ES323195A1 - Tris (hydroxymethyl) aminomethane theophylline acetate - Google Patents

Tris (hydroxymethyl) aminomethane theophylline acetate

Info

Publication number
ES323195A1
ES323195A1 ES0323195A ES323195A ES323195A1 ES 323195 A1 ES323195 A1 ES 323195A1 ES 0323195 A ES0323195 A ES 0323195A ES 323195 A ES323195 A ES 323195A ES 323195 A1 ES323195 A1 ES 323195A1
Authority
ES
Spain
Prior art keywords
aminomethane
hydroxymethyl
tris
theophylline
acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0323195A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Laboratorios Ferrer SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Ferrer SL filed Critical Laboratorios Ferrer SL
Priority to ES0323195A priority Critical patent/ES323195A1/en
Publication of ES323195A1 publication Critical patent/ES323195A1/en
Priority to GB7186/67A priority patent/GB1113600A/en
Priority to DE19671695358 priority patent/DE1695358A1/en
Priority to BE694127D priority patent/BE694127A/xx
Priority to FR95468A priority patent/FR1511911A/en
Priority to US616780A priority patent/US3562273A/en
Priority to CH240367A priority patent/CH469659A/en
Priority to US00069225A priority patent/US3718664A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Tris - (hydroxymethyl) - aminomethane derivatives, having antiacidotic action, are produced by reaction of monocarboxylic aminated organic acids or inorganic salts thereof with tris - (hydroxymethyl) - aminomethane or acid addition salts thereof. Specified novel derivatives are the theophylline-7-N-acetate, 6,8-thioctate, orotate and pangamate of tris-(hydroxymethyl)-aminomethane.
ES0323195A 1966-02-17 1966-02-17 Tris (hydroxymethyl) aminomethane theophylline acetate Expired ES323195A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES0323195A ES323195A1 (en) 1966-02-17 1966-02-17 Tris (hydroxymethyl) aminomethane theophylline acetate
GB7186/67A GB1113600A (en) 1966-02-17 1967-02-15 Tris-(hydroxymethyl)-aminomethane salts
DE19671695358 DE1695358A1 (en) 1966-02-17 1967-02-16 Derivatives of tris (hydroxymethyl) aminomethane
BE694127D BE694127A (en) 1966-02-17 1967-02-16
FR95468A FR1511911A (en) 1966-02-17 1967-02-17 Process for the preparation of tri-hydroxy-methyl-aminomethane derivatives
US616780A US3562273A (en) 1966-02-17 1967-02-17 Tris (hydroxymethyl) aminomethane theophylline acetate
CH240367A CH469659A (en) 1966-02-17 1967-02-17 Process for obtaining tri-hydroxy-methyl-aminomethane derivatives
US00069225A US3718664A (en) 1966-02-17 1970-09-03 Tris (hydroxymethyl) aminomethane salt of thioctic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES0323195A ES323195A1 (en) 1966-02-17 1966-02-17 Tris (hydroxymethyl) aminomethane theophylline acetate

Publications (1)

Publication Number Publication Date
ES323195A1 true ES323195A1 (en) 1966-12-01

Family

ID=8442738

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0323195A Expired ES323195A1 (en) 1966-02-17 1966-02-17 Tris (hydroxymethyl) aminomethane theophylline acetate

Country Status (7)

Country Link
US (1) US3562273A (en)
BE (1) BE694127A (en)
CH (1) CH469659A (en)
DE (1) DE1695358A1 (en)
ES (1) ES323195A1 (en)
FR (1) FR1511911A (en)
GB (1) GB1113600A (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL162361C (en) * 1974-09-10 Dufour Claude Etude PROCESS FOR PREPARING A SALT OF THEOPHYLLINACETIC ACID AND OF A PHARMACEUTICAL PREPARATION WITH MUCOLYTIC ACTION CONTAINING THIS SALT, AND PHARMACEUTICAL OBJECTS.
GB2024087B (en) * 1978-06-29 1982-08-25 Yoshino Kogyosho Co Ltd Blow moulding polyester container
ES2038733T3 (en) * 1987-12-04 1993-08-01 Asta Medica Ag PROCEDURE FOR PREPARING AN INJECTABLE SOLUTION OF THIOCTIC ACID SALT WITH THROMETHANOL AND / OR BASIC AMINO ACIDS.
US5136096A (en) * 1989-08-31 1992-08-04 University Of South Florida Multifunctional synthons as used in the preparation of cascade polymers or unimolecular micelles
DE4433764A1 (en) 1994-09-22 1996-03-28 Asta Medica Ag Dosage forms containing alpha-lipoic acid, solid salts of R-thioctic acid with improved release and bioavailability
DE10137381A1 (en) * 2001-07-31 2003-02-13 Viatris Gmbh New crystalline modifications of R-thioctic acid trometamol salt, useful as antiinflammatory agent, for treating diabetes mellitus or as appetite suppressant
EP1984348A2 (en) * 2006-02-10 2008-10-29 Multi Formulations Ltd. Method for improving the oral administration of alpha-lipoic acid
US9090638B2 (en) 2008-04-17 2015-07-28 Thomas Daly Biological buffers with wide buffering ranges
US7939659B2 (en) * 2008-04-17 2011-05-10 Thomas Daly Biological buffers with wide buffering ranges
US8822728B2 (en) 2008-04-17 2014-09-02 Thomas Daly Biological buffers with wide buffering ranges
US8034951B2 (en) * 2008-04-17 2011-10-11 Thomas Daly Biological buffers with wide buffering ranges
US20170313920A1 (en) 2010-10-06 2017-11-02 Thomas P. Daly Biological Buffers with Wide Buffering Ranges
US9447310B2 (en) 2008-04-17 2016-09-20 Thomas P. Daly Biological buffers with wide buffering ranges
US8519141B2 (en) 2008-04-17 2013-08-27 Thomas Daly Biological buffers with wide buffering ranges
US8334402B2 (en) * 2008-04-17 2012-12-18 Thomas Daly Biological buffers with wide buffering ranges
US7635791B2 (en) * 2008-04-17 2009-12-22 Tpat Ip Llc Biological buffers with wide buffering ranges
KR100935554B1 (en) 2009-06-24 2010-01-07 주식회사 셀트리온제약 Piperazine dithioctate and pharmaceutical composition including the same
US9475754B2 (en) 2011-10-06 2016-10-25 Thomas P. Daly Biological buffers with wide buffering ranges
CN103360393B (en) * 2013-07-29 2016-01-06 上海万巷制药有限公司 The preparation method of theophylline acetic acid
CN113200959A (en) * 2020-12-16 2021-08-03 南京海融制药有限公司 Lipoic acid tromethamine salt crystal form and preparation method thereof

Also Published As

Publication number Publication date
CH469659A (en) 1969-03-15
DE1695358A1 (en) 1972-04-13
BE694127A (en) 1967-07-31
FR1511911A (en) 1968-02-02
GB1113600A (en) 1968-05-15
US3562273A (en) 1971-02-09

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