GT200600035A - Aminopiridinas como inhibidores de beta-secretasa - Google Patents
Aminopiridinas como inhibidores de beta-secretasaInfo
- Publication number
- GT200600035A GT200600035A GT200600035A GT200600035A GT200600035A GT 200600035 A GT200600035 A GT 200600035A GT 200600035 A GT200600035 A GT 200600035A GT 200600035 A GT200600035 A GT 200600035A GT 200600035 A GT200600035 A GT 200600035A
- Authority
- GT
- Guatemala
- Prior art keywords
- beta
- secretasa
- aminopiridins
- inhibitors
- bio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
LA PRESENTE INVENCIÓN PROVEE COMPUESTOS DE AMINOPIRIDINA DE FÓRMULA I, ADEMÁS DICHA INVENCION INCLUYE MÉTODOS DE USO DE LOS COMPUESTOS DE FÓRMULA I PARA INHIBIR LA BETA-SECRETASA (BACE) Y PARA TRATAR LOS DEPÓSITOS BETA-AMILOIDES Y LOS ENMARAÑAMIENTOS NEUROFIBRILANTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64906805P | 2005-02-01 | 2005-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200600035A true GT200600035A (es) | 2006-09-11 |
Family
ID=36481239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200600035A GT200600035A (es) | 2005-02-01 | 2006-01-31 | Aminopiridinas como inhibidores de beta-secretasa |
Country Status (19)
Country | Link |
---|---|
US (2) | US7732457B2 (es) |
EP (1) | EP1844035A1 (es) |
JP (1) | JP2008528622A (es) |
KR (1) | KR20070107062A (es) |
CN (1) | CN101111489A (es) |
AR (1) | AR053120A1 (es) |
AU (1) | AU2006211159A1 (es) |
BR (1) | BRPI0607094A2 (es) |
CA (1) | CA2593857A1 (es) |
CR (1) | CR9272A (es) |
GT (1) | GT200600035A (es) |
IL (1) | IL184303A0 (es) |
MX (1) | MX2007009313A (es) |
NO (1) | NO20073310L (es) |
RU (1) | RU2007124935A (es) |
SV (1) | SV2007002397A (es) |
TW (1) | TW200639166A (es) |
WO (1) | WO2006083760A1 (es) |
ZA (1) | ZA200706345B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
KR20070026811A (ko) | 2004-06-16 | 2007-03-08 | 와이어쓰 | 베타-세크리타제 억제제로서의 디페닐이미다조피리미딘 및디페닐이미다졸 아민 |
EP1756087B1 (en) * | 2004-06-16 | 2009-10-07 | Wyeth | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
US20080287399A1 (en) * | 2004-12-14 | 2008-11-20 | Astrazeneca Ab | Substituted Aminopyridines and Uses Thereof |
WO2006076284A2 (en) * | 2005-01-14 | 2006-07-20 | Wyeth | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE |
CN101146769A (zh) | 2005-02-14 | 2008-03-19 | 惠氏公司 | 作为β-分泌酶抑制剂的唑基酰基胍 |
AU2006266167A1 (en) * | 2005-06-30 | 2007-01-11 | Wyeth | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation |
TW200738683A (en) * | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
JP2009509957A (ja) * | 2005-09-26 | 2009-03-12 | ワイス | β−セクレターゼ阻害剤としてのアミノ−5−[4−(ジフルオロメトキシ)フェニル]−5−フェニルイミダゾロン化合物 |
JP2009520027A (ja) * | 2005-12-19 | 2009-05-21 | ワイス | 2−アミノ−5−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用 |
WO2007100536A1 (en) * | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
US7700606B2 (en) * | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
WO2008036196A2 (en) * | 2006-09-21 | 2008-03-27 | Wyeth | Indolylalkylpyridin-2-amines for the inhibition of beta-secretase |
EP2102165A2 (en) * | 2006-11-24 | 2009-09-23 | AC Immune S.A. | N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
PE20090160A1 (es) * | 2007-03-20 | 2009-02-11 | Wyeth Corp | COMPUESTOS AMINO-5-[4-(DIFLUOROMETOXI)FENIL SUSTITUIDO]-5-FENILIMIDAZOLONA COMO INHIBIDORES DE ß-SECRETASA |
CL2008000791A1 (es) * | 2007-03-23 | 2008-05-30 | Wyeth Corp | Compuestos derivados de 2-amino-5-(4-difluorometoxi-fenil)-5-fenil-imidazolidin-4-ona; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de una enfermedad asociada con la actividad bace excesiva, tales como enferm |
JP5530514B2 (ja) | 2009-06-11 | 2014-06-25 | アッヴィ・バハマズ・リミテッド | Hcv感染を治療するための抗ウィルス化合物 |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
JP5584352B2 (ja) | 2010-03-15 | 2014-09-03 | アムジエン・インコーポレーテツド | β−セクレターゼ調節剤としてのアミノ−ジヒドロオキサジン系およびアミノ−ジヒドロチアジン系スピロ化合物ならびにそれらの医学的用途 |
US8883782B2 (en) | 2010-03-15 | 2014-11-11 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use |
EP2550266B1 (en) | 2010-03-24 | 2018-05-09 | Amitech Therapeutics Solutions, Inc. | Heterocyclic compounds useful for kinase inhibition |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
US8921363B2 (en) | 2010-08-05 | 2014-12-30 | Amgen Inc. | Derivatives of 1 H-isoindol-3-amine, 1 H-iso-aza-indol-3amine, 3,4-dihydroisoquinolin-1-amine, and 1,4-dihydroisoquinolin-3-amine as beta-secretase inhibitors |
CN103153053B (zh) | 2010-08-18 | 2015-02-18 | 萨穆梅德有限公司 | 作为联蛋白信号通路激活剂的二酮与羟基酮 |
EP2643325A1 (en) | 2010-11-23 | 2013-10-02 | Amgen Inc. | Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use |
EP2673279A1 (en) | 2011-02-07 | 2013-12-18 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use |
US8962859B2 (en) | 2011-02-15 | 2015-02-24 | Amgen Inc. | Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
US9725469B2 (en) | 2012-11-15 | 2017-08-08 | Amgen, Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
ME03296B (me) | 2013-02-22 | 2019-07-20 | Samumed Llc | Gama-diketoni kao aktivatori wnt/beta-kateninakog signalnog puta |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
AU2015305373B2 (en) | 2014-08-20 | 2020-12-10 | Samumed, Llc | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
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IE45198B1 (en) | 1976-06-05 | 1982-07-14 | Wyeth John & Brother Ltd | Guanidine derivatives |
DE2901362A1 (de) | 1978-01-25 | 1979-07-26 | Sandoz Ag | Guanidinderivate, ihre herstellung und verwendung |
GB1588096A (en) | 1978-05-20 | 1981-04-15 | Wyeth & Bros Ltd John | Pyrrole derivatives |
GB9511694D0 (en) | 1995-06-09 | 1995-08-02 | Fujisawa Pharmaceutical Co | Benzamide derivatives |
ZA967800B (en) | 1995-09-20 | 1997-04-03 | Yamanouchi Pharma Co Ltd | Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them |
GB9611046D0 (en) | 1996-05-25 | 1996-07-31 | Wivenhoe Techn Ltd | Pharmacological compounds |
GB2323841A (en) | 1997-04-04 | 1998-10-07 | Ferring Bv Group Holdings | Pyridine derivatives with anti-tumor and anti-inflammatory activity |
TW544448B (en) | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
US6492408B1 (en) | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
DE10024319A1 (de) | 2000-05-17 | 2001-11-22 | Merck Patent Gmbh | Bisacylguanidine |
DE10046993A1 (de) | 2000-09-22 | 2002-04-11 | Aventis Pharma Gmbh | Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament |
AU2002352189A1 (en) * | 2001-11-30 | 2003-06-10 | Smithkline Beecham P.L.C. | Hydroxyethylene compounds with asp2 inhibitory activity |
WO2003053938A1 (en) | 2001-12-20 | 2003-07-03 | Novo Nordisk A/S | Benzimidazols and indols as glucagon receptor antagonists/inverse agonisten |
WO2003064396A1 (en) | 2002-02-01 | 2003-08-07 | Elan Pharmaceuticals, Inc. | Hydroxyalkanoyl aminopyrazoles and related compounds |
US6974829B2 (en) | 2002-05-07 | 2005-12-13 | Elan Pharmaceuticals, Inc. | Succinoyl aminopyrazoles and related compounds |
AU2003299791A1 (en) | 2002-12-20 | 2004-07-22 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
GB0308318D0 (en) * | 2003-04-10 | 2003-05-14 | Merck Sharp & Dohme | Therapeutic agents |
CL2004000849A1 (es) * | 2003-04-21 | 2005-01-28 | Elan Pharmaceuticals Inc Pharm | Compuestos derivados de benzamidas-2-hidroxi-3-diaminoalcanos, utiles para el tratamiento o la prevencion de alzheimer, sindrome de down, hemorragia cerebral hereditaria, demencias degenerativas y otras. |
EP1644354A1 (en) | 2003-07-01 | 2006-04-12 | Bayer CropScience GmbH | 3-pyridylcarboxamide derivatives as pesticidal agents |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
EP1699455B1 (en) | 2003-12-15 | 2013-05-08 | Merck Sharp & Dohme Corp. | Heterocyclic aspartyl protease inhibitors |
EP1756087B1 (en) | 2004-06-16 | 2009-10-07 | Wyeth | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
KR20070026811A (ko) | 2004-06-16 | 2007-03-08 | 와이어쓰 | 베타-세크리타제 억제제로서의 디페닐이미다조피리미딘 및디페닐이미다졸 아민 |
WO2006076284A2 (en) | 2005-01-14 | 2006-07-20 | Wyeth | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE |
WO2006088694A1 (en) | 2005-02-14 | 2006-08-24 | Wyeth | SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS |
CN101146769A (zh) | 2005-02-14 | 2008-03-19 | 惠氏公司 | 作为β-分泌酶抑制剂的唑基酰基胍 |
WO2006088705A1 (en) | 2005-02-14 | 2006-08-24 | Wyeth | Terphenyl guanidines as [beta symbol] -secretase inhibitors |
TW200738683A (en) | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
AU2006266167A1 (en) | 2005-06-30 | 2007-01-11 | Wyeth | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation |
TW200730523A (en) | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
JP2009509957A (ja) | 2005-09-26 | 2009-03-12 | ワイス | β−セクレターゼ阻害剤としてのアミノ−5−[4−(ジフルオロメトキシ)フェニル]−5−フェニルイミダゾロン化合物 |
JP2009520027A (ja) | 2005-12-19 | 2009-05-21 | ワイス | 2−アミノ−5−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用 |
WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
US7700606B2 (en) | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
-
2006
- 2006-01-26 KR KR1020077019308A patent/KR20070107062A/ko not_active Application Discontinuation
- 2006-01-26 RU RU2007124935/04A patent/RU2007124935A/ru not_active Application Discontinuation
- 2006-01-26 WO PCT/US2006/003186 patent/WO2006083760A1/en active Application Filing
- 2006-01-26 CN CNA2006800036609A patent/CN101111489A/zh active Pending
- 2006-01-26 BR BRPI0607094-9A patent/BRPI0607094A2/pt not_active IP Right Cessation
- 2006-01-26 CA CA002593857A patent/CA2593857A1/en not_active Abandoned
- 2006-01-26 AU AU2006211159A patent/AU2006211159A1/en not_active Abandoned
- 2006-01-26 EP EP06719856A patent/EP1844035A1/en not_active Withdrawn
- 2006-01-26 JP JP2007553315A patent/JP2008528622A/ja not_active Withdrawn
- 2006-01-26 MX MX2007009313A patent/MX2007009313A/es unknown
- 2006-01-27 TW TW095103606A patent/TW200639166A/zh unknown
- 2006-01-31 US US11/344,432 patent/US7732457B2/en not_active Expired - Fee Related
- 2006-01-31 AR ARP060100342A patent/AR053120A1/es unknown
- 2006-01-31 GT GT200600035A patent/GT200600035A/es unknown
- 2006-02-01 SV SV2006002397A patent/SV2007002397A/es not_active Application Discontinuation
-
2007
- 2007-06-28 NO NO20073310A patent/NO20073310L/no not_active Application Discontinuation
- 2007-06-28 IL IL184303A patent/IL184303A0/en unknown
- 2007-07-23 CR CR9272A patent/CR9272A/es not_active Application Discontinuation
- 2007-07-31 ZA ZA200706345A patent/ZA200706345B/xx unknown
-
2010
- 2010-04-20 US US12/763,612 patent/US20100204245A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2007009313A (es) | 2007-09-12 |
NO20073310L (no) | 2007-09-26 |
US20060173049A1 (en) | 2006-08-03 |
US20100204245A1 (en) | 2010-08-12 |
AR053120A1 (es) | 2007-04-25 |
SV2007002397A (es) | 2007-02-16 |
KR20070107062A (ko) | 2007-11-06 |
US7732457B2 (en) | 2010-06-08 |
WO2006083760A1 (en) | 2006-08-10 |
CA2593857A1 (en) | 2006-08-10 |
TW200639166A (en) | 2006-11-16 |
BRPI0607094A2 (pt) | 2009-08-04 |
CN101111489A (zh) | 2008-01-23 |
IL184303A0 (en) | 2007-10-31 |
RU2007124935A (ru) | 2009-03-10 |
ZA200706345B (en) | 2009-08-26 |
AU2006211159A1 (en) | 2006-08-10 |
JP2008528622A (ja) | 2008-07-31 |
EP1844035A1 (en) | 2007-10-17 |
CR9272A (es) | 2007-10-03 |
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