HK1162498A1 - Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd copd 5--2- - Google Patents
Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd copd 5--2-Info
- Publication number
- HK1162498A1 HK1162498A1 HK12102965.3A HK12102965A HK1162498A1 HK 1162498 A1 HK1162498 A1 HK 1162498A1 HK 12102965 A HK12102965 A HK 12102965A HK 1162498 A1 HK1162498 A1 HK 1162498A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- copd
- pyrazolyl
- useful
- treatment
- tosylate salt
- Prior art date
Links
- DIJINXJFZUSKMG-UHFFFAOYSA-N 5-(1H-pyrazol-5-yl)-1H-pyridin-2-one Chemical class O=c1ccc(c[nH]1)-c1cc[nH]n1 DIJINXJFZUSKMG-UHFFFAOYSA-N 0.000 title 1
- 125000005490 tosylate group Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15409909P | 2009-02-20 | 2009-02-20 | |
PCT/GB2010/050271 WO2010094964A1 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1162498A1 true HK1162498A1 (en) | 2012-08-31 |
Family
ID=42046174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12102965.3A HK1162498A1 (en) | 2009-02-20 | 2012-03-26 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd copd 5--2- |
Country Status (16)
Country | Link |
---|---|
US (2) | US8232296B2 (xx) |
EP (1) | EP2398792B1 (xx) |
JP (1) | JP5543982B2 (xx) |
KR (1) | KR20110127158A (xx) |
CN (1) | CN102405219B (xx) |
AR (1) | AR075523A1 (xx) |
AU (1) | AU2010215269B2 (xx) |
BR (1) | BRPI1008396B8 (xx) |
CA (1) | CA2752319C (xx) |
ES (1) | ES2469916T3 (xx) |
HK (1) | HK1162498A1 (xx) |
MX (1) | MX2011008389A (xx) |
RU (1) | RU2526038C2 (xx) |
TW (1) | TW201036957A (xx) |
UY (1) | UY32461A (xx) |
WO (1) | WO2010094964A1 (xx) |
Families Citing this family (24)
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SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200808763A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
CL2008003301A1 (es) * | 2007-11-06 | 2009-10-16 | Astrazeneca Ab | Compuestos derivados de 3,4-dihidropirazina-2-carboxamida, inhibidores de la elastasa de neutrofilos humanos; composiciones farmacéuticas; procesos de preparación de compuestos y composición farmacéutica; y uso en el tratamiento de síndrome de dificultad respiratoria de los adultos, fibrosis quística, cáncer, entre otras. |
EP2247299A4 (en) * | 2007-12-21 | 2012-06-06 | Univ Rochester | MOLECULAR TARGETS FOR THE TREATMENT OF INFLAMMATION |
TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
WO2011039528A1 (en) * | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
US9475041B2 (en) * | 2012-04-24 | 2016-10-25 | Basf Se | Zeolitic materials and methods for their preparation using alkenyltrialkylammonium compounds |
US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
KR101763498B1 (ko) * | 2012-09-26 | 2017-07-31 | 달리안 인스티튜트 오브 케미컬 피직스, 차이니즈 아카데미 오브 사이언시즈 | Sapo-34 분자체 및 그 합성 방법 |
EA026545B1 (ru) * | 2012-09-26 | 2017-04-28 | Далянь Инститьют Оф Кемикал Физикс, Чайниз Академи Оф Сайэнс | Молекулярное сито sapo-34 и способ его получения |
KR102233757B1 (ko) * | 2013-03-06 | 2021-03-30 | 노파르티스 아게 | 유기 화합물의 제제 |
RU2542100C1 (ru) * | 2013-12-24 | 2015-02-20 | Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской Академии Наук (ИХС РАН) | Сокристаллическая форма теофиллина с дифлунисалом или диклофенаком |
US9221807B2 (en) * | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
WO2016128917A1 (en) * | 2015-02-12 | 2016-08-18 | Basf Se | Process for the preparation of a dealuminated zeolitic material having the bea framework structure |
US20160257573A1 (en) * | 2015-03-03 | 2016-09-08 | Uop Llc | High surface area pentasil zeolite and process for making same |
JP7041146B2 (ja) * | 2016-10-28 | 2022-03-23 | アストラゼネカ・アクチエボラーグ | (1R,2R)-2-[4-(3-メチル-1H-ピラゾール-5-イル)ベンゾイル]-N-(4-オキソ-4,5,6,7-テトラヒドロピラゾロ[1,5-a]ピラジン-3-イル)シクロヘキサンカルボキサミド |
CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
CN112851643B (zh) * | 2019-11-28 | 2024-01-16 | 广东东阳光药业股份有限公司 | 嘧啶苯甲酰胺化合物的盐酸盐及其用途 |
IL297211A (en) | 2020-04-16 | 2022-12-01 | Mereo Biopharma 4 Ltd | Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency |
WO2022033471A1 (zh) * | 2020-08-10 | 2022-02-17 | 上海润石医药科技有限公司 | 含邻氨基吡啶炔基的化合物的盐及其制备方法和应用 |
AU2022373971A1 (en) | 2021-10-20 | 2024-04-04 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
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TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
-
2010
- 2010-02-12 TW TW099104696A patent/TW201036957A/zh unknown
- 2010-02-16 US US12/706,313 patent/US8232296B2/en active Active
- 2010-02-18 AR ARP100100488A patent/AR075523A1/es unknown
- 2010-02-18 JP JP2011550649A patent/JP5543982B2/ja active Active
- 2010-02-18 MX MX2011008389A patent/MX2011008389A/es active IP Right Grant
- 2010-02-18 AU AU2010215269A patent/AU2010215269B2/en active Active
- 2010-02-18 WO PCT/GB2010/050271 patent/WO2010094964A1/en active Application Filing
- 2010-02-18 EP EP10705178.1A patent/EP2398792B1/en active Active
- 2010-02-18 BR BRPI1008396A patent/BRPI1008396B8/pt active IP Right Grant
- 2010-02-18 KR KR1020117019327A patent/KR20110127158A/ko not_active Application Discontinuation
- 2010-02-18 RU RU2011135627/04A patent/RU2526038C2/ru active
- 2010-02-18 CA CA2752319A patent/CA2752319C/en active Active
- 2010-02-18 CN CN2010800174198A patent/CN102405219B/zh active Active
- 2010-02-18 ES ES10705178.1T patent/ES2469916T3/es active Active
- 2010-02-19 UY UY0001032461A patent/UY32461A/es unknown
-
2012
- 2012-03-26 HK HK12102965.3A patent/HK1162498A1/xx unknown
- 2012-06-27 US US13/534,687 patent/US20120269872A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI1008396A2 (pt) | 2017-06-27 |
AU2010215269B2 (en) | 2013-06-27 |
JP2012518623A (ja) | 2012-08-16 |
EP2398792A1 (en) | 2011-12-28 |
BRPI1008396B8 (pt) | 2021-05-25 |
ES2469916T3 (es) | 2014-06-20 |
JP5543982B2 (ja) | 2014-07-09 |
UY32461A (es) | 2010-09-30 |
TW201036957A (en) | 2010-10-16 |
KR20110127158A (ko) | 2011-11-24 |
CA2752319A1 (en) | 2010-08-26 |
CA2752319C (en) | 2016-10-04 |
US8232296B2 (en) | 2012-07-31 |
EP2398792B1 (en) | 2014-04-09 |
CN102405219B (zh) | 2013-11-06 |
BRPI1008396B1 (pt) | 2020-11-10 |
AR075523A1 (es) | 2011-04-06 |
US20100216843A1 (en) | 2010-08-26 |
US20120269872A1 (en) | 2012-10-25 |
AU2010215269A1 (en) | 2011-08-25 |
RU2526038C2 (ru) | 2014-08-20 |
CN102405219A (zh) | 2012-04-04 |
RU2011135627A (ru) | 2013-03-27 |
WO2010094964A1 (en) | 2010-08-26 |
MX2011008389A (es) | 2011-09-01 |
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