FI66427C - Foerfarande foer framstaellning av en ny som laekemedel anvaendbar foerening monacolin k - Google Patents
Foerfarande foer framstaellning av en ny som laekemedel anvaendbar foerening monacolin k Download PDFInfo
- Publication number
- FI66427C FI66427C FI800506A FI800506A FI66427C FI 66427 C FI66427 C FI 66427C FI 800506 A FI800506 A FI 800506A FI 800506 A FI800506 A FI 800506A FI 66427 C FI66427 C FI 66427C
- Authority
- FI
- Finland
- Prior art keywords
- monacolin
- culture
- culture medium
- som
- foerfarande foer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1785679 | 1979-02-20 | ||
JP54017856A JPS5925599B2 (ja) | 1979-02-20 | 1979-02-20 | 新生理活性物質モナコリンkおよびその製造法 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI800506A FI800506A (fi) | 1980-08-21 |
FI66427B FI66427B (fi) | 1984-06-29 |
FI66427C true FI66427C (fi) | 1984-10-10 |
Family
ID=11955290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI800506A FI66427C (fi) | 1979-02-20 | 1980-02-20 | Foerfarande foer framstaellning av en ny som laekemedel anvaendbar foerening monacolin k |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS5925599B2 (fr) |
KR (1) | KR830002801B1 (fr) |
AT (1) | AT373915B (fr) |
AU (1) | AU532626B2 (fr) |
BE (1) | BE881825A (fr) |
CA (1) | CA1129794A (fr) |
CH (1) | CH645890A5 (fr) |
DD (1) | DD154494A5 (fr) |
DE (2) | DE3051175C2 (fr) |
DK (2) | DK149095C (fr) |
ES (1) | ES8103171A1 (fr) |
FI (1) | FI66427C (fr) |
FR (1) | FR2449685B1 (fr) |
GB (1) | GB2046737B (fr) |
HU (1) | HU182069B (fr) |
IE (1) | IE49743B1 (fr) |
IT (1) | IT1175260B (fr) |
MX (1) | MX6314E (fr) |
NL (1) | NL191540C (fr) |
NO (1) | NO153974C (fr) |
NZ (1) | NZ192919A (fr) |
PH (1) | PH15145A (fr) |
PL (1) | PL124304B1 (fr) |
SE (1) | SE453301B (fr) |
SG (1) | SG6784G (fr) |
SU (2) | SU1158048A3 (fr) |
ZA (1) | ZA80962B (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb−530b誘導体およびその製造法 |
US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
US4997848A (en) | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
CA2062023A1 (fr) | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Nouvelles souches fongiques et leur utilisation pour la production d'antibiotiques |
EP0629184A1 (fr) * | 1992-03-04 | 1994-12-21 | Fujisawa Pharmaceutical Co., Ltd. | DERIVES DE TETRALINE EN TANT QU'INHIBITEURS D'HMG-CoA REDUCTASE |
NZ247617A (en) | 1992-05-15 | 1995-07-26 | Sankyo Co | Octahydronaphthalene oxime derivatives and pharmaceutical compositions |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
CA2289553C (fr) | 1998-03-20 | 2004-05-18 | Biogal Gyogyszergyar Rt. | Processus de fermentation metabolique controlee pour la production d'acide hydroxyle de lovastatine |
HUP0300073A3 (en) | 2000-02-24 | 2004-10-28 | Teva Gyogyszergyar Zartkoeruee | Method of purifying a fermentation broth |
IL151583A0 (en) | 2000-03-03 | 2003-04-10 | Plus Chemicals Bv | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
KR20010095780A (ko) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | 배아 홍국 |
IN192861B (fr) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
CN1273608C (zh) | 2001-02-09 | 2006-09-06 | 荷兰联合利华有限公司 | 通过发酵制备一种或多种抑制素的方法 |
KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
KR20020093147A (ko) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | 성인병 예방 및 치료 보조제 |
KR100710500B1 (ko) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | 홍국균을 이용한 모나콜린 k 생산방법 |
EP2373609B1 (fr) | 2008-12-19 | 2013-10-16 | KRKA, D.D., Novo Mesto | Utilisation de composés amphiphiles pour la cristallisation régulée de statines et d'intermédiaires de statines |
EP2327682A1 (fr) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines. |
RO128803A0 (ro) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | Compoziţie pentru tratamentul sau prevenirea dislipidemiilor |
CN110331151A (zh) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | 紫色红曲菌mokH基因过表达菌株的构建方法 |
CN111297938A (zh) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | 一种辅助降血脂组合物中洛伐他汀的检测方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (fr) | 1974-06-07 | 1981-03-18 | ||
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
AU535944B2 (en) * | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/ja not_active Expired
-
1980
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/ko active
- 1980-02-19 CA CA345,983A patent/CA1129794A/fr not_active Expired
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 DD DD80219159A patent/DD154494A5/de unknown
- 1980-02-20 PL PL1980222120A patent/PL124304B1/pl unknown
- 1980-02-20 HU HU80397A patent/HU182069B/hu unknown
- 1980-02-20 SE SE8001339A patent/SE453301B/sv not_active IP Right Cessation
- 1980-02-20 DK DK73080A patent/DK149095C/da not_active IP Right Cessation
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/xx unknown
- 1980-02-20 NO NO800451A patent/NO153974C/no unknown
- 1980-02-20 SU SU802887300A patent/SU1158048A3/ru active
- 1980-02-20 AT AT0092980A patent/AT373915B/de not_active IP Right Cessation
- 1980-02-20 IT IT67262/80A patent/IT1175260B/it active
- 1980-02-20 CH CH136680A patent/CH645890A5/de not_active IP Right Cessation
- 1980-02-20 BE BE0/199476A patent/BE881825A/fr not_active IP Right Cessation
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 NL NL8001041A patent/NL191540C/xx not_active IP Right Cessation
- 1980-02-20 DE DE3006216A patent/DE3006216C2/de not_active Expired
- 1980-02-20 ES ES488796A patent/ES8103171A1/es not_active Expired
- 1980-02-20 MX MX808652U patent/MX6314E/es unknown
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-02-20 FI FI800506A patent/FI66427C/fi not_active IP Right Cessation
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 FR FR8003662A patent/FR2449685B1/fr not_active Expired
- 1980-09-12 SU SU802977031A patent/SU969702A1/ru active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889D0/da not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |
Owner name: SANKYO COMPANY LIMITED |