03-08 Carola Ponzetto Differentiation therapy for sarcomas
EP2435583B1 (fr) * 2009-05-25 2014-07-09 Università degli Studi di Roma "La Sapienza" Mir-31 pour le traitement de la dystrophie musculaire de duchenne
US10421961B2 (en) 2009-06-10 2019-09-24 Exostem Biotec Ltd Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells
US20100322909A1 (en) 2009-06-17 2010-12-23 The University Of Pittsburgh - Of The Commonwealth System Of Higher Education Th1-associated micrornas and their use for tumor immunotherapy
WO2010151755A2 (fr) * 2009-06-25 2010-12-29 The Brigham And Women's Hospital, Inc. Traitement de maladies inflammatoires à l'aide du microarn mir-124
WO2011012136A1 (fr) * 2009-07-28 2011-02-03 Exiqon A/S Procédé de classification d'un échantillon de cellules humaines comme cancéreux
FR2948687B1 (fr) * 2009-07-29 2015-09-04 Centre Nat Rech Scient Utilisation de microarn pour le traitement de pathologies respiratoires chroniques
WO2011014697A1 (fr) * 2009-07-31 2011-02-03 The Translational Genomics Research Institute Méthodes d’évaluation du risque de progression d’un cancer
WO2011017408A1 (fr) * 2009-08-05 2011-02-10 The Ohio State University Research Foundation Thérapie anti-mir-1 pour cicatrisation
ES2585360T3 (es) * 2009-08-05 2016-10-05 Curna, Inc. Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS)
EP2283846A1 (fr) 2009-08-12 2011-02-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Composés de miARN pour le traitement du carcinome de la prostate
US8796238B2 (en) 2009-09-17 2014-08-05 Sigma-Aldrich Co. Llc Short RNA mimetics
US20130065949A1 (en) * 2009-10-14 2013-03-14 Baylor College Of Medicine Microrna mirna-31 as a therapeutic approach for the treatment of cancer
WO2011059752A1 (fr) * 2009-10-28 2011-05-19 Board Of Regents Of The University Of Texas System Procédés et compositions pour un traitement anti-egfr
US8648017B2 (en) 2009-11-04 2014-02-11 Diamir, Llc Methods of using small RNA from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
CA2781571A1 (fr) * 2009-11-24 2011-06-03 The University Of Western Australia Modulation de ligands de recepteur de facteur de croissance epidermique
EP2327783A1 (fr) * 2009-11-27 2011-06-01 Universitätsklinikum Freiburg Composition pharmaceutique comprenant de l'ARNmi-100 et son utilisation dans la modulation de la croissance des vaisseaux sanguins
US8354520B2 (en) * 2009-12-10 2013-01-15 Kaohsiung Medical University Composition and method for treating atherosclerosis, method for determining if a subject has atherosclerosis and method of screening an anti-atherosclerotic drug
US20120315640A1 (en) 2009-12-21 2012-12-13 Hidetoshi Tahara Senescence marker, method for evaluating senescence inhibitor, and cancer inhibitor
EP2518144B1 (fr) * 2009-12-21 2015-08-05 Hiroshima University Marqueur de vieillissement, procédé pour évaluer un inhibiteur de vieillisement, et inhibiteur de cancer
WO2011084815A1 (fr) * 2009-12-21 2011-07-14 Board Of Trustees Of Southern Illinois University Inhibition de l'invasion et de la métastase des cellules cancéreuses médiées par l'ubc9
US20130012403A1 (en) * 2009-12-23 2013-01-10 George Washington University Compositions and Methods for Identifying Autism Spectrum Disorders
EP2341145A1 (fr) * 2009-12-30 2011-07-06 febit holding GmbH Empreinte ARNm dans le diagnostic de maladies
US8846631B2 (en) 2010-01-14 2014-09-30 Regulus Therapeutics Inc. MicroRNA compositions and methods
WO2011091209A1 (fr) * 2010-01-21 2011-07-28 North Carolina State University Modificateurs à petite molécule de microarn mir-122
JP2011188849A (ja) * 2010-02-18 2011-09-29 Okayama Univ 抗腫瘍効果を有するｍｉＲ−７発現プラスミド
US8841269B2 (en) * 2010-02-23 2014-09-23 Creighton University Polynucleotides for use in treating and diagnosing cancers
WO2011108930A1 (fr) * 2010-03-04 2011-09-09 Interna Technologies Bv Molécule de miarn définie par sa source et ses utilisations thérapeutiques et en diagnostic pour maladies ou états associés à l'emt
WO2011111715A1 (fr) * 2010-03-09 2011-09-15 協和発酵キリン株式会社 Acide nucléique apte à réguler le cycle cellulaire
PL2556171T3 (pl) 2010-04-05 2016-04-29 Prognosys Biosciences Inc Oznaczenia biologiczne kodowane przestrzennie
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
DK2561078T3 (en) 2010-04-23 2019-01-14 Cold Spring Harbor Laboratory NEW STRUCTURALLY DESIGNED SHRNAs
WO2011150420A1 (fr) * 2010-05-28 2011-12-01 Baylor College Of Medicine Nanoparticules d'or modifiées à des fins thérapeutiques
JP6109069B2 (ja) 2010-06-04 2017-04-05 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム ｍｉＲ−３７８による代謝調節
WO2011154402A1 (fr) * 2010-06-09 2011-12-15 Chanel Parfums Beaute Inhibiteurs de micro-arn destinés à être utilisés pour prévenir et/ou atténuer le vieillissement de la peau et/ou pour hydrater la peau
EP2591106A1 (fr) 2010-07-06 2013-05-15 InteRNA Technologies B.V. Miarn et ses utilisations diagnostiques et thérapeutiques pour des maladies ou des états associés au mélanome, ou pour des maladies ou des états associés à la voie braf activée
CN103189511B (zh) 2010-07-12 2016-10-12 国立大学法人鸟取大学 利用siRNA导入的新型hiPSC制作法
US8580513B2 (en) * 2010-07-20 2013-11-12 Trustees Of Dartmouth College Methods for determining response to neoadjuvant therapy and survival using MicroRNA-10b
WO2012012716A2 (fr) 2010-07-23 2012-01-26 Regulus Therapeutics, Inc. Ciblage de microarn pour le traitement de la fibrose
US10385314B2 (en) 2010-08-16 2019-08-20 Exostem Biotec Ltd. Methods of generating oligodendrocytes and cell populations comprising same
CA2808372C (fr) 2010-08-16 2021-11-16 Brainstem Biotec Ltd. Procedes de generations d'oligodentrocytes et de populations cellulaires les comprenant
RU2013104137A (ru) * 2010-08-17 2014-09-27 Университэ Де Женева Изоформы bard1 при раке легкого и колоректальном раке и их применение
US8642342B2 (en) 2010-08-19 2014-02-04 Regents Of The University Of Michigan Methods for regulating neural differentiation
EP2426217A1 (fr) * 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Procédés analytiques pour acides nucléiques libres dans les cellules et applications
US9006195B2 (en) * 2010-09-13 2015-04-14 California Institute Of Technology Regulation of hematopoietic stem cell functions through microRNAs
WO2012044265A1 (fr) * 2010-09-27 2012-04-05 Sabanci Universitesi Utilisation d'arnmi pour diagnostiquer, prévenir, traiter et suivre les maladies impliquant des anomalies de type macro-autophagie
EP2622076A1 (fr) 2010-09-30 2013-08-07 University of Zürich Traitement d'un lymphome à cellules b avec un microarn
ES2606146T3 (es) * 2010-11-12 2017-03-22 The Ohio State University Research Foundation Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal
EP2638912A4 (fr) * 2010-11-12 2015-01-21 Nat Univ Corp Ehime Univ Compositions contenant des oligonucléotides antisens par rapport à des micro-arn
CN103313706A (zh) 2010-11-15 2013-09-18 俄亥俄州立大学研究基金会 控制释放粘膜粘合***
EP2772550B1 (fr) 2010-11-17 2017-03-29 Interpace Diagnostics, LLC Micro-ARN comme biomarqueurs pour différencier des néoplasmes de thyroïde bénins et malins
US10744151B1 (en) * 2010-12-01 2020-08-18 Gowey Research Group PLLC Micro-RNA profiling, compositions, and methods of treating diseases
JP5946466B2 (ja) * 2010-12-01 2016-07-06 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル ｍｉＲＮＡの発現を分析することによって大腸癌の転帰を予測するための方法
US11344505B1 (en) 2010-12-01 2022-05-31 Gowey Research Group, Pllc Herbal formulations of carnivorous plants and methods for treating inflammation
US10758578B2 (en) 2010-12-01 2020-09-01 Gowey Research Group PLLC Herbal formulations of carnivorous plants and methods for treating inflammation
US11414663B2 (en) 2010-12-01 2022-08-16 Gowey Research Group, Pllc Micro-RNA profiling, compositions, and methods of treating diseases
EP2652151A2 (fr) 2010-12-15 2013-10-23 Miragen Therapeutics Inhibiteurs de microarn comprenant des nucléotides bloqués
US20140045924A1 (en) * 2010-12-15 2014-02-13 Medimmune, Llc Melanoma treatments
SG191174A1 (en) * 2010-12-20 2013-07-31 Agency Science Tech & Res Targeting glioma stem cells by sequence-specific functional inhibition of pro-survival oncomir-138
EP2474617A1 (fr) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR pour traiter une nouvelle angiogenèse
KR20140020900A (ko) 2011-02-03 2014-02-19 미르나 테라퓨틱스 인코포레이티드 Ｍｉｒ―34의 합성 모방체
CA2826043A1 (fr) 2011-02-03 2012-08-09 Mirna Therapeutics, Inc. Mimetiques synthetiques de mir-124
US20120225925A1 (en) * 2011-02-07 2012-09-06 Biomirna Holdings Ltd. Micro-RNA Biomarkers and Methods of Using Same
EP2683387A4 (fr) 2011-03-07 2014-09-03 Univ Ohio State Activité mutatrice induite par l'inflammation des liaisons au microarn-155 (mir-155) et le cancer
JP2014514921A (ja) * 2011-03-30 2014-06-26 独立行政法人理化学研究所 機能性核酸分子、及びその利用
WO2012135817A2 (fr) * 2011-03-31 2012-10-04 University Of Houston Microarn-130a, b en tant que suppresseur de tumeur et agent de sensibilisation pour chimiothérapie
WO2012140234A1 (fr) 2011-04-13 2012-10-18 Vib Vzw Modulation du miarn dans les maladies caractérisées par une angiogenèse aberrante
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CN103620019B (zh) 2011-04-18 2017-06-06 迪阿米尔有限责任公司 基于miRNA的通用筛选试验(UST)
WO2012145743A1 (fr) * 2011-04-22 2012-10-26 University Of Houston Microarn-140-5p en tant que suppresseur de tumeur et agent de sensibilisation pour une chimiothéraphie
TWI698445B (zh) 2011-04-25 2020-07-11 法商賽諾菲公司 微型ｒｎａ化合物及調控ｍｉｒ－２１活性之方法
EE201100037A (et) * 2011-05-16 2012-12-17 Tartu Ülikool MikroRNAde kasutamine biomarkeritena ja sihtm„rkidena raku proliferatiivsete omaduste m?jutamiseks ja meetod ning komplekt nende ekspressioonitaseme tuvastamiseks
CA2840403A1 (fr) 2011-06-27 2013-01-03 Galderma Research & Development Nouveaux marqueurs de differenciation des th17 pour l'acne et leurs utilisations
WO2013000870A1 (fr) * 2011-06-27 2013-01-03 Galderma Research & Development Nouveaux marqueurs de différenciation des th17 pour l'acné et leurs utilisations
US8747860B2 (en) 2011-07-06 2014-06-10 Institute For Systems Biology Methods and compositions to modulate antiviral and immune activity responses
EP2740266A1 (fr) 2011-08-01 2014-06-11 Thomson Licensing Système et procédé pour des communications en téléprésence
CN112426538A (zh) 2011-08-04 2021-03-02 耶达研究及发展有限公司 微rna和包含微rna的组合物
US8987224B2 (en) 2011-08-05 2015-03-24 Baylor College Of Medicine MicroRNA-198 as a tumor suppressor in pancreatic cancer
WO2013023982A1 (fr) 2011-08-12 2013-02-21 Westfaelische Wilhelms-Universitaet Muenster Nouveaux composés pour le traitement des maladies inflammatoires de l'intestin
WO2013032962A2 (fr) * 2011-08-28 2013-03-07 The Board Of Trustees Of The Leland Stanford Junior University Microarn pour traiter un accident vasculaire cérébral, une lésion cérébrale ischémique, une lésion cérébrale traumatique et une maladie neurodégénérative
US9434944B2 (en) 2011-08-31 2016-09-06 University Of Zurich Modulators of miR-323-3p for the prevention or treatment of rheumatoid arthritis
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
CA2844577A1 (fr) 2011-09-13 2013-03-21 Ottawa Hospital Research Institute Inhibiteurs de micro-arn microrna inhibitors
AU2013201303C1 (en) 2011-10-06 2016-06-23 MiRagen Therapeutics, Inc. Control of whole body energy homeostasis by microRNA regulation
WO2013056217A1 (fr) 2011-10-14 2013-04-18 The Ohio State University Méthodes et matériaux relatifs au cancer des ovaires
EP2584040A1 (fr) 2011-10-17 2013-04-24 Pharmahungary 2000 Kft. Composés pour le traitement de lésions ischémiques
WO2013065791A1 (fr) * 2011-11-02 2013-05-10 公立大学法人大阪市立大学 Molécule d'acide nucléique double brin utilisable à des fins de régulation de l'expression génique
EP3106168A3 (fr) * 2011-11-30 2017-02-22 Cedars-Sinai Medical Center Ciblage des microarn mir-409-5p, mir-379 et mir-154* pour traiter la métastase osseuse du cancer de la prostate et le cancer du poumon résistant aux médicaments
CA2857712A1 (fr) * 2011-12-01 2013-06-06 Cincinnati Children's Hospital Medical Center Materiels et methodes se rapportant a une chimio-prevention par nsaid dans un cancer colorectal
JP2015501645A (ja) * 2011-12-10 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション 肺がんの腫瘍発生および化学療法耐性を低減するために有用なｍｉＲＮＡならびに関連する組成物および方法
JP2015501843A (ja) 2011-12-13 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション ｍｉＲ−２１およびｍｉＲ−２９ａ、エキソソーム阻害、およびがん転移に関する方法および組成物
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
JP2015511121A (ja) 2012-01-20 2015-04-16 ジ・オハイオ・ステート・ユニバーシティ 浸潤性および予後に関する乳がんバイオマーカーシグネチャー
US10034902B2 (en) 2012-02-22 2018-07-31 Exostem Biotec Ltd. MicroRNAs for the generation of astrocytes
EP2844745A2 (fr) 2012-02-22 2015-03-11 Brainstem Biotec Ltd. Génération de cellules souches neuronales et de motoneurones
BR112014021401B1 (pt) 2012-03-09 2022-10-11 Interdigital Madison Patent Holdings Método para processar um comando de transporte em um controlador de conteúdo local e método para processar um primeiro comando de transporte em um controlador de conteúdo local para controlar conteúdo compartilhado
EA030211B1 (ru) 2012-04-25 2018-07-31 Регьюлэс Терапьютикс Инк. Соединения на основе микрорнк и способы модулирования активности mir-21
WO2013166240A1 (fr) * 2012-05-02 2013-11-07 The Board Of Regents Of The University Of Texas System Micro-arn impliqués dans la dégénérescence maculaire
US9334498B2 (en) 2012-05-10 2016-05-10 Uab Research Foundation Methods and compositions for modulating MIR-204 activity
WO2013180038A1 (fr) 2012-05-26 2013-12-05 株式会社ボナック Molécule d'acide nucléique simple brin pour réguler l'expression d'un gène ayant une fonction d'administration
ES2801875T3 (es) 2012-06-21 2021-01-14 Miragen Therapeutics Inc Inhibidores basados en oligonucleótidos que comprenden un motivo de ácido nucleico bloqueado
US9163235B2 (en) 2012-06-21 2015-10-20 MiRagen Therapeutics, Inc. Inhibitors of the miR-15 family of micro-RNAs
EP2871239B1 (fr) * 2012-07-06 2018-08-29 Takara Bio Inc. Cellule capable de produire un vecteur viral de type adéno-associé (aav)
SG11201500615WA (en) 2012-07-27 2015-04-29 Agency Science Tech & Res Method of promoting wound healing
EP2879678B1 (fr) 2012-07-31 2023-03-01 Yeda Research and Development Co. Ltd. Enoxacin pour le traitement de la sclérose latérale amyotrophique
ES2534210T3 (es) * 2012-08-29 2015-04-20 Chanel Parfums Beauté Inhibidores de micro-ARN para uso para prevenir y/o atenuar el envejecimiento cutáneo
EP2702998A1 (fr) 2012-08-31 2014-03-05 IMBA-Institut für Molekulare Biotechnologie GmbH Régulateur ARNmi thérapeutiques et de diagnostic dans une maladie des reins
US20150344961A1 (en) * 2012-09-11 2015-12-03 New York University Sera Based miRNAs as Non-Invasive Biomarkers in Melanoma
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
US9944991B2 (en) 2012-11-02 2018-04-17 Dana-Farber Cancer Institute, Inc. Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
US9340787B2 (en) * 2012-11-15 2016-05-17 Yale University Compositions and methods of using micro RNAs
US20140243387A1 (en) * 2012-12-18 2014-08-28 Icahn School Of Medicine At Mount Sinai Methods for improving cardiac contractility
ES2828510T3 (es) * 2013-02-15 2021-05-26 Univ Nat Corp Tokyo Medical & Dental Agente terapéutico para tratar un cáncer en el que NRF2 está estabilizado
US20160002628A1 (en) * 2013-03-11 2016-01-07 Georgia Tech Research Corporation Methods and compositions for managing vascular conditions
US9006200B2 (en) * 2013-03-13 2015-04-14 Asbestos Diseases Research Foundation MicroRNA-based approach to treating malignant pleural mesothelioma
EP2968567A2 (fr) 2013-03-15 2016-01-20 Mirna Therapeutics, Inc. Traitements combinés du cancer à l'aide de micro-arn et d'inhibiteurs d'egfr-tki
US9752143B2 (en) 2013-03-15 2017-09-05 MiRagen Therapeutics, Inc. Locked nucleic acid inhibitor of miR-145 and uses thereof
US20160032383A1 (en) * 2013-03-15 2016-02-04 Albert Einstein College Of Medicine Of Yeshiva University PANEL OF microRNA BIOMARKERS IN HEALTHY AGING
US20140288149A1 (en) 2013-03-15 2014-09-25 Graham Lord Mir-142 and antagonists thereof for treating disease
WO2014168616A1 (fr) 2013-04-10 2014-10-16 Thomson Licensing Hiérarchisation et manipulation de têtes de pair dans un système de téléprésence
JP2016169158A (ja) * 2013-06-14 2016-09-23 北海道公立大学法人 札幌医科大学 大腸癌を治療および／または診断するための組成物ならびにその利用
GB201310755D0 (en) * 2013-06-17 2013-07-31 Ucl Business Plc Therapy
JP2016526826A (ja) 2013-06-20 2016-09-05 トムソン ライセンシングＴｈｏｍｓｏｎ Ｌｉｃｅｎｓｉｎｇ コンテンツの分散型再生の同期化を支援するシステム及び方法
JP2016530232A (ja) 2013-06-24 2016-09-29 ミルナ セラピューティクス，インク． Ｍｉｒ−３４活性のバイオマーカー
CN118240918A (zh) 2013-06-25 2024-06-25 普罗格诺西斯生物科学公司 采用微流控装置的空间编码生物分析
US9862943B1 (en) * 2013-06-27 2018-01-09 California Institute Of Technology Long noncoding RNAs and cell reprogramming and differentiation
JP6443889B2 (ja) * 2013-08-08 2018-12-26 国立大学法人大阪大学 尿路上皮癌の診断または治療剤
KR101566586B1 (ko) * 2013-08-21 2015-11-16 서울대학교산학협력단 miRNA를 표적으로 하는 뇌전증 또는 발작 관련 질환의 예방 또는 치료용 약학 조성물 및 방법
WO2015044890A2 (fr) * 2013-09-26 2015-04-02 Friedrich Miescher Institute For Biomedical Research Outils et méthodes utilisant les micro-arn 182, 96 et/ou 183 pour le traitement de pathologies
US20150089870A1 (en) * 2013-10-01 2015-04-02 Wayne State University Population control of invasive plant species and restoration of native plant communities
KR101598070B1 (ko) * 2013-10-17 2016-02-26 한국과학기술연구원 마약 중독 예방 및 치료용 약제학적 조성물
WO2015066034A1 (fr) 2013-10-28 2015-05-07 Icahn School Of Medicine At Mount Sinai Compositions et procédés pour moduler l'excitabilité neuronale et le comportement moteur
KR101559131B1 (ko) * 2013-11-18 2015-10-07 한국원자력의학원 ｍｉＲＮＡ를 포함하는 방사선 민감성 증진용 조성물
AU2014348273A1 (en) 2013-11-18 2016-06-09 Diamir, Llc Methods of using mIRNAs from bodily fluids for detection and monitoring of Parkinson's disease (PD)
WO2015092707A2 (fr) 2013-12-17 2015-06-25 Csir Procédé d'identification d'inhibiteurs miarn et d'agents mimétiques miarn humains anti-vih, et composés pharmaceutiques anti-vih
JP6486836B2 (ja) 2013-12-26 2019-03-20 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
CN112646812A (zh) * 2013-12-27 2021-04-13 株式会社博纳克 控制基因表达的人工匹配型miRNA及其用途
JP6492014B2 (ja) * 2013-12-27 2019-03-27 株式会社ボナック 遺伝子発現制御のための人工マッチ型ｍｉＲＮＡおよびその用途
JP2017506228A (ja) 2014-02-05 2017-03-02 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． セロトニン放出ホルモン、アドレナリン放出ホルモン、ノルアドレナリン放出ホルモン、グルタミン酸放出ホルモンおよび副腎皮質刺激ホルモン放出ホルモン関連の医学的状態の処置および診断のためのマイクロｒｎａおよび該マイクロｒｎａを含む組成物
JPWO2015133637A1 (ja) * 2014-03-07 2017-04-06 国立大学法人京都大学 マイクロｒｎａ封入ナノ粒子及びその医薬用途
EP3126496A1 (fr) 2014-04-01 2017-02-08 Mirna Therapeutics, Inc. Schémas posologiques de dosage de micro arn
EP2940151A1 (fr) * 2014-05-02 2015-11-04 Ruprecht-Karls-Universität Heidelberg Circulation de microRNA en tant que marqueur de détection précoce et marqueur pronostique
AU2015279542B2 (en) * 2014-06-26 2021-07-29 Icahn School Of Medicine At Mount Sinai Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets
US20170207684A1 (en) * 2014-07-15 2017-07-20 Mitsuba Corporation Brushless wiper motor
LU92499B1 (en) 2014-07-16 2016-01-18 Univ Muenster Wilhelms Mirna 320a as biomarker for inflammatory bowel disease
ES2558262B2 (es) 2014-08-01 2016-07-14 Universidad Católica De Valencia "San Vicente Mártir" Método de diagnóstico de fibromialgia basado en microRNAs
US9487783B2 (en) 2014-08-07 2016-11-08 Regulus Therapeutics Inc. Targeting microRNAs for metabolic disorders
WO2016054094A1 (fr) * 2014-09-30 2016-04-07 Research Institute At Nationwide Children's Hospital Compositions et procédés destinés au traitement de la fibrose hépatique
US11027023B2 (en) * 2014-12-27 2021-06-08 Bonac Corporation Natural type miRNA for controlling gene expression, and use of same
SG10201906716QA (en) 2015-01-20 2019-08-27 Miragen Therapeutics Inc Mir-92 inhibitors and uses thereof
GB201504772D0 (en) 2015-03-20 2015-05-06 Univ Aston Preeclampsia
EP3273971A4 (fr) 2015-03-27 2018-12-05 Yeda Research and Development Co. Ltd. Méthodes de traitement des maladies des motoneureones
WO2016158809A1 (fr) 2015-03-27 2016-10-06 株式会社ボナック Molécule d'acide nucléique monocaténaire ayant une fonction d'administration et une capacité à réguler l'expression génique
EP4119677B1 (fr) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Analyse de plusieurs acides nucléiques spatialement différenciés de spécimens biologiques
JPWO2016167366A1 (ja) * 2015-04-17 2018-04-05 国立大学法人 東京大学 眼疾患治療剤
WO2016183414A1 (fr) * 2015-05-14 2016-11-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Systèmes et méthodes de caractérisation de maladies granulomateuses
WO2016190899A1 (fr) * 2015-05-23 2016-12-01 Beem Alan M H Banques de pri-miarn et leurs procédés de production et d'utilisation
WO2017020009A1 (fr) * 2015-07-30 2017-02-02 Regents Of The University Of Minnesota Régulation de spécification mésodermique
EP3334436A4 (fr) 2015-08-13 2019-05-29 SomaGenics Inc. Procédés et compositions faisant appel à de petits arn en épingle à cheveux courts et à des microarn pour la cicatrisation des plaies
US10556019B2 (en) * 2015-08-21 2020-02-11 Universitätsklinikum Jena Human microRNAs for treatment of malignant tumours
EP3357498A4 (fr) 2015-09-28 2019-05-15 National University Corporation Chiba University Procédé de suppression de tumeurs par inhibition de la famille mir-200
US11180810B2 (en) 2015-09-29 2021-11-23 Research Institute At Nationwide Children's Hospital Methods for detecting hepatic fibrosis and responsiveness to therapy
JP6666002B2 (ja) * 2015-10-07 2020-03-13 国立大学法人京都大学 Ｔｄｐ−４３プロテノパシーの予防又は治療用組成物
US10526657B2 (en) * 2015-12-10 2020-01-07 Universitat Fur Bodenkultur Wien Compositions and methods for the diagnosis and treatment of bone fractures and disorders
EP3181698A1 (fr) 2015-12-16 2017-06-21 European Molecular Biology Laboratory (EMBL) Micro-arn mir-142 comme marqueur de cellules souches
US11041006B2 (en) 2015-12-28 2021-06-22 Riken Compositions for use in recovering or ameliorating deterioration of physiological functions due to aging
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
CN105543225A (zh) * 2016-01-07 2016-05-04 华东师范大学 miR143及其诱导物LTA在制备抑制痤疮炎症药物中的应用
US10771508B2 (en) 2016-01-19 2020-09-08 Nadejda Sarmova Systems and methods for establishing a virtual shared experience for media playback
US11364258B2 (en) 2016-03-04 2022-06-21 Rhode Island Hospital Methods for treating chondrosarcoma using microrna(miR)
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
CN109477090B (zh) * 2016-04-14 2022-03-22 e-NA生物科技公司 微小rna-143衍生物
WO2017192601A1 (fr) * 2016-05-02 2017-11-09 University Of Massachusetts Différenciation des lymphocytes t et régulation de la fonction de ces derniers
US11013752B2 (en) * 2016-06-03 2021-05-25 Hough Ear Institute Combination therapies for inner ear sensory hair cell regeneration/replacement
US10874688B2 (en) 2016-10-31 2020-12-29 Gifu University Double-stranded nucleic acid molecule and use thereof
CN110290794A (zh) 2016-11-01 2019-09-27 纽约州州立大学研究基金会 5-卤代尿嘧啶修饰的微rna及其在癌症治疗中的用途
CN107058470B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
WO2018191895A1 (fr) 2017-04-19 2018-10-25 深圳市汇顶科技股份有限公司 Procédé et dispositif de détection d'intensité lumineuse et terminal intelligent
JP7083818B2 (ja) * 2017-04-28 2022-06-13 一丸ファルコス株式会社 プラセンタ抽出物
WO2018204829A1 (fr) * 2017-05-04 2018-11-08 University Of Maryland, Baltimore Procédés pour empêcher des défauts de tube neural dans une grossesse diabétique
CN110636853A (zh) * 2017-05-19 2019-12-31 佐治亚州立大学研究基金会公司 重组溶瘤病毒
US20210139895A1 (en) * 2017-06-16 2021-05-13 Prostemics Co., Ltd. Pharmaceutical composition for preventing or treating cancer
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
WO2019116234A1 (fr) 2017-12-12 2019-06-20 Nestec S.A. Procédés de détermination de variations de composition d'arn ribosomique de microbiome
JP7318166B2 (ja) 2018-03-14 2023-08-01 ベス イスラエル デアコネス メディカル センター マイクロｒｎａ２２の阻害剤
WO2019195765A1 (fr) * 2018-04-06 2019-10-10 University Of Massachusetts Microarn régulés par mlk dans l'angiogenèse et le développement de tumeurs
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
KR102115960B1 (ko) * 2018-11-28 2020-05-27 송미연 인간 중간엽 줄기세포를 갑상선 호르몬 분비세포로 분화 방법
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
CA3139919A1 (fr) * 2019-03-11 2020-09-17 Ochsner Health System Reseau de regulation de microarn en tant que biomarqueurs de crise chez des patients presentant une hemorragie intracerebrale spontanee
WO2020198137A1 (fr) * 2019-03-25 2020-10-01 The Trustees Of The University Of Pennsylvania Thérapie régénérative basée sur des mimétiques de miarn-302 pour améliorer la récupération d'un hôte d'une pneumonie provoquée par streptococcus pneumoniae
EP3976820A1 (fr) 2019-05-30 2022-04-06 10X Genomics, Inc. Procédés de détection de l'hétérogénéité spatiale d'un échantillon biologique
US10844380B1 (en) 2019-06-17 2020-11-24 Biorchestra Co., Ltd. Uses for prevention or treatment of brain diseases using microrna
US11198908B2 (en) 2019-06-17 2021-12-14 Biorchestra Co., Ltd. Method for diagnosis of Alzheimer's disease using microRNA
CN110551809A (zh) * 2019-08-21 2019-12-10 昆明医科大学第一附属医院 miR-124在脊髓损伤修复中的用途
EP4025711A2 (fr) 2019-11-08 2022-07-13 10X Genomics, Inc. Amélioration de la spécificité de la liaison d'un analyte
WO2021091611A1 (fr) 2019-11-08 2021-05-14 10X Genomics, Inc. Agents de capture d'analytes marqués spatialement pour le multiplexage d'analytes
ES2946357T3 (es) 2019-12-23 2023-07-17 10X Genomics Inc Métodos para el análisis espacial usando ligación con molde de ARN
CA3162845A1 (fr) * 2019-12-23 2021-07-01 Anastasia Khvorova Oligonucleotides servant a la modulation d'expression de gene propre a un tissu
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
US20230210883A1 (en) * 2020-03-13 2023-07-06 Duke University Compositions for the treatment of nash and associated disorders and methods of using same
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
EP4153775A1 (fr) 2020-05-22 2023-03-29 10X Genomics, Inc. Mesure spatio-temporelle simultanée de l'expression génique et de l'activité cellulaire
WO2021237087A1 (fr) 2020-05-22 2021-11-25 10X Genomics, Inc. Analyse spatiale pour détecter des variants de séquence
WO2021242834A1 (fr) 2020-05-26 2021-12-02 10X Genomics, Inc. Procédé de réinitialisation d'un réseau
WO2021247568A1 (fr) 2020-06-02 2021-12-09 10X Genomics, Inc. Trancriptomique spatiale pour les récepteurs d'antigènes
WO2021247543A2 (fr) 2020-06-02 2021-12-09 10X Genomics, Inc. Procédés de banques d'acides nucléiques
WO2021252499A1 (fr) 2020-06-08 2021-12-16 10X Genomics, Inc. Méthodes de détermination de marge chirurgicale et méthodes d'utilisation associées
WO2021252591A1 (fr) 2020-06-10 2021-12-16 10X Genomics, Inc. Procédés de détermination d'un emplacement d'un analyte dans un échantillon biologique
WO2021263111A1 (fr) 2020-06-25 2021-12-30 10X Genomics, Inc. Analyse spatiale de la méthylation de l'adn
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
CN112190592B (zh) * 2020-08-25 2022-03-11 苏州市立医院(北区) miRNA在制备防治骨关节炎药物的应用、miRNA高表达的外泌体和应用
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022076774A2 (fr) * 2020-10-08 2022-04-14 The Trustees Of Columbia University In The City Of New York Traitement et détection de fibrose hépatique et de maladie hépatique au moyen de microarn
CN112375823B (zh) * 2020-10-22 2022-09-16 上海交通大学医学院附属瑞金医院 miRNA抑制剂在制备治疗和/或预防淋巴瘤的药物中的应用
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (fr) 2020-12-21 2022-06-30 10X Genomics, Inc. Procédés, compositions et systèmes pour capturer des sondes et/ou des codes à barres
EP4301870A1 (fr) 2021-03-18 2024-01-10 10X Genomics, Inc. Capture multiplex de gène et expression de protéines à partir d'un échantillon biologique
WO2022272269A1 (fr) * 2021-06-22 2022-12-29 The Curators Of The University Of Missouri Biomarqueurs à analytes multiples pour le cancer pulmonaire
EP4196605A1 (fr) 2021-09-01 2023-06-21 10X Genomics, Inc. Procédés, compositions et kits pour bloquer une sonde de capture sur un réseau spatial
WO2023118546A2 (fr) 2021-12-23 2023-06-29 Boehringer Ingelheim International Gmbh Procédés et molécules pour interférence arn (arni)
US11541116B1 (en) 2022-01-07 2023-01-03 Kojin Therapeutics, Inc. Methods and compositions for inducing ferroptosis in vivo
KR102583230B1 (ko) * 2023-03-16 2023-09-27 재단법인 전남바이오산업진흥원 뇌경색 예방 또는 치료용 조성물

Family Cites Families (497)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2007A (en) * 1841-03-16 Improvement in the mode of harvesting grain
US2006A (en) * 1841-03-16 Clamp for crimping leather
US1529202A (en) 1924-07-16 1925-03-10 Joseph H Miller Festooning machine for carrying paper and the like
GB1529202A (en) 1976-02-20 1978-10-18 Ciba Geigy Ag Spectral sensitising dyes
US5221619A (en) 1977-11-08 1993-06-22 Genentech, Inc. Method and means for microbial polypeptide expression
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
US5583013A (en) 1977-11-08 1996-12-10 Genentech, Inc. Method and means for microbial polypeptide expression
JPS55116259A (en) 1979-03-01 1980-09-06 Fuji Photo Film Co Ltd Microimmunoassay method
EP0047472B1 (fr) 1980-09-02 1985-04-24 Fuji Photo Film Co., Ltd. Méthode pour la mesure immunochimique de composés en traces
JPS5745460A (en) 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Inspection sheet for measuring trace component and inspecting method using said sheet
NL8200523A (nl) 1982-02-11 1983-09-01 Univ Leiden Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna.
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4828979A (en) 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3529478A1 (de) 1985-08-16 1987-02-19 Boehringer Mannheim Gmbh 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
US4682195A (en) 1985-09-30 1987-07-21 General Electric Company Insulated gate device with configured emitter contact pad
US4959463A (en) 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4876187A (en) 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US4910300A (en) 1985-12-11 1990-03-20 Chiron Corporation Method for making nucleic acid probes
CA1284931C (fr) 1986-03-13 1991-06-18 Henry A. Erlich Procede de detection de variations specifiques de nucleotides et de polymorphismes genetiques dans les acides nucleiques
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
EP0266032A1 (fr) 1986-08-29 1988-05-04 Beecham Group Plc Enzyme fibrinolytique modifiée
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US4816571A (en) 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
US4952500A (en) 1988-02-01 1990-08-28 University Of Georgia Research Foundation, Inc. Cloning systems for Rhodococcus and related bacteria
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US4999290A (en) 1988-03-31 1991-03-12 The Board Of Regents, The University Of Texas System Detection of genomic abnormalities with unique aberrant gene transcripts
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5602244A (en) 1988-05-26 1997-02-11 Competitive Technologies, Inc. Polynucleotide phosphorodithioate compounds
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5708154A (en) 1989-02-24 1998-01-13 City Of Hope RNA-DNA hybrid molecules of nucleic acid
US6867195B1 (en) 1989-03-21 2005-03-15 Vical Incorporated Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5302523A (en) 1989-06-21 1994-04-12 Zeneca Limited Transformation of plant cells
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5550318A (en) 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5141813A (en) 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
GB8920097D0 (en) 1989-09-06 1989-10-18 Ici Plc Amplification processes
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5322783A (en) 1989-10-17 1994-06-21 Pioneer Hi-Bred International, Inc. Soybean transformation by microparticle bombardment
DE69034150T2 (de) 1989-10-24 2005-08-25 Isis Pharmaceuticals, Inc., Carlsbad 2'-Modifizierte Oligonukleotide
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
EP0430881A3 (en) 1989-11-29 1991-10-23 Ciba-Geigy Ag Photochromic compounds, process for their preparation and their use
US5486603A (en) 1990-01-08 1996-01-23 Gilead Sciences, Inc. Oligonucleotide having enhanced binding affinity
US5872232A (en) 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
US5859221A (en) 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6153737A (en) 1990-01-11 2000-11-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US5214136A (en) 1990-02-20 1993-05-25 Gilead Sciences, Inc. Anthraquinone-derivatives oligonucleotides
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5470967A (en) 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
GB9009980D0 (en) 1990-05-03 1990-06-27 Amersham Int Plc Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
US5610289A (en) 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
BR9106702A (pt) 1990-07-27 1993-06-08 Isis Pharmaceuticals Inc Analogo de oligonucleotideos e processos para modular a producao de uma proteina por um organismo e para tratar um organismo
US5223618A (en) 1990-08-13 1993-06-29 Isis Pharmaceuticals, Inc. 4'-desmethyl nucleoside analog compounds
US5623070A (en) 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US5965364A (en) 1990-10-09 1999-10-12 Benner; Steven Albert Method for selecting functional deoxyribonucleotide derivatives
WO1992007095A1 (fr) 1990-10-15 1992-04-30 Stratagene Procede de reaction en chaine de polymerase arbitrairement amorcee destine a produire une empreinte genetique de genomes
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
US5672697A (en) 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US6287792B1 (en) 1991-06-17 2001-09-11 The Regents Of The University Of California Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
AU662906B2 (en) 1991-06-26 1995-09-21 F. Hoffmann-La Roche Ag Methods for detection of carcinoma metastases by nucleic acid amplification
US6369209B1 (en) * 1999-05-03 2002-04-09 Isis Pharmaceuticals, Inc. Oligonucleotides having A-DNA form and B-DNA form conformational geometry
WO1993004169A1 (fr) 1991-08-20 1993-03-04 Genpharm International, Inc. Ciblage de genes dans des cellules animales au moyen de produits de synthese d'adn isogeniques
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5610042A (en) 1991-10-07 1997-03-11 Ciba-Geigy Corporation Methods for stable transformation of wheat
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5256555A (en) 1991-12-20 1993-10-26 Ambion, Inc. Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions
US5700922A (en) 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5260191A (en) 1992-01-30 1993-11-09 Agracetus, Inc. Method for diagnosing tumors
US5652099A (en) 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
EP0628051B1 (fr) 1992-02-12 2003-07-02 Chromagen, Inc. Utilisation de n-nucleosides fluorescents et de leurs analogues structurels fluorescents
DE4204650C1 (fr) 1992-02-15 1993-07-08 Hoffmeister, Helmut, Dr., 4400 Muenster, De
WO1993017126A1 (fr) 1992-02-19 1993-09-02 The Public Health Research Institute Of The City Of New York, Inc. Nouvelles configurations d'oligonucleotides et utilisation de ces configurations pour le tri, l'isolement, le sequençage et la manipulation des acides nucleiques
US5262311A (en) 1992-03-11 1993-11-16 Dana-Farber Cancer Institute, Inc. Methods to clone polyA mRNA
WO1993018176A1 (fr) 1992-03-11 1993-09-16 Dana-Farber Cancer Institute Procedes de clonage d'arn messager
JP2775346B2 (ja) 1992-04-03 1998-07-16 アプライド バイオシステムズ，インコーポレイテッド プローブ構成物および方法
GB9208545D0 (en) 1992-04-21 1992-06-03 Gatsby Charitable Foundation T Virus resistant plants
US5428148A (en) 1992-04-24 1995-06-27 Beckman Instruments, Inc. N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
WO1994000977A1 (fr) 1992-07-07 1994-01-20 Japan Tobacco Inc. Procede de transformation d'une monocotyledone
US5702932A (en) 1992-07-20 1997-12-30 University Of Florida Microinjection methods to transform arthropods with exogenous DNA
EP0652965A1 (fr) 1992-07-27 1995-05-17 Pioneer Hi-Bred International, Inc. Procede ameliore de transformation induite par agrobacterium de cellules de soja cultivees
US5438131A (en) 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
GB9222888D0 (en) 1992-10-30 1992-12-16 British Tech Group Tomography
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5858988A (en) 1993-02-24 1999-01-12 Wang; Jui H. Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
US5801005A (en) 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US5580726A (en) 1994-04-29 1996-12-03 Geron Corporation Method and Kit for enhanced differential display
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
EP0730663B1 (fr) 1993-10-26 2003-09-24 Affymetrix, Inc. Reseaux de sondes d'acide nucleique sur des microplaquettes biologiques
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
WO1995014106A2 (fr) 1993-11-17 1995-05-26 Id Biomedical Corporation Detection cyclique par scission de sondes de sequences d'acides nucleiques
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
GB9401833D0 (en) 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
EP1813684A3 (fr) 1994-02-14 2009-11-18 Smithkline Beecham Corporation Gènes s'y exprimant différemment chez des sujets sains et des sujets malades
DE4406524A1 (de) 1994-02-28 1995-08-31 Boehringer Mannheim Gmbh 3'-RNA-Markierung mit Terminaler Transferase
US5972901A (en) 1994-03-23 1999-10-26 Case Western Reserve University Serpin enzyme complex receptor--mediated gene transfer
US5844107A (en) 1994-03-23 1998-12-01 Case Western Reserve University Compacted nucleic acids and their delivery to cells
ES2316148T3 (es) 1994-03-23 2009-04-01 Ohio University Acidos nucleicos compactados y su suministro a celulas.
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5656610A (en) 1994-06-21 1997-08-12 University Of Southern California Producing a protein in a mammal by injection of a DNA-sequence into the tongue
US6146886A (en) 1994-08-19 2000-11-14 Ribozyme Pharmaceuticals, Inc. RNA polymerase III-based expression of therapeutic RNAs
GB9506466D0 (en) 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US5574146A (en) 1994-08-30 1996-11-12 Beckman Instruments, Inc. Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
US5554744A (en) 1994-09-23 1996-09-10 Hybridon, Inc. Method for loading solid supports for nucleic acid synthesis
US6096314A (en) 1994-10-07 2000-08-01 Yeda Research And Development Co. Ltd. Peptides and pharmaceutical compositions comprising them
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
EP1505159B1 (fr) 1995-03-17 2008-05-28 John Wayne Cancer Institute Dépistage des métastases dans le sein à l'aide d'un titrage par marqueurs multiples
US5801155A (en) 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
DE19518505A1 (de) 1995-05-19 1996-11-21 Max Planck Gesellschaft Verfahren zur Genexpressionsanalyse
US5981501A (en) 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
IL122290A0 (en) 1995-06-07 1998-04-05 Inex Pharmaceuticals Corp Lipid-nucleic acid complex its preparation and use
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US6111095A (en) 1995-06-07 2000-08-29 Merck & Co., Inc. Capped synthetic RNA, analogs, and aptamers
US6998268B2 (en) 1995-07-03 2006-02-14 Dainippon Sumitomo Pharma Co. Ltd. Gene preparations
US5637683A (en) 1995-07-13 1997-06-10 Cornell Research Foundation, Inc. Nucleic acid analog with amide linkage and method of making that analog
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US5705629A (en) 1995-10-20 1998-01-06 Hybridon, Inc. Methods for H-phosphonate synthesis of mono- and oligonucleotides
US6418382B2 (en) 1995-10-24 2002-07-09 Curagen Corporation Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
US5871697A (en) 1995-10-24 1999-02-16 Curagen Corporation Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
US20040142895A1 (en) 1995-10-26 2004-07-22 Sirna Therapeutics, Inc. Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
US5998203A (en) * 1996-04-16 1999-12-07 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
EP0880598A4 (fr) 1996-01-23 2005-02-23 Affymetrix Inc Evaluation rapide de difference d'abondance d'acides nucleiques, avec un systeme d'oligonucleotides haute densite
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5670663A (en) 1996-02-14 1997-09-23 Regents Of The University Of California Recovery of taxanes from conifers
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
DE69738687D1 (de) 1996-04-12 2008-06-26 Phri Properties Inc Sonden, kits und assays
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5863727A (en) 1996-05-03 1999-01-26 The Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US6184037B1 (en) 1996-05-17 2001-02-06 Genemedicine, Inc. Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US5739169A (en) 1996-05-31 1998-04-14 Procept, Incorporated Aromatic compounds for inhibiting immune response
ATE295427T1 (de) 1996-06-04 2005-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US6770291B2 (en) 1996-08-30 2004-08-03 The United States Of America As Represented By The Department Of Health And Human Services Liposome complexes for increased systemic delivery
GB9618050D0 (en) 1996-08-29 1996-10-09 Cancer Res Campaign Tech Global amplification of nucleic acids
US5981274A (en) 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
US5886165A (en) 1996-09-24 1999-03-23 Hybridon, Inc. Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
DE69841038D1 (fr) 1997-03-07 2009-09-17 Siemens Healthcare Diagnostics
WO1998040489A1 (fr) 1997-03-10 1998-09-17 Japan Tobacco Inc. Sequences de bases antisens
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
NO972006D0 (no) 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
EP1027033B1 (fr) 1997-05-14 2009-07-22 The University Of British Columbia Encapsulation hautement éfficace d'acides nucléiques dans des vésicules lipidiques
US6262252B1 (en) 1997-05-19 2001-07-17 Mirus, Inc. Single-step method for labeling nucleic acids with mustard or aziridine labeling reagents
US5919626A (en) 1997-06-06 1999-07-06 Orchid Bio Computer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
US6368799B1 (en) 1997-06-13 2002-04-09 Affymetrix, Inc. Method to detect gene polymorphisms and monitor allelic expression employing a probe array
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US5994624A (en) 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
WO1999022018A2 (fr) 1997-10-27 1999-05-06 Boston Probes, Inc. Procedes, trousses et compositions ayant trait a des balises moleculaires de pna (acide nucleique peptidique)
ATE537270T1 (de) 1997-10-30 2011-12-15 Cold Spring Harbor Lab Sondenanordnungen und deren verwendungen für verfahren zur dns-unterscheidung
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6458533B1 (en) 1997-12-19 2002-10-01 High Throughput Genomics, Inc. High throughput assay system for monitoring ESTs
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6121058A (en) 1998-01-02 2000-09-19 Intel Corporation Method for removing accumulated solder from probe card probing features
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6269846B1 (en) 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
US5942398A (en) 1998-02-26 1999-08-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glutx and uses thereof
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
JP2003525017A (ja) 1998-04-20 2003-08-26 リボザイム・ファーマシューティカルズ・インコーポレーテッド 遺伝子発現を調節しうる新規な化学組成を有する核酸分子
US6037129A (en) 1998-05-28 2000-03-14 Medical University Of South Carolina Multi-marker RT-PCR panel for detecting metastatic breast cancer
FR2780059B1 (fr) 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
US6576420B1 (en) 1998-06-23 2003-06-10 Regents Of The University Of California Method for early diagnosis of, and determination of prognosis in, cancer
GB9815799D0 (en) 1998-07-21 1998-09-16 Pharmagene Lab Limited Quantitative analysis of gene expression
US6730477B1 (en) 1998-08-04 2004-05-04 Diadexus, Inc. Method of diagnosing, monitoring and staging breast cancer
US6140054A (en) 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
US6361947B1 (en) 1998-10-27 2002-03-26 Affymetrix, Inc. Complexity management and analysis of genomic DNA
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
GB9904991D0 (en) 1999-03-05 1999-04-28 Univ Nottingham Genetic screening
ATE465168T1 (de) 1999-03-18 2010-05-15 Exiqon As Xylo-lna analoge
US6383752B1 (en) 1999-03-31 2002-05-07 Hybridon, Inc. Pseudo-cyclic oligonucleobases
US6103576A (en) * 1999-04-13 2000-08-15 Microchip Technology Incorporated Dielectric layer of a memory cell having a stacked oxide sidewall and method of fabricating same
AU776362B2 (en) 1999-05-04 2004-09-09 Roche Innovation Center Copenhagen A/S L-ribo-LNA analogues
US6638717B2 (en) 1999-05-19 2003-10-28 Aventis Pharmaceuticals, Inc. Microarray-based subtractive hybridzation
EP1180016B1 (fr) 1999-05-24 2006-09-27 Introgen Therapeutics, Inc. Methodes et compositions de therapie genique non-virale pour le traitement des maladies hyperproliferatives
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
EP1206234A4 (fr) 1999-06-03 2005-06-01 Jessie L S Au Methodes et compositions permettant de moduler la proliferation et la mort cellulaire
WO2000075356A1 (fr) 1999-06-04 2000-12-14 Lin Shi Lung Amplification en chaine d'arn par polymerase
US6964847B1 (en) 1999-07-14 2005-11-15 Packard Biosciences Company Derivative nucleic acids and uses thereof
US6201112B1 (en) 1999-07-22 2001-03-13 Agilent Technologies Inc. Method for 3′ end-labeling ribonucleic acids
US7005261B1 (en) 1999-07-29 2006-02-28 British Biocell International Limited Method for detecting nucleic acid target sequences involving in vitro transcription from an RNA polymerase promoter
US6140500A (en) 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US6511832B1 (en) 1999-10-06 2003-01-28 Texas A&M University System In vitro synthesis of capped and polyadenylated mRNAs using baculovirus RNA polymerase
US20020094546A1 (en) 1999-10-07 2002-07-18 Shimkets Richard A. Growth factor polypeptides and nucleic acids encoding same
AU1086501A (en) 1999-10-15 2001-04-30 Carnegie Institution Of Washington Rna interference pathway genes as tools for targeted genetic interference
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US6458382B1 (en) 1999-11-12 2002-10-01 Mirus Corporation Nucleic acid transfer complexes
US6435245B1 (en) 1999-11-18 2002-08-20 Pitney Bowes Inc. System for folding and tabbing sheets
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
DE10160151A1 (de) 2001-01-09 2003-06-26 Ribopharma Ag Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
CA2392474A1 (fr) 1999-11-26 2001-05-31 Jonathan M. Rothberg Reseaux de sondes d'acides nucleiques
US6383749B2 (en) 1999-12-02 2002-05-07 Clontech Laboratories, Inc. Methods of labeling nucleic acids for use in array based hybridization assays
US7205105B2 (en) 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
AU2001234608A1 (en) 2000-01-28 2001-08-07 Genetrace Systems, Inc. Methods for analysis of gene expression
US8202979B2 (en) * 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US20020065406A1 (en) 2000-03-24 2002-05-30 Meyers Rachel A. 18221, a novel dual specificity phosphatase and uses thereof
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US20030084471A1 (en) 2000-03-16 2003-05-01 David Beach Methods and compositions for RNA interference
WO2001070095A2 (fr) 2000-03-23 2001-09-27 Diadexus, Inc. Compositions et methodes pour diagnostiquer, controler, determiner le stade, presenter en image et traiter un cancer de la prostate
WO2001072780A2 (fr) 2000-03-27 2001-10-04 Diadexus, Inc. Compositions et methodes permettant le diagnostic, le controle, la stadification, l'imagerie et le traitement du cancer des glandes mammaires
AU2001251013A1 (en) 2000-03-28 2001-10-08 Diadexus, Inc. Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer
US20020119156A1 (en) 2000-03-29 2002-08-29 Sei-Yu Chen Compositions and methods of diagnosing, monitoring, staging, imaging and treating lung cancer
KR101215789B1 (ko) 2000-03-30 2012-12-26 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
US20020068307A1 (en) 2000-03-30 2002-06-06 Jason Pluta Compositions and methods for diagnosing, monitoring, staging, imaging and treating stomach cancer
US6573048B1 (en) 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
AU2001269690A1 (en) 2000-05-10 2001-11-20 David A. Sirbasku Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth
US20020042388A1 (en) 2001-05-01 2002-04-11 Cooper Mark J. Lyophilizable and enhanced compacted nucleic acids
EP2279757A3 (fr) 2000-06-02 2011-08-03 Bracco Suisse SA Composés pour le ciblage de cellules endothéliales
CA2414396A1 (fr) 2000-06-26 2002-01-03 The United States Of America, As Represented By The Secretary Of Agricul Ture Production de vaccins par utilisation de plantes transgeniques ou de virus de plantes modifies comme vecteurs d'expression et proteines de coque virales transencapsidees utiliseescomme systemes de presentation d'epitopes
JP2004501666A (ja) 2000-06-30 2004-01-22 エピゲノミクス　アーゲー 薬理ゲノミクスのメチル化状態分析のための方法及び核酸
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
MXPA03000906A (es) 2000-07-31 2005-02-24 Hoffmann La Roche Derivados de piperazina.
US6797471B2 (en) 2000-08-04 2004-09-28 Board Of Regents, The University Of Texas System Detection and diagnosis of smoking related cancers
JP2002067789A (ja) * 2000-09-05 2002-03-08 Yazaki Corp ランプユニットの電線接続構造
AU2001292842A1 (en) 2000-09-19 2002-04-02 Diadexus, Inc. Compositions and methods relating to prostate specific genes and proteins
US20030082604A1 (en) 2000-09-27 2003-05-01 Swanson Melvin J. High density arrays
US6350580B1 (en) 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
US7162371B1 (en) 2000-10-11 2007-01-09 Georgia Tech Research Corporation Differentially-expressed conifer cDNAs, and their use in improving somatic embryogenesis
US6617112B2 (en) 2000-10-11 2003-09-09 Monsanto Technology Llc Methods for gene array analysis of nuclear runoff transcripts
US20020150626A1 (en) 2000-10-16 2002-10-17 Kohane Daniel S. Lipid-protein-sugar particles for delivery of nucleic acids
AU2002243429A1 (en) * 2000-10-24 2002-06-24 Isis Pharmaceuticals, Inc. Antisense modulation of tnfr1 expression
US7001724B1 (en) 2000-11-28 2006-02-21 Applera Corporation Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases
CZ302719B6 (cs) 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
GB0029360D0 (en) 2000-12-01 2001-01-17 Univ Nottingham Humanised antibodies and uses thereof
DK1229130T3 (en) 2000-12-04 2014-02-24 Primagen B V TEST BASED ON nucleic acids OF ENDOSYMBIONTISKE, cellular organelles
US20030099976A1 (en) 2001-01-17 2003-05-29 Tai-Jay Chang Androgen receptor complex-associated protein
WO2002057496A2 (fr) 2001-01-18 2002-07-25 Socratech L.L.C. Etablissement du profil de l'expression genetique de l'endothelium dans la maladie d'alzheimer
US7015047B2 (en) 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US20040110191A1 (en) 2001-01-31 2004-06-10 Winkler Matthew M. Comparative analysis of nucleic acids using population tagging
US20040058373A1 (en) 2001-01-31 2004-03-25 Winkler Matthew M. Competitive amplification of fractionated targets from multiple nucleic acid samples
WO2002064835A2 (fr) 2001-01-31 2002-08-22 Ambion, Inc. Methodes d'analyse d'empreintes d'acides nucleiques
WO2002073504A1 (fr) 2001-03-14 2002-09-19 Gene Logic, Inc. Systeme et procede d'extraction et d'utilisation de donnees d'expression genique provenant de multiples sources
EP1386004A4 (fr) 2001-04-05 2005-02-16 Ribozyme Pharm Inc Modulation de l'expression genique associee a la proliferation inflammatoire et a la croissance de neurites, par des procedes faisant intervenir l'acide nucleique
US20030170623A1 (en) 2001-04-13 2003-09-11 Jingwen Chen Multiplexed gene analysis on a mobile solid support
WO2002086071A2 (fr) 2001-04-20 2002-10-31 Ludwig Institute For Cancer Research Antigenes du cancer et des testicules
AU2002311869A1 (en) 2001-04-27 2002-11-11 Sunnybrook And Women's College Health Sciences Centre Breast cancer-associated genes and uses thereof
US20030203865A1 (en) 2001-04-30 2003-10-30 Pierrot Harvie Lipid-comprising drug delivery complexes and methods for their production
AUPR480901A0 (en) 2001-05-04 2001-05-31 Genomics Research Partners Pty Ltd Diagnostic method for assessing a condition of a performance animal
US20040209832A1 (en) 2001-11-30 2004-10-21 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
WO2003070917A2 (fr) * 2002-02-20 2003-08-28 Sirna Therapeutics, Inc. Inhibition induite par l'interference de l'arn de l'expression genique myc et myb ou de l'expression de genes intervenant dans les voies myc et myb faisant appel a un acide nucleique interferant court (sina)
CA2448915A1 (fr) 2001-06-01 2002-12-12 Prosanos Corporation Procede de traitement de donnees pour la stratification de maladies et l'estimation de l'evolution de maladies
US7171311B2 (en) 2001-06-18 2007-01-30 Rosetta Inpharmatics Llc Methods of assigning treatment to breast cancer patients
US20040086504A1 (en) 2001-06-21 2004-05-06 Deepak Sampath Cyr61 as a target for treatment and diagnosis of breast cancer
AU2002315413A1 (en) 2001-06-22 2003-01-08 Gene Logic, Inc. Platform for management and mining of genomic data
WO2003001985A2 (fr) 2001-06-28 2003-01-09 Dermtech International Methode de depistage de melanome
US7553939B2 (en) 2001-06-29 2009-06-30 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
US20030143571A1 (en) 2001-08-08 2003-07-31 North Carolina State University Infectious disease microarray
AU2002331777A1 (en) 2001-08-30 2003-03-18 Spectral Genomics, Inc. Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
US20030198627A1 (en) * 2001-09-01 2003-10-23 Gert-Jan Arts siRNA knockout assay method and constructs
US7078180B2 (en) 2001-09-05 2006-07-18 The Children's Hospital Of Philadelphia Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors
AU2002333801B2 (en) 2001-09-06 2008-07-24 Merck Patent Gmbh Genetic analysis of biological samples in arrayed expanded representations of their nucleic acids
EP1425090A2 (fr) 2001-09-07 2004-06-09 Corning Incorporated Ensemble de micro-colonnes sur plate-forme pour analyses a fort debit
DE60234369D1 (de) 2001-09-19 2009-12-24 Alexion Pharma Inc Manipulierte matrizen und ihre verwendung bei der single-primer-amplifikation
WO2003024388A2 (fr) 2001-09-20 2003-03-27 Cornell Research Foundation, Inc. Methodes et compositions de traitement ou de prevention de troubles cutanes au moyen d'agents de liaison specifiques pour un antigene membranaire specifique de la prostate
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
EP2428568B1 (fr) * 2001-09-28 2018-04-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Molécules de micro arn
EP1434883A2 (fr) 2001-10-02 2004-07-07 Azign Bioscience A/S Reseaux d'affichage differentiels specifiques
WO2003091426A1 (fr) 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations d'acides nucleiques, reseaux et procedes d'utilisation de ceux-ci
IL161733A0 (en) 2001-11-02 2005-11-20 Insert Therapeutics Inc Methods and compositions for therapeutic use of rna interference
US20030087298A1 (en) 2001-11-02 2003-05-08 Roland Green Detection of hybridization on oligonucleotide microarray through covalently labeling microarray probe
US20040063654A1 (en) 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
CA2467456A1 (fr) 2001-11-19 2003-05-30 Protometrix, Inc. Procede d'utilisation d'une proteine non anticorps permettant de detecter et de mesurer un analyte
JP2005513457A (ja) 2001-12-19 2005-05-12 アフィメトリックス インコーポレイテッド アレイプレートおよびアレイプレートを構築するための方法
WO2003057148A2 (fr) 2001-12-27 2003-07-17 Agy Therapeutics, Inc. Utilisation de cibles biomoleculaires dans le traitement et la visualisation de tumeurs
US7141372B2 (en) 2002-01-18 2006-11-28 Health Research Incorporated Universal RT-coupled PCR method for the specific amplification of mRNA
US20030215842A1 (en) 2002-01-30 2003-11-20 Epigenomics Ag Method for the analysis of cytosine methylation patterns
CA2474530A1 (fr) 2002-02-07 2003-08-14 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Microreseau diagnostique et procede d'utilisation associe
US20030232356A1 (en) 2002-02-08 2003-12-18 Dooley Thomas P. Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays
EP1488228A4 (fr) 2002-03-07 2008-09-17 Univ Utah Res Found Procedes d'identification de sous-ensembles importants de genes exprimes de maniere differentielle en fonction d'analyse de donnees de microreseau a variables multiples
US20070025997A1 (en) 2002-04-03 2007-02-01 Usha Nagavarapu Use of biomolecular targets in the treatment and visualization of brain tumors
WO2003085125A1 (fr) 2002-04-03 2003-10-16 Agy Therapeutics, Inc. Utilisation de cibles biomoleculaires dans le traitement et la visualisation de tumeurs cerebrales
US7006680B2 (en) 2002-05-03 2006-02-28 Vialogy Corp. System and method for characterizing microarray output data
EP1504126B1 (fr) 2002-05-03 2014-02-26 Duke University Procede de regulation de l'expression genique
WO2003100382A1 (fr) 2002-05-20 2003-12-04 Northrop Grumman Corporation Systeme de detection d'agents biologiques a source ponctuelle automatique
WO2003100012A2 (fr) 2002-05-24 2003-12-04 Nimblegen Systems, Inc. Jeux ordonnes de microechantillons et procede permettant de declencher une reaction d'hybridation pour plusieurs echantillons sur un seul jeu ordonne
AUPS261402A0 (en) 2002-05-28 2002-06-20 Compusign Pty Ltd Array monitoring
US20030228579A1 (en) 2002-06-05 2003-12-11 Uri Alon Ordering genes by analysis of expression kinetics
EP1527176B2 (fr) 2002-08-05 2017-03-22 Silence Therapeutics GmbH Nouvelles formes de molecules d'arn interferant
US8729036B2 (en) * 2002-08-07 2014-05-20 University Of Massachusetts Compositions for RNA interference and methods of use thereof
US20040029121A1 (en) 2002-08-08 2004-02-12 Susan Cottrell Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
US20040029128A1 (en) 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
EP1560924A4 (fr) 2002-08-16 2006-05-31 Wayne John Cancer Inst Mappage lymphatique moleculaire de ganglions lymphatiques sentinelles
AU2003270654A1 (en) 2002-09-12 2004-04-30 Baylor College Of Medecine System and method for image segmentation
EP1556506A1 (fr) 2002-09-19 2005-07-27 The Chancellor, Masters And Scholars Of The University Of Oxford Reseaux moleculaires et detection de molecule unique
CA2500224C (fr) 2002-09-25 2015-04-28 University Of Massachusetts Silencage genique in vivo effectue par un siarn stable et chimiquement modifie
AU2003291287A1 (en) 2002-11-01 2004-06-07 John Fonda Crary Apkc isoforms in nervous system disorders and cancer
EP1418241A1 (fr) 2002-11-08 2004-05-12 PrimaGen Holding B.V. Procédé de quantifier le rapport de deux séquences d'acides nucléiques
AU2003291433B2 (en) 2002-11-13 2008-05-22 Thomas Jefferson University Compositions and methods for cancer diagnosis and therapy
US7655785B1 (en) 2002-11-14 2010-02-02 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US20040175732A1 (en) * 2002-11-15 2004-09-09 Rana Tariq M. Identification of micrornas and their targets
WO2004046324A2 (fr) 2002-11-15 2004-06-03 University Of Massachusetts Interference d'arn cible allele
JPWO2004050125A1 (ja) 2002-12-03 2006-03-30 株式会社高研 腫瘍細胞の増殖及び／又は浸潤の抑制剤
JP4230457B2 (ja) * 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
CN101061236A (zh) 2003-01-13 2007-10-24 艾默瑞大学 在正常细胞和癌细胞中检测基因表达的方法
ATE389728T1 (de) 2003-01-16 2008-04-15 Univ North Carolina State Verarmung an endogenen primordialen keimzellen in vogelspezies
WO2004066183A2 (fr) * 2003-01-22 2004-08-05 European Molecular Biology Laboratory Microarn
US20040147027A1 (en) 2003-01-28 2004-07-29 Troy Carol M. Complex for facilitating delivery of dsRNA into a cell and uses thereof
EP1592791A2 (fr) 2003-02-10 2005-11-09 National Institute of Advanced Industrial Science and Technology Regulation de l'expression genetique par interference d'adn
US7816337B2 (en) 2003-02-18 2010-10-19 Roche Madison Inc. Reversible attachment of a membrane active polymer to a polynucleotide
US20040224337A1 (en) 2003-03-04 2004-11-11 Erik Foehr Use of biomolecular targets in the treatment and visualization of tumors
EP1604022A2 (fr) 2003-03-06 2005-12-14 Oligo Engine, Inc. Modulation de l'expression genetique au moyen d'hybrides adn/arn
US20050112604A1 (en) 2003-03-14 2005-05-26 Akihide Fujimoto Loss of heterozygosity of the DNA markers in the 12q22-23 region
WO2004086949A2 (fr) 2003-03-25 2004-10-14 John Wayne Cancer Institute Marqueurs d'adn utilises dans la gestion du cancer
JP4605799B2 (ja) * 2003-04-02 2011-01-05 ダーマコン， インコーポレイテッド Ｒｎａ干渉において使用するための修飾ポリヌクレオチド
US20040198640A1 (en) 2003-04-02 2004-10-07 Dharmacon, Inc. Stabilized polynucleotides for use in RNA interference
CA2488224A1 (fr) 2003-04-03 2004-10-21 Alnylam Pharmaceuticals, Inc. Conjugues d'arni
US20040229211A1 (en) 2003-05-13 2004-11-18 Yeung Wah Hin Alex Sensitive diagnostic testing methodology using multiplex real time PCR with one dye (MOD) and its use as in severe acute respiratory syndrome (SARS)
US7640114B2 (en) 2003-05-21 2009-12-29 The Wistar Institute Of Anatomy & Biology Method of diagnosis of cancer based on gene expression profiles in cells
US7750144B2 (en) 2003-06-02 2010-07-06 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of RNA silencing
ES2864206T3 (es) 2003-06-02 2021-10-13 Univ Massachusetts Métodos y composiciones para mejorar la eficacia y la especificidad del ARNi
PL1633767T3 (pl) 2003-06-02 2019-07-31 University Of Massachusetts Sposoby i kompozycje do kontrolowania wydajności wyciszania rna
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
EP1648914A4 (fr) 2003-07-31 2009-12-16 Regulus Therapeutics Inc Composes oligomeres et compositions utilisables pour moduler des petits arn non-codants
US8106180B2 (en) * 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
US20050037362A1 (en) 2003-08-11 2005-02-17 Eppendorf Array Technologies, S.A. Detection and quantification of siRNA on microarrays
US20060183128A1 (en) 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
WO2005017145A1 (fr) 2003-08-13 2005-02-24 Japan Biological Informatics Consortium Methode d'identification reelle ou presumee d'un gene soumis a une regulation commandee par un arn fonctionnel et utilisation de cette methode
US20070031840A1 (en) 2003-11-10 2007-02-08 Noxxon Pharma Ag Nucleic acids specifically binding bioactive ghrelin
US20050130172A1 (en) 2003-12-16 2005-06-16 Bayer Corporation Identification and verification of methylation marker sequences
US20050130170A1 (en) 2003-12-16 2005-06-16 Jeanne Harvey Identification and verification of methylation marker sequences
WO2005078139A2 (fr) 2004-02-09 2005-08-25 Thomas Jefferson University Diagnostic et traitement de cancers a l'aide de microarn present dans ou au voisinage de caracteristiques chromosomiennes liees aux cancers
AU2005214904B2 (en) * 2004-02-13 2011-07-21 Rockefeller University Anti-microRNA oligonucleotide molecules
US20050182005A1 (en) 2004-02-13 2005-08-18 Tuschl Thomas H. Anti-microRNA oligonucleotide molecules
KR100522307B1 (ko) * 2004-02-19 2005-10-19 변영철 화장용브러시
US7402389B2 (en) 2004-02-24 2008-07-22 The Translational Genomics Research Institute (Tgen) Compositions and methods for prognosis of cancers
US20060195266A1 (en) 2005-02-25 2006-08-31 Yeatman Timothy J Methods for predicting cancer outcome and gene signatures for use therein
WO2005102456A1 (fr) 2004-03-27 2005-11-03 The Arizona Board Of Regents On Behalf Of The University Of Arizona Composition et methode de traitement du cancer
US20060134639A1 (en) 2004-04-06 2006-06-22 Huffel Christophe V Method for the determination of cellular transcriptional regulation
US7365058B2 (en) * 2004-04-13 2008-04-29 The Rockefeller University MicroRNA and methods for inhibiting same
BRPI0509979A (pt) 2004-04-20 2007-10-16 Genaco Biomedical Products Inc método para detectar ncrna
EP2338996A3 (fr) 2004-05-04 2013-12-18 The Board Of Trustees Of The Leland Stanford Junior University Procédés et compositions pour réduire les quantités de génome viral dans une cellule cible
CA2566519C (fr) 2004-05-14 2020-04-21 Rosetta Genomics Ltd. Micro-arn et utilisations connexes
WO2005116261A2 (fr) 2004-05-24 2005-12-08 Albert Einstein College Of Medecine Of Yeshiva University Biopuces d'expression d'arn
EP2471924A1 (fr) 2004-05-28 2012-07-04 Asuragen, INC. Procédés et compositions impliquant du microARN
US7575863B2 (en) 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
US20050287539A1 (en) 2004-06-29 2005-12-29 Emmanuel Labourier Methods and compositions for preparing capped RNA
AU2005328382C1 (en) 2004-07-21 2013-01-24 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
JP5192234B2 (ja) 2004-08-10 2013-05-08 アルナイラム ファーマシューティカルズ， インコーポレイテッド 化学修飾オリゴヌクレオチド
EP2298897B1 (fr) 2004-09-02 2013-08-14 Yale University Régulation d'oncogènes par des micro-ARN
US20060057595A1 (en) 2004-09-16 2006-03-16 Applera Corporation Compositions, methods, and kits for identifying and quantitating small RNA molecules
US7642348B2 (en) 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
US7592441B2 (en) 2004-10-04 2009-09-22 Rosetta Genomics Ltd Liver cancer-related nucleic acids
US20090186353A1 (en) 2004-10-04 2009-07-23 Rosetta Genomics Ltd. Cancer-related nucleic acids
US7825229B2 (en) 2005-03-25 2010-11-02 Rosetta Genomics Ltd. Lung cancer-related nucleic acids
US20060078894A1 (en) 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
WO2006042328A2 (fr) 2004-10-12 2006-04-20 John Wayne Cancer Institute Traitement du cancer et compositions
FR2877350B1 (fr) 2004-11-03 2010-08-27 Centre Nat Rech Scient IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE
CA2850323A1 (fr) 2004-11-12 2006-12-28 Asuragen, Inc. Procedes et compositions comprenant des molecules de micro-arn et des molecules d'inhibiteur de micro-arn
US7074622B2 (en) 2004-11-15 2006-07-11 Eastman Kodak Company Method and system for sorting and separating particles
US20060252057A1 (en) 2004-11-30 2006-11-09 Mitch Raponi Lung cancer prognostics
US20060154275A1 (en) 2004-12-02 2006-07-13 The Board Of Trustees Of The Leland Stanford Junior University Regulated genes in cervical cancer
US20060185027A1 (en) 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
WO2006069584A2 (fr) 2004-12-29 2006-07-06 Exiqon A/S Nouvelles compositions d'oligonucleotides et sequences de sondes utiles pour la detection et l'analyse de microarn et de leurs marn cibles
WO2006113679A2 (fr) 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Administration d'arnsi par compositions lipidiques neutres
AU2006211960A1 (en) 2005-02-08 2006-08-17 Board Of Regents, The University Of Texas System Compositions and methods involving MDA-7 for the treatment of cancer
US7495073B2 (en) 2005-03-24 2009-02-24 Asia Hepato Gene Company Short isoform of Annexin A10 at chromosome 4q, termed Annexin 10s (ANXA10s) and methods of use
US20090062184A1 (en) 2005-03-24 2009-03-05 Dainippon Sumitomo Pharma Co., Ltd. Fine particulate preparation comprising complex of nucleic acid molecule and collagen
GB2425311A (en) * 2005-04-15 2006-10-25 Ist Superiore Sanita Micro RNA against kit protein
WO2006119365A2 (fr) 2005-05-02 2006-11-09 Cold Spring Harbor Laboratory Compositions et procedes destines au diagnostic et au traitement du cancer
US20070072201A1 (en) * 2005-05-16 2007-03-29 Kohne David E Method for producing improved nucleic acid oligomer functional homogeneity and functional characteristic information and results and oligomer application results
US20060265771A1 (en) * 2005-05-17 2006-11-23 Lewis David L Monitoring microrna expression and function
GB0601102D0 (en) 2006-01-19 2006-03-01 Nuclea Biomarkers Llc Kinase Peptides And Antibodies
US20070054287A1 (en) 2005-05-31 2007-03-08 Applera Corporation Method for identifying medically important cell populations using micro rna as tissue specific biomarkers
WO2006128245A1 (fr) 2005-06-03 2006-12-07 Southern Adelaide Health Service-Flinders Medical Centre Ciblage de cellules presentant un microarn d'expression modifiee
US20070065844A1 (en) 2005-06-08 2007-03-22 Massachusetts Institute Of Technology Solution-based methods for RNA expression profiling
US20070048758A1 (en) 2005-06-09 2007-03-01 Epoch Biosciences, Inc. Improved primer-based amplification methods
US20060292616A1 (en) 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
KR101140575B1 (ko) * 2005-06-30 2012-05-02 엘지디스플레이 주식회사 액정표시장치 검사공정
CN105902559A (zh) 2005-08-01 2016-08-31 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
IL177006A0 (en) 2005-08-02 2006-12-10 Veridex Llc Predicting bone relapse of breast cancer
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
US20070041934A1 (en) 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
CN101296702B (zh) 2005-09-12 2012-11-28 俄亥俄州立大学研究基金会 用于诊断或治疗bcl2相关癌症的组合物和方法
US20070117815A1 (en) 2005-11-04 2007-05-24 James Pluda Method of treating cancers with SAHA and pemetrexed
US7390792B2 (en) 2005-12-15 2008-06-24 Board Of Regents, The University Of Texas System MicroRNA1 therapies
EP1976567B1 (fr) 2005-12-28 2020-05-13 The Scripps Research Institute Utilisation de transcrits d'arn antisens et non codants naturels comme cibles de médicaments
EP1966390A1 (fr) 2005-12-29 2008-09-10 Exiqon A/S Detection de l'origine tissulaire d'un cancer
EP2468890B1 (fr) 2006-01-05 2014-03-19 The Ohio State University Research Foundation Procédés à base de micro ARN et compositions pour le diagnostic et le traitement des cancers solides du poumons ou de seins
EP2586455B1 (fr) 2006-01-05 2014-06-25 The Ohio State University Research Foundation Anomalies d'expressions de MicroARN dans des tumeurs endocrines pancréatiques acinaires
CN103993082B (zh) 2006-01-05 2017-01-11 俄亥俄州立大学研究基金会 用于肺癌的诊断、预后和治疗的基于微小rna 的方法和组合物
US20070259827A1 (en) 2006-01-25 2007-11-08 University Of Massachusetts Compositions and methods for enhancing discriminatory RNA interference
EP2388327A1 (fr) 2006-01-27 2011-11-23 Isis Pharmaceuticals, Inc. Composés oligomères et compositions pour une utilisation dans la modulation de micro ARN
EP2522750A1 (fr) 2006-03-02 2012-11-14 The Ohio State University Profil d'expression de micro-ARN associé au cancer du pancréas
US7955848B2 (en) 2006-04-03 2011-06-07 Trustees Of Dartmouth College MicroRNA biomarkers for human breast and lung cancer
JP5131927B2 (ja) 2006-06-16 2013-01-30 大正製薬株式会社 Ｒｐｎ２遺伝子発現抑制剤の用途
US20080076674A1 (en) 2006-07-06 2008-03-27 Thomas Litman Novel oligonucleotide compositions and probe sequences useful for detection and analysis of non coding RNAs associated with cancer
EP2455492B1 (fr) 2006-07-13 2013-11-20 The Ohio State University Research Foundation Procédés basés sur le micro-ARN et compositions pour le diagnostic et le traitement de maladies liées au côlon
WO2008014008A2 (fr) 2006-07-28 2008-01-31 The Johns Hopkins University Compositions et procédés pour moduler l'angiogenèse
CA2664383C (fr) 2006-09-19 2017-08-22 Asuragen, Inc. Micro arn exprimes par differenciation dans les maladies du pancreas, et leur utilisation
EP2145001A2 (fr) 2006-09-19 2010-01-20 Asuragen, Inc. Gènes régulés mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p et voies de signalisation utiles comme cibles dans une intervention thérapeutique
WO2008036741A2 (fr) 2006-09-19 2008-03-27 Asuragen, Inc. Gènes et voies régulés par mir-200 servant de cibles dans le cadre d'une intervention thérapeutique
US20080131878A1 (en) 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
AU2007333107A1 (en) 2006-12-08 2008-06-19 Asuragen, Inc. miR-21 regulated genes and pathways as targets for therapeutic intervention
AU2007333109A1 (en) 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro RNAs
EP2104734A2 (fr) 2006-12-08 2009-09-30 Asuragen, INC. Gènes et voies génétiques régulés par le mir-20 en tant que cibles en vue d'une intervention thérapeutique
CN101622348A (zh) 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
CA2671270A1 (fr) 2006-12-29 2008-07-17 Asuragen, Inc. Genes et voies regules par mir-16 utiles comme cibles pour intervention therapeutique
WO2008088858A2 (fr) 2007-01-17 2008-07-24 The Johns Hopkins University Compositions et procédés comprenant des microarn pour traiter une néoplasie
WO2008092099A2 (fr) 2007-01-26 2008-07-31 Rosetta Genomics, Ltd. Compositions et procédés de traitement de malignités hématopoïétiques
US20100310583A1 (en) 2007-01-31 2010-12-09 Immune Disease Institute Let-7 microrna and mimetics thereof as therapeutics for cancer
SI2147122T1 (sl) 2007-04-20 2015-01-30 Sigma-Tau Pharma Limited Encimatska terapija proti raku
EP2610347B1 (fr) 2007-04-30 2015-04-15 The Ohio State University Research Foundation Procédés de détermination du pronostic d'un sujet avec un cancer du pancréas
AU2008247427A1 (en) * 2007-05-03 2008-11-13 Rosetta Inpharmatics Llc Compositions comprising miR34 therapeutic agents for treating cancer
US20090131354A1 (en) 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090232893A1 (en) 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
CN101801419A (zh) 2007-06-08 2010-08-11 米尔纳疗法公司 作为治疗干预的靶标的miR-34调控的基因和路径
WO2009036332A1 (fr) 2007-09-14 2009-03-19 Asuragen, Inc. Microarn exprimés de manière différentielle dans le cancer du col de l'utérus et leurs utilisations
US7993831B2 (en) 2007-09-14 2011-08-09 Asuragen, Inc. Methods of normalization in microRNA detection assays
WO2009052386A1 (fr) 2007-10-18 2009-04-23 Asuragen, Inc. Micro arn exprimés différentiellement dans des maladies pulmonaires et leurs utilisations
CN101980712B (zh) 2007-10-29 2015-02-18 雷古拉斯治疗公司 用于肝癌治疗的靶向微小rna
US8071562B2 (en) * 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
US20110009469A1 (en) * 2007-12-05 2011-01-13 The Johns Hopkins University Compositions and methods of treating neoplasia
WO2009086156A2 (fr) 2007-12-21 2009-07-09 Asuragen, Inc. Gènes et voies régulés par mir-10 servant de cibles dans le cadre d'une intervention thérapeutique
WO2009100430A2 (fr) 2008-02-08 2009-08-13 Asuragen, Inc Micro arn (mirna) exprimés différentiellement dans des nœuds lymphoïdes prélevés chez des patients atteints d’un cancer
EP2096171A1 (fr) * 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg Cibles microARN (miARN) et en aval à des fins de diagnostic et thérapeutiques
US20110052502A1 (en) 2008-02-28 2011-03-03 The Ohio State University Research Foundation MicroRNA Signatures Associated with Human Chronic Lymphocytic Leukemia (CCL) and Uses Thereof
EP2268832A2 (fr) 2008-03-06 2011-01-05 Asuragen, INC. Marqueurs microrna pour la récurrence d un cancer colorectal
WO2009109665A1 (fr) * 2008-03-07 2009-09-11 Santaris Pharma A/S Compositions pharmaceutiques pour le traitement de maladies associées aux microarn
US20090253780A1 (en) 2008-03-26 2009-10-08 Fumitaka Takeshita COMPOSITIONS AND METHODS RELATED TO miR-16 AND THERAPY OF PROSTATE CANCER
US20090258928A1 (en) 2008-04-08 2009-10-15 Asuragen, Inc. Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
EP2306978A2 (fr) 2008-06-06 2011-04-13 Mirna Therapeutics, Inc. Nouvelles compositions pour l'administration in vivo d'agents arni
US20100090959A1 (en) 2008-10-14 2010-04-15 Sony Ericsson Mobile Communications Ab Forming a keyboard from a combination of keys displayed on a touch sensitive display and on a separate keypad
US20100179213A1 (en) 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
JP2012515532A (ja) * 2009-01-20 2012-07-12 ラモット アット テル アビブ ユニバーシティ， リミテッド Ｍｉｒ−２１プロモーター駆動性標的がん治療
US7665785B1 (en) 2009-04-08 2010-02-23 Newton Paul A Column pipe catch tool
US8778903B2 (en) * 2009-10-21 2014-07-15 Trustees Of Dartmouth College MicroRNA-10 antagonists and MicroRNA-10 targets for use in the treatment of a glioma
WO2011059752A1 (fr) 2009-10-28 2011-05-19 Board Of Regents Of The University Of Texas System Procédés et compositions pour un traitement anti-egfr
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
CA2781571A1 (fr) 2009-11-24 2011-06-03 The University Of Western Australia Modulation de ligands de recepteur de facteur de croissance epidermique
US8846631B2 (en) 2010-01-14 2014-09-30 Regulus Therapeutics Inc. MicroRNA compositions and methods
EP2622076A1 (fr) 2010-09-30 2013-08-07 University of Zürich Traitement d'un lymphome à cellules b avec un microarn
CA2826043A1 (fr) * 2011-02-03 2012-08-09 Mirna Therapeutics, Inc. Mimetiques synthetiques de mir-124
KR20140020900A (ko) 2011-02-03 2014-02-19 미르나 테라퓨틱스 인코포레이티드 Ｍｉｒ―34의 합성 모방체
US8785709B2 (en) 2011-03-30 2014-07-22 University Of Louisville Research Foundation, Inc. Catalytic isomerisation of linear olefinic hydrocarbons
TWI698445B (zh) 2011-04-25 2020-07-11 法商賽諾菲公司 微型ｒｎａ化合物及調控ｍｉｒ－２１活性之方法
JP2015501645A (ja) 2011-12-10 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション 肺がんの腫瘍発生および化学療法耐性を低減するために有用なｍｉＲＮＡならびに関連する組成物および方法
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
EP2968567A2 (fr) 2013-03-15 2016-01-20 Mirna Therapeutics, Inc. Traitements combinés du cancer à l'aide de micro-arn et d'inhibiteurs d'egfr-tki
JP2016530232A (ja) 2013-06-24 2016-09-29 ミルナ セラピューティクス，インク． Ｍｉｒ−３４活性のバイオマーカー
EP3126496A1 (fr) 2014-04-01 2017-02-08 Mirna Therapeutics, Inc. Schémas posologiques de dosage de micro arn

Also Published As

Publication number Publication date
US20170037404A1 (en) 2017-02-09
CA2587189A1 (fr) 2006-12-28
EP2302052B1 (fr) 2015-01-07
US20150344881A1 (en) 2015-12-03
US20150352046A1 (en) 2015-12-10
EP2281887A1 (fr) 2011-02-09
EP2292756B1 (fr) 2014-07-16
US20140350086A1 (en) 2014-11-27
EP2302052A1 (fr) 2011-03-30
EP2284265A1 (fr) 2011-02-16
ES2503740T3 (es) 2014-10-07
AU2005333165A1 (en) 2006-12-28
US8946177B2 (en) 2015-02-03
ES2503742T3 (es) 2014-10-07
US20130303591A1 (en) 2013-11-14
US20080050744A1 (en) 2008-02-28
JP2014217384A (ja) 2014-11-20
EP2287303B1 (fr) 2014-07-02
ES2534301T3 (es) 2015-04-21
EP2322616A1 (fr) 2011-05-18
EP2281889A1 (fr) 2011-02-09
US7960359B2 (en) 2011-06-14
ES2534300T3 (es) 2015-04-21
EP2292756A1 (fr) 2011-03-09
EP2302053A1 (fr) 2011-03-30
CA2857879A1 (fr) 2006-12-28
CA2857901A1 (fr) 2006-12-28
US20140314833A1 (en) 2014-10-23
US20150299705A1 (en) 2015-10-22
EP2302056B1 (fr) 2015-01-07
EP2302051B1 (fr) 2015-01-07
PL2302055T3 (pl) 2015-02-27
US20150004221A1 (en) 2015-01-01
CA2850323A1 (fr) 2006-12-28
DK2302055T3 (da) 2014-10-13
US8058250B2 (en) 2011-11-15
JP2014217386A (ja) 2014-11-20
EP2302054A1 (fr) 2011-03-30
JP2010178741A (ja) 2010-08-19
EP2298894A1 (fr) 2011-03-23
US20140348908A1 (en) 2014-11-27
EP2284265B1 (fr) 2015-01-07
AU2005333165B2 (en) 2012-07-19
US20130143945A1 (en) 2013-06-06
US20080176766A1 (en) 2008-07-24
EP2281888B1 (fr) 2015-01-07
EP2808390A1 (fr) 2014-12-03
US9051571B2 (en) 2015-06-09
US9068219B2 (en) 2015-06-30
WO2006137941A9 (fr) 2007-03-08
WO2006137941A3 (fr) 2008-01-03
US20150344883A1 (en) 2015-12-03
JP2016165292A (ja) 2016-09-15
JP2012228254A (ja) 2012-11-22
ES2507544T3 (es) 2014-10-15
EP2281888A1 (fr) 2011-02-09
ES2534302T3 (es) 2015-04-21
JP2014012020A (ja) 2014-01-23
JP2014223080A (ja) 2014-12-04
EP2314688B1 (fr) 2014-07-16
ES2503765T3 (es) 2014-10-07
ES2534304T3 (es) 2015-04-21
EP2281886B1 (fr) 2014-07-16
US20140031415A1 (en) 2014-01-30
JP2014217381A (ja) 2014-11-20
EP2281889B1 (fr) 2014-07-30
EP2302054B1 (fr) 2014-07-16
US9506061B2 (en) 2016-11-29
EP2302055B1 (fr) 2014-08-27
US20090176723A1 (en) 2009-07-09
US20150275213A1 (en) 2015-10-01
ES2534303T3 (es) 2015-04-21
EP2287303A1 (fr) 2011-02-23
JP5389690B2 (ja) 2014-01-15
US9447414B2 (en) 2016-09-20
EP2292755A1 (fr) 2011-03-09
US8173611B2 (en) 2012-05-08
CA2857881A1 (fr) 2006-12-28
CA2857880A1 (fr) 2006-12-28
US20150342981A1 (en) 2015-12-03
EP2298893A1 (fr) 2011-03-23
US9382537B2 (en) 2016-07-05
JP2008519606A (ja) 2008-06-12
JP2014217387A (ja) 2014-11-20
JP5596085B2 (ja) 2014-09-24
EP2302051A1 (fr) 2011-03-30
US20150284719A1 (en) 2015-10-08
US20140348907A1 (en) 2014-11-27
US20150361431A1 (en) 2015-12-17
US20110313025A1 (en) 2011-12-22
WO2006137941A2 (fr) 2006-12-28
US20150005366A1 (en) 2015-01-01
JP2014217385A (ja) 2014-11-20
CA2857878A1 (fr) 2006-12-28
EP2808389A1 (fr) 2014-12-03
US20150284720A1 (en) 2015-10-08
ES2503743T3 (es) 2014-10-07
ES2503738T3 (es) 2014-10-07
ES2503739T3 (es) 2014-10-07
US20120065248A1 (en) 2012-03-15
JP5620556B2 (ja) 2014-11-05
US20080171715A1 (en) 2008-07-17
EP2281886A1 (fr) 2011-02-09
ES2503741T3 (es) 2014-10-07
EP2314688A1 (fr) 2011-04-27
US8563708B2 (en) 2013-10-22
US8765709B2 (en) 2014-07-01
EP2302056A1 (fr) 2011-03-30
EP2302055A1 (fr) 2011-03-30
EP2298894B1 (fr) 2014-07-16
SI2302055T1 (sl) 2015-01-30
EP1838852A2 (fr) 2007-10-03

Similar Documents

Publication Publication Date Title
HK1204656A1 (en) Methods and compositions involving mirna and mirna inhibitor molecules mirna mirna
EP1954708A4 (fr) Methodes et compositions dans lesquelles sont utilises des genes intrinseques
EP2010676A4 (fr) Procede et kit pour quantification moleculaire de chromosomes
EP2035014A4 (fr) Préparations et méthodes à base de fucoïdane
PT2101766T (pt) Composições e métodos de utilização de (r)-pramipexole
GB0522287D0 (en) Method and compositions
EP1895838A4 (fr) Preparations et methodes
GB0604973D0 (en) Purification method and kit
GB0525314D0 (en) Method and composition
EP2101731A4 (fr) Procédés et compositions d'endoxifène
HK1223968A1 (zh) 狂犬病病毒組合物和方法
GB0603295D0 (en) Methods and kits
IL247957A0 (en) Anti-ephrinb2 antibodies and methods of using them
PL2101766T3 (pl) Kompozycje i sposoby stosowania (R)-pramipeksolu
HK1137756A1 (en) Substituted dihydropyrazolones and use thereof as hif-prolyl-4 -hydroxylase inhibitors hif--4-
EP2088865A4 (fr) Procédés et compositions autour de guggulphospholipides
GB0617171D0 (en) Novel compositions and methods
GB0524927D0 (en) Compositions and method
EP2132251A4 (fr) Composition et procédé
ZA200802969B (en) Composition and method
EP1807512A4 (fr) Compositions et méthodes de transcription inverse
GB0625208D0 (en) Composition and method
GB0522655D0 (en) Composition and method
GB0511235D0 (en) Compositions and method
GB0600261D0 (en) Composition and method