ES8407061A1 - Procedimiento para la obtencion de liposomas unilaminares. - Google Patents

Procedimiento para la obtencion de liposomas unilaminares.

Info

Publication number
ES8407061A1
ES8407061A1 ES519810A ES519810A ES8407061A1 ES 8407061 A1 ES8407061 A1 ES 8407061A1 ES 519810 A ES519810 A ES 519810A ES 519810 A ES519810 A ES 519810A ES 8407061 A1 ES8407061 A1 ES 8407061A1
Authority
ES
Spain
Prior art keywords
aqueous phase
liposomes
lipids
unilamellar liposomes
spontaneous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519810A
Other languages
English (en)
Other versions
ES519810A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES519810A0 publication Critical patent/ES519810A0/es
Publication of ES8407061A1 publication Critical patent/ES8407061A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LIPOSOMAS UNILAMINARES.CONSISTEN EN: A) DISPERSAR UN LIPIDO DE FORMULA (I) O UN LIPIDO ADICIONAL EN FASE ACUOSA A PH SUPERIOR A 7 CON ADICION DE UNA SOLUCION BASICA FISIOLOGICAMENTE TOLERABLE; Y B) DISPERSAR UN LIPIDO DE FORMULA (I) O UN LIPIDO ADICIONAL EN FASE ACUOSA CON ADICION DE UN ACIDO FISIOLOGICAMENTE TOLERABLE TAL COMO LISOFOSFATIDICO, FOSFATIDICO, O PH INFERIOR A 7 Y NEUTRALIZAR LA FASE ACUOSA, PARA OBTENER LIPOSOMAS UNILAMINARES, LOS CUALES SON ENRIQUECIDOS Y/O SEPARADOS POSTERIORMENTE, DONDE M ES 0 O 1; R1Y R2 ES H, HIDROXI, ALQUILO INFERIOR C 1 A 4, Y OTROS; R3 ES HIDROGENO O ALQUILO INFERIOR CON C 1 A 4; R4 ES H, ALQUILO INFERIOR CON C 1 A 7, UN RESTO CARBOHIDRATADO CON C 5 A 12 Y OTROS.TIENE APLICACION COMO SOPORTES DE SUSTANCIAS ACTIVAS TALES COMO PROTEINAS, ANTICUERPOS, ENZIMAS, HORMONAS, VITAMINAS O GENES.
ES519810A 1982-02-17 1983-02-15 Procedimiento para la obtencion de liposomas unilaminares. Expired ES8407061A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH98182 1982-02-17
CH23783 1983-01-17

Publications (2)

Publication Number Publication Date
ES519810A0 ES519810A0 (es) 1984-08-16
ES8407061A1 true ES8407061A1 (es) 1984-08-16

Family

ID=25683978

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519810A Expired ES8407061A1 (es) 1982-02-17 1983-02-15 Procedimiento para la obtencion de liposomas unilaminares.

Country Status (14)

Country Link
US (1) US4619794A (es)
EP (1) EP0088046B1 (es)
AU (1) AU558810B2 (es)
CA (1) CA1219215A (es)
DE (1) DE3374837D1 (es)
DK (1) DK157063C (es)
ES (1) ES8407061A1 (es)
FI (1) FI79245C (es)
GR (1) GR81377B (es)
IE (1) IE54642B1 (es)
IL (1) IL67916A0 (es)
NO (1) NO168154C (es)
NZ (1) NZ203299A (es)
PT (1) PT76245B (es)

Families Citing this family (574)

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EP0088046B1 (de) 1987-12-09
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AU558810B2 (en) 1987-02-12
CA1219215A (en) 1987-03-17
NO830521L (no) 1983-08-18
IE54642B1 (en) 1989-12-20
US4619794A (en) 1986-10-28
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DK67483D0 (da) 1983-02-16
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DK67483A (da) 1983-08-18
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FI830486L (fi) 1983-08-18
FI79245B (fi) 1989-08-31
GR81377B (es) 1984-12-11
FI79245C (fi) 1989-12-11
EP0088046A2 (de) 1983-09-07
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NO168154B (no) 1991-10-14
PT76245A (de) 1983-03-01

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