FR2368276A1 - Nouvel antibiotique provenant de streptomyces clavuligerus et son procede de preparation - Google Patents

Nouvel antibiotique provenant de streptomyces clavuligerus et son procede de preparation

Info

Publication number
FR2368276A1
FR2368276A1 FR7603281A FR7603281A FR2368276A1 FR 2368276 A1 FR2368276 A1 FR 2368276A1 FR 7603281 A FR7603281 A FR 7603281A FR 7603281 A FR7603281 A FR 7603281A FR 2368276 A1 FR2368276 A1 FR 2368276A1
Authority
FR
France
Prior art keywords
preparation process
streptomyces clavuligerus
new antibiotic
acid
clavuligerus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7603281A
Other languages
English (en)
Other versions
FR2368276B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Glaxo Wellcome SA
Glaxo Laboratories Ltd
Original Assignee
Laboratoires Glaxo SA
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB540975A external-priority patent/GB1543563A/en
Application filed by Laboratoires Glaxo SA, Glaxo Laboratories Ltd filed Critical Laboratoires Glaxo SA
Publication of FR2368276A1 publication Critical patent/FR2368276A1/fr
Application granted granted Critical
Publication of FR2368276B1 publication Critical patent/FR2368276B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention a pour objet l'acide clavulanique et/ou d'un de ses sels. Pour préparer cet acide on soumet une souche de Streptomyces clavuligerus à culture et on récupère l'acide clavulanique et/ou son sel du milieu de culture. Le composé ci-dessus est un antibiotique de valeur
FR7603281A 1975-02-07 1976-02-06 Nouvel antibiotique provenant de streptomyces clavuligerus et son procede de preparation Granted FR2368276A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB540975A GB1543563A (en) 1975-02-07 1975-02-07 Beta-lactam antibiotic in purified form
GB1107675 1975-03-17

Publications (2)

Publication Number Publication Date
FR2368276A1 true FR2368276A1 (fr) 1978-05-19
FR2368276B1 FR2368276B1 (fr) 1979-03-16

Family

ID=26239868

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7603281A Granted FR2368276A1 (fr) 1975-02-07 1976-02-06 Nouvel antibiotique provenant de streptomyces clavuligerus et son procede de preparation

Country Status (15)

Country Link
US (3) US4490294A (fr)
JP (2) JPS51101994A (fr)
AT (1) AT353409B (fr)
AU (1) AU509313B2 (fr)
CH (1) CH624956A5 (fr)
DE (1) DE2604697A1 (fr)
DK (1) DK141099B (fr)
ES (1) ES444948A1 (fr)
FI (1) FI63580C (fr)
FR (1) FR2368276A1 (fr)
IE (1) IE43790B1 (fr)
IT (2) IT1059403B (fr)
NL (1) NL7601227A (fr)
SE (1) SE421796B (fr)
YU (1) YU40452B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
GB1542405A (en) * 1975-04-15 1979-03-21 Beecham Group Ltd Clavulanic acid derivatives
DE2862254D1 (en) * 1977-12-02 1983-06-16 Beecham Group Plc A process for the preparation of ether derivatives of clavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB9702216D0 (en) * 1997-02-04 1997-03-26 Smithkline Beecham Plc Novel product
GB9702218D0 (en) * 1997-02-04 1997-03-26 Smithkline Beecham Plc Novel product
PT867515E (pt) * 1997-03-24 2000-05-31 Cipan Companhia Ind P De Antib Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel
JPH11254368A (ja) * 1998-03-12 1999-09-21 Central Motor Co Ltd 部材保持装置
MXPA00012930A (es) * 1998-07-03 2002-05-08 Dsm Nv Proceso de fermentacion para producir acido clavulanico en una concentracion baja de aminoacidos libres.
PT102181A (pt) * 1998-07-20 2000-01-31 Dsm Nv Processo melhorado para a producao de acido clavulanico
IL155194A0 (en) * 2000-10-05 2003-11-23 Biogal Pharmaceutical Co Ltd Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US20040072815A1 (en) * 2002-02-12 2004-04-15 Koppel Gary A. Antibiotic composition and method
KR100461278B1 (ko) * 2002-10-23 2004-12-10 현대자동차주식회사 용접 대상물의 위치규제 및 취출장치
BR112020006001A2 (pt) 2017-10-02 2020-10-13 Metabolic Explorer método para produção de sais de ácido orgânico a partir de caldo de fermentação

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754693A (fr) * 1969-08-12 1971-02-11 Lilly Co Eli Nouvel antibiotique et procede pour le preparer
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
DE2604697C2 (fr) 1992-10-29
ES444948A1 (es) 1977-08-16
AT353409B (de) 1979-11-12
IT1066098B (it) 1985-03-04
IE43790B1 (en) 1981-06-03
DK141099B (da) 1980-01-14
US4367175A (en) 1983-01-04
ATA83476A (de) 1979-04-15
YU29076A (en) 1982-08-31
AU1089176A (en) 1977-08-11
NL7601227A (nl) 1976-08-10
FI63580B (fi) 1983-03-31
SE421796B (sv) 1982-02-01
DK141099C (fr) 1980-07-21
CH624956A5 (de) 1981-08-31
US4490295A (en) 1984-12-25
YU40452B (en) 1986-02-28
JPS51101994A (fr) 1976-09-08
IE43790L (en) 1976-08-07
AU509313B2 (en) 1980-05-08
US4490294A (en) 1984-12-25
FI760285A (fr) 1976-08-08
FR2368276B1 (fr) 1979-03-16
IT1059403B (it) 1982-05-31
SE7601337L (sv) 1976-11-03
DK49876A (fr) 1976-08-08
FI63580C (fi) 1983-07-11
JPH0222281A (ja) 1990-01-25
DE2604697A1 (de) 1976-08-19

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Legal Events

Date Code Title Description
TP Transmission of property