FI59391C - Foerfarande foer framstaellning av terapeutiskt verksamma racemiska bisalkanolaminer och deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av terapeutiskt verksamma racemiska bisalkanolaminer och deras syraadditionssalter Download PDF

Info

Publication number
FI59391C
FI59391C FI667/73A FI66773A FI59391C FI 59391 C FI59391 C FI 59391C FI 667/73 A FI667/73 A FI 667/73A FI 66773 A FI66773 A FI 66773A FI 59391 C FI59391 C FI 59391C
Authority
FI
Finland
Prior art keywords
general formula
group
compounds
choh
hal
Prior art date
Application number
FI667/73A
Other languages
English (en)
Finnish (fi)
Other versions
FI59391B (fi
Inventor
Herbert Koeppe
Helmut Staehle
Werner Kummer
Gojko Muacevic
Werner Traunecker
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19722210620 external-priority patent/DE2210620C2/de
Priority claimed from DE19722260620 external-priority patent/DE2260620A1/de
Priority claimed from DE19722260444 external-priority patent/DE2260444A1/de
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Application granted granted Critical
Publication of FI59391B publication Critical patent/FI59391B/fi
Publication of FI59391C publication Critical patent/FI59391C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FI667/73A 1935-11-15 1973-03-05 Foerfarande foer framstaellning av terapeutiskt verksamma racemiska bisalkanolaminer och deras syraadditionssalter FI59391C (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FR157273X 1935-11-15
FR157273X 1935-11-15
DE2210620 1972-03-06
DE19722210620 DE2210620C2 (de) 1972-03-06 1972-03-06 Bis-Phenoxypropanolamine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE19722260620 DE2260620A1 (de) 1972-12-11 1972-12-11 Messerturbomuehle
DE2260620 1972-12-11
DE19722260444 DE2260444A1 (de) 1972-12-11 1972-12-11 Neue bis-alkanol-aminderivate, deren saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2260444 1972-12-11

Publications (2)

Publication Number Publication Date
FI59391B FI59391B (fi) 1981-04-30
FI59391C true FI59391C (fi) 1981-08-10

Family

ID=27431439

Family Applications (1)

Application Number Title Priority Date Filing Date
FI667/73A FI59391C (fi) 1935-11-15 1973-03-05 Foerfarande foer framstaellning av terapeutiskt verksamma racemiska bisalkanolaminer och deras syraadditionssalter

Country Status (12)

Country Link
US (1) US3888898A (ja)
JP (1) JPS5825657B2 (ja)
AT (5) AT325023B (ja)
CH (7) CH601182A5 (ja)
DK (1) DK141660C (ja)
ES (7) ES412333A1 (ja)
FI (1) FI59391C (ja)
FR (1) FR2175055B1 (ja)
GB (1) GB1431341A (ja)
NL (1) NL7303097A (ja)
NO (1) NO137049C (ja)
SE (1) SE413402B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975539A (en) * 1935-11-15 1976-08-17 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing an N,N-bis-(3-phenoxy-2-hydroxy-propyl)-alkylenediamine and method of use
US4024281A (en) * 1972-05-26 1977-05-17 Smithkline Corporation N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines
US4041074A (en) * 1973-07-19 1977-08-09 Imperial Chemical Industries Limited 1-Hydroxyaryl-2-amidoalkylaminoethanol derivatives
US4029783A (en) * 1973-08-03 1977-06-14 Boehringer Mannheim G.M.B.H. N-substituted 1-amino-3-phenoxy-propan-2-ol compounds and therapeutic compositions containing them
FI65987C (fi) * 1973-12-12 1984-08-10 Ici Ltd Foerfarande foer framstaellning av nya terapeutiskt anvaendbara alkanolaminderivat
US4041075A (en) * 1973-12-12 1977-08-09 Imperial Chemical Industries Limited Phenoxy-alkanolamine derivatives
US4139623A (en) * 1974-05-14 1979-02-13 C-G Corp. Cyclic-substituted derivatives of 1-amino-2-propanol
DE2555920C2 (de) * 1974-12-24 1983-12-15 Rohm and Haas Co., 19105 Philadelphia, Pa. Mehrzweckzusatz für Benzin und eine ihn enthaltende Kraftstoffmischung
US4013777A (en) * 1975-08-22 1977-03-22 Smithkline Corporation Bis-phenoxypropanolamines
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
IE47053B1 (en) * 1977-05-23 1983-12-14 Ici Ltd Cardiac stimulants
US4163053A (en) * 1977-12-27 1979-07-31 Schering Corporation Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides
US4351848A (en) * 1978-03-16 1982-09-28 Drug Science Foundation 1-((1-Methylethyl)amino)-3-(((4-alkylthio)1-naphthalenyl)oxy)-2-propanol
DE3068678D1 (en) * 1979-08-10 1984-08-30 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
US4342783A (en) * 1980-06-30 1982-08-03 Synthelabo Anti-glaucoma agent
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
US4751278A (en) * 1987-04-29 1988-06-14 Ciba-Geigy Corporation Adducts of monoepoxides and selected diamines
US6001824A (en) * 1988-02-08 1999-12-14 The Trustees Of Columbia University Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
WO1989007098A1 (en) * 1988-02-08 1989-08-10 The Trustees Of Columbia University In The City Of Butyrl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
JP3356289B2 (ja) * 1995-06-26 2002-12-16 コンキャット リミティド 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
US3541130A (en) * 1967-02-06 1970-11-17 Boehringer Sohn Ingelheim 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
DE1901549B2 (de) * 1968-09-30 1978-04-13 Veb Fahlberg-List, Chemische Und Pharmazeutische Fabriken, Ddr 3011 Magdeburg N,N'-Bis-[3-(2'-äthoxyphenoxy)-2-hydroxypropyl] -ethylendiamin, Verfahren zu dessen Herstellung und Arzneimittel auf dessen Basis
BE754604A (fr) * 1969-08-08 1971-02-08 Boehringer Sohn Ingelheim Le 1-(2-nitrilophenoxy)-2-hydroxy-3-ethyl-aminopropane et ses sels

Also Published As

Publication number Publication date
US3888898A (en) 1975-06-10
ATA157273A (de) 1975-02-15
CH601182A5 (ja) 1978-06-30
NL7303097A (ja) 1973-09-10
DK141660C (da) 1980-10-20
AT323131B (de) 1975-06-25
AU5294473A (en) 1974-09-12
JPS48103532A (ja) 1973-12-25
ES412333A1 (es) 1976-01-01
CH599924A5 (ja) 1978-06-15
NO137049C (no) 1977-12-21
CH605634A5 (ja) 1978-10-13
CH605630A5 (ja) 1978-10-13
AT325022B (de) 1975-09-25
DK141660B (da) 1980-05-19
CH605632A5 (ja) 1978-10-13
AT325023B (de) 1975-09-25
ES431262A1 (es) 1977-02-01
SE413402B (sv) 1980-05-27
ES431261A1 (es) 1977-02-01
AT326107B (de) 1975-11-25
FI59391B (fi) 1981-04-30
NO137049B (no) 1977-09-12
GB1431341A (en) 1976-04-07
ES431265A1 (es) 1976-10-16
CH605633A5 (ja) 1978-10-13
FR2175055A1 (ja) 1973-10-19
AT323132B (de) 1975-06-25
ES431263A1 (es) 1977-02-01
CH605631A5 (ja) 1978-10-13
FR2175055B1 (ja) 1976-08-13
ES431266A1 (es) 1976-10-16
JPS5825657B2 (ja) 1983-05-28
ES431264A1 (es) 1976-10-16

Similar Documents

Publication Publication Date Title
FI59391C (fi) Foerfarande foer framstaellning av terapeutiskt verksamma racemiska bisalkanolaminer och deras syraadditionssalter
KR890001545B1 (ko) 벤자제핀 유도체의 제조방법
FI69066C (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 1-aryloxi-2-hydroxi-3-alkylenaminopropaner samt deras fysiologiskt laempliga syraadditionssalter
FI78479B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara aryloxi-hydroxipropylenpiperazinylacetanilider.
US4423049A (en) 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
FI70406C (fi) Foerfarande foer framstaellning av farmaceutiskt aktivt karbazolyl-(4)-oxipropanolamin-derivat
US4202978A (en) (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
FI66371C (fi) Foerfarande foer framstaellning av heterocykliska oxipropanolaminderivater
US4490369A (en) Benzazepine derivatives, their pharmaceutical compositions and method of use
EP0477778B1 (en) Benzene, pyridine and pyrimidine derivative
CA1062717A (en) 1-aryloxy-2-hydroxy-3-alkinylaminopropanes and processes for production thereof
US3974156A (en) 2-(Substituted anilino) methylmorpholine compounds
NO126734B (ja)
US5082847A (en) Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility
US4363808A (en) N-(3-Phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
JPS6330894B2 (ja)
JPH08268983A (ja) 中間体として有用なアニリン誘導体
US4144340A (en) Basic substituted xanthine derivatives
IL25510A (en) Phenoxypropylamines,their preparation and use
US4281189A (en) Sulfonamide intermediates for adrenergic blocking agents
SU440824A1 (ja)
IE61393B1 (en) Cyclobutenediones useful as intermediates
US4276294A (en) Benzofurylpiperazines
NO132835B (ja)
HU197312B (en) Process for producing tetrahydroisoquinoline derivatives and pharmaceuticals comprising such active ingredient