FR2398748A1 - Nouveaux derives d'imidazoquinazoline, leur preparation et leur application en tant que medicaments - Google Patents

Nouveaux derives d'imidazoquinazoline, leur preparation et leur application en tant que medicaments

Info

Publication number
FR2398748A1
FR2398748A1 FR7821396A FR7821396A FR2398748A1 FR 2398748 A1 FR2398748 A1 FR 2398748A1 FR 7821396 A FR7821396 A FR 7821396A FR 7821396 A FR7821396 A FR 7821396A FR 2398748 A1 FR2398748 A1 FR 2398748A1
Authority
FR
France
Prior art keywords
preparation
application
imidazoquinazoline
medicinal products
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7821396A
Other languages
English (en)
Other versions
FR2398748B1 (fr
Inventor
Madhukar Subraya Chodnekar
Ado Kaiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2398748A1 publication Critical patent/FR2398748A1/fr
Application granted granted Critical
Publication of FR2398748B1 publication Critical patent/FR2398748B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés d'imidazoquinazoline, leur préparation et leur application en tant que médicaments. Les composés de l'invention répondent à la formule :
FR7821396A 1977-07-25 1978-07-19 Nouveaux derives d'imidazoquinazoline, leur preparation et leur application en tant que medicaments Granted FR2398748A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
CH577678 1978-05-26

Publications (2)

Publication Number Publication Date
FR2398748A1 true FR2398748A1 (fr) 1979-02-23
FR2398748B1 FR2398748B1 (fr) 1981-09-04

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7821396A Granted FR2398748A1 (fr) 1977-07-25 1978-07-19 Nouveaux derives d'imidazoquinazoline, leur preparation et leur application en tant que medicaments

Country Status (29)

Country Link
US (1) US4256748A (fr)
EP (1) EP0000718B1 (fr)
JP (1) JPS5441894A (fr)
AR (1) AR218500A1 (fr)
AT (1) AT363479B (fr)
AU (1) AU519688B2 (fr)
BR (1) BR7804763A (fr)
CA (1) CA1094555A (fr)
CS (1) CS203014B2 (fr)
DE (2) DE2832138A1 (fr)
DK (1) DK144128C (fr)
ES (2) ES471981A1 (fr)
FI (1) FI63409C (fr)
FR (1) FR2398748A1 (fr)
GB (1) GB2001638B (fr)
GR (1) GR72968B (fr)
HU (1) HU177643B (fr)
IE (1) IE47280B1 (fr)
IL (1) IL55183A (fr)
IT (1) IT1097337B (fr)
MC (1) MC1199A1 (fr)
MY (1) MY8500249A (fr)
NL (1) NL7807507A (fr)
NO (1) NO150800C (fr)
NZ (1) NZ187921A (fr)
PH (1) PH14642A (fr)
PT (1) PT68342A (fr)
SE (1) SE7808111L (fr)
YU (1) YU177578A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422649A1 (fr) * 1978-04-10 1979-11-09 Bristol Myers Co Iminoquinazolines et leur utilisation a la preparation de la 6,7-dichloro-1,5-dihydroimidazo(2,1-b)quinazoline-2(3h)-one

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
CA1131631A (fr) * 1979-06-20 1982-09-14 Madhukar S. Chodnekar Derives de la quinazoline et preparations pharmaceutiques
EP0029559A3 (fr) * 1979-11-24 1981-09-30 Sandoz Ag 5,10 Dihydroimidazo (2,1-b) quinazoléines, leur préparation et compositions pharmaceutiques les contenant
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
EP0054180A3 (fr) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Procédé pour la préparation de dérivés de l'imidazoquinazoline
JPS57178234U (fr) * 1981-05-06 1982-11-11
US4455311A (en) * 1981-08-28 1984-06-19 Hoffmann-La Roche Inc. Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
JPS604186A (ja) * 1983-06-21 1985-01-10 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン化合物
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
AU581205B2 (en) * 1984-02-15 1989-02-16 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-B) quinazolinyl) oxyalkylamides
GB8514207D0 (en) * 1985-06-05 1985-07-10 Pfizer Ltd Cardiac stimulants
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
CZ281628B6 (cs) * 1991-07-29 1996-11-13 Warner-Lambert Company Deriváty chinazolinu a farmaceutické přípravky na jejich bázi
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
AU3885901A (en) * 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
ES2344062T5 (es) * 2003-01-23 2013-04-26 Shire Biopharmaceuticals Holdings Ireland Limited Formulación y procedimientos para el tratamiento de la trombocitopenia
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8436006B2 (en) * 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
GB0623750D0 (en) 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
EP2170930B3 (fr) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0810005D0 (en) * 2008-06-02 2008-07-09 Shire Llc Substituted quinazolines
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
GB0822970D0 (en) 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en) 2011-03-01 2018-04-16 Synergy Pharmaceuticals Inc PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
EP2958577A2 (fr) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Agonistes du recepteur de la guanylate cyclase pour l'utilisation dans l'irrigation du colon
WO2014151206A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
EP3004138B1 (fr) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Agonistes ultra-purs de guanylate cyclase c, leur procédé de production et d'utilisation
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport
EP4201403A1 (fr) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Composés tirapazamine et quazinone à utiliser dans le traitement des gangliosidoses gm2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305575A1 (de) * 1972-02-04 1973-08-09 Bristol Myers Co Neue blutdrucksenkende mittel und verfahren zu deren herstellung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1645917A1 (de) 1962-10-26 1970-09-24 American Home Prod Verfahren zur Herstellung von 5-Aryl-3-acyloxy-1,2-dihydro-3H-1,4-benzodiazepin-2-onen
GB1037375A (en) * 1964-08-07 1966-07-27 Hoffmann La Roche A process for the manufacture of benzodiazepine derivatives
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983119A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305575A1 (de) * 1972-02-04 1973-08-09 Bristol Myers Co Neue blutdrucksenkende mittel und verfahren zu deren herstellung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422649A1 (fr) * 1978-04-10 1979-11-09 Bristol Myers Co Iminoquinazolines et leur utilisation a la preparation de la 6,7-dichloro-1,5-dihydroimidazo(2,1-b)quinazoline-2(3h)-one

Also Published As

Publication number Publication date
IT7826019A0 (it) 1978-07-24
GR72968B (fr) 1984-01-20
AU519688B2 (en) 1981-12-17
MC1199A1 (fr) 1979-03-19
NO150800B (no) 1984-09-10
NZ187921A (en) 1981-03-16
DE2861688D1 (en) 1982-04-29
GB2001638B (en) 1982-02-10
EP0000718A2 (fr) 1979-02-21
NO150800C (no) 1984-12-27
AT363479B (de) 1981-08-10
FI63409C (fi) 1983-06-10
MY8500249A (en) 1985-12-31
EP0000718B1 (fr) 1982-03-24
ES476955A1 (es) 1979-10-16
PH14642A (en) 1981-10-12
DE2832138A1 (de) 1979-02-08
ATA535178A (de) 1981-01-15
AR218500A1 (es) 1980-06-13
CS203014B2 (en) 1981-02-27
IL55183A0 (en) 1978-09-29
FI63409B (fi) 1983-02-28
HU177643B (en) 1981-11-28
IE47280B1 (en) 1984-02-08
FI782248A (fi) 1979-01-26
NL7807507A (nl) 1979-01-29
IL55183A (en) 1981-11-30
EP0000718A3 (en) 1979-06-13
DK328978A (da) 1979-01-26
BR7804763A (pt) 1979-04-10
ES471981A1 (es) 1979-10-16
IE781478L (en) 1979-01-25
CA1094555A (fr) 1981-01-27
AU3812778A (en) 1980-01-24
SE7808111L (sv) 1979-01-26
US4256748A (en) 1981-03-17
NO782541L (no) 1979-01-26
DK144128B (da) 1981-12-14
YU177578A (en) 1983-01-21
FR2398748B1 (fr) 1981-09-04
JPS5441894A (en) 1979-04-03
DK144128C (da) 1982-05-17
GB2001638A (en) 1979-02-07
IT1097337B (it) 1985-08-31
PT68342A (en) 1978-08-01

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