FR2449685A1 - Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation - Google Patents

Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation

Info

Publication number
FR2449685A1
FR2449685A1 FR8003662A FR8003662A FR2449685A1 FR 2449685 A1 FR2449685 A1 FR 2449685A1 FR 8003662 A FR8003662 A FR 8003662A FR 8003662 A FR8003662 A FR 8003662A FR 2449685 A1 FR2449685 A1 FR 2449685A1
Authority
FR
France
Prior art keywords
microorganisms
culture
preparing
same
agent prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8003662A
Other languages
English (en)
Other versions
FR2449685B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2449685A1 publication Critical patent/FR2449685A1/fr
Application granted granted Critical
Publication of FR2449685B1 publication Critical patent/FR2449685B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'INVENTION A POUR OBJET UN NOUVEAU COMPOSE, DESIGNE MONACOLINE K, DE FORMULE: (CF DESSIN DANS BOPI) AYANT NOTAMMENT UNE PRECIEUSE ACTIVITE ANTIHYPERCHOLESTEROLEMIQUE. ON PEUT LE PREPARER EN CULTIVANT DES MICROORGANISMES APPROPRIES DU GENRE MONASCUS, EN PARTICULIER LA SOUCHE MONASCUS RUBER 1005 (FERM 4822).
FR8003662A 1979-02-20 1980-02-20 Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation Expired FR2449685B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法

Publications (2)

Publication Number Publication Date
FR2449685A1 true FR2449685A1 (fr) 1980-09-19
FR2449685B1 FR2449685B1 (fr) 1985-06-28

Family

ID=11955290

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8003662A Expired FR2449685B1 (fr) 1979-02-20 1980-02-20 Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation

Country Status (27)

Country Link
JP (1) JPS5925599B2 (fr)
KR (1) KR830002801B1 (fr)
AT (1) AT373915B (fr)
AU (1) AU532626B2 (fr)
BE (1) BE881825A (fr)
CA (1) CA1129794A (fr)
CH (1) CH645890A5 (fr)
DD (1) DD154494A5 (fr)
DE (2) DE3006216C2 (fr)
DK (2) DK149095C (fr)
ES (1) ES488796A0 (fr)
FI (1) FI66427C (fr)
FR (1) FR2449685B1 (fr)
GB (1) GB2046737B (fr)
HU (1) HU182069B (fr)
IE (1) IE49743B1 (fr)
IT (1) IT1175260B (fr)
MX (1) MX6314E (fr)
NL (1) NL191540C (fr)
NO (1) NO153974C (fr)
NZ (1) NZ192919A (fr)
PH (1) PH15145A (fr)
PL (1) PL124304B1 (fr)
SE (1) SE453301B (fr)
SG (1) SG6784G (fr)
SU (2) SU1158048A3 (fr)
ZA (1) ZA80962B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456141A1 (fr) * 1979-05-11 1980-12-05 Sankyo Co Procede de preparation de la monacoline k
FR2479222A1 (fr) * 1980-03-31 1981-10-02 Sankyo Co Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol, leur procede de preparation et leur application en therapeutique
EP0074222A1 (fr) * 1981-08-27 1983-03-16 Sankyo Company Limited Dérivés de MB-530B, leur préparation et compositions pharmaceutiques les contenant
WO1993017991A1 (fr) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. DERIVES DE TETRALINE EN TANT QU'INHIBITEURS D'HMG-CoA REDUCTASE

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (fr) 1992-02-10 1993-08-11 Jagroop S. Dahiya Nouvelles souches fongiques et leur utilisation pour la production d'antibiotiques
ZA933359B (en) 1992-05-15 1993-12-08 Sankyo Co Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
IL132822A0 (en) 1998-03-20 2001-03-19 Biogal Gyogyszergyar Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
SK12012002A3 (sk) 2000-02-24 2003-02-04 Biogal Gyogyszergyar Rt. Spôsob purifikácie fermentačného bujónu
CZ20023201A3 (cs) 2000-03-03 2003-09-17 Plus Chemicals S. A. Způsob čištění lovastatinu a simvastatinu na produkt se sníženou hladinou dimerních nečistot
KR20010095780A (ko) * 2000-04-12 2001-11-07 나가오카 마사시 배아 홍국
IN192861B (fr) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
DE60218822T2 (de) * 2001-02-09 2007-07-12 Unilever N.V. Nahrungsmittel enthaltend sojaprotein und statin
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (ko) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 성인병 예방 및 치료 보조제
KR100710500B1 (ko) 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 ｋ 생산방법
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.
WO2010069593A1 (fr) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Utilisation de composés amphiphiles pour la cristallisation régulée de statines et d'intermédiaires de statines
RO128803A0 (ro) 2012-10-12 2013-09-30 Ion Gigel Fulga Compoziţie pentru tratamentul sau prevenirea dislipidemiilor
CN110331151A (zh) * 2019-04-11 2019-10-15 北京工商大学 紫色红曲菌mokH基因过表达菌株的构建方法
CN111297938A (zh) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 一种辅助降血脂组合物中洛伐他汀的检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453425A (en) * 1974-06-07 1976-10-20 Sankyo Co 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same
FR2456141A1 (fr) * 1979-05-11 1980-12-05 Sankyo Co Procede de preparation de la monacoline k
EP0022478B1 (fr) * 1979-06-15 1983-02-23 Merck & Co. Inc. Polyhydro-3,7-diméthyl-8-(2-(tétrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-éthyl)-1-naphtylényl-2-méthylbutanoates, les hydroxy-acides correspondants, procédé de préparation et compositions pharmaceutiques les contenant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453425A (en) * 1974-06-07 1976-10-20 Sankyo Co 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same
FR2313035A1 (fr) * 1974-06-07 1976-12-31 Sankyo Co Substances a action physiologique et leur procede de preparation par fermentation
FR2456141A1 (fr) * 1979-05-11 1980-12-05 Sankyo Co Procede de preparation de la monacoline k
EP0022478B1 (fr) * 1979-06-15 1983-02-23 Merck & Co. Inc. Polyhydro-3,7-diméthyl-8-(2-(tétrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-éthyl)-1-naphtylényl-2-méthylbutanoates, les hydroxy-acides correspondants, procédé de préparation et compositions pharmaceutiques les contenant

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456141A1 (fr) * 1979-05-11 1980-12-05 Sankyo Co Procede de preparation de la monacoline k
FR2479222A1 (fr) * 1980-03-31 1981-10-02 Sankyo Co Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol, leur procede de preparation et leur application en therapeutique
EP0074222A1 (fr) * 1981-08-27 1983-03-16 Sankyo Company Limited Dérivés de MB-530B, leur préparation et compositions pharmaceutiques les contenant
WO1993017991A1 (fr) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. DERIVES DE TETRALINE EN TANT QU'INHIBITEURS D'HMG-CoA REDUCTASE

Also Published As

Publication number Publication date
SU969702A1 (ru) 1982-10-30
MX6314E (es) 1985-04-01
HU182069B (en) 1983-12-28
NL191540C (nl) 1995-09-04
ATA92980A (de) 1983-07-15
AU5567380A (en) 1980-08-28
SG6784G (en) 1985-02-08
FI800506A (fi) 1980-08-21
PH15145A (en) 1982-08-24
DK21889D0 (da) 1989-01-18
JPS5925599B2 (ja) 1984-06-19
NO153974B (no) 1986-03-17
BE881825A (fr) 1980-08-20
PL222120A1 (fr) 1980-10-20
DK73080A (da) 1980-08-21
DD154494A5 (de) 1982-03-24
KR830002030A (ko) 1983-05-21
NO153974C (no) 1986-06-25
IT8067262A0 (it) 1980-02-20
FR2449685B1 (fr) 1985-06-28
AU532626B2 (en) 1983-10-06
CH645890A5 (de) 1984-10-31
IE800321L (en) 1980-08-20
DK149095B (da) 1986-01-20
SE453301B (sv) 1988-01-25
FI66427B (fi) 1984-06-29
GB2046737A (en) 1980-11-19
IE49743B1 (en) 1985-12-11
GB2046737B (en) 1983-01-12
SU1158048A3 (ru) 1985-05-23
NZ192919A (en) 1984-07-06
NL8001041A (nl) 1980-08-22
DE3006216A1 (de) 1980-09-04
JPS55111790A (en) 1980-08-28
DE3051175C2 (fr) 1989-12-21
AT373915B (de) 1984-03-12
ES8103171A1 (es) 1981-02-16
FI66427C (fi) 1984-10-10
NL191540B (nl) 1995-05-01
IT1175260B (it) 1987-07-01
SE8001339L (sv) 1980-08-21
CA1129794A (fr) 1982-08-17
DK21889A (da) 1989-01-18
PL124304B1 (en) 1983-01-31
DK149095C (da) 1986-06-16
ZA80962B (en) 1981-03-25
DE3006216C2 (de) 1985-10-31
NO800451L (no) 1980-08-21
ES488796A0 (es) 1981-02-16
KR830002801B1 (ko) 1983-12-16

Similar Documents

Publication Publication Date Title
FR2449685A1 (fr) Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation
FR2456141A1 (fr) Procede de preparation de la monacoline k
GB1453425A (en) 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same
FR2379531A1 (fr) Nouvelle substance physiologiquement active inhibant l'activite enzymatique de l'esterase et son mode de production
FR2376211A1 (fr) Nouveau glucane et procede de sa preparation
PL297843A1 (en) Trace elements containing additive, method of obtaining same, preparation incorporating such additive and application of such preparation
JPS56106598A (en) Preparation of l-arginine by fermentation method
JPS56113718A (en) Bifunctional terpenoid, its preparation, and ulcer preventive agent comprising it
JPS56128774A (en) New physiologically active substance ebelactone and its preparation
FR2361465A1 (fr) Methode de detection d'un micro-organisme specifique
JPS6438049A (en) Antimicrobial agent for human or animal
JPS5763080A (en) Preparation of bacterial cell having high nitrilase activity
WIRTSCHAFTER et al. The metabolism of Trichomonas vaginalis: The oxidative pathway
CA2092705A1 (fr) Compose presentant une action antitumorale, nsc-lsc1, et procede de fabrication dudit compose
Horikoshi et al. Accumulation of uranium by Chlorella cells grown under autotrophic, heterotrophic and mixotrophic culture conditions
Ensminger Pigment production by Haemophilus parapertussis
JPS55148098A (en) Concentration and purification of interferon
FR2399436A1 (fr) Antibiotique c-14482 a1
JPS5545322A (en) Preparation of mitomycins by fermentation
Simon et al. Hydroxylated unsaturated fatty acid from cultures of a Filoboletus species
FR2400522A1 (fr) Facteur d'epargne des glucocorticoides et son procede de preparation
Love et al. Green fluorescent pigment accumulated by a mutant of Cellvibrio gilvus
DE2026595A1 (de) Verfahren zur Herstellung von Antibiotika
JPS55118396A (en) Preparation of mitomycin derivative
GB1388198A (en) Antibiotic fr-1923 and a process for the preparation thereof