BRPI0408494A - terapia combinada contra tumores compreendendo nemorubicina com terapia de radiação - Google Patents

terapia combinada contra tumores compreendendo nemorubicina com terapia de radiação

Info

Publication number
BRPI0408494A
BRPI0408494A BRPI0408494-2A BRPI0408494A BRPI0408494A BR PI0408494 A BRPI0408494 A BR PI0408494A BR PI0408494 A BRPI0408494 A BR PI0408494A BR PI0408494 A BRPI0408494 A BR PI0408494A
Authority
BR
Brazil
Prior art keywords
therapy
nemorubicin
radiation therapy
combined tumor
radiation
Prior art date
Application number
BRPI0408494-2A
Other languages
English (en)
Inventor
Maria Cristina Rosa Geroni
Maria Adele Pacciarini
Antonino Suarato
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of BRPI0408494A publication Critical patent/BRPI0408494A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

"TERAPIA COMBINADA CONTRA TUMORES COMPREENDENDO NEMORUBICINA COM TERAPIA DE RADIAçãO". A presente invenção refere-se a um derivado morfolinil antraciclina para uso como rádio-sensibilizador, para administração combinada com terapia de radiação, de modo que possa ser revelado um efeito sinérgico.
BRPI0408494-2A 2003-03-18 2004-03-03 terapia combinada contra tumores compreendendo nemorubicina com terapia de radiação BRPI0408494A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03075781 2003-03-18
PCT/EP2004/050246 WO2004082579A2 (en) 2003-03-18 2004-03-03 Nemorubicin as radiosensitizer in combination with radiation therapy against tumors

Publications (1)

Publication Number Publication Date
BRPI0408494A true BRPI0408494A (pt) 2006-04-04

Family

ID=33016931

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408494-2A BRPI0408494A (pt) 2003-03-18 2004-03-03 terapia combinada contra tumores compreendendo nemorubicina com terapia de radiação

Country Status (8)

Country Link
EP (1) EP1603575A2 (pt)
AU (1) AU2004222526A1 (pt)
BR (1) BRPI0408494A (pt)
CA (1) CA2519289A1 (pt)
MX (1) MXPA05009851A (pt)
NO (1) NO20054349L (pt)
RU (1) RU2005132175A (pt)
WO (1) WO2004082579A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007035489A2 (en) * 2005-09-16 2007-03-29 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing cancer using pyridine carboxaldehyde pyridine thiosemicarbazone radiosensitizing agents
EP2152236B1 (en) 2007-05-11 2015-09-02 Nerviano Medical Sciences S.r.l. Pharmaceutical composition of an anthracycline
US8742076B2 (en) 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
JP6067222B2 (ja) 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途
MX2013005972A (es) 2010-12-02 2013-08-09 Nerviano Medical Sciences Srl Proceso para la preparacion de derivados de morfolinil antraciclina.
EP3191134B1 (en) 2014-09-12 2019-11-20 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP3215513B1 (en) * 2014-11-05 2019-05-08 Nerviano Medical Sciences S.r.l. Functionalized morpholinyl anthracycline derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB2296495B (en) * 1994-12-23 1998-04-15 Erba Carlo Spa Anthracycline derivatives
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
ES2299692T3 (es) * 2002-04-02 2008-06-01 Nerviano Medical Sciences S.R.L. Terapia combinada contra tumores que comprende derivados de distmicina acriloil sustituido y radioterapia.

Also Published As

Publication number Publication date
CA2519289A1 (en) 2004-09-30
WO2004082579A2 (en) 2004-09-30
EP1603575A2 (en) 2005-12-14
WO2004082579A3 (en) 2004-11-11
AU2004222526A1 (en) 2004-09-30
RU2005132175A (ru) 2006-01-27
MXPA05009851A (es) 2005-12-06
NO20054349L (no) 2005-10-11

Similar Documents

Publication Publication Date Title
DK1689724T3 (da) Quinazolinonforbindelser som anticancermidler
CA2683786C (en) Use of tapentadol in the treatment of pain and with a reduced incidence of tapentadol-induced side-effects
WO2005070930A3 (en) Tetrahydrocarboline compounds as anticancer agents
SG160412A1 (en) Anti-igfr1 antibody therapeutic combinations
UY28941A1 (es) Indazoles sustituidos, composiciones que los contienen, procedimiento de preparacion y su uso
MX2009013989A (es) Terapia en combinacion para depresion.
MX2007004955A (es) Metodo de tratar cancer con formulaciones de compeusto de platino a base de lipido administradas intraperitonealmente.
UY28213A1 (es) Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
IL168104A0 (en) Meso-substituted porphyrins
CY1110329T1 (el) Πεγκυλιωμενη λιποσωμιακη δοξορουβικινη σε συνδυασμο με εκτεϊνασκιδινη 743
WO2000006134A3 (en) Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
TW200505454A (en) Heteroaryl-fused pyrimidinyl compounds as anticancer agents
AR071728A1 (es) Terapia con intervalos para el tratamiento del tinnitus
ECSP088515A (es) Mezclas fungicidas que contienen boscalida y pirimetanilo
MX2010005012A (es) Composiciones para el tratamieno y prevencion de inflamacion de los parpados que comprenden un ingrediente osmoticamente activo y un vasocosntrictor.
AR035293A1 (es) Composicion oftalmica.
HRPK20041072B3 (en) Use of docetaxel/doxorubicin/cyclophosphamide in adjuvant therapy of breast and ovarian cancer
NO20054349L (no) Kombinert terapi mot kreft omfattende nemorubicin med stralingsterapi
TR200103271T2 (tr) İnflamasyon aracılığıyla gerçekleşen infeksiyon için anti-inflamatuar tedavi.
AR036321A1 (es) Metodo y formulacion farmaceutica para el tratamiento de la discinesia de aparicion tardia.
WO2007087462A3 (en) Methods and compositions for cancer therapy using a novel adenovirus
MX2009009533A (es) Conjugados de hidroxipolimero modificado con efecto letal en celulas tumorales.
HK1074840A1 (en) Novel dithiolopyrrolones with therapeutic activity
AR057155A1 (es) Metodo de administracion de la 5-(2-clorofenil)-1,2-dihidro-7-fluor-8-metoxi-3-metil-pirazolo[3,4-b][1,4]benzodiazepina
MXPA05009849A (es) Terapia combinada que comprende nemorubicina y un inhibidor de la ciclooxigenasa-2.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]