HK1184790A1 - Process for the preparation of morpholinyl anthracycline derivatives - Google Patents

Process for the preparation of morpholinyl anthracycline derivatives

Info

Publication number
HK1184790A1
HK1184790A1 HK13112045.5A HK13112045A HK1184790A1 HK 1184790 A1 HK1184790 A1 HK 1184790A1 HK 13112045 A HK13112045 A HK 13112045A HK 1184790 A1 HK1184790 A1 HK 1184790A1
Authority
HK
Hong Kong
Prior art keywords
preparation
anthracycline derivatives
morpholinyl anthracycline
morpholinyl
derivatives
Prior art date
Application number
HK13112045.5A
Other languages
English (en)
Chinese (zh)
Inventor
Michele Caruso
Vittoria Lupi
Matteo Salsa
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of HK1184790A1 publication Critical patent/HK1184790A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
HK13112045.5A 2010-12-02 2013-10-25 Process for the preparation of morpholinyl anthracycline derivatives HK1184790A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41894910P 2010-12-02 2010-12-02
PCT/IB2011/055410 WO2012073217A1 (en) 2010-12-02 2011-12-01 Process for the preparation of morpholinyl anthracycline derivatives

Publications (1)

Publication Number Publication Date
HK1184790A1 true HK1184790A1 (en) 2014-01-30

Family

ID=45464648

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13112045.5A HK1184790A1 (en) 2010-12-02 2013-10-25 Process for the preparation of morpholinyl anthracycline derivatives

Country Status (12)

Country Link
US (1) US8470984B2 (xx)
EP (1) EP2646456B1 (xx)
JP (1) JP6008864B2 (xx)
KR (1) KR101897307B1 (xx)
CN (1) CN103270043B (xx)
BR (1) BR112013013127B1 (xx)
CA (1) CA2818713C (xx)
ES (1) ES2533710T3 (xx)
HK (1) HK1184790A1 (xx)
MX (1) MX2013005972A (xx)
RU (1) RU2563638C2 (xx)
WO (1) WO2012073217A1 (xx)

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JP6067222B2 (ja) * 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途
EP3925627A1 (en) 2012-05-15 2021-12-22 Concortis Biosystems, Corp Drug-conjugates and uses thereof
KR20150032886A (ko) 2012-08-02 2015-03-30 제넨테크, 인크. 항-etbr 항체 및 면역접합체
EP2777714A1 (en) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
EP2991993B1 (en) * 2013-04-29 2018-06-06 Nerviano Medical Sciences S.r.l. Morpholinyl anthracycline derivatives
CA2926161C (en) 2013-10-04 2023-03-14 Engeneic Molecular Delivery Pty Ltd Combination tumor treatment with drug-loaded, bispecific ligand-targeted minicells and interferon-gamma
CA2934030A1 (en) 2013-10-15 2015-04-23 Sorrento Therapeutics Inc. Drug-conjugates with a targeting molecule and two different drugs
DK3191135T3 (da) 2014-09-12 2020-10-12 Genentech Inc Anti-HER2-antistoffer og immunokonjugater
EP3191134B1 (en) 2014-09-12 2019-11-20 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
MA40579A (fr) 2014-09-12 2016-03-17 Genentech Inc Anticorps anti-cll-1 et immunoconjugués
EP3200765A4 (en) 2014-10-03 2018-05-30 EnGeneIC Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
EP3215513B1 (en) 2014-11-05 2019-05-08 Nerviano Medical Sciences S.r.l. Functionalized morpholinyl anthracycline derivatives
SG10202101603TA (en) 2014-12-23 2021-03-30 Nbe Therapeutics Ag Binding protein drug conjugates comprising anthracycline derivatives
US10590165B2 (en) 2015-01-28 2020-03-17 Sorrento Therapeutics, Inc. Antibody drug conjugates
CA2976064A1 (en) * 2015-02-06 2016-08-11 Sorrento Therapeutics, Inc. Antibody drug conjugates
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
EA201891066A1 (ru) 2015-10-30 2018-10-31 ЭнБиИ-ТЕРАПЬЮТИКС АГ Антитела к ror1
WO2017127664A1 (en) 2016-01-20 2017-07-27 The Scripps Research Institute Ror1 antibody compositions and related methods
SG11202000846WA (en) 2017-08-07 2020-02-27 Nbe Therapeutics Ag Anthracycline-based antibody drug conjugates having high in vivo tolerability
GB201908886D0 (en) 2019-06-20 2019-08-07 Almac Discovery Ltd Anthracycline derivatives
CN110776501B (zh) * 2019-08-22 2021-04-02 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体
GB202020154D0 (en) 2020-12-18 2021-02-03 Almac Discovery Ltd ROR1-specific variant antigen binding molecules
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

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US4826964A (en) 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
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CA2519310A1 (en) * 2003-03-18 2004-09-30 Maria Adele Pacciarini Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
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EP4026840A1 (en) 2005-07-18 2022-07-13 Seagen Inc. Beta-glucuronide-linker drug conjugates
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JP6067222B2 (ja) 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途

Also Published As

Publication number Publication date
ES2533710T3 (es) 2015-04-14
KR20140005888A (ko) 2014-01-15
JP2013544279A (ja) 2013-12-12
RU2563638C2 (ru) 2015-09-20
BR112013013127A2 (pt) 2016-08-23
RU2013123456A (ru) 2015-01-10
WO2012073217A1 (en) 2012-06-07
CN103270043A (zh) 2013-08-28
CN103270043B (zh) 2015-12-16
EP2646456B1 (en) 2015-01-21
BR112013013127B1 (pt) 2021-06-22
KR101897307B1 (ko) 2018-09-10
CA2818713A1 (en) 2012-06-07
US20120142906A1 (en) 2012-06-07
JP6008864B2 (ja) 2016-10-19
CA2818713C (en) 2019-03-26
EP2646456A1 (en) 2013-10-09
US8470984B2 (en) 2013-06-25
MX2013005972A (es) 2013-08-09

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