EA200901504A1 - Производные пиразолона, как ингибиторы pde4 - Google Patents
Производные пиразолона, как ингибиторы pde4Info
- Publication number
- EA200901504A1 EA200901504A1 EA200901504A EA200901504A EA200901504A1 EA 200901504 A1 EA200901504 A1 EA 200901504A1 EA 200901504 A EA200901504 A EA 200901504A EA 200901504 A EA200901504 A EA 200901504A EA 200901504 A1 EA200901504 A1 EA 200901504A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrazolona
- derivatives
- pde4 inhibitors
- phosphodiesterase
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
В заявке описаны соединения формулы 1, в которой R1, R7, R8, R9 и n обладают значениями, приведенными в описании, которые являются новыми эффективными ингибиторами фосфодиэстеразы типа 4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07108314 | 2007-05-16 | ||
PCT/EP2008/055867 WO2008138939A1 (en) | 2007-05-16 | 2008-05-14 | Pyrazolone derivatives as pde4 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200901504A1 true EA200901504A1 (ru) | 2010-04-30 |
EA018984B1 EA018984B1 (ru) | 2013-12-30 |
Family
ID=38179942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200901504A EA018984B1 (ru) | 2007-05-16 | 2008-05-14 | Производные пиразолона как ингибиторы pde4 |
Country Status (31)
Country | Link |
---|---|
US (3) | US8304436B2 (ru) |
EP (3) | EP2148876B1 (ru) |
JP (2) | JP5529010B2 (ru) |
KR (1) | KR101601284B1 (ru) |
CN (2) | CN103463086B (ru) |
AR (1) | AR066576A1 (ru) |
AT (1) | ATE526326T1 (ru) |
AU (1) | AU2008250069B2 (ru) |
BR (1) | BRPI0811214A2 (ru) |
CA (1) | CA2686909C (ru) |
CO (1) | CO6220956A2 (ru) |
CY (1) | CY1112152T1 (ru) |
DK (1) | DK2148876T3 (ru) |
EA (1) | EA018984B1 (ru) |
EC (1) | ECSP099738A (ru) |
ES (2) | ES2427442T3 (ru) |
HK (2) | HK1141017A1 (ru) |
HR (1) | HRP20110940T1 (ru) |
IL (1) | IL201959A (ru) |
ME (1) | ME00952B (ru) |
MX (1) | MX2009012062A (ru) |
MY (1) | MY154498A (ru) |
NZ (1) | NZ581547A (ru) |
PL (1) | PL2148876T3 (ru) |
PT (1) | PT2148876E (ru) |
RS (1) | RS52074B (ru) |
SI (1) | SI2148876T1 (ru) |
TW (2) | TWI460174B (ru) |
UA (1) | UA100019C2 (ru) |
WO (1) | WO2008138939A1 (ru) |
ZA (1) | ZA200906423B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS52074B (en) * | 2007-05-16 | 2012-06-30 | Nycomed Gmbh | PIRAZOLONE DERIVATED AS PDE4 INHIBITORS |
AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
JP5642661B2 (ja) * | 2009-03-05 | 2014-12-17 | 塩野義製薬株式会社 | Npyy5受容体拮抗作用を有するピペリジンおよびピロリジン誘導体 |
WO2011136752A1 (en) * | 2010-04-26 | 2011-11-03 | Mahmut Bilgic | Combined pharmaceutical composition comprising carmoterol and ciclesonide for the treatment of respiratory diseases |
JP5609614B2 (ja) * | 2010-12-15 | 2014-10-22 | 東ソー株式会社 | 新規アリールアミンデンドリマー状化合物、その製造方法およびその用途 |
WO2014144772A1 (en) | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
WO2021245192A1 (en) | 2020-06-04 | 2021-12-09 | Topadur Pharma Ag | Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2903460A (en) | 1956-04-07 | 1959-09-08 | Sandoz Ag | Pyrazolone derivatives |
US4550119A (en) | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
IE71647B1 (en) | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
AU4717693A (en) | 1992-07-28 | 1994-02-14 | Rhone-Poulenc Rorer Limited | Inhibitors of c-amp phosphodiesterase and tnf |
RU2137754C1 (ru) | 1993-07-02 | 1999-09-20 | Бик Гульден Ломберг Хемише Фабрик ГмбХ | Фторалкоксизамещенные бензамиды, способ их получения и фармацевтическая композиция на их основе |
JP4146894B2 (ja) | 1994-07-22 | 2008-09-10 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロベンゾフラン |
EE03968B1 (et) | 1997-01-15 | 2003-02-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Ftalasinoonid |
US6418201B1 (en) | 2000-02-22 | 2002-07-09 | Intel Corporation | Multiple platform voice processing system with optimized resource allocation |
CN1524080A (zh) | 2001-02-15 | 2004-08-25 | ��̹��ҽҩ��˾ | 作为pde4抑制剂的2,3-二氮杂萘酮哌啶子基衍生物 |
KR100551183B1 (ko) | 2001-04-20 | 2006-02-13 | 화이자 프로덕츠 인크. | 1,3-치환 인덴 및 아릴-융합 아자폴리시클릭 화합물의제조 방법 |
PL363312A1 (en) | 2001-04-25 | 2004-11-15 | Altana Pharma Ag | Novel phthalazinones |
AU2003251693A1 (en) | 2002-08-10 | 2004-03-11 | Altana Pharma Ag | Pyridazinone-derivatives as pde4 inhibitors |
JP2005538140A (ja) | 2002-08-10 | 2005-12-15 | アルタナ ファルマ アクチエンゲゼルシャフト | Pde4インヒビターとしてのピペリジン−ピリダゾン及びフタラゾン |
WO2004018449A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
NZ538646A (en) | 2002-08-20 | 2008-03-28 | Biosurface Eng Tech Inc | A synthetic heparin-binding growth factor analog |
AR045536A1 (es) * | 2003-08-29 | 2005-11-02 | Ranbaxy Lab Ltd | Inhibidores de la fosfodiesterasa tipo -iv |
EP1716133B1 (en) | 2004-02-04 | 2008-03-26 | Nycomed GmbH | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
EP1720854A1 (en) * | 2004-02-04 | 2006-11-15 | Altana Pharma AG | Phthalzinone derivatives as pde4 inhibitors |
JP2006169138A (ja) * | 2004-12-14 | 2006-06-29 | Kyorin Pharmaceut Co Ltd | ピラゾロピリジンピラゾロン誘導体とその付加塩及びpde阻害剤 |
RS52074B (en) * | 2007-05-16 | 2012-06-30 | Nycomed Gmbh | PIRAZOLONE DERIVATED AS PDE4 INHIBITORS |
-
2008
- 2008-05-14 RS RS20110570A patent/RS52074B/en unknown
- 2008-05-14 EA EA200901504A patent/EA018984B1/ru not_active IP Right Cessation
- 2008-05-14 KR KR1020097025745A patent/KR101601284B1/ko not_active IP Right Cessation
- 2008-05-14 MX MX2009012062A patent/MX2009012062A/es active IP Right Grant
- 2008-05-14 ME MEP-2009-327A patent/ME00952B/me unknown
- 2008-05-14 CN CN201310349480.8A patent/CN103463086B/zh not_active Expired - Fee Related
- 2008-05-14 CA CA2686909A patent/CA2686909C/en not_active Expired - Fee Related
- 2008-05-14 DK DK08759563.3T patent/DK2148876T3/da active
- 2008-05-14 NZ NZ581547A patent/NZ581547A/en not_active IP Right Cessation
- 2008-05-14 MY MYPI20094317A patent/MY154498A/en unknown
- 2008-05-14 PT PT08759563T patent/PT2148876E/pt unknown
- 2008-05-14 CN CN2008800119475A patent/CN101657441B/zh not_active Expired - Fee Related
- 2008-05-14 EP EP08759563A patent/EP2148876B1/en active Active
- 2008-05-14 PL PL08759563T patent/PL2148876T3/pl unknown
- 2008-05-14 JP JP2010507909A patent/JP5529010B2/ja not_active Expired - Fee Related
- 2008-05-14 SI SI200830491T patent/SI2148876T1/sl unknown
- 2008-05-14 BR BRPI0811214-2A2A patent/BRPI0811214A2/pt active Search and Examination
- 2008-05-14 AU AU2008250069A patent/AU2008250069B2/en not_active Ceased
- 2008-05-14 WO PCT/EP2008/055867 patent/WO2008138939A1/en active Application Filing
- 2008-05-14 US US12/451,348 patent/US8304436B2/en not_active Expired - Fee Related
- 2008-05-14 AT AT08759563T patent/ATE526326T1/de active
- 2008-05-14 UA UAA200912770A patent/UA100019C2/uk unknown
- 2008-05-14 ES ES11182678T patent/ES2427442T3/es active Active
- 2008-05-14 EP EP12174018A patent/EP2508520A1/en not_active Withdrawn
- 2008-05-14 EP EP11182678.0A patent/EP2402330B1/en active Active
- 2008-05-14 ES ES08759563T patent/ES2374337T3/es active Active
- 2008-05-15 AR ARP080102055A patent/AR066576A1/es not_active Application Discontinuation
- 2008-05-16 TW TW102129216A patent/TWI460174B/zh not_active IP Right Cessation
- 2008-05-16 TW TW097118165A patent/TWI414521B/zh not_active IP Right Cessation
-
2009
- 2009-09-15 ZA ZA200906423A patent/ZA200906423B/xx unknown
- 2009-10-16 CO CO09115665A patent/CO6220956A2/es active IP Right Grant
- 2009-11-05 IL IL201959A patent/IL201959A/en not_active IP Right Cessation
- 2009-11-13 EC EC2009009738A patent/ECSP099738A/es unknown
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2010
- 2010-08-03 HK HK10107416.9A patent/HK1141017A1/xx not_active IP Right Cessation
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2011
- 2011-12-15 HR HR20110940T patent/HRP20110940T1/hr unknown
- 2011-12-20 CY CY20111101261T patent/CY1112152T1/el unknown
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2012
- 2012-09-14 US US13/618,026 patent/US8865745B2/en not_active Expired - Fee Related
-
2014
- 2014-04-16 JP JP2014084704A patent/JP5850972B2/ja not_active Expired - Fee Related
- 2014-05-28 HK HK14105008.3A patent/HK1191574A1/zh not_active IP Right Cessation
- 2014-08-29 US US14/473,338 patent/US9090597B2/en not_active Expired - Fee Related
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