FR2361910A1 - Procede pour la production de polysaccharides contenant de l'azote et ayant des proprietes antitumorales, produits obtenus et leur utilisation en tant que medicament - Google Patents
Procede pour la production de polysaccharides contenant de l'azote et ayant des proprietes antitumorales, produits obtenus et leur utilisation en tant que medicamentInfo
- Publication number
- FR2361910A1 FR2361910A1 FR7710263A FR7710263A FR2361910A1 FR 2361910 A1 FR2361910 A1 FR 2361910A1 FR 7710263 A FR7710263 A FR 7710263A FR 7710263 A FR7710263 A FR 7710263A FR 2361910 A1 FR2361910 A1 FR 2361910A1
- Authority
- FR
- France
- Prior art keywords
- extract
- production
- fungus
- substance
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Production d'un polysaccharide, contenant de l'azote, ayant une activité anti-tumeurs, par extraction d'un champignon du groupe des basidiomycètes avec un solvant aqueux. On soumet un champignon, appartenant au genre Coriolus des polyporacées, à une extraction avec une solution alcaline aqueuse (telle qu'une solution de NaOH) dont la concentration est comprise entre 0,01 N et 2 N, puis on raffine l'extrait, ainsi obtenu, en le soumettant à au moins une opération choisie parmi les techniques d'ultrafiltration et d'osmose inverse afin d'éliminer, à partir dudit extrait, les substances de bas poids moléculaires, ayant des poids moléculaires inférieurs à 5 000. Obtention d'une substance qui, sous forme d'une poudre préparée par concentration et cryodessiccation de l'extrait, est de couleur brune, est facilement soluble dans l'eau, la solution étant dépourvue d'une saveur amère et d'une odeur désagréable, une telle substance étant dotée d'un haut pouvoir inhibiteur à l'encontre du développement de tumeurs solides du type sarcome-180 et possédant aussi d'autres très intéressantes propriétés pharmacodynamiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8066476A JPS536412A (en) | 1976-07-07 | 1976-07-07 | Preparation of n-containing polysaccharides |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2361910A1 true FR2361910A1 (fr) | 1978-03-17 |
FR2361910B1 FR2361910B1 (fr) | 1983-01-21 |
Family
ID=13724621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7710263A Granted FR2361910A1 (fr) | 1976-07-07 | 1977-04-05 | Procede pour la production de polysaccharides contenant de l'azote et ayant des proprietes antitumorales, produits obtenus et leur utilisation en tant que medicament |
Country Status (29)
Country | Link |
---|---|
US (2) | US4202969A (fr) |
JP (1) | JPS536412A (fr) |
AR (1) | AR213963A1 (fr) |
AT (1) | AT360145B (fr) |
AU (1) | AU497455B2 (fr) |
BE (1) | BE852987A (fr) |
BG (1) | BG33007A3 (fr) |
BR (1) | BR7703439A (fr) |
CA (1) | CA1072034A (fr) |
CH (1) | CH628649A5 (fr) |
CS (1) | CS219880B2 (fr) |
DD (1) | DD130249A5 (fr) |
DE (2) | DE2713458C2 (fr) |
DK (1) | DK145505C (fr) |
ES (1) | ES457722A1 (fr) |
FR (1) | FR2361910A1 (fr) |
GB (1) | GB1571075A (fr) |
HU (1) | HU175947B (fr) |
IN (1) | IN145169B (fr) |
IT (1) | IT1075700B (fr) |
MX (1) | MX4243E (fr) |
NL (1) | NL169616C (fr) |
PH (1) | PH12242A (fr) |
PL (1) | PL102730B1 (fr) |
RO (1) | RO70328A (fr) |
SE (1) | SE436170B (fr) |
SU (1) | SU730277A3 (fr) |
YU (1) | YU39795B (fr) |
ZA (1) | ZA773442B (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2359203A1 (fr) * | 1976-07-22 | 1978-02-17 | Kureha Chemical Ind Co Ltd | Polysaccharides, leur procede de preparation et medicaments les contenant |
FR2361909A1 (fr) * | 1976-07-07 | 1978-03-17 | Kureha Chemical Ind Co Ltd | Procede pour la preparation de polysaccharides contenant de l'azote, et ayant des proprietes antitumorales, produits obtenus et leur utilisation en tant que medicaments |
FR2444464A1 (fr) * | 1978-12-19 | 1980-07-18 | Fabre Sa Pierre | Proteoglycanes bacteriens purifies, procede pour leur preparation et vaccin les contenant |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4851395A (en) * | 1976-07-07 | 1989-07-25 | Kureha Kagaku Kogyo Kabushiki Kausha | Nitrogen-containing polysaccharide |
JPS5394012A (en) * | 1977-01-27 | 1978-08-17 | Kureha Chem Ind Co Ltd | Novel polysaccharide and its preparation |
JPS5626198A (en) * | 1979-08-08 | 1981-03-13 | Takara Shuzo Co Ltd | Preparation of antitumor substance |
JPS5932480B2 (ja) * | 1981-02-10 | 1984-08-09 | 呉羽化学工業株式会社 | 新規な糖蛋白複合体 |
AU549856B2 (en) * | 1981-02-27 | 1986-02-20 | Otsuka Pharmaceutical Factory, Inc. | Glycoprotein inhibiting toxoplasma multiplication |
US4614733A (en) * | 1981-12-31 | 1986-09-30 | Kureha Kagaku Kogyo Kabushiki Kaisha | Polysaccharides pharmaceutical compositions and the use thereof |
US4417415A (en) * | 1982-04-26 | 1983-11-29 | Battelle Development Corporation | Process for culturing a microalga, and extracting a polysaccharide therefrom |
JPS5913729A (ja) * | 1982-07-15 | 1984-01-24 | Mutsunori Fujiwara | 含窒素多糖体の製造方法 |
JPS5926109U (ja) * | 1982-08-10 | 1984-02-18 | 福井鋲螺株式会社 | 拡開性取付具 |
DE3448151C2 (fr) * | 1983-08-11 | 1989-11-02 | Kureha Kagaku Kogyo K.K., Nihonbashi, Tokio/Tokyo, Jp | |
EP0295956B1 (fr) * | 1987-06-18 | 1996-09-11 | Kureha Kagaku Kogyo Kabushiki Kaisha | Utilisation d'un polysaccharide lié a une protéine pour préparer un médicament destiné au traitement du SIDA. |
CA1339308C (fr) * | 1987-06-18 | 1997-08-19 | Koichi Niimura | Polysaccharides et medicament antiviral renfermant des polysaccharides comme ingredients actifs |
JPH0825890B2 (ja) * | 1987-06-18 | 1996-03-13 | 呉羽化学工業株式会社 | 抗ウイルス剤 |
JPH0643336B2 (ja) * | 1988-06-30 | 1994-06-08 | 呉羽化学工業株式会社 | 血管増殖抑制剤 |
JP2782443B2 (ja) * | 1988-12-26 | 1998-07-30 | 將純 吉原 | 抗エイズウィルス剤 |
CA2156767A1 (fr) * | 1994-08-25 | 1996-02-26 | Kenichi Matsunaga | Agent liant pour facteur de croissance |
US7048932B2 (en) * | 2002-05-22 | 2006-05-23 | The Chinese University Of Hong Kong | Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor |
US7829098B2 (en) * | 2005-11-08 | 2010-11-09 | Vita Green Health Products Co., Ltd | Herbal powder extracts and methods of preparing and using the same |
US7854936B2 (en) * | 2008-01-14 | 2010-12-21 | Active Organics, Inc. | Anti-inflammatory hydrolysate of C. versicolor |
CN103298476A (zh) | 2010-10-06 | 2013-09-11 | 培力有限公司 | 采绒革盖菌提取物及其制备方法和用途 |
CN103113442B (zh) * | 2013-02-28 | 2015-04-22 | 华南理工大学 | 一种从冬虫夏草菌丝体中提取虫草多糖和腺苷的方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2004994A1 (fr) * | 1968-03-28 | 1969-12-05 | Taito Co | |
FR2070133A1 (fr) * | 1969-10-15 | 1971-09-10 | Kureha Chemical Ind Co Ltd | |
FR2193031A1 (fr) * | 1972-07-17 | 1974-02-15 | Ajinomoto Kk | |
JPS4948896A (fr) * | 1972-09-16 | 1974-05-11 | ||
FR2261755A1 (en) * | 1974-02-25 | 1975-09-19 | Thomas Andre | Glyco protein and mucopolysaccharides extraction - from naturally occuring materials fr use in cosmetics |
FR2335235A1 (fr) * | 1975-12-18 | 1977-07-15 | Kureha Chemical Ind Co Ltd | Procede de preparation de substances anti-tumorales |
FR2337144A1 (fr) * | 1976-01-01 | 1977-07-29 | Kureha Chemical Ind Co Ltd | Polysaccharides a liaison de proteine |
FR2361909A1 (fr) * | 1976-07-07 | 1978-03-17 | Kureha Chemical Ind Co Ltd | Procede pour la preparation de polysaccharides contenant de l'azote, et ayant des proprietes antitumorales, produits obtenus et leur utilisation en tant que medicaments |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3436311A (en) * | 1966-02-28 | 1969-04-01 | Pillsbury Co | Fungal polysaccharide composition and method for making same |
US3759896A (en) * | 1968-03-28 | 1973-09-18 | T Yamamoto | Process for manufacture of polysaccharides with antitumor action |
US3436346A (en) * | 1968-06-10 | 1969-04-01 | Pillsbury Co | Process for preparing filterable aqueous polysaccharide solutions |
US3754925A (en) * | 1970-03-24 | 1973-08-28 | Takeda Chemical Industries Ltd | New thermo gelable polysaccharide containing foodstuffs |
US4051314A (en) * | 1970-10-14 | 1977-09-27 | Kureha Kagaku Kogyo Kabushiki Kaisha | Polysaccharides and method for producing same |
US3933788A (en) * | 1971-11-11 | 1976-01-20 | Kelco Company | Polysaccharide and bacterial fermentation process for its preparation |
JPS4924211A (fr) * | 1972-07-01 | 1974-03-04 | ||
JPS5315495A (en) * | 1976-07-22 | 1978-02-13 | Kureha Chem Ind Co Ltd | Preparation of polysaccharides |
JPS5446830A (en) * | 1977-09-16 | 1979-04-13 | Kureha Chem Ind Co Ltd | Pesticide for plant viral disease |
-
1976
- 1976-07-07 JP JP8066476A patent/JPS536412A/ja active Granted
-
1977
- 1977-03-21 YU YU737/77A patent/YU39795B/xx unknown
- 1977-03-21 SE SE7703195A patent/SE436170B/xx not_active IP Right Cessation
- 1977-03-26 DE DE2713458A patent/DE2713458C2/de not_active Expired
- 1977-03-26 DE DE2759978A patent/DE2759978C2/de not_active Expired
- 1977-03-28 IN IN464/CAL/1977A patent/IN145169B/en unknown
- 1977-03-29 BE BE176205A patent/BE852987A/fr not_active IP Right Cessation
- 1977-03-29 GB GB13271/77A patent/GB1571075A/en not_active Expired
- 1977-03-29 CS CS772084A patent/CS219880B2/cs unknown
- 1977-03-30 NL NLAANVRAGE7703434,A patent/NL169616C/xx not_active IP Right Cessation
- 1977-03-30 CA CA275,105A patent/CA1072034A/fr not_active Expired
- 1977-03-30 AT AT219277A patent/AT360145B/de not_active IP Right Cessation
- 1977-03-31 RO RO7789869A patent/RO70328A/fr unknown
- 1977-03-31 CH CH403577A patent/CH628649A5/de not_active IP Right Cessation
- 1977-04-05 DK DK151877A patent/DK145505C/da not_active IP Right Cessation
- 1977-04-05 FR FR7710263A patent/FR2361910A1/fr active Granted
- 1977-04-11 DD DD7700198342A patent/DD130249A5/xx unknown
- 1977-04-12 AU AU24167/77A patent/AU497455B2/en not_active Expired
- 1977-04-12 ES ES457722A patent/ES457722A1/es not_active Expired
- 1977-04-13 PL PL1977197374A patent/PL102730B1/pl unknown
- 1977-04-15 IT IT22507/77A patent/IT1075700B/it active
- 1977-04-19 US US05/788,992 patent/US4202969A/en not_active Expired - Lifetime
- 1977-04-20 SU SU772472207A patent/SU730277A3/ru active
- 1977-05-20 PH PH19793A patent/PH12242A/en unknown
- 1977-05-27 BR BR7703439A patent/BR7703439A/pt unknown
- 1977-06-07 ZA ZA00773442A patent/ZA773442B/xx unknown
- 1977-06-08 MX MX775785U patent/MX4243E/es unknown
- 1977-06-17 AR AR268091A patent/AR213963A1/es active
- 1977-07-06 BG BG7736817A patent/BG33007A3/xx unknown
- 1977-07-07 HU HU77KU518A patent/HU175947B/hu unknown
-
1984
- 1984-03-06 US US06/585,037 patent/US4699787A/en not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2004994A1 (fr) * | 1968-03-28 | 1969-12-05 | Taito Co | |
FR2070133A1 (fr) * | 1969-10-15 | 1971-09-10 | Kureha Chemical Ind Co Ltd | |
FR2193031A1 (fr) * | 1972-07-17 | 1974-02-15 | Ajinomoto Kk | |
JPS4948896A (fr) * | 1972-09-16 | 1974-05-11 | ||
FR2261755A1 (en) * | 1974-02-25 | 1975-09-19 | Thomas Andre | Glyco protein and mucopolysaccharides extraction - from naturally occuring materials fr use in cosmetics |
FR2335235A1 (fr) * | 1975-12-18 | 1977-07-15 | Kureha Chemical Ind Co Ltd | Procede de preparation de substances anti-tumorales |
FR2337144A1 (fr) * | 1976-01-01 | 1977-07-29 | Kureha Chemical Ind Co Ltd | Polysaccharides a liaison de proteine |
FR2361909A1 (fr) * | 1976-07-07 | 1978-03-17 | Kureha Chemical Ind Co Ltd | Procede pour la preparation de polysaccharides contenant de l'azote, et ayant des proprietes antitumorales, produits obtenus et leur utilisation en tant que medicaments |
Non-Patent Citations (1)
Title |
---|
CA1974 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2361909A1 (fr) * | 1976-07-07 | 1978-03-17 | Kureha Chemical Ind Co Ltd | Procede pour la preparation de polysaccharides contenant de l'azote, et ayant des proprietes antitumorales, produits obtenus et leur utilisation en tant que medicaments |
FR2359203A1 (fr) * | 1976-07-22 | 1978-02-17 | Kureha Chemical Ind Co Ltd | Polysaccharides, leur procede de preparation et medicaments les contenant |
FR2444464A1 (fr) * | 1978-12-19 | 1980-07-18 | Fabre Sa Pierre | Proteoglycanes bacteriens purifies, procede pour leur preparation et vaccin les contenant |
EP0013851A1 (fr) * | 1978-12-19 | 1980-08-06 | Pierre Fabre S.A. | Protéoglycanes bactériens purifiés, procédé pour leur préparation et vaccin les contenant |
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