GB2296495B - Anthracycline derivatives - Google Patents
Anthracycline derivativesInfo
- Publication number
- GB2296495B GB2296495B GB9426075A GB9426075A GB2296495B GB 2296495 B GB2296495 B GB 2296495B GB 9426075 A GB9426075 A GB 9426075A GB 9426075 A GB9426075 A GB 9426075A GB 2296495 B GB2296495 B GB 2296495B
- Authority
- GB
- United Kingdom
- Prior art keywords
- anthracycline derivatives
- anthracycline
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9426075A GB2296495B (en) | 1994-12-23 | 1994-12-23 | Anthracycline derivatives |
IT95MI002614A IT1277073B1 (en) | 1994-12-23 | 1995-12-13 | ANTHRACYCLINIC DERIVATIVES |
DE19547958.0A DE19547958B4 (en) | 1994-12-23 | 1995-12-21 | Anthracycline derivatives |
JP33521695A JP4081148B2 (en) | 1994-12-23 | 1995-12-22 | Anthracycline derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9426075A GB2296495B (en) | 1994-12-23 | 1994-12-23 | Anthracycline derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9426075D0 GB9426075D0 (en) | 1995-02-22 |
GB2296495A GB2296495A (en) | 1996-07-03 |
GB2296495B true GB2296495B (en) | 1998-04-15 |
Family
ID=10766488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9426075A Expired - Lifetime GB2296495B (en) | 1994-12-23 | 1994-12-23 | Anthracycline derivatives |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP4081148B2 (en) |
DE (1) | DE19547958B4 (en) |
GB (1) | GB2296495B (en) |
IT (1) | IT1277073B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021031599A1 (en) * | 2019-08-22 | 2021-02-25 | 联宁(苏州)生物制药有限公司 | Method for preparing drug toxin pnu-159682 of antibody drug conjugate, and intermediate therein |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2315067B (en) * | 1996-07-11 | 2000-02-16 | Pharmacia Spa | Morpholinyl anthracycline derivatives |
AU767394C (en) * | 1999-12-29 | 2005-04-21 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
BRPI0408494A (en) * | 2003-03-18 | 2006-04-04 | Pharmacia Italia Spa | combined tumor therapy comprising nemorubicin with radiation therapy |
AU2004222527A1 (en) * | 2003-03-18 | 2004-09-30 | Pharmacia Italia Spa | Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor |
ES2547552T3 (en) | 2008-02-01 | 2015-10-07 | Genentech, Inc. | Nemorubicin metabolite and similar reagents, antibody-drug conjugates and methods |
EP2277884B1 (en) | 2008-04-11 | 2017-08-23 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd | Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof |
BRPI0911647A2 (en) * | 2008-04-11 | 2015-10-13 | Tianjin Hemay Bio Tech Co Ltd | compounds with high activity anthracycline antibiotics, preparation methods and their use. |
AU2009270988A1 (en) | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
RU2563638C2 (en) | 2010-12-02 | 2015-09-20 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Method of obtaining morpholinylanthracycline derivatives |
ES2633359T3 (en) * | 2012-03-06 | 2017-09-20 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd. | Tetracyclic anthraquinone derivatives |
ES2695162T3 (en) * | 2013-04-29 | 2019-01-02 | Nerviano Medical Sciences Srl | New derivatives of morpholinyl anthracycline |
JP6785780B2 (en) | 2014-11-05 | 2020-11-18 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Functionalized morpholinyl anthracycline derivative |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4301277A (en) * | 1980-10-20 | 1981-11-17 | Sri International | 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin |
JPS57163393A (en) * | 1981-03-27 | 1982-10-07 | Microbial Chem Res Found | Novel anthracyclin derivative and its preparation |
JPS59212499A (en) * | 1983-05-13 | 1984-12-01 | アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド | 4-demethoxy-3'-deamino-3'(4-morpholinyl) derivative |
US4585859A (en) * | 1983-05-24 | 1986-04-29 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
-
1994
- 1994-12-23 GB GB9426075A patent/GB2296495B/en not_active Expired - Lifetime
-
1995
- 1995-12-13 IT IT95MI002614A patent/IT1277073B1/en active IP Right Grant
- 1995-12-21 DE DE19547958.0A patent/DE19547958B4/en not_active Expired - Lifetime
- 1995-12-22 JP JP33521695A patent/JP4081148B2/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021031599A1 (en) * | 2019-08-22 | 2021-02-25 | 联宁(苏州)生物制药有限公司 | Method for preparing drug toxin pnu-159682 of antibody drug conjugate, and intermediate therein |
AU2020333565B2 (en) * | 2019-08-22 | 2022-07-21 | Levena Biopharma Co., Ltd. | Method for preparing drug toxin PNU-159682 of antibody drug conjugate, and intermediate therein |
Also Published As
Publication number | Publication date |
---|---|
DE19547958A1 (en) | 1996-06-27 |
DE19547958B4 (en) | 2015-01-22 |
ITMI952614A0 (en) | 1995-12-13 |
GB9426075D0 (en) | 1995-02-22 |
JPH08231581A (en) | 1996-09-10 |
JP4081148B2 (en) | 2008-04-23 |
ITMI952614A1 (en) | 1997-06-13 |
GB2296495A (en) | 1996-07-03 |
IT1277073B1 (en) | 1997-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
730A | Proceeding under section 30 patents act 1977 | ||
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
PE20 | Patent expired after termination of 20 years |
Expiry date: 20141222 |