FI87766B - Foerfarande foer framstaellning av terapeutiskt aktiva n-(2'-aminofenyl)bensamidderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktiva n-(2'-aminofenyl)bensamidderivat Download PDF

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Publication number
FI87766B
FI87766B FI871733A FI871733A FI87766B FI 87766 B FI87766 B FI 87766B FI 871733 A FI871733 A FI 871733A FI 871733 A FI871733 A FI 871733A FI 87766 B FI87766 B FI 87766B
Authority
FI
Finland
Prior art keywords
aminophenyl
benzamide
prepared
amino
mmol
Prior art date
Application number
FI871733A
Other languages
English (en)
Finnish (fi)
Other versions
FI87766C (sv
FI871733A0 (fi
FI871733A (fi
Inventor
Ute Weiershausen
Gerhard Satzinger
Karl-Otto Vollmer
Wolfgang Herrmann
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863613571 external-priority patent/DE3613571A1/de
Priority claimed from DE19863625359 external-priority patent/DE3625359A1/de
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of FI871733A0 publication Critical patent/FI871733A0/fi
Publication of FI871733A publication Critical patent/FI871733A/fi
Application granted granted Critical
Publication of FI87766B publication Critical patent/FI87766B/fi
Publication of FI87766C publication Critical patent/FI87766C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (6)

1. Förfarande för framställning av terapeutiskt aktiva N-(2’-aminofenyl)bensamidderivat med den allmänna 5 formeln II nh2 .€γ^"0 "" 10 väri R är en osubstituerad eller med hydroxyl substituerad C^-acylaminogrupp, kännetecknat därav, att föreningarna med de allmänna formlerna lila och b: |[1 (III a och b) a) b) väri -COA är en reaktiv syragrupp, R betecknar sanuna som 20 ovan och X är en med en skyddsgrupp försedd aminogrupp eller en nitrogrupp, bringas att reagera med varandra pä ett i och för sig känt sätt och den s& erhällna föreningen med formeln IV ^ ™ väri X och R betecknar samma som ovan, reduceras eller om-30 vandlas medelst avspjälning av skyddsgruppen tili motsva-rande förening med formeln II.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer 4-acetamino-N-(2’-aminofenyl)bensamid. 16 87766
3. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att man framställer 4-isobutyryl-amino-N-(2'-aminofenyl)bensamid.
4. Förfarande enligt patentkravet 1, känne-5 tecknat därav, att man framställer 4-formylamino- N- (2'-aminofenyl)bensamid.
5. Förfarande enligt patentkravet 1, känne-tecknat därav, att man framställer 4-(β-hydroxipro-pionyl)amino-N-(2'-aminofenyl)bensamid. 10
6. Förfarande enligt patentkravet 1, känne- tecknat därav, att man framställer glykoloylamino-N-(2'-aminofenyl)bensamid.
FI871733A 1986-04-22 1987-04-21 Förfarande för framställning av terapeutiskt aktiva N-(2'-aminofenyl)b ensamidderivat FI87766C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3613571 1986-04-22
DE19863613571 DE3613571A1 (de) 1986-04-22 1986-04-22 N-(2'-aminophenyl)-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung neoplastischer erkrankungen
DE19863625359 DE3625359A1 (de) 1986-07-26 1986-07-26 N-(2'-aminophenyl)-benzamid-derivat, verfahren zu dessen herstellung und dessen verwendung bei der bekaempfung neoplastischer erkrankungen
DE3625359 1986-07-26

Publications (4)

Publication Number Publication Date
FI871733A0 FI871733A0 (fi) 1987-04-21
FI871733A FI871733A (fi) 1987-10-23
FI87766B true FI87766B (fi) 1992-11-13
FI87766C FI87766C (sv) 1993-02-25

Family

ID=25843119

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871733A FI87766C (sv) 1986-04-22 1987-04-21 Förfarande för framställning av terapeutiskt aktiva N-(2'-aminofenyl)b ensamidderivat

Country Status (19)

Country Link
US (1) US5137918A (sv)
EP (1) EP0242851B1 (sv)
JP (1) JPH0825977B2 (sv)
CN (1) CN1012498B (sv)
AT (1) AT388913B (sv)
CA (1) CA1334760C (sv)
CS (1) CS262448B2 (sv)
DE (1) DE3763191D1 (sv)
DK (1) DK170771B1 (sv)
ES (1) ES2095824T3 (sv)
FI (1) FI87766C (sv)
GR (1) GR3000562T3 (sv)
HU (1) HU197295B (sv)
IE (1) IE60332B1 (sv)
IL (1) IL82265A (sv)
NO (1) NO168353C (sv)
NZ (1) NZ219974A (sv)
PH (1) PH23928A (sv)
PT (1) PT84737B (sv)

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US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
WO1998047500A1 (en) * 1997-04-24 1998-10-29 Warner-Lambert Company Use of acetyldinaline for the manufacture of a medicament for the treatment of renal cell carcinoma
AP2001002109A0 (en) * 1998-09-25 2001-03-31 Warner Lambert Co Chemotherapy of cancer with acetyldinaline in combination with gemcitabine, capecitabine or cisplatin.
CA2386876A1 (en) * 1999-11-10 2001-05-17 Warner-Lambert Company Combination chemotherapy
CZ20022216A3 (cs) * 2001-07-02 2003-05-14 Warner-Lambert Company Kombinační chemoterapie
AR034897A1 (es) * 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
KR20100107509A (ko) * 2001-09-14 2010-10-05 9222-9129 퀘벡 인코포레이티드 히스톤 데아세틸라아제의 억제제
US6897220B2 (en) * 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
US7868204B2 (en) * 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
TW200426138A (en) * 2002-12-10 2004-12-01 Hoffmann La Roche Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents
TW200424174A (en) * 2003-02-06 2004-11-16 Hoffmann La Roche New TP diamide
US7208491B2 (en) 2003-02-07 2007-04-24 Hoffmann-La Roche Inc. N-monoacylated o-phenylenediamines
TW200424187A (en) 2003-04-04 2004-11-16 Hoffmann La Roche New oxime derivatives and their use as pharmaceutically active agents
KR101153335B1 (ko) * 2003-09-24 2012-07-05 메틸진 인코포레이티드 히스톤 데아세틸라제의 억제제
CA2552279C (en) 2003-12-02 2014-07-15 The Ohio State University Research Foundation Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
US8598168B2 (en) * 2006-04-07 2013-12-03 Methylgene Inc. Inhibitors of histone deacetylase
WO2007136858A2 (en) 2006-05-19 2007-11-29 H. Lee Moffitt Cancer Center & Research Institute Small molecule inhibitors of stat3 with anti-tumor activity
WO2009076234A2 (en) * 2007-12-07 2009-06-18 University Of Maryland, Baltimore Synthesis methods of histone deacetylase inhibitors (hdacis)
WO2010036404A2 (en) * 2008-05-09 2010-04-01 University Of Maryland, Baltimore Novel retinamide retinoic acid metabolism blocking agents
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EP3222628A1 (en) 2008-12-23 2017-09-27 Gilead Pharmasset LLC Nucleoside phosphoramidates
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
US8729130B2 (en) 2011-07-01 2014-05-20 The Broad Institute, Inc. Methods of using novel solid forms of tacedinaline
EP2701699B1 (en) 2011-04-28 2019-10-16 The Broad Institute, Inc. Inhibitors of histone deacetylase
US9790184B2 (en) * 2012-07-27 2017-10-17 The Broad Institute, Inc. Inhibitors of histone deacetylase
WO2014100438A1 (en) 2012-12-20 2014-06-26 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
CN104058983B (zh) * 2014-07-02 2016-01-13 郑攀锋 一种医药原料酰胺类化合物的合成方法

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DE1493783A1 (de) * 1965-07-12 1969-01-30 Goedecke Ag Verfahren zur Herstellung von 2-Amino-4'-(diaethylamino)-2'-methyl-benzanilid
DE1643264A1 (de) * 1967-12-20 1971-06-09 Basf Ag Verfahren zur Herstellung von Aminoaniliden
US4004029A (en) * 1974-05-13 1977-01-18 The Upjohn Company Compositions and method for treating epilepsy and convulsions
DE3305755A1 (de) * 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
CH653670A5 (de) * 1983-03-03 1986-01-15 Hoffmann La Roche Benzamid-derivate.
US4642379A (en) * 1985-08-30 1987-02-10 Eli Lilly And Company Intermediates for anticonvulsant agents

Also Published As

Publication number Publication date
JPH0825977B2 (ja) 1996-03-13
IL82265A0 (en) 1987-10-30
CS273687A2 (en) 1988-07-15
FI87766C (sv) 1993-02-25
CN87103096A (zh) 1987-11-18
EP0242851B1 (de) 1990-06-13
DK198487A (da) 1987-10-23
CN1012498B (zh) 1991-05-01
CS262448B2 (en) 1989-03-14
NO871640D0 (no) 1987-04-21
GR3000562T3 (en) 1991-07-31
NO871640L (no) 1987-10-23
PH23928A (en) 1990-01-23
NZ219974A (en) 1989-08-29
DE3763191D1 (de) 1990-07-19
ATA265187A (de) 1989-02-15
US5137918A (en) 1992-08-11
IE871046L (en) 1987-10-22
JPS63115852A (ja) 1988-05-20
IL82265A (en) 1991-01-31
ES2095824T3 (es) 1997-03-01
NO168353B (no) 1991-11-04
CA1334760C (en) 1995-03-14
FI871733A0 (fi) 1987-04-21
IE60332B1 (en) 1994-06-29
EP0242851A1 (de) 1987-10-28
FI871733A (fi) 1987-10-23
PT84737A (en) 1987-05-01
HU197295B (en) 1989-03-28
DK198487D0 (da) 1987-04-15
DK170771B1 (da) 1996-01-15
NO168353C (no) 1992-02-12
PT84737B (pt) 1989-12-29
HUT43808A (en) 1987-12-28
AT388913B (de) 1989-09-25

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FG Patent granted

Owner name: GOEDECKE AKTIENGESELLSCHAFT

MA Patent expired