FR2374307A1 - Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant - Google Patents

Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant

Info

Publication number
FR2374307A1
FR2374307A1 FR7738126A FR7738126A FR2374307A1 FR 2374307 A1 FR2374307 A1 FR 2374307A1 FR 7738126 A FR7738126 A FR 7738126A FR 7738126 A FR7738126 A FR 7738126A FR 2374307 A1 FR2374307 A1 FR 2374307A1
Authority
FR
France
Prior art keywords
obtaining
pharmaceutical composition
composition containing
dihydropyridine derivatives
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738126A
Other languages
English (en)
Other versions
FR2374307B1 (fr
Inventor
Yoshinari Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of FR2374307A1 publication Critical patent/FR2374307A1/fr
Application granted granted Critical
Publication of FR2374307B1 publication Critical patent/FR2374307B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de la 1,4-dihydropyridine. Ces composés répondent à la formule :
FR7738126A 1976-12-17 1977-12-16 Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant Granted FR2374307A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Publications (2)

Publication Number Publication Date
FR2374307A1 true FR2374307A1 (fr) 1978-07-13
FR2374307B1 FR2374307B1 (fr) 1981-02-13

Family

ID=10465031

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738126A Granted FR2374307A1 (fr) 1976-12-17 1977-12-16 Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant

Country Status (15)

Country Link
JP (1) JPS5948828B2 (fr)
AR (2) AR221478A1 (fr)
AT (1) AT367401B (fr)
AU (1) AU518206B2 (fr)
BE (1) BE861964A (fr)
CH (1) CH633266A5 (fr)
DE (1) DE2756226A1 (fr)
DK (2) DK563377A (fr)
ES (3) ES465137A1 (fr)
FR (1) FR2374307A1 (fr)
GB (1) GB1591089A (fr)
HU (1) HU176454B (fr)
NL (1) NL7714066A (fr)
SE (2) SE7714374L (fr)
ZA (1) ZA777532B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435471A1 (fr) * 1978-09-08 1980-04-04 Fujisawa Pharmaceutical Co Derives de dihydropyridine, procedes d'obtention et compositions pharmaceutiques en contenant
FR2438654A1 (fr) * 1978-10-10 1980-05-09 Fujisawa Pharmaceutical Co Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose
FR2523128A1 (fr) * 1982-03-10 1983-09-16 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et medicaments contenant ces derives

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
DE3269219D1 (en) * 1981-11-17 1986-03-27 Fisons Plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
HU197881B (en) * 1982-08-06 1989-06-28 Banyu Pharma Co Ltd Process for producing new carbamoyl-oxy-alkyl-carboxy-lic acid derivatives
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
FI862343A (fi) 1985-06-17 1986-12-18 Warner Lambert Co Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
EP0226271B1 (fr) * 1985-08-21 1990-11-22 GLAXO S.p.A. Dihydro-1,4 pyridines, leur préparation et composition pharmaceutique
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN103951608B (zh) * 2009-08-04 2016-04-27 喜德生（苏州）医药科技有限公司 尼伐地平晶型及其制备方法
CN103254122B (zh) * 2013-06-19 2015-04-22 湖南师范大学 一种心血管药物尼伐地平的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2236497A1 (fr) * 1973-07-12 1975-02-07 Bayer Ag
FR2315930A1 (fr) * 1975-07-02 1977-01-28 Fujisawa Pharmaceutical Co Derives de 1,4-dihydropyridine et leur procede de preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH607848A5 (fr) * 1974-06-04 1978-11-30 Bayer Ag

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2236497A1 (fr) * 1973-07-12 1975-02-07 Bayer Ag
FR2315930A1 (fr) * 1975-07-02 1977-01-28 Fujisawa Pharmaceutical Co Derives de 1,4-dihydropyridine et leur procede de preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435471A1 (fr) * 1978-09-08 1980-04-04 Fujisawa Pharmaceutical Co Derives de dihydropyridine, procedes d'obtention et compositions pharmaceutiques en contenant
FR2438654A1 (fr) * 1978-10-10 1980-05-09 Fujisawa Pharmaceutical Co Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose
FR2523128A1 (fr) * 1982-03-10 1983-09-16 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et medicaments contenant ces derives

Also Published As

Publication number Publication date
AT367401B (de) 1982-07-12
HU176454B (en) 1981-03-28
DK172182A (da) 1982-04-16
DE2756226A1 (de) 1978-06-29
BE861964A (fr) 1978-06-16
ES474233A1 (es) 1979-11-01
ATA901877A (de) 1981-11-15
SE7714374L (sv) 1978-06-18
ES474234A1 (es) 1979-04-01
AR221887A1 (es) 1981-03-31
ZA777532B (en) 1978-10-25
JPS5948828B2 (ja) 1984-11-29
NL7714066A (nl) 1978-06-20
SE8204312D0 (sv) 1982-07-13
FR2374307B1 (fr) 1981-02-13
ES465137A1 (es) 1979-01-01
AU3165777A (en) 1979-06-21
AR221478A1 (es) 1981-02-13
CH633266A5 (en) 1982-11-30
SE8204312L (sv) 1982-07-13
AU518206B2 (en) 1981-09-17
JPS5395977A (en) 1978-08-22
GB1591089A (en) 1981-06-10
DK563377A (da) 1978-06-18

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