GB1317210A - Reduction of thebaine - Google Patents

Reduction of thebaine

Info

Publication number
GB1317210A
GB1317210A GB5892670A GB1317210DA GB1317210A GB 1317210 A GB1317210 A GB 1317210A GB 5892670 A GB5892670 A GB 5892670A GB 1317210D A GB1317210D A GB 1317210DA GB 1317210 A GB1317210 A GB 1317210A
Authority
GB
United Kingdom
Prior art keywords
thebaine
dihydrothebaine
reduction
dihydrocodeinone
azodicarboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5892670A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MACARLAN SMITH Ltd
Original Assignee
MACARLAN SMITH Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MACARLAN SMITH Ltd filed Critical MACARLAN SMITH Ltd
Publication of GB1317210A publication Critical patent/GB1317210A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Abstract

1317210 8,14-Dihydrothebaine MACFARLAN SMITH Ltd 24 Nov 1971 [11 Dec 1970] 58926/70 Heading C2C 8,14-Dihydrothebaine is prepared by heating thebaine with at least one thermally decomposable compound selected from optionally substituted alkyl, aryl and aralkyl sulphonic acid hydrazides and disodium azodicarboxylate (the latter being used in the presence of a proton-supplying substance). It may subsequently be hydrolysed to give dihydrocodeinone.
GB5892670A 1970-12-11 1970-12-11 Reduction of thebaine Expired GB1317210A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5892670 1970-12-11

Publications (1)

Publication Number Publication Date
GB1317210A true GB1317210A (en) 1973-05-16

Family

ID=10482707

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5892670A Expired GB1317210A (en) 1970-12-11 1970-12-11 Reduction of thebaine

Country Status (17)

Country Link
US (1) US3812132A (en)
JP (1) JPS5511678B1 (en)
AU (1) AU459401B2 (en)
BE (1) BE776304A (en)
CA (1) CA958412A (en)
CH (1) CH556340A (en)
CS (1) CS176251B2 (en)
DE (1) DE2159348A1 (en)
DK (1) DK139974B (en)
FR (1) FR2117924B1 (en)
GB (1) GB1317210A (en)
HU (1) HU164465B (en)
IL (1) IL38268A (en)
NL (1) NL175622C (en)
PL (1) PL81441B1 (en)
SE (1) SE388422B (en)
YU (1) YU39064B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59142770A (en) * 1983-02-02 1984-08-16 Trio Kenwood Corp Driving mechanism of cassette tape recorder
WO2006005112A1 (en) * 2004-07-09 2006-01-19 Tasmanian Alkaloids Pty Ltd Process for the synthesis of hydromorphone
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
EP2073636B1 (en) 2006-10-17 2012-09-05 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
US9131649B2 (en) 2008-03-07 2015-09-15 Tasmanian Alkaloids Pty. Ltd Papaver somniferum strain with high concentration of thebaine
US8541647B2 (en) 2008-05-29 2013-09-24 Tasmania Alkaloids Pty, Ltd. Papaver somniferum with high concentration of codeine
PL2480555T3 (en) * 2009-09-22 2016-05-31 SpecGx LLC Methods for producing hydrocodone, hydromorphone or a derivative thereof
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
GB2517000B (en) 2013-08-02 2018-05-09 Johnson Matthey Plc Process for the synthesis of oxymorphone alkaloid and oxymorphone salts
US9273060B2 (en) 2014-03-05 2016-03-01 Johnson Matthey Public Limited Company Processes for making hydrocodone, hydromorphone and their derivatives
WO2015134003A1 (en) 2014-03-05 2015-09-11 Johnson Matthey Public Limited Company Processes for making hydrocodone, hydromorphone and their derivatives
US10155771B2 (en) 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids

Also Published As

Publication number Publication date
NL7117082A (en) 1972-06-13
SE388422B (en) 1976-10-04
CH556340A (en) 1974-11-29
DK139974B (en) 1979-05-28
JPS5511678B1 (en) 1980-03-26
YU39064B (en) 1984-04-30
US3812132A (en) 1974-05-21
CA958412A (en) 1974-11-26
YU308671A (en) 1982-06-30
AU459401B2 (en) 1975-03-27
NL175622C (en) 1984-12-03
HU164465B (en) 1974-02-28
FR2117924A1 (en) 1972-07-28
DK139974C (en) 1979-12-10
NL175622B (en) 1984-07-02
DE2159348A1 (en) 1972-06-15
AU3646971A (en) 1973-06-07
IL38268A (en) 1974-11-29
PL81441B1 (en) 1975-08-30
BE776304A (en) 1972-06-06
IL38268A0 (en) 1972-01-27
CS176251B2 (en) 1977-06-30
FR2117924B1 (en) 1975-02-07

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee