FR2301503A1 - Procede de preparation de 1 alpha, 25-dihydroxycholecalciferol - Google Patents

Procede de preparation de 1 alpha, 25-dihydroxycholecalciferol

Info

Publication number
FR2301503A1
FR2301503A1 FR7604939A FR7604939A FR2301503A1 FR 2301503 A1 FR2301503 A1 FR 2301503A1 FR 7604939 A FR7604939 A FR 7604939A FR 7604939 A FR7604939 A FR 7604939A FR 2301503 A1 FR2301503 A1 FR 2301503A1
Authority
FR
France
Prior art keywords
dihydroxycholecalciferol
alpha
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7604939A
Other languages
English (en)
Other versions
FR2301503B1 (fr
Inventor
Milan Radoje Uskokovic
Thomas Albert Narwid
Jerome Anthony Iacobelli
Enrico Baggiolini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2301503A1 publication Critical patent/FR2301503A1/fr
Application granted granted Critical
Publication of FR2301503B1 publication Critical patent/FR2301503B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7604939A 1975-02-24 1976-02-23 Procede de preparation de 1 alpha, 25-dihydroxycholecalciferol Granted FR2301503A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/552,027 US3993675A (en) 1975-02-24 1975-02-24 Process for the preparation of 1α,25-dihydroxycholecalciferol

Publications (2)

Publication Number Publication Date
FR2301503A1 true FR2301503A1 (fr) 1976-09-17
FR2301503B1 FR2301503B1 (fr) 1980-02-29

Family

ID=24203649

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7604939A Granted FR2301503A1 (fr) 1975-02-24 1976-02-23 Procede de preparation de 1 alpha, 25-dihydroxycholecalciferol

Country Status (9)

Country Link
US (1) US3993675A (fr)
JP (2) JPS591278B2 (fr)
AT (1) AT351187B (fr)
BE (1) BE838823A (fr)
CH (1) CH622533A5 (fr)
DE (1) DE2607322C2 (fr)
FR (1) FR2301503A1 (fr)
GB (2) GB1539062A (fr)
NL (1) NL173172C (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457282A1 (fr) * 1979-05-23 1980-12-19 Roussel Uclaf Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament
EP0028484A1 (fr) * 1979-10-23 1981-05-13 Teijin Limited Procédé de préparation de composés ayant une activité de type vitamine D3 et des cholesta-5,7,diène précurseurs et produits obtenus

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4058538A (en) * 1975-01-27 1977-11-15 The Upjohn Company 3α,5α-Cyclo-6β-alkoxy-α22 -bis-nor cholestene derivatives
US4206131A (en) * 1978-06-19 1980-06-03 The Upjohn Company Compounds and process
JPS557215A (en) * 1978-06-30 1980-01-19 Teijin Ltd Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative
US4225525A (en) * 1979-02-08 1980-09-30 Hoffmann-La Roche Inc. Vitamin D3 metabolite derivatives
US4196133A (en) * 1979-03-05 1980-04-01 Wisconsin Alumni Research Foundation 24,24-Difluoro-25-hydroxycholecalciferol
US4201881A (en) * 1979-03-28 1980-05-06 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4264513A (en) * 1979-05-21 1981-04-28 Wisconsin Alumni Research Foundation 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same
EP0070588B1 (fr) * 1981-07-17 1986-05-07 Duphar International Research B.V Procédé de préparation de dérivés de 1 alpha-hydroxy vitamine D ou de 1 alpha-hydroxy prévitamine D et d'adducts de prévitamine D ou de tachysterol avec des diénophiles appropriés
DE68907483T2 (de) * 1988-04-21 1993-10-21 Leo Pharm Prod Ltd Vitamin d analoge.
US5952317A (en) * 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US8715708B2 (en) * 2005-08-31 2014-05-06 University Of Maryland Cyclic acetal biomaterials
US20210283064A1 (en) * 2020-02-25 2021-09-16 The Chinese University Of Hong Kong Stable, bioadhesive, and diffusion-restrictive coacervate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol
US3901928A (en) * 1973-01-10 1975-08-26 Robert Henry Hesse 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
US3887545A (en) * 1973-11-12 1975-06-03 Hoffmann La Roche Synthesis of 1{60 -hydroxylated cholesterol derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457282A1 (fr) * 1979-05-23 1980-12-19 Roussel Uclaf Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament
EP0028484A1 (fr) * 1979-10-23 1981-05-13 Teijin Limited Procédé de préparation de composés ayant une activité de type vitamine D3 et des cholesta-5,7,diène précurseurs et produits obtenus

Also Published As

Publication number Publication date
NL7601872A (nl) 1976-08-26
ATA126776A (de) 1978-12-15
FR2301503B1 (fr) 1980-02-29
JPS5912666B2 (ja) 1984-03-24
BE838823A (fr) 1976-08-23
GB1539061A (en) 1979-01-24
AT351187B (de) 1979-07-10
CH622533A5 (fr) 1981-04-15
DE2607322A1 (de) 1976-09-02
JPS58116457A (ja) 1983-07-11
US3993675A (en) 1976-11-23
DE2607322C2 (de) 1983-06-01
NL173172C (nl) 1983-12-16
JPS51108050A (fr) 1976-09-25
JPS591278B2 (ja) 1984-01-11
GB1539062A (en) 1979-01-24

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse