FI101795B1 - Menetelmiä diritromysiinin muodon II valmistamiseksi ja eristämiseksi sekä välituotteena käyttökelpoinen kiteinen diritromysiinin solvaatti - Google Patents

Menetelmiä diritromysiinin muodon II valmistamiseksi ja eristämiseksi sekä välituotteena käyttökelpoinen kiteinen diritromysiinin solvaatti

Info

Publication number: FI101795B1
Authority: FI; Finland
Prior art keywords: dirithromycin; solvate; isolation; useful; preparation
Prior art date: 1991-04-29

Application number

FI921877A

Other languages

English (en)

Swedish (sv)

Other versions

FI921877A0 (fi

FI921877A (fi

FI101795B (fi

Inventor

James Michael Greene

Holly Marie Hankins

Gregory Alan Stephenson

David Dale Wirth

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-29

Filing date

1992-04-27

Publication date

1998-08-31

1992-04-27 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1992-04-27 Publication of FI921877A0 publication Critical patent/FI921877A0/fi

1992-10-30 Publication of FI921877A publication Critical patent/FI921877A/fi

1998-08-31 Application granted granted Critical

1998-08-31 Publication of FI101795B1 publication Critical patent/FI101795B1/fi

1998-08-31 Publication of FI101795B publication Critical patent/FI101795B/fi

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Formation And Processing Of Food Products (AREA)

FI921877A 1991-04-29 1992-04-27 Menetelmiä diritromysiinin muodon II valmistamiseksi ja eristämiseksi sekä välituotteena käyttökelpoinen kiteinen diritromysiinin solvaatti FI101795B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US69284291A	1991-04-29	1991-04-29
US69284291		1991-04-29

Publications (4)

Publication Number	Publication Date
FI921877A0 FI921877A0 (fi)	1992-04-27
FI921877A FI921877A (fi)	1992-10-30
FI101795B1 true FI101795B1 (fi)	1998-08-31
FI101795B FI101795B (fi)	1998-08-31

Family

ID=24782254

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI921876A FI921876A (fi)	1991-04-29	1992-04-27	Farmaceutisk komposition innehaollande diritromycin
FI921877A FI101795B (fi)	1991-04-29	1992-04-27	Menetelmiä diritromysiinin muodon II valmistamiseksi ja eristämiseksi sekä välituotteena käyttökelpoinen kiteinen diritromysiinin solvaatti

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
FI921876A FI921876A (fi)	1991-04-29	1992-04-27	Farmaceutisk komposition innehaollande diritromycin

Country Status (27)

Country	Link
EP (2)	EP0511800B1 (fi)
JP (2)	JP3333545B2 (fi)
KR (2)	KR100194307B1 (fi)
CN (2)	CN1069197C (fi)
AT (2)	ATE144425T1 (fi)
AU (2)	AU655978B2 (fi)
BR (2)	BR9201540A (fi)
CA (2)	CA2067275C (fi)
CY (2)	CY1946A (fi)
CZ (2)	CZ282021B6 (fi)
DE (2)	DE69214710T2 (fi)
DK (2)	DK0511800T3 (fi)
ES (2)	ES2093779T3 (fi)
FI (2)	FI921876A (fi)
GR (2)	GR3020439T3 (fi)
HK (2)	HK153696A (fi)
HU (2)	HU215917B (fi)
IE (2)	IE76296B1 (fi)
IL (2)	IL101705A (fi)
MX (2)	MX9201946A (fi)
MY (2)	MY114226A (fi)
NO (2)	NO180450C (fi)
NZ (2)	NZ242505A (fi)
RU (2)	RU2070203C1 (fi)
TW (2)	TW216399B (fi)
YU (2)	YU44392A (fi)
ZA (2)	ZA922776B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW271400B (fi) *	1992-07-30	1996-03-01	Pfizer
CR5278A (es) *	1995-03-24	1996-07-04	Lilly Co Eli	Formulacion oral de 2-metil-tieno-benzodiacepina
DE29724846U1 (de) *	1996-07-29	2004-12-16	Abbott Laboratories, Abbott Park	Herstellung von kristalliner Form II von Clarithromycin
ID21762A (id) *	1996-09-24	1999-07-22	Lilly Co Eli	Formulasi partikel bersaput
US6390690B1 (en)	2000-05-17	2002-05-21	3M Innovative Properties Company	Fiber optic connector for coupling devices on intersecting planes
CN101547931B (zh) *	2006-12-05	2012-11-14	辉瑞有限公司	促动内酯多晶型
CN102145008B (zh) *	2010-12-29	2013-06-05	辰欣药业股份有限公司	一种地红霉素药物组合物及其制备方法
CN107151261B (zh) *	2017-06-09	2020-06-12	广州大光制药有限公司	一种地红霉素化合物的晶型及其结晶制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT342770B (de) *	1975-04-07	1978-04-25	Thomae Gmbh Dr K	Verfahren zur herstellung neuer erythromycinderivate
DE2515075C2 (de) *	1975-04-07	1985-10-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Erythromycinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0184921A3 (en) *	1984-12-08	1986-10-29	Beecham Group Plc	Erythromycin derivatives
DE3524572A1 (de) *	1985-07-10	1987-01-15	Thomae Gmbh Dr K	Feste arzneimittelformen zur peroralen anwendung enthaltend 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethyliden)-oxy)-(9s)-erythromycin und verfahren zu ihrer herstellung

1992
- 1992-04-15 ZA ZA922776A patent/ZA922776B/xx unknown
- 1992-04-15 ZA ZA922777A patent/ZA922777B/xx unknown
- 1992-04-24 YU YU44392A patent/YU44392A/sh unknown
- 1992-04-24 IL IL10170592A patent/IL101705A/en active IP Right Grant
- 1992-04-24 YU YU44492A patent/YU44492A/sh unknown
- 1992-04-27 ES ES92303753T patent/ES2093779T3/es not_active Expired - Lifetime
- 1992-04-27 HU HU9203168A patent/HU215917B/hu not_active IP Right Cessation
- 1992-04-27 NZ NZ242505A patent/NZ242505A/xx not_active IP Right Cessation
- 1992-04-27 CZ CS921276A patent/CZ282021B6/cs not_active IP Right Cessation
- 1992-04-27 CZ CS921277A patent/CZ282218B6/cs not_active IP Right Cessation
- 1992-04-27 DK DK92303753.5T patent/DK0511800T3/da active
- 1992-04-27 CA CA002067275A patent/CA2067275C/en not_active Expired - Fee Related
- 1992-04-27 ES ES92303752T patent/ES2088098T3/es not_active Expired - Lifetime
- 1992-04-27 HU HU9201398A patent/HU213613B/hu not_active IP Right Cessation
- 1992-04-27 MY MYPI92000718A patent/MY114226A/en unknown
- 1992-04-27 BR BR929201540A patent/BR9201540A/pt not_active Application Discontinuation
- 1992-04-27 DE DE69214710T patent/DE69214710T2/de not_active Expired - Fee Related
- 1992-04-27 FI FI921876A patent/FI921876A/fi not_active Application Discontinuation
- 1992-04-27 JP JP10732592A patent/JP3333545B2/ja not_active Expired - Fee Related
- 1992-04-27 BR BR929201541A patent/BR9201541A/pt not_active Application Discontinuation
- 1992-04-27 NO NO921616A patent/NO180450C/no unknown
- 1992-04-27 CN CN92103161A patent/CN1069197C/zh not_active Expired - Fee Related
- 1992-04-27 CY CY194692A patent/CY1946A/xx unknown
- 1992-04-27 JP JP04107514A patent/JP3135672B2/ja not_active Expired - Fee Related
- 1992-04-27 DE DE69211220T patent/DE69211220T2/de not_active Expired - Fee Related
- 1992-04-27 IE IE921346A patent/IE76296B1/en not_active IP Right Cessation
- 1992-04-27 CN CN92103160A patent/CN1030611C/zh not_active Expired - Fee Related
- 1992-04-27 MY MYPI92000719A patent/MY109498A/en unknown
- 1992-04-27 MX MX9201946A patent/MX9201946A/es not_active IP Right Cessation
- 1992-04-27 KR KR1019920007116A patent/KR100194307B1/ko not_active IP Right Cessation
- 1992-04-27 IE IE921345A patent/IE74885B1/en not_active IP Right Cessation
- 1992-04-27 DK DK92303752.7T patent/DK0511799T3/da active
- 1992-04-27 FI FI921877A patent/FI101795B/fi active
- 1992-04-27 RU SU925011639A patent/RU2070203C1/ru not_active IP Right Cessation
- 1992-04-27 AT AT92303753T patent/ATE144425T1/de not_active IP Right Cessation
- 1992-04-27 CA CA002067274A patent/CA2067274C/en not_active Expired - Fee Related
- 1992-04-27 RU SU925011642A patent/RU2045953C1/ru not_active IP Right Cessation
- 1992-04-27 EP EP92303753A patent/EP0511800B1/en not_active Expired - Lifetime
- 1992-04-27 IL IL101704A patent/IL101704A/en not_active IP Right Cessation
- 1992-04-27 EP EP92303752A patent/EP0511799B1/en not_active Expired - Lifetime
- 1992-04-27 KR KR1019920007117A patent/KR100193742B1/ko not_active IP Right Cessation
- 1992-04-27 MX MX9201944A patent/MX9201944A/es unknown
- 1992-04-27 NZ NZ242506A patent/NZ242506A/xx not_active IP Right Cessation
- 1992-04-27 NO NO921617A patent/NO179504C/no unknown
- 1992-04-27 AT AT92303752T patent/ATE138924T1/de not_active IP Right Cessation
- 1992-04-28 AU AU15257/92A patent/AU655978B2/en not_active Ceased
- 1992-04-28 AU AU15255/92A patent/AU646734B2/en not_active Ceased
- 1992-06-09 TW TW081103332A patent/TW216399B/zh active
- 1992-06-09 TW TW081103328A patent/TW315371B/zh active
1996
- 1996-07-02 GR GR960401812T patent/GR3020439T3/el unknown
- 1996-08-08 HK HK153696A patent/HK153696A/xx not_active IP Right Cessation
- 1996-11-20 GR GR960403099T patent/GR3021706T3/el unknown
- 1996-12-12 HK HK215096A patent/HK215096A/xx not_active IP Right Cessation
1997
- 1997-09-05 CY CY197597A patent/CY1975A/xx unknown

Also Published As

Publication number	Publication date
RU2070203C1 (ru)	1996-12-10
IL101705A0 (en)	1992-12-30
ES2093779T3 (es)	1997-01-01
HU215917B (hu)	1999-03-29
NO180450B (no)	1997-01-13
GR3021706T3 (en)	1997-02-28
FI921876A0 (fi)	1992-04-27
KR920019364A (ko)	1992-11-19
AU1525592A (en)	1992-11-05
MX9201944A (es)	1992-11-01
DK0511800T3 (da)	1997-04-21
KR100193742B1 (ko)	1999-06-15
FI921877A0 (fi)	1992-04-27
IE74885B1 (en)	1997-08-13
FI921876A (fi)	1992-10-30
EP0511799A1 (en)	1992-11-04
DE69211220T2 (de)	1996-11-07
EP0511799B1 (en)	1996-06-05
CN1069197C (zh)	2001-08-08
NO179504C (no)	1996-10-23
NO921616L (no)	1992-10-30
ATE138924T1 (de)	1996-06-15
IE76296B1 (en)	1997-10-08
JPH05117154A (ja)	1993-05-14
IE921345A1 (en)	1992-11-04
ZA922776B (en)	1993-10-15
HU9201398D0 (en)	1992-07-28
AU646734B2 (en)	1994-03-03
GR3020439T3 (en)	1996-10-31
HK215096A (en)	1996-12-13
CS127792A3 (en)	1992-11-18
NO921617D0 (no)	1992-04-27
CA2067274C (en)	2002-10-15
DE69214710D1 (de)	1996-11-28
NZ242505A (en)	1993-06-25
HUT62595A (en)	1993-05-28
DE69214710T2 (de)	1997-03-13
EP0511800A1 (en)	1992-11-04
TW315371B (fi)	1997-09-11
AU1525792A (en)	1992-11-05
RU2045953C1 (ru)	1995-10-20
YU44392A (sh)	1994-12-28
CY1946A (en)	1992-04-27
CN1030611C (zh)	1996-01-03
HU213613B (en)	1997-08-28
JP3333545B2 (ja)	2002-10-15
CA2067275A1 (en)	1992-10-30
FI921877A (fi)	1992-10-30
DK0511799T3 (da)	1996-06-24
JPH05117289A (ja)	1993-05-14
AU655978B2 (en)	1995-01-19
HUT63956A (en)	1993-11-29
TW216399B (fi)	1993-11-21
MY109498A (en)	1997-02-28
ZA922777B (en)	1993-10-15
YU44492A (sh)	1994-06-24
CN1066270A (zh)	1992-11-18
CZ282021B6 (cs)	1997-04-16
CA2067275C (en)	2002-11-26
FI101795B (fi)	1998-08-31
CS127692A3 (en)	1992-11-18
HK153696A (en)	1996-08-16
IL101705A (en)	1996-01-31
CA2067274A1 (en)	1992-10-30
NO921617L (no)	1992-10-30
ATE144425T1 (de)	1996-11-15
NZ242506A (en)	1993-09-27
NO921616D0 (no)	1992-04-27
IE921346A1 (en)	1992-11-04
NO180450C (no)	1997-04-23
MY114226A (en)	2002-09-30
KR100194307B1 (ko)	1999-06-15
BR9201540A (pt)	1992-12-01
IL101704A0 (en)	1992-12-30
CN1066186A (zh)	1992-11-18
HU9203168D0 (en)	1992-12-28
DE69211220D1 (de)	1996-07-11
CZ282218B6 (cs)	1997-06-11
KR920019365A (ko)	1992-11-19
IL101704A (en)	1998-02-22
ES2088098T3 (es)	1996-08-01
MX9201946A (es)	1992-11-01
BR9201541A (pt)	1992-12-01
JP3135672B2 (ja)	2001-02-19
EP0511800B1 (en)	1996-10-23
CY1975A (en)	1997-09-05
NO179504B (no)	1996-07-15

Publication	Publication Date	Title
AU531146B2 (en)	1983-08-11	Piperidine derivatives
AU536463B2 (en)	1984-05-10	Piperidine derivatives
DK536288D0 (da)	1988-09-27	2-anilino-pyrimidin-derivater
FI942345A0 (fi)	1994-05-20	Menetelmä proliiniboronaattiesterin valmistamiseksi
DK295288A (da)	1988-12-02	(1h-azol-1-ylmethyl)substituerede benzotriazolderivater
DK0606248T3 (da)	2003-06-23	Heteroarylaminer som hidtil ukendte acetylcholinesteraseinhibitorer
IT1217284B (it)	1990-03-22	Dispositivo di regolazione per la sincronizzazione di alcuni azionamenti
NO920965D0 (no)	1992-03-12	Fremgangsmaate for fremstilling av etylen-alfa-olefinkopolymerer
FI101795B1 (fi)	1998-08-31	Menetelmiä diritromysiinin muodon II valmistamiseksi ja eristämiseksi sekä välituotteena käyttökelpoinen kiteinen diritromysiinin solvaatti
NO895195D0 (no)	1989-12-21	Fremgangsmaate for fremstilling av piperidinderivater samtmellomprodukter.
NO920049D0 (no)	1992-01-03	Fremgangsmaate for fremstilling av 3-eksometylencefamsulfoksydestere
FI923624A (fi)	1993-03-14	Dubbelt tillslutbart och avloppsventilsystem med foerbaettrad stroemningshanteringsegenskap
IT1231519B (it)	1991-12-07	Composizioni poliolefiniche per pellicole foto-biodegradabili
PT87359A (pt)	1989-05-31	Process for the preparation of pyrrolidine derivatives
NO942218D0 (no)	1994-06-13	Fremgangsmåte for fremstilling av karbonatsammensetning
AU6020280A (en)	1981-02-12	Drill table height adjustment
FR2614392B1 (fr)	1989-10-13	Four crematoire perfectionne
FI923360A (fi)	1993-01-25	Foerfarande foer framstaellning av dimetylacetoacetamid
IT8947902A0 (it)	1989-05-02	Procedimento per preparare composti antibiotici
NO921538D0 (no)	1992-04-21	Fremgangsmaate for fremstilling av et glycidylazid-polymerazid
KR930009339U (ko)	1993-05-26	프리크랙 발생용 복식지그
NO933622D0 (no)	1993-10-08	Benzendimetanol som er egnet for mikronisering
DK299184D0 (da)	1984-06-19	Vaekstinhibitor for cariogene bakterier
ES2032573T3 (es)	1993-02-16	Procedimiento de preparacion de derivados de 4,4-dimetil-tetrahidropir-2-ona.
ATE93197T1 (de)	1993-09-15	Abschliessbare dose.